HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 1

External ID: CHEMBL2340378

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2013
Volume: 23
Issue: 6
First Page: 1636
Last Page: 1638
DOI: 10.1016/j.bmcl.2013.01.084

Target ChEMBL ID: CHEMBL261
ChEMBL Target Name: Carbonic anhydrase I
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
790	Ki	=	790000	nM	Outside typical range
1.2	Ki	=	1200	nM
118000	Ki	=	118000000	nM	Outside typical range
310	Ki	=	310000	nM	Outside typical range
12000	Ki	=	12000000	nM	Outside typical range
31700	Ki	=	31700000	nM	Outside typical range
15000	Ki	=	15000000	nM	Outside typical range
63000	Ki	=	63000000	nM	Outside typical range
300000	Ki	>	300000000	nM	Outside typical range
570	Ki	=	570000	nM	Outside typical range
660	Ki	=	660000	nM	Outside typical range
25770	Ki	=	25770000	nM	Outside typical range
107	Ki	=	107000	nM	Outside typical range
310	Ki	=	310000	nM	Outside typical range
8.7	Ki	=	8700	nM
640	Ki	=	640000	nM	Outside typical range
0.7	Ki	=	700	nM
300	Ki	=	300000	nM	Outside typical range
0.5	Ki	=	500	nM
0.6	Ki	=	600	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 2

External ID: CHEMBL2340377

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2013
Volume: 23
Issue: 6
First Page: 1636
Last Page: 1638
DOI: 10.1016/j.bmcl.2013.01.084

Target ChEMBL ID: CHEMBL205
ChEMBL Target Name: Carbonic anhydrase II
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
3100	Ki	=	3100000	nM	Outside typical range
1510	Ki	=	1510000	nM	Outside typical range
112000	Ki	=	112000000	nM	Outside typical range
1130	Ki	=	1130000	nM	Outside typical range
85000	Ki	=	85000000	nM	Outside typical range
49200	Ki	=	49200000	nM	Outside typical range
73000	Ki	=	73000000	nM	Outside typical range
200000	Ki	>	200000000	nM	Outside typical range
300000	Ki	>	300000000	nM	Outside typical range
830	Ki	=	830000	nM	Outside typical range
920	Ki	=	920000	nM	Outside typical range
48500	Ki	=	48500000	nM	Outside typical range
84	Ki	=	84000	nM
760	Ki	=	760000	nM	Outside typical range
8.8	Ki	=	8800	nM
950	Ki	=	950000	nM	Outside typical range
30	Ki	=	30000	nM
26000	Ki	=	26000000	nM	Outside typical range
20	Ki	=	20000	nM
40	Ki	=	40000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL2340376

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2013
Volume: 23
Issue: 6
First Page: 1636
Last Page: 1638
DOI: 10.1016/j.bmcl.2013.01.084

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
5	Ki	=	5000	nM
830	Ki	=	830000	nM	Outside typical range
720	Ki	=	720000	nM	Outside typical range
73	Ki	=	73000	nM
750	Ki	=	750000	nM	Outside typical range
440	Ki	=	440000	nM	Outside typical range
660	Ki	=	660000	nM	Outside typical range
820	Ki	=	820000	nM	Outside typical range
4080	Ki	=	4080000	nM	Outside typical range
550	Ki	=	550000	nM	Outside typical range
340	Ki	=	340000	nM	Outside typical range
660	Ki	=	660000	nM	Outside typical range
920	Ki	=	920000	nM	Outside typical range
540	Ki	=	540000	nM	Outside typical range
380	Ki	=	380000	nM	Outside typical range
560	Ki	=	560000	nM	Outside typical range
600	Ki	=	600000	nM	Outside typical range
6050	Ki	=	6050000	nM	Outside typical range
760	Ki	=	760000	nM	Outside typical range
690	Ki	=	690000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL2342885

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2013
Volume: 23
Issue: 6
First Page: 1626
Last Page: 1630
DOI: 10.1016/j.bmcl.2013.01.087

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
7.4	Ki	=	7400	nM
800	Ki	=	800000	nM	Outside typical range
650	Ki	=	650000	nM	Outside typical range
72	Ki	=	72000	nM
500	Ki	=	500000	nM	Outside typical range
92	Ki	=	92000	nM
420	Ki	=	420000	nM	Outside typical range
570	Ki	=	570000	nM	Outside typical range
670	Ki	=	670000	nM	Outside typical range
480	Ki	=	480000	nM	Outside typical range
450	Ki	=	450000	nM	Outside typical range
750	Ki	=	750000	nM	Outside typical range
930	Ki	=	930000	nM	Outside typical range
750	Ki	=	750000	nM	Outside typical range
180	Ki	=	180000	nM	Outside typical range
680	Ki	=	680000	nM	Outside typical range
630	Ki	=	630000	nM	Outside typical range
700	Ki	=	700000	nM	Outside typical range
540	Ki	=	540000	nM	Outside typical range
580	Ki	=	580000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 2

External ID: CHEMBL2343319

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem Lett
Year: 2013
Volume: 23
Issue: 6
First Page: 1626
Last Page: 1630
DOI: 10.1016/j.bmcl.2013.01.087

Target ChEMBL ID: CHEMBL205
ChEMBL Target Name: Carbonic anhydrase II
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
63000	Ki	=	63000000	nM	Outside typical range
3100	Ki	=	3100000	nM	Outside typical range
1510	Ki	=	1510000	nM	Outside typical range
112000	Ki	=	112000000	nM	Outside typical range
1130	Ki	=	1130000	nM	Outside typical range
85000	Ki	=	85000000	nM	Outside typical range
49200	Ki	=	49200000	nM	Outside typical range
73000	Ki	=	73000000	nM	Outside typical range
200000	Ki	>	200000000	nM	Outside typical range
300000	Ki	>	300000000	nM	Outside typical range
830	Ki	=	830000	nM	Outside typical range
920	Ki	=	920000	nM	Outside typical range
48500	Ki	=	48500000	nM	Outside typical range
84	Ki	=	84000	nM
460	Ki	=	460000	nM	Outside typical range
570	Ki	=	570000	nM	Outside typical range
950	Ki	=	950000	nM	Outside typical range
26000	Ki	=	26000000	nM	Outside typical range
760	Ki	=	760000	nM	Potential transcription error
20	Ki	=	20000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL2343318

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2013
Volume: 23
Issue: 6
First Page: 1626
Last Page: 1630
DOI: 10.1016/j.bmcl.2013.01.087

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
570	Ki	=	570000	nM	Outside typical range
8	Ki	=	8000	nM
460	Ki	=	460000	nM	Outside typical range
24500	Ki	=	24500000	nM	Outside typical range
4	Ki	=	4000	nM
660	Ki	=	660000	nM	Outside typical range
6	Ki	=	6000	nM
840	Ki	=	840000	nM	Outside typical range
620	Ki	=	620000	nM	Outside typical range
710	Ki	=	710000	nM	Outside typical range
530	Ki	=	530000	nM	Outside typical range
900	Ki	=	900000	nM	Outside typical range
830	Ki	=	830000	nM	Outside typical range
870	Ki	=	870000	nM	Outside typical range
690	Ki	=	690000	nM	Outside typical range
660	Ki	=	660000	nM	Outside typical range
860	Ki	=	860000	nM	Outside typical range
710	Ki	=	710000	nM	Outside typical range
50900	Ki	=	50900000	nM	Outside typical range
620	Ki	=	620000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3997502

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem
Year: 2017
Volume: 25
Issue: 6
First Page: 2010
Last Page: 2015
DOI: 10.1016/j.bmc.2017.02.032

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
7100	Ki	=	7100000	nM	Outside typical range
320	Ki	=	320000	nM	Outside typical range
100000	Ki	>	100000000	nM	Outside typical range
6500	Ki	=	6500000	nM	Outside typical range
89	Ki	=	89000	nM
3000	Ki	=	3000000	nM	Outside typical range
92	Ki	=	92000	nM
8600	Ki	=	8600000	nM	Outside typical range
8200	Ki	=	8200000	nM	Outside typical range
100000	Ki	>	100000000	nM	Outside typical range
6000	Ki	=	6000000	nM	Outside typical range
12700	Ki	=	12700000	nM	Outside typical range
34100	Ki	=	34100000	nM	Outside typical range
100000	Ki	>	100000000	nM	Outside typical range
6000	Ki	=	6000000	nM	Outside typical range
3400	Ki	=	3400000	nM	Outside typical range
15600	Ki	=	15600000	nM	Outside typical range
8000	Ki	=	8000000	nM	Outside typical range
100000	Ki	>	100000000	nM	Outside typical range
13000	Ki	=	13000000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL2073325

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2012
Volume: 22
Issue: 17
First Page: 5630
Last Page: 5634
DOI: 10.1016/j.bmcl.2012.06.106

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
480	Ki	=	480000	nM	Outside typical range
4	Ki	=	4000	nM
490	Ki	=	490000	nM	Outside typical range
570	Ki	=	570000	nM	Outside typical range
9	Ki	=	9000	nM
33200	Ki	=	33200000	nM	Outside typical range
5	Ki	=	5000	nM
39300	Ki	=	39300000	nM	Outside typical range
820	Ki	=	820000	nM	Outside typical range
41700	Ki	=	41700000	nM	Outside typical range
520	Ki	=	520000	nM	Outside typical range
530	Ki	=	530000	nM	Outside typical range
690	Ki	=	690000	nM	Outside typical range
84600	Ki	=	84600000	nM	Outside typical range
750	Ki	=	750000	nM	Outside typical range
60	Ki	=	60000	nM
670	Ki	=	670000	nM	Outside typical range
800	Ki	=	800000	nM	Outside typical range
860	Ki	=	860000	nM	Outside typical range
790	Ki	=	790000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL2073326

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2012
Volume: 22
Issue: 17
First Page: 5630
Last Page: 5634
DOI: 10.1016/j.bmcl.2012.06.106

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
5	Ki	=	5000	nM
830	Ki	=	830000	nM	Outside typical range
720	Ki	=	720000	nM	Outside typical range
73	Ki	=	73000	nM
750	Ki	=	750000	nM	Outside typical range
440	Ki	=	440000	nM	Outside typical range
660	Ki	=	660000	nM	Outside typical range
820	Ki	=	820000	nM	Outside typical range
4080	Ki	=	4080000	nM	Outside typical range
550	Ki	=	550000	nM	Outside typical range
340	Ki	=	340000	nM	Outside typical range
660	Ki	=	660000	nM	Outside typical range
920	Ki	=	920000	nM	Outside typical range
540	Ki	=	540000	nM	Outside typical range
380	Ki	=	380000	nM	Outside typical range
560	Ki	=	560000	nM	Outside typical range
600	Ki	=	600000	nM	Outside typical range
6050	Ki	=	6050000	nM	Outside typical range
760	Ki	=	760000	nM	Outside typical range
690	Ki	=	690000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 2

External ID: CHEMBL2406403

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem Lett
Year: 2013
Volume: 23
Issue: 14
First Page: 4067
Last Page: 4071
DOI: 10.1016/j.bmcl.2013.05.063

Target ChEMBL ID: CHEMBL205
ChEMBL Target Name: Carbonic anhydrase II
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
63000	Ki	=	63000000	nM	Outside typical range
3100	Ki	=	3100000	nM	Outside typical range
1500	Ki	=	1500000	nM	Outside typical range
112000	Ki	=	112000000	nM	Outside typical range
1130	Ki	=	1130000	nM	Outside typical range
85000	Ki	=	85000000	nM	Outside typical range
49200	Ki	=	49200000	nM	Outside typical range
73000	Ki	=	73000000	nM	Outside typical range
200000	Ki	>	200000000	nM	Outside typical range
300000	Ki	>	300000000	nM	Outside typical range
830	Ki	=	830000	nM	Outside typical range
920	Ki	=	920000	nM	Outside typical range
48500	Ki	=	48500000	nM	Outside typical range
84	Ki	=	84000	nM
460	Ki	=	460000	nM	Outside typical range
570	Ki	=	570000	nM	Outside typical range
950	Ki	=	950000	nM	Outside typical range
26000	Ki	=	26000000	nM	Outside typical range
760	Ki	=	760000	nM	Potential transcription error
20	Ki	=	20000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL4044729

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem
Year: 2017
Volume: 25
Issue: 17
First Page: 4800
Last Page: 4804
DOI: 10.1016/j.bmc.2017.07.033

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
100000	Ki	>	100000000	nM	Outside typical range
310	Ki	=	310000	nM	Outside typical range
100000	Ki	>	100000000	nM	Outside typical range
9400	Ki	=	9400000	nM	Outside typical range
91	Ki	=	91000	nM
7400	Ki	=	7400000	nM	Outside typical range
90	Ki	=	90000	nM
12800	Ki	=	12800000	nM	Outside typical range
100000	Ki	>	100000000	nM	Outside typical range
100000	Ki	>	100000000	nM	Outside typical range
4900	Ki	=	4900000	nM	Outside typical range
100000	Ki	>	100000000	nM	Outside typical range
9300	Ki	=	9300000	nM	Outside typical range
100000	Ki	>	100000000	nM	Outside typical range
9400	Ki	=	9400000	nM	Outside typical range
100000	Ki	>	100000000	nM	Outside typical range
23500	Ki	=	23500000	nM	Outside typical range
4200	Ki	=	4200000	nM	Outside typical range
19600	Ki	=	19600000	nM	Outside typical range
100000	Ki	>	100000000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL2415219

Protocol: N/A

Comment: Journal: Bioorg Med Chem
Year: 2013
Volume: 21
Issue: 15
First Page: 4472
Last Page: 4476
DOI: 10.1016/j.bmc.2013.05.058

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
7530	Ki	=	7530000	nM	Outside typical range
19600	Ki	=	19600000	nM	Outside typical range
6340	Ki	=	6340000	nM	Outside typical range
61	Ki	=	61000	nM
8320	Ki	=	8320000	nM	Outside typical range
680	Ki	=	680000	nM	Outside typical range
13500	Ki	=	13500000	nM	Outside typical range
100000	Ki	>	100000000	nM	Outside typical range
9120	Ki	=	9120000	nM	Outside typical range
3160	Ki	=	3160000	nM	Outside typical range
1530	Ki	=	1530000	nM	Outside typical range
8130	Ki	=	8130000	nM	Outside typical range
10300	Ki	=	10300000	nM	Outside typical range
9270	Ki	=	9270000	nM	Outside typical range
9250	Ki	=	9250000	nM	Outside typical range
8920	Ki	=	8920000	nM	Outside typical range
19200	Ki	=	19200000	nM	Outside typical range
23700	Ki	=	23700000	nM	Outside typical range
45900	Ki	=	45900000	nM	Outside typical range
9600	Ki	=	9600000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL2415218

Protocol: N/A

Comment: Journal: Bioorg Med Chem
Year: 2013
Volume: 21
Issue: 15
First Page: 4472
Last Page: 4476
DOI: 10.1016/j.bmc.2013.05.058

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
9600	Ki	=	9600000	nM	Outside typical range
8360	Ki	=	8360000	nM	Outside typical range
8910	Ki	=	8910000	nM	Outside typical range
97	Ki	=	97000	nM
10400	Ki	=	10400000	nM	Outside typical range
1010	Ki	=	1010000	nM	Outside typical range
9740	Ki	=	9740000	nM	Outside typical range
15100	Ki	=	15100000	nM	Outside typical range
12700	Ki	=	12700000	nM	Outside typical range
1440	Ki	=	1440000	nM	Outside typical range
1370	Ki	=	1370000	nM	Outside typical range
5210	Ki	=	5210000	nM	Outside typical range
2050	Ki	=	2050000	nM	Outside typical range
5720	Ki	=	5720000	nM	Outside typical range
2340	Ki	=	2340000	nM	Outside typical range
4240	Ki	=	4240000	nM	Outside typical range
16500	Ki	=	16500000	nM	Outside typical range
8230	Ki	=	8230000	nM	Outside typical range
20100	Ki	=	20100000	nM	Outside typical range
5590	Ki	=	5590000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Trypanosoma cruzi

External ID: CHEMBL2415217

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem
Year: 2013
Volume: 21
Issue: 15
First Page: 4472
Last Page: 4476
DOI: 10.1016/j.bmc.2013.05.058

Target ChEMBL ID: CHEMBL368
ChEMBL Target Name: Trypanosoma cruzi
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
700	Ki	=	700000	nM	Outside typical range
1120	Ki	=	1120000	nM	Outside typical range
660	Ki	=	660000	nM	Outside typical range
120	Ki	=	120000	nM	Outside typical range
580	Ki	=	580000	nM	Outside typical range
620	Ki	=	620000	nM	Outside typical range
690	Ki	=	690000	nM	Outside typical range
6900	Ki	=	6900000	nM	Outside typical range
900	Ki	=	900000	nM	Outside typical range
720	Ki	=	720000	nM	Outside typical range
710	Ki	=	710000	nM	Outside typical range
760	Ki	=	760000	nM	Outside typical range
650	Ki	=	650000	nM	Outside typical range
780	Ki	=	780000	nM	Outside typical range
93	Ki	=	93000	nM
800	Ki	=	800000	nM	Outside typical range
24300	Ki	=	24300000	nM	Outside typical range
80	Ki	=	80000	nM
44	Ki	=	44000	nM
7100	Ki	=	7100000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL2214978

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2012
Volume: 22
Issue: 23
First Page: 7142
Last Page: 7145
DOI: 10.1016/j.bmcl.2012.09.065

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
340	Ki	=	340000	nM	Outside typical range
510	Ki	=	510000	nM	Outside typical range
15700	Ki	=	15700000	nM	Outside typical range
7600	Ki	=	7600000	nM	Outside typical range
10000	Ki	=	10000000	nM	Outside typical range
5	Ki	=	5000	nM
980	Ki	=	980000	nM	Outside typical range
760	Ki	=	760000	nM	Outside typical range
410	Ki	=	410000	nM	Outside typical range
660	Ki	=	660000	nM	Outside typical range
32900	Ki	=	32900000	nM	Outside typical range
650	Ki	=	650000	nM	Outside typical range
350	Ki	=	350000	nM	Outside typical range
490	Ki	=	490000	nM	Outside typical range
870	Ki	=	870000	nM	Outside typical range
520	Ki	=	520000	nM	Outside typical range
400	Ki	=	400000	nM	Outside typical range
380	Ki	=	380000	nM	Outside typical range
760	Ki	=	760000	nM	Outside typical range
200000	Ki	>	200000000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 2

External ID: CHEMBL2214975

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem Lett
Year: 2012
Volume: 22
Issue: 23
First Page: 7142
Last Page: 7145
DOI: 10.1016/j.bmcl.2012.09.065

Target ChEMBL ID: CHEMBL205
ChEMBL Target Name: Carbonic anhydrase II
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
1510	Ki	=	1510000	nM	Outside typical range
112000	Ki	=	112000000	nM	Outside typical range
85000	Ki	=	85000000	nM	Outside typical range
73000	Ki	=	73000000	nM	Outside typical range
200000	Ki	>	200000000	nM	Outside typical range
390	Ki	=	390000	nM	Outside typical range
300000	Ki	>	300000000	nM	Outside typical range
830	Ki	=	830000	nM	Outside typical range
920	Ki	=	920000	nM	Outside typical range
48500	Ki	=	48500000	nM	Outside typical range
84	Ki	=	84000	nM
460	Ki	=	460000	nM	Outside typical range
570	Ki	=	570000	nM	Outside typical range
950	Ki	=	950000	nM	Outside typical range
26000	Ki	=	26000000	nM	Outside typical range
760	Ki	=	760000	nM	Potential transcription error
20	Ki	=	20000	nM
40	Ki	=	40000	nM
35000	Ki	=	35000000	nM	Outside typical range
200000	Ki	>	200000000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 1

External ID: CHEMBL2214976

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2012
Volume: 22
Issue: 23
First Page: 7142
Last Page: 7145
DOI: 10.1016/j.bmcl.2012.09.065

Target ChEMBL ID: CHEMBL261
ChEMBL Target Name: Carbonic anhydrase I
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
1.2	Ki	=	1200	nM
118000	Ki	=	118000000	nM	Outside typical range
12000	Ki	=	12000000	nM	Outside typical range
15000	Ki	=	15000000	nM	Outside typical range
63000	Ki	=	63000000	nM	Outside typical range
21	Ki	=	21000	nM
300000	Ki	>	300000000	nM	Outside typical range
570	Ki	=	570000	nM	Outside typical range
660	Ki	=	660000	nM	Outside typical range
25770	Ki	=	25770000	nM	Outside typical range
107	Ki	=	107000	nM	Outside typical range
790	Ki	=	790000	nM	Outside typical range
540	Ki	=	540000	nM	Outside typical range
640	Ki	=	640000	nM	Outside typical range
300	Ki	=	300000	nM	Outside typical range
310	Ki	=	310000	nM	Outside typical range
0.5	Ki	=	500	nM
0.6	Ki	=	600	nM
7000	Ki	=	7000000	nM	Outside typical range
200000	Ki	>	200000000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase

External ID: CHEMBL2406401

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2013
Volume: 23
Issue: 14
First Page: 4067
Last Page: 4071
DOI: 10.1016/j.bmcl.2013.05.063

Target ChEMBL ID: CHEMBL3932
ChEMBL Target Name: Carbonic anhydrase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment	Data Validity Comment
6800	Ki	=	6800000	nM		Outside typical range
	Ki				Not Determined
5800	Ki	=	5800000	nM		Outside typical range
	Ki				Not Determined
	Ki				Not Determined
42000	Ki	=	42000000	nM		Outside typical range
	Ki				Not Determined
6700	Ki	=	6700000	nM		Outside typical range
200000	Ki	>	200000000	nM		Outside typical range
200000	Ki	>	200000000	nM		Outside typical range
	Ki				Not Determined
	Ki				Not Determined
	Ki				Not Determined
	Ki				Not Determined
	Ki				Not Determined
	Ki				Not Determined
	Ki				Not Determined
160000	Ki	=	160000000	nM		Outside typical range
	Ki				Not Determined
680	Ki	=	680000	nM		Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL2406399

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2013
Volume: 23
Issue: 14
First Page: 4067
Last Page: 4071
DOI: 10.1016/j.bmcl.2013.05.063

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
3100	Ki	=	3100000	nM	Outside typical range
4	Ki	=	4000	nM
73	Ki	=	73000	nM
85500	Ki	=	85500000	nM	Outside typical range
9.2	Ki	=	9200	nM
960	Ki	=	960000	nM	Outside typical range
90	Ki	=	90000	nM
890	Ki	=	890000	nM	Outside typical range
8700	Ki	=	8700000	nM	Outside typical range
950	Ki	=	950000	nM	Outside typical range
10800	Ki	=	10800000	nM	Outside typical range
16700	Ki	=	16700000	nM	Outside typical range
78900	Ki	=	78900000	nM	Outside typical range
8700	Ki	=	8700000	nM	Outside typical range
89500	Ki	=	89500000	nM	Outside typical range
18500	Ki	=	18500000	nM	Outside typical range
71600	Ki	=	71600000	nM	Outside typical range
8700	Ki	=	8700000	nM	Outside typical range
7700	Ki	=	7700000	nM	Outside typical range
41	Ki	=	41000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 2

External ID: CHEMBL4044725

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem
Year: 2017
Volume: 25
Issue: 17
First Page: 4800
Last Page: 4804
DOI: 10.1016/j.bmc.2017.07.033

Target ChEMBL ID: CHEMBL205
ChEMBL Target Name: Carbonic anhydrase II
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
63000	Ki	=	63000000	nM	Outside typical range
3100	Ki	=	3100000	nM	Outside typical range
1500	Ki	=	1500000	nM	Outside typical range
112000	Ki	=	112000000	nM	Outside typical range
1130	Ki	=	1130000	nM	Outside typical range
85000	Ki	=	85000000	nM	Outside typical range
49200	Ki	=	49200000	nM	Outside typical range
73000	Ki	=	73000000	nM	Outside typical range
200000	Ki	>	200000000	nM	Outside typical range
300000	Ki	>	300000000	nM	Outside typical range
830	Ki	=	830000	nM	Outside typical range
920	Ki	=	920000	nM	Outside typical range
48500	Ki	=	48500000	nM	Outside typical range
84	Ki	=	84000	nM
760	Ki	=	760000	nM	Outside typical range
8.8	Ki	=	8800	nM
200000	Ki	=	200000000	nM	Outside typical range
30	Ki	=	30000	nM
26000	Ki	=	26000000	nM	Outside typical range
20	Ki	=	20000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3750045

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2016
Volume: 24
Issue: 4
First Page: 835
Last Page: 840
DOI: 10.1016/j.bmc.2016.01.005

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
8800	Ki	=	8800000	nM	Outside typical range
580	Ki	=	580000	nM	Outside typical range
100000	Ki	>	100000000	nM	Outside typical range
8300	Ki	=	8300000	nM	Outside typical range
8	Ki	=	8000	nM
1700	Ki	=	1700000	nM	Outside typical range
38	Ki	=	38000	nM
1400	Ki	=	1400000	nM	Outside typical range
9400	Ki	=	9400000	nM	Outside typical range
100000	Ki	>	100000000	nM	Outside typical range
1800	Ki	=	1800000	nM	Outside typical range
5100	Ki	=	5100000	nM	Outside typical range
7300	Ki	=	7300000	nM	Outside typical range
4500	Ki	=	4500000	nM	Outside typical range
4300	Ki	=	4300000	nM	Outside typical range
5800	Ki	=	5800000	nM	Outside typical range
4700	Ki	=	4700000	nM	Outside typical range
2500	Ki	=	2500000	nM	Outside typical range
8700	Ki	=	8700000	nM	Outside typical range
4400	Ki	=	4400000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase

External ID: CHEMBL3595048

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem
Year: 2015
Volume: 23
Issue: 15
First Page: 4405
Last Page: 4409
DOI: 10.1016/j.bmc.2015.06.021

Target ChEMBL ID: CHEMBL3932
ChEMBL Target Name: Carbonic anhydrase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment	Data Validity Comment
6800	Ki	=	6800000	nM		Outside typical range
	Ki				Not Determined
5800	Ki	=	5800000	nM		Outside typical range
	Ki				Not Determined
	Ki				Not Determined
42000	Ki	=	42000000	nM		Outside typical range
	Ki				Not Determined
6700	Ki	=	6700000	nM		Outside typical range
200000	Ki	>	200000000	nM		Outside typical range
200000	Ki	>	200000000	nM		Outside typical range
	Ki				Not Determined
	Ki				Not Determined
	Ki				Not Determined
	Ki				Not Determined
	Ki				Not Determined
	Ki				Not Determined
	Ki				Not Determined
	Ki				Not Determined
90	Ki	=	90000	nM
160000	Ki	=	160000000	nM		Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL4044726

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem
Year: 2017
Volume: 25
Issue: 17
First Page: 4800
Last Page: 4804
DOI: 10.1016/j.bmc.2017.07.033

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
7100	Ki	=	7100000	nM	Outside typical range
320	Ki	=	320000	nM	Outside typical range
100000	Ki	>	100000000	nM	Outside typical range
6500	Ki	=	6500000	nM	Outside typical range
89	Ki	=	89000	nM
3000	Ki	=	3000000	nM	Outside typical range
92	Ki	=	92000	nM
8600	Ki	=	8600000	nM	Outside typical range
8200	Ki	=	8200000	nM	Outside typical range
100000	Ki	>	100000000	nM	Outside typical range
6000	Ki	=	6000000	nM	Outside typical range
12700	Ki	=	12700000	nM	Outside typical range
34100	Ki	=	34100000	nM	Outside typical range
100000	Ki	>	100000000	nM	Outside typical range
6000	Ki	=	6000000	nM	Outside typical range
3400	Ki	=	3400000	nM	Outside typical range
15600	Ki	=	15600000	nM	Outside typical range
6800	Ki	=	6800000	nM	Outside typical range
8000	Ki	=	8000000	nM	Outside typical range
100000	Ki	>	100000000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3595049

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem
Year: 2015
Volume: 23
Issue: 15
First Page: 4405
Last Page: 4409
DOI: 10.1016/j.bmc.2015.06.021

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
3100	Ki	=	3100000	nM	Outside typical range
4	Ki	=	4000	nM
73	Ki	=	73000	nM
85500	Ki	=	85500000	nM	Outside typical range
9.2	Ki	=	9200	nM
960	Ki	=	960000	nM	Outside typical range
90	Ki	=	90000	nM
890	Ki	=	890000	nM	Outside typical range
8700	Ki	=	8700000	nM	Outside typical range
950	Ki	=	950000	nM	Outside typical range
10800	Ki	=	10800000	nM	Outside typical range
16700	Ki	=	16700000	nM	Outside typical range
78900	Ki	=	78900000	nM	Outside typical range
8700	Ki	=	8700000	nM	Outside typical range
910	Ki	=	910000	nM	Outside typical range
97	Ki	=	97000	nM
18500	Ki	=	18500000	nM	Outside typical range
71600	Ki	=	71600000	nM	Outside typical range
710	Ki	=	710000	nM	Outside typical range
8700	Ki	=	8700000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 2

External ID: CHEMBL3595047

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem
Year: 2015
Volume: 23
Issue: 15
First Page: 4405
Last Page: 4409
DOI: 10.1016/j.bmc.2015.06.021

Target ChEMBL ID: CHEMBL205
ChEMBL Target Name: Carbonic anhydrase II
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
63000	Ki	=	63000000	nM	Outside typical range
3100	Ki	=	3100000	nM	Outside typical range
1500	Ki	=	1500000	nM	Outside typical range
112000	Ki	=	112000000	nM	Outside typical range
1130	Ki	=	1130000	nM	Outside typical range
85000	Ki	=	85000000	nM	Outside typical range
49200	Ki	=	49200000	nM	Outside typical range
73000	Ki	=	73000000	nM	Outside typical range
200000	Ki	>	200000000	nM	Outside typical range
300000	Ki	>	300000000	nM	Outside typical range
830	Ki	=	830000	nM	Outside typical range
920	Ki	=	920000	nM	Outside typical range
48500	Ki	=	48500000	nM	Outside typical range
84	Ki	=	84000	nM
86	Ki	=	86000	nM
8.8	Ki	=	8800	nM
570	Ki	=	570000	nM	Outside typical range
950	Ki	=	950000	nM	Outside typical range
30	Ki	=	30000	nM
26000	Ki	=	26000000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3595050

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem
Year: 2015
Volume: 23
Issue: 15
First Page: 4405
Last Page: 4409
DOI: 10.1016/j.bmc.2015.06.021

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
8800	Ki	=	8800000	nM	Outside typical range
800	Ki	=	800000	nM	Outside typical range
30500	Ki	=	30500000	nM	Outside typical range
8500	Ki	=	8500000	nM	Outside typical range
81	Ki	=	81000	nM
4500	Ki	=	4500000	nM	Outside typical range
84	Ki	=	84000	nM
2400	Ki	=	2400000	nM	Outside typical range
100000	Ki	>	100000000	nM	Outside typical range
100000	Ki	>	100000000	nM	Outside typical range
5400	Ki	=	5400000	nM	Outside typical range
7700	Ki	=	7700000	nM	Outside typical range
9100	Ki	=	9100000	nM	Outside typical range
9500	Ki	=	9500000	nM	Outside typical range
8000	Ki	=	8000000	nM	Outside typical range
8900	Ki	=	8900000	nM	Outside typical range
7600	Ki	=	7600000	nM	Outside typical range
6400	Ki	=	6400000	nM	Outside typical range
6000	Ki	=	6000000	nM	Outside typical range
8900	Ki	=	8900000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3595051

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem
Year: 2015
Volume: 23
Issue: 15
First Page: 4405
Last Page: 4409
DOI: 10.1016/j.bmc.2015.06.021

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
6700	Ki	=	6700000	nM	Outside typical range
960	Ki	=	960000	nM	Outside typical range
100000	Ki	>	100000000	nM	Outside typical range
6100	Ki	=	6100000	nM	Outside typical range
82	Ki	=	82000	nM
6200	Ki	=	6200000	nM	Outside typical range
87	Ki	=	87000	nM
2500	Ki	=	2500000	nM	Outside typical range
100000	Ki	>	100000000	nM	Outside typical range
100000	Ki	>	100000000	nM	Outside typical range
6700	Ki	=	6700000	nM	Outside typical range
8500	Ki	=	8500000	nM	Outside typical range
100000	Ki	>	100000000	nM	Outside typical range
9100	Ki	=	9100000	nM	Outside typical range
7800	Ki	=	7800000	nM	Outside typical range
34600	Ki	=	34600000	nM	Outside typical range
100000	Ki	>	100000000	nM	Outside typical range
8000	Ki	=	8000000	nM	Outside typical range
1700	Ki	=	1700000	nM	Outside typical range
100000	Ki	>	100000000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 2

External ID: CHEMBL1781043

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem Lett
Year: 2011
Volume: 21
Issue: 12
First Page: 3591
Last Page: 3595
DOI: 10.1016/j.bmcl.2011.04.105

Target ChEMBL ID: CHEMBL205
ChEMBL Target Name: Carbonic anhydrase II
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
63000	Ki	=	63000000	nM	Outside typical range
3100	Ki	=	3100000	nM	Outside typical range
1510	Ki	=	1510000	nM	Outside typical range
112000	Ki	=	112000000	nM	Outside typical range
1130	Ki	=	1130000	nM	Outside typical range
85000	Ki	=	85000000	nM	Outside typical range
49200	Ki	=	49200000	nM	Outside typical range
73000	Ki	=	73000000	nM	Outside typical range
200000	Ki	>	200000000	nM	Outside typical range
300000	Ki	>	300000000	nM	Outside typical range
830	Ki	=	830000	nM	Outside typical range
920	Ki	=	920000	nM	Outside typical range
970	Ki	=	970000	nM	Outside typical range
750	Ki	=	750000	nM	Outside typical range
86	Ki	=	86000	nM
8.8	Ki	=	8800	nM
950	Ki	=	950000	nM	Outside typical range
690	Ki	=	690000	nM	Outside typical range
30	Ki	=	30000	nM
26000	Ki	=	26000000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 1

External ID: CHEMBL1953638

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem Lett
Year: 2012
Volume: 22
Issue: 3
First Page: 1314
Last Page: 1316
DOI: 10.1016/j.bmcl.2011.12.085

Target ChEMBL ID: CHEMBL261
ChEMBL Target Name: Carbonic anhydrase I
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
660	Ki	=	660000	nM	Outside typical range
990	Ki	=	990000	nM	Outside typical range
110	Ki	=	110000	nM	Outside typical range
85	Ki	=	85000	nM
790	Ki	=	790000	nM	Outside typical range
8.7	Ki	=	8700	nM
101	Ki	=	101000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL1781046

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem Lett
Year: 2011
Volume: 21
Issue: 12
First Page: 3591
Last Page: 3595
DOI: 10.1016/j.bmcl.2011.04.105

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
700	Ki	=	700000	nM	Outside typical range
320	Ki	=	320000	nM	Outside typical range
920	Ki	=	920000	nM	Outside typical range
48400	Ki	=	48400000	nM	Outside typical range
8.8	Ki	=	8800	nM
640	Ki	=	640000	nM	Outside typical range
9.1	Ki	=	9100	nM
540	Ki	=	540000	nM	Outside typical range
940	Ki	=	940000	nM	Outside typical range
970	Ki	=	970000	nM	Outside typical range
250	Ki	=	250000	nM	Outside typical range
220	Ki	=	220000	nM	Outside typical range
74900	Ki	=	74900000	nM	Outside typical range
85200	Ki	=	85200000	nM	Outside typical range
640	Ki	=	640000	nM	Outside typical range
890	Ki	=	890000	nM	Outside typical range
69000	Ki	=	69000000	nM	Outside typical range
63400	Ki	=	63400000	nM	Outside typical range
720	Ki	=	720000	nM	Outside typical range
800	Ki	=	800000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase

External ID: CHEMBL1953640

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem Lett
Year: 2012
Volume: 22
Issue: 3
First Page: 1314
Last Page: 1316
DOI: 10.1016/j.bmcl.2011.12.085

Target ChEMBL ID: CHEMBL1944499
ChEMBL Target Name: Astrosclerin-3
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
450	Ki	=	450000	nM	Outside typical range
27800	Ki	=	27800000	nM	Outside typical range
880	Ki	=	880000	nM	Outside typical range
8.9	Ki	=	8900	nM
22800	Ki	=	22800000	nM	Outside typical range
72	Ki	=	72000	nM
13500	Ki	=	13500000	nM	Outside typical range
76300	Ki	=	76300000	nM	Outside typical range
13	Ki	=	13000	nM
940	Ki	=	940000	nM	Outside typical range
670	Ki	=	670000	nM	Outside typical range
750	Ki	=	750000	nM	Outside typical range
88100	Ki	=	88100000	nM	Outside typical range
680	Ki	=	680000	nM	Outside typical range
770	Ki	=	770000	nM	Outside typical range
76700	Ki	=	76700000	nM	Outside typical range
710	Ki	=	710000	nM	Outside typical range
390	Ki	=	390000	nM	Outside typical range
230	Ki	=	230000	nM	Outside typical range
10400	Ki	=	10400000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 2

External ID: CHEMBL1953639

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem Lett
Year: 2012
Volume: 22
Issue: 3
First Page: 1314
Last Page: 1316
DOI: 10.1016/j.bmcl.2011.12.085

Target ChEMBL ID: CHEMBL205
ChEMBL Target Name: Carbonic anhydrase II
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
920	Ki	=	920000	nM	Outside typical range
970	Ki	=	970000	nM	Outside typical range
750	Ki	=	750000	nM	Outside typical range
86	Ki	=	86000	nM
460	Ki	=	460000	nM	Outside typical range
8.8	Ki	=	8800	nM
690	Ki	=	690000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3095734

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2013
Volume: 23
Issue: 24
First Page: 6706
Last Page: 6710
DOI: 10.1016/j.bmcl.2013.10.037

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
4100	Ki	=	4100000	nM	Outside typical range
360	Ki	=	360000	nM	Outside typical range
4200	Ki	=	4200000	nM	Outside typical range
470	Ki	=	470000	nM	Outside typical range
9	Ki	=	9000	nM
2100	Ki	=	2100000	nM	Outside typical range
7	Ki	=	7000	nM
650	Ki	=	650000	nM	Outside typical range
7900	Ki	=	7900000	nM	Outside typical range
4800	Ki	=	4800000	nM	Outside typical range
1200	Ki	=	1200000	nM	Outside typical range
3300	Ki	=	3300000	nM	Outside typical range
2700	Ki	=	2700000	nM	Outside typical range
9200	Ki	=	9200000	nM	Outside typical range
3600	Ki	=	3600000	nM	Outside typical range
2100	Ki	=	2100000	nM	Outside typical range
2500	Ki	=	2500000	nM	Outside typical range
63400	Ki	=	63400000	nM	Outside typical range
4900	Ki	=	4900000	nM	Outside typical range
1000	Ki	=	1000000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 1

External ID: CHEMBL1648929

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem
Year: 2011
Volume: 19
Issue: 1
First Page: 243
Last Page: 248
DOI: 10.1016/j.bmc.2010.11.031

Target ChEMBL ID: CHEMBL261
ChEMBL Target Name: Carbonic anhydrase I
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
570	Ki	=	570000	nM	Outside typical range
660	Ki	=	660000	nM	Outside typical range
990	Ki	=	990000	nM	Outside typical range
110	Ki	=	110000	nM	Outside typical range
85	Ki	=	85000	nM
8.7	Ki	=	8700	nM
920	Ki	=	920000	nM	Outside typical range
0.31	Ki	=	310	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL1781047

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem Lett
Year: 2011
Volume: 21
Issue: 12
First Page: 3591
Last Page: 3595
DOI: 10.1016/j.bmcl.2011.04.105

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
320	Ki	=	320000	nM	Outside typical range
6.7	Ki	=	6700	nM
750	Ki	=	750000	nM	Outside typical range
72000	Ki	=	72000000	nM	Outside typical range
6.2	Ki	=	6200	nM
27900	Ki	=	27900000	nM	Outside typical range
16.3	Ki	=	16300	nM
6530	Ki	=	6530000	nM	Outside typical range
710	Ki	=	710000	nM	Outside typical range
630	Ki	=	630000	nM	Outside typical range
490	Ki	=	490000	nM	Outside typical range
370	Ki	=	370000	nM	Outside typical range
940	Ki	=	940000	nM	Outside typical range
16200	Ki	=	16200000	nM	Outside typical range
920	Ki	=	920000	nM	Outside typical range
510	Ki	=	510000	nM	Outside typical range
830	Ki	=	830000	nM	Outside typical range
58300	Ki	=	58300000	nM	Outside typical range
310	Ki	=	310000	nM	Outside typical range
640	Ki	=	640000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 2

External ID: CHEMBL1648930

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem
Year: 2011
Volume: 19
Issue: 1
First Page: 243
Last Page: 248
DOI: 10.1016/j.bmc.2010.11.031

Target ChEMBL ID: CHEMBL205
ChEMBL Target Name: Carbonic anhydrase II
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
830	Ki	=	830000	nM	Outside typical range
920	Ki	=	920000	nM	Outside typical range
970	Ki	=	970000	nM	Outside typical range
750	Ki	=	750000	nM	Outside typical range
86	Ki	=	86000	nM
8.8	Ki	=	8800	nM
950	Ki	=	950000	nM	Outside typical range
0.76	Ki	=	760	nM	Potential transcription error

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 2

External ID: CHEMBL3095740

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem Lett
Year: 2013
Volume: 23
Issue: 24
First Page: 6706
Last Page: 6710
DOI: 10.1016/j.bmcl.2013.10.037

Target ChEMBL ID: CHEMBL205
ChEMBL Target Name: Carbonic anhydrase II
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
63000	Ki	=	63000000	nM	Outside typical range
3100	Ki	=	3100000	nM	Outside typical range
1510	Ki	=	1510000	nM	Outside typical range
112000	Ki	=	112000000	nM	Outside typical range
1130	Ki	=	1130000	nM	Outside typical range
85000	Ki	=	85000000	nM	Outside typical range
49200	Ki	=	49200000	nM	Outside typical range
73000	Ki	=	73000000	nM	Outside typical range
200000	Ki	>	200000000	nM	Outside typical range
300000	Ki	>	300000000	nM	Outside typical range
830	Ki	=	830000	nM	Outside typical range
920	Ki	=	920000	nM	Outside typical range
48500	Ki	=	48500000	nM	Outside typical range
84	Ki	=	84000	nM
460	Ki	=	460000	nM	Outside typical range
570	Ki	=	570000	nM	Outside typical range
950	Ki	=	950000	nM	Outside typical range
26000	Ki	=	26000000	nM	Outside typical range
760	Ki	=	760000	nM	Potential transcription error
20	Ki	=	20000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3830507

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2016
Volume: 24
Issue: 18
First Page: 4410
Last Page: 4414
DOI: 10.1016/j.bmc.2016.07.034

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
4980	Ki	=	4980000	nM	Outside typical range
530	Ki	=	530000	nM	Outside typical range
9190	Ki	=	9190000	nM	Outside typical range
6670	Ki	=	6670000	nM	Outside typical range
68	Ki	=	68000	nM
960	Ki	=	960000	nM	Outside typical range
50	Ki	=	50000	nM
2840	Ki	=	2840000	nM	Outside typical range
7020	Ki	=	7020000	nM	Outside typical range
8280	Ki	=	8280000	nM	Outside typical range
870	Ki	=	870000	nM	Outside typical range
9050	Ki	=	9050000	nM	Outside typical range
28600	Ki	=	28600000	nM	Outside typical range
9130	Ki	=	9130000	nM	Outside typical range
1970	Ki	=	1970000	nM	Outside typical range
7240	Ki	=	7240000	nM	Outside typical range
8710	Ki	=	8710000	nM	Outside typical range
7120	Ki	=	7120000	nM	Outside typical range
8640	Ki	=	8640000	nM	Outside typical range
970	Ki	=	970000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3376123

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2014
Volume: 24
Issue: 18
First Page: 4402
Last Page: 4406
DOI: 10.1016/j.bmcl.2014.08.014

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
3100	Ki	=	3100000	nM	Outside typical range
4	Ki	=	4000	nM
73	Ki	=	73000	nM
85500	Ki	=	85500000	nM	Outside typical range
9.2	Ki	=	9200	nM
960	Ki	=	960000	nM	Outside typical range
90	Ki	=	90000	nM
890	Ki	=	890000	nM	Outside typical range
8700	Ki	=	8700000	nM	Outside typical range
950	Ki	=	950000	nM	Outside typical range
10800	Ki	=	10800000	nM	Outside typical range
16700	Ki	=	16700000	nM	Outside typical range
78900	Ki	=	78900000	nM	Outside typical range
8700	Ki	=	8700000	nM	Outside typical range
7700	Ki	=	7700000	nM	Outside typical range
97	Ki	=	97000	nM
71600	Ki	=	71600000	nM	Outside typical range
8700	Ki	=	8700000	nM	Outside typical range
41	Ki	=	41000	nM
92	Ki	=	92000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 2

External ID: CHEMBL3375544

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2014
Volume: 24
Issue: 18
First Page: 4402
Last Page: 4406
DOI: 10.1016/j.bmcl.2014.08.014

Target ChEMBL ID: CHEMBL205
ChEMBL Target Name: Carbonic anhydrase II
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
63000	Ki	=	63000000	nM	Outside typical range
3100	Ki	=	3100000	nM	Outside typical range
1500	Ki	=	1500000	nM	Outside typical range
112000	Ki	=	112000000	nM	Outside typical range
1130	Ki	=	1130000	nM	Outside typical range
85000	Ki	=	85000000	nM	Outside typical range
49200	Ki	=	49200000	nM	Outside typical range
73000	Ki	=	73000000	nM	Outside typical range
200000	Ki	>	200000000	nM	Outside typical range
200000	Ki	>	200000000	nM	Outside typical range
830	Ki	=	830000	nM	Outside typical range
920	Ki	=	920000	nM	Outside typical range
48500	Ki	=	48500000	nM	Outside typical range
84	Ki	=	84000	nM
760	Ki	=	760000	nM	Outside typical range
8.8	Ki	=	8800	nM
950	Ki	=	950000	nM	Outside typical range
26000	Ki	=	26000000	nM	Outside typical range
20	Ki	=	20000	nM
40	Ki	=	40000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 1

External ID: CHEMBL1781041

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem Lett
Year: 2011
Volume: 21
Issue: 12
First Page: 3591
Last Page: 3595
DOI: 10.1016/j.bmcl.2011.04.105

Target ChEMBL ID: CHEMBL261
ChEMBL Target Name: Carbonic anhydrase I
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
8400	Ki	=	8400000	nM	Outside typical range
790	Ki	=	790000	nM	Outside typical range
1.2	Ki	=	1200	nM
118000	Ki	=	118000000	nM	Outside typical range
310	Ki	=	310000	nM	Outside typical range
12000	Ki	=	12000000	nM	Outside typical range
31700	Ki	=	31700000	nM	Outside typical range
15000	Ki	=	15000000	nM	Outside typical range
63000	Ki	=	63000000	nM	Outside typical range
300000	Ki	>	300000000	nM	Outside typical range
570	Ki	=	570000	nM	Outside typical range
660	Ki	=	660000	nM	Outside typical range
990	Ki	=	990000	nM	Outside typical range
110	Ki	=	110000	nM	Outside typical range
85	Ki	=	85000	nM
8.7	Ki	=	8700	nM
920	Ki	=	920000	nM	Outside typical range
101	Ki	=	101000	nM	Outside typical range
0.7	Ki	=	700	nM
300	Ki	=	300000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL1102769

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2010
Volume: 20
Issue: 5
First Page: 1548
Last Page: 1550
DOI: 10.1016/j.bmcl.2010.01.081

Standard Type	Standard Relation	Standard Value
Ratio	=	1.3
Ratio	=	12.4

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 14

External ID: CHEMBL1102768

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem Lett
Year: 2010
Volume: 20
Issue: 5
First Page: 1548
Last Page: 1550
DOI: 10.1016/j.bmcl.2010.01.081

Target ChEMBL ID: CHEMBL3510
ChEMBL Target Name: Carbonic anhydrase XIV
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
790	Kinact	=	0.79	mM
1330	Kinact	=	1.33	mM
640	Kinact	=	0.64	mM
870	Kinact	=	0.87	mM
1170	Kinact	=	1.17	mM
660	Kinact	=	0.66	mM
650	Kinact	=	0.65	mM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 12

External ID: CHEMBL1102767

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem Lett
Year: 2010
Volume: 20
Issue: 5
First Page: 1548
Last Page: 1550
DOI: 10.1016/j.bmcl.2010.01.081

Target ChEMBL ID: CHEMBL3242
ChEMBL Target Name: Carbonic anhydrase XII
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
870	Kinact	=	0.87	mM
1150	Kinact	=	1.15	mM
530	Kinact	=	0.53	mM
660	Kinact	=	0.66	mM
680	Kinact	=	0.68	mM
120	Kinact	=	0.12	mM
800	Kinact	=	0.8	mM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 2

External ID: CHEMBL3118986

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2014
Volume: 24
Issue: 4
First Page: 1127
Last Page: 1132
DOI: 10.1016/j.bmcl.2013.12.124

Target ChEMBL ID: CHEMBL205
ChEMBL Target Name: Carbonic anhydrase II
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
63000	Ki	=	63000000	nM	Outside typical range
3100	Ki	=	3100000	nM	Outside typical range
1510	Ki	=	1510000	nM	Outside typical range
112000	Ki	=	112000000	nM	Outside typical range
1130	Ki	=	1130000	nM	Outside typical range
85000	Ki	=	85000000	nM	Outside typical range
49200	Ki	=	49200000	nM	Outside typical range
73000	Ki	=	73000000	nM	Outside typical range
200000	Ki	>	200000000	nM	Outside typical range
300000	Ki	>	300000000	nM	Outside typical range
830	Ki	=	830000	nM	Outside typical range
920	Ki	=	920000	nM	Outside typical range
48500	Ki	=	48500000	nM	Outside typical range
84	Ki	=	84000	nM
760	Ki	=	760000	nM	Outside typical range
8.8	Ki	=	8800	nM
950	Ki	=	950000	nM	Outside typical range
30	Ki	=	30000	nM
26000	Ki	=	26000000	nM	Outside typical range
20	Ki	=	20000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 9

External ID: CHEMBL1102766

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem Lett
Year: 2010
Volume: 20
Issue: 5
First Page: 1548
Last Page: 1550
DOI: 10.1016/j.bmcl.2010.01.081

Target ChEMBL ID: CHEMBL3594
ChEMBL Target Name: Carbonic anhydrase IX
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
820	Kinact	=	0.82	mM
690	Kinact	=	0.69	mM
810	Kinact	=	0.81	mM
1100	Kinact	=	1.1	mM
700	Kinact	=	0.7	mM
9.7	Kinact	=	0.0097	mM
620	Kinact	=	0.62	mM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3118987

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2014
Volume: 24
Issue: 4
First Page: 1127
Last Page: 1132
DOI: 10.1016/j.bmcl.2013.12.124

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
5800	Ki	=	5800000	nM	Outside typical range
2	Ki	=	2000	nM
450	Ki	=	450000	nM	Outside typical range
660	Ki	=	660000	nM	Outside typical range
9	Ki	=	9000	nM
6600	Ki	=	6600000	nM	Outside typical range
8	Ki	=	8000	nM
4800	Ki	=	4800000	nM	Outside typical range
96500	Ki	=	96500000	nM	Outside typical range
770	Ki	=	770000	nM	Outside typical range
630	Ki	=	630000	nM	Outside typical range
290	Ki	=	290000	nM	Outside typical range
830	Ki	=	830000	nM	Outside typical range
570	Ki	=	570000	nM	Outside typical range
590	Ki	=	590000	nM	Outside typical range
620	Ki	=	620000	nM	Outside typical range
550	Ki	=	550000	nM	Outside typical range
960	Ki	=	960000	nM	Outside typical range
59100	Ki	=	59100000	nM	Outside typical range
610	Ki	=	610000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3118988

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2014
Volume: 24
Issue: 4
First Page: 1127
Last Page: 1132
DOI: 10.1016/j.bmcl.2013.12.124

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
7900	Ki	=	7900000	nM	Outside typical range
6	Ki	=	6000	nM
77	Ki	=	77000	nM
7300	Ki	=	7300000	nM	Outside typical range
94	Ki	=	94000	nM
3500	Ki	=	3500000	nM	Outside typical range
84	Ki	=	84000	nM
4700	Ki	=	4700000	nM	Outside typical range
77900	Ki	=	77900000	nM	Outside typical range
910	Ki	=	910000	nM	Outside typical range
570	Ki	=	570000	nM	Outside typical range
240	Ki	=	240000	nM	Outside typical range
940	Ki	=	940000	nM	Outside typical range
850	Ki	=	850000	nM	Outside typical range
1170	Ki	=	1170000	nM	Outside typical range
530	Ki	=	530000	nM	Outside typical range
600	Ki	=	600000	nM	Outside typical range
660	Ki	=	660000	nM	Outside typical range
320	Ki	=	320000	nM	Outside typical range
64	Ki	=	64000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL1648933

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem
Year: 2011
Volume: 19
Issue: 1
First Page: 243
Last Page: 248
DOI: 10.1016/j.bmc.2010.11.031

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
660	Ki	=	660000	nM	Outside typical range
0.61	Ki	=	610	nM
350	Ki	=	350000	nM	Outside typical range
0.044	Ki	=	44	nM
4.25	Ki	=	4250	nM
330	Ki	=	330000	nM	Outside typical range
5.86	Ki	=	5860	nM
530	Ki	=	530000	nM	Outside typical range
570	Ki	=	570000	nM	Outside typical range
4150	Ki	=	4150000	nM	Outside typical range
850	Ki	=	850000	nM	Outside typical range
66	Ki	=	66000	nM
49	Ki	=	49000	nM
48	Ki	=	48000	nM
39	Ki	=	39000	nM
22	Ki	=	22000	nM
21	Ki	=	21000	nM
60	Ki	=	60000	nM
52	Ki	=	52000	nM
98	Ki	=	98000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 2

External ID: CHEMBL3375525

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2014
Volume: 24
Issue: 18
First Page: 4389
Last Page: 4396
DOI: 10.1016/j.bmcl.2014.08.015

Target ChEMBL ID: CHEMBL205
ChEMBL Target Name: Carbonic anhydrase II
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
63000	Ki	=	63000000	nM	Outside typical range
3.1	Ki	=	3100	nM
1510	Ki	=	1510000	nM	Outside typical range
112000	Ki	=	112000000	nM	Outside typical range
1130	Ki	=	1130000	nM	Outside typical range
85000	Ki	=	85000000	nM	Outside typical range
49200	Ki	=	49200000	nM	Outside typical range
73000	Ki	=	73000000	nM	Outside typical range
200000	Ki	>	200000000	nM	Outside typical range
300000	Ki	>	300000000	nM	Outside typical range
830	Ki	=	830000	nM	Outside typical range
920	Ki	=	920000	nM	Outside typical range
48500	Ki	=	48500000	nM	Outside typical range
84	Ki	=	84000	nM
760	Ki	=	760000	nM	Outside typical range
8.8	Ki	=	8800	nM
690	Ki	=	690000	nM	Outside typical range
26000	Ki	=	26000000	nM	Outside typical range
20	Ki	=	20000	nM
40	Ki	=	40000	nM

534-18-9 靶点实验数据