HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：BindingDB 靶标：N/A

External ID: BindingDB_3463_1

Protocol: N/A

Comment: Compounds with any of Ki, IC50, Kd, or EC50 activity value <= 10uM are labeled as "Active".
If multiple measurements are available for a given compound, it is labeled as "Active" if any of the measurements meet the criterion. Activity values are checked in the order of Ki, IC50, Kd, and EC50. The first entry that meets the above activity threshold is used to determine "Standard Type", "Standard Relation", and "PubChem Standard Value". Otherwise, the first non-empty entry will be used to set those values.

Standard Type	Standard Relation	PubChem Standard Value	IC50 Qualifier	IC50	Target Accession(s)	Ligand	Target
IC50		30		30000	Q92905	BDBM224012	COP9 signalosome complex subunit 5
IC50		4.5		4500	Q96FJ0	BDBM224012	AMSH-like protease
IC50		2.8		2800	O00487	BDBM224013	26S proteasome non-ATPase regulatory subunit 14
IC50	>	100	>	100000	O00487	BDBM50264534	26S proteasome non-ATPase regulatory subunit 14
IC50	>	100	>	100000	O00487	BDBM50264536	26S proteasome non-ATPase regulatory subunit 14
IC50	>	100	>	100000	O00487	BDBM50264545	26S proteasome non-ATPase regulatory subunit 14
IC50	>	100	>	100000	O00487	BDBM50264546	26S proteasome non-ATPase regulatory subunit 14
IC50		15		15000	O00487	BDBM50264563	26S proteasome non-ATPase regulatory subunit 14
IC50		1		1000	O00487	BDBM400988	26S proteasome non-ATPase regulatory subunit 14
IC50		15		15000	Q92905	BDBM400988	COP9 signalosome complex subunit 5
IC50		1.2		1200	Q96FJ0	BDBM400988	AMSH-like protease

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：26S proteasome non-ATPase regulatory subunit 14

External ID: CHEMBL4049704

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Med Chem
Year: 2017
Volume: 60
Issue: 4
First Page: 1343
Last Page: 1361
DOI: 10.1021/acs.jmedchem.6b01379

Target ChEMBL ID: CHEMBL2007629
ChEMBL Target Name: 26S proteasome non-ATPase regulatory subunit 14
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
1.3	IC50	=	1300	nM
100	IC50	>	100000	nM
0.8	IC50	=	800	nM
6.4	IC50	=	6400	nM
40	IC50	>	40000	nM
20	IC50	>	20000	nM
50	IC50	>	50000	nM
0.8	IC50	=	800	nM
100	IC50	>	100000	nM
1	IC50	=	1000	nM
2.5	IC50	=	2500	nM
100	IC50	>	100000	nM
0.9	IC50	=	900	nM
0.2	IC50	<	200	nM
0.8	IC50	=	800	nM

529-36-2 靶点实验数据