HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：L1210

External ID: CHEMBL1016113

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Eur. J. Med. Chem.
Year: 2009
Volume: 44
Issue: 1
First Page: 54
Last Page: 62
DOI: 10.1016/j.ejmech.2008.03.015

Target ChEMBL ID: CHEMBL386
ChEMBL Target Name: L1210
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
500	IC50	>	500000	nM	Outside typical range
281	IC50	=	281000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：MRC5

External ID: CHEMBL5387604

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Eur J Med Chem
Year: 2023
Volume: 250
First Page: 115191
Last Page: 115191
DOI: 10.1016/j.ejmech.2023.115191

Target ChEMBL ID: CHEMBL614181
ChEMBL Target Name: MRC5
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
4.85	IC50	=	4850	nM
100	IC50	>	100000	nM
31.27	IC50	=	31270	nM
100	IC50	>	100000	nM
47.68	IC50	=	47680	nM
8.65	IC50	=	8650	nM
3.67	IC50	=	3670	nM
13.44	IC50	=	13440	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：HT-1080

External ID: CHEMBL5387603

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Eur J Med Chem
Year: 2023
Volume: 250
First Page: 115191
Last Page: 115191
DOI: 10.1016/j.ejmech.2023.115191

Target ChEMBL ID: CHEMBL614580
ChEMBL Target Name: HT-1080
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
5.41	IC50	=	5410	nM
100	IC50	>	100000	nM
3.82	IC50	=	3820	nM
100	IC50	>	100000	nM
7.2	IC50	=	7200	nM
5.48	IC50	=	5480	nM
35.91	IC50	=	35910	nM
1.99	IC50	=	1990	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NON-PROTEIN TARGET

External ID: CHEMBL1016111

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Eur. J. Med. Chem.
Year: 2009
Volume: 44
Issue: 1
First Page: 54
Last Page: 62
DOI: 10.1016/j.ejmech.2008.03.015

Target ChEMBL ID: CHEMBL3879801
ChEMBL Target Name: NON-PROTEIN TARGET
ChEMBL Target Type: NON-MOLECULAR - Target has not been defined at a molecular level, only the non-molecular entity which is affected (e.g., organism, cell line etc)
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
500	IC50	>	500000	nM	Outside typical range
230	IC50	=	230000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：HepG2

External ID: CHEMBL5387602

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Eur J Med Chem
Year: 2023
Volume: 250
First Page: 115191
Last Page: 115191
DOI: 10.1016/j.ejmech.2023.115191

Target ChEMBL ID: CHEMBL395
ChEMBL Target Name: HepG2
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
1.38	IC50	=	1380	nM
100	IC50	>	100000	nM
10.64	IC50	=	10640	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM
37.09	IC50	=	37090	nM
1.93	IC50	=	1930	nM
1.36	IC50	=	1360	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：CCRF-CEM

External ID: CHEMBL1016112

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Eur. J. Med. Chem.
Year: 2009
Volume: 44
Issue: 1
First Page: 54
Last Page: 62
DOI: 10.1016/j.ejmech.2008.03.015

Target ChEMBL ID: CHEMBL382
ChEMBL Target Name: CCRF-CEM
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
500	IC50	>	500000	nM	Outside typical range
1	IC50	=	1000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：A549

External ID: CHEMBL5387601

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Eur J Med Chem
Year: 2023
Volume: 250
First Page: 115191
Last Page: 115191
DOI: 10.1016/j.ejmech.2023.115191

Target ChEMBL ID: CHEMBL392
ChEMBL Target Name: A549
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
7.36	IC50	=	7360	nM
100	IC50	>	100000	nM
11.32	IC50	=	11320	nM
100	IC50	>	100000	nM
2.97	IC50	=	2970	nM
2.02	IC50	=	2020	nM
3.32	IC50	=	3320	nM
1.18	IC50	=	1180	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NCI-H460

External ID: CHEMBL5387600

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Eur J Med Chem
Year: 2023
Volume: 250
First Page: 115191
Last Page: 115191
DOI: 10.1016/j.ejmech.2023.115191

Target ChEMBL ID: CHEMBL396
ChEMBL Target Name: NCI-H460
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
2.34	IC50	=	2340	nM
100	IC50	>	100000	nM
26.9	IC50	=	26900	nM
100	IC50	>	100000	nM
14.38	IC50	=	14380	nM
7.11	IC50	=	7110	nM
2.88	IC50	=	2880	nM
5.68	IC50	=	5680	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：11908 靶标：N/A

External ID: RMI-FANCM-MM2

Protocol: FP HTS. Screening took place at the University of Wisconsin Small Molecule Screening and Synthesis Facility. A master mix of RMI core complex and F-MM2 (30 microL per well) was plated in black 384 shallow well plates (ThermoFisher, Waltham, MA), using a BioTek "MicroFlo Select" reagent dispenser. Compounds were added using a Beckman FX liquid handler; 0.33 microL of 10 mM stock was added for a final compound concentration of 33 microM. MM2 and cMM2 were each added to 4 wells of master mix per plate to a final concentration of 10 muM to serve as controls. Following compound addition, plates were covered, centrifuged briefly, and incubated for 20 minutes at room temperature. FP measurements were taking using a Tecan "Safire 2" microplate reader. Instrument settings were as follows: top read, EX 470, EM 525/20, G-factor 0.89947. A suitable gain was calculated from the first plate of each day. Z' scores for were calculated for each plate; plates with Z' scores <0.5 were rerun prior to analysis.

Comment:

Concentration uM	Data readout
33	55
33	63
33	65
33	63
33	61
33	62
33	61
33	58
33	71
33	61
33	64
33	83
33	158
33	84
33	104
33	60
33	62
33	59
33	58
33	59

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：HL-60

External ID: CHEMBL1021171

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Eur. J. Med. Chem.
Year: 2009
Volume: 44
Issue: 1
First Page: 54
Last Page: 62
DOI: 10.1016/j.ejmech.2008.03.015

Target ChEMBL ID: CHEMBL383
ChEMBL Target Name: HL-60
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
400	CC50	>	400000	nM
400	CC50	>	400000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL1021172

Protocol: N/A

Comment: Journal: Eur. J. Med. Chem.
Year: 2009
Volume: 44
Issue: 1
First Page: 54
Last Page: 62
DOI: 10.1016/j.ejmech.2008.03.015

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
400	CC50	>	400000	nM
400	CC50	>	400000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：HSC-3

External ID: CHEMBL1021169

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Eur. J. Med. Chem.
Year: 2009
Volume: 44
Issue: 1
First Page: 54
Last Page: 62
DOI: 10.1016/j.ejmech.2008.03.015

Target ChEMBL ID: CHEMBL612279
ChEMBL Target Name: HSC-3
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
400	CC50	>	400000	nM
400	CC50	>	400000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：HepG2-CD81

External ID: CHEMBL4483864

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Science
Year: 2018
Volume: 362
Issue: 6419
DOI: 10.1126/science.aat9446

Target ChEMBL ID: CHEMBL4543887
ChEMBL Target Name: HepG2-CD81
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Data Source: Winzeler Lab Plasmodium Screening

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
3.48	HEPG2TOX ASSAY - CC90	=	3.48	uM
1.05	HEPG2TOX ASSAY - CC50	=	1.05	uM
1.05	HEPG2TOX ASSAY - CC90	=	1.05	uM
6.54	HEPG2TOX ASSAY - CC50	=	6.54	uM
4.75	HEPG2TOX ASSAY - CC90	=	4.75	uM
1.63	HEPG2TOX ASSAY - CC50	=	1.63	uM
1.63	HEPG2TOX ASSAY - CC90	=	1.63	uM
7.48	HEPG2TOX ASSAY - CC50	=	7.48	uM
3.26	HEPG2TOX ASSAY - CC90	=	3.26	uM
0.0189	HEPG2TOX ASSAY - CC50	=	0.0189	uM
6.77	HEPG2TOX ASSAY - CC90	=	6.77	uM
7.54	HEPG2TOX ASSAY - CC50	=	7.54	uM
12.4	HEPG2TOX ASSAY - CC90	>	12.4	uM
6.3	HEPG2TOX ASSAY - CC50	=	6.3	uM
6.3	HEPG2TOX ASSAY - CC90	=	6.3	uM
9.05	HEPG2TOX ASSAY - CC50	=	9.05	uM
14.9	HEPG2TOX ASSAY - CC90	>	14.9	uM
12.7	HEPG2TOX ASSAY - CC50	>	12.7	uM
12.7	HEPG2TOX ASSAY - CC90	>	12.7	uM
8.37	HEPG2TOX ASSAY - CC50	>	8.37	uM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：HSC-4

External ID: CHEMBL1021170

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Eur. J. Med. Chem.
Year: 2009
Volume: 44
Issue: 1
First Page: 54
Last Page: 62
DOI: 10.1016/j.ejmech.2008.03.015

Target ChEMBL ID: CHEMBL1075469
ChEMBL Target Name: HSC-4
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
400	CC50	>	400000	nM
400	CC50	>	400000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Plasmodium berghei

External ID: CHEMBL4483863

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Science
Year: 2018
Volume: 362
Issue: 6419
DOI: 10.1126/science.aat9446

Target ChEMBL ID: CHEMBL612653
ChEMBL Target Name: Plasmodium berghei
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Data Source: Winzeler Lab Plasmodium Screening

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
9.56	LUCIFERASE EXPRESSION CONTROL - IC90	>	9.56	uM
1.17	LUCIFERASE INFECTION ASSAY - IC50	=	1.17	uM
1.41	LUCIFERASE INFECTION ASSAY - IC90	=	1.41	uM
10	LUCIFERASE EXPRESSION CONTROL - IC50	>	10	uM
9.72	LUCIFERASE EXPRESSION CONTROL - IC90	>	9.72	uM
9.01	LUCIFERASE INFECTION ASSAY - IC50	>	9.01	uM
9.01	LUCIFERASE INFECTION ASSAY - IC90	>	9.01	uM
9.01	LUCIFERASE EXPRESSION CONTROL - IC50	>	9.01	uM
9.01	LUCIFERASE EXPRESSION CONTROL - IC90	>	9.01	uM
8.99	LUCIFERASE INFECTION ASSAY - IC50	=	8.99	uM
10	LUCIFERASE INFECTION ASSAY - IC90	>	10	uM
10	LUCIFERASE EXPRESSION CONTROL - IC50	>	10	uM
9.81	LUCIFERASE EXPRESSION CONTROL - IC90	>	9.81	uM
3.23	LUCIFERASE INFECTION ASSAY - IC50	=	3.23	uM
6.33	LUCIFERASE INFECTION ASSAY - IC90	>	6.33	uM
6.33	LUCIFERASE EXPRESSION CONTROL - IC50	>	6.33	uM
8.74	LUCIFERASE EXPRESSION CONTROL - IC90	>	8.74	uM
10	LUCIFERASE INFECTION ASSAY - IC50	>	10	uM
10	LUCIFERASE INFECTION ASSAY - IC90	>	10	uM
10	LUCIFERASE EXPRESSION CONTROL - IC50	>	10	uM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：HSC-2

External ID: CHEMBL1021168

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Eur. J. Med. Chem.
Year: 2009
Volume: 44
Issue: 1
First Page: 54
Last Page: 62
DOI: 10.1016/j.ejmech.2008.03.015

Target ChEMBL ID: CHEMBL1075468
ChEMBL Target Name: HSC-2
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
400	CC50	>	400000	nM
344	CC50	=	344000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mus musculus

External ID: CHEMBL1021175

Protocol: N/A

Comment: Journal: Eur. J. Med. Chem.
Year: 2009
Volume: 44
Issue: 1
First Page: 54
Last Page: 62
DOI: 10.1016/j.ejmech.2008.03.015

Target ChEMBL ID: CHEMBL375
ChEMBL Target Name: Mus musculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Non-toxic

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL1021173

Protocol: N/A

Comment: Journal: Eur. J. Med. Chem.
Year: 2009
Volume: 44
Issue: 1
First Page: 54
Last Page: 62
DOI: 10.1016/j.ejmech.2008.03.015

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
400	CC50	>	400000	nM
400	CC50	>	400000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：Center for Chemical Genomics, University of Michigan 靶标：N/A

External ID: TargetID_659_CEMA

Protocol: Black, standard capacity streptavidin-coated 384-well plates (Pierce 15407) were first washed with 50 L of phosphate buffer (100 mM, pH 7.0; PB7) three times using a Biotek 405 ELX plate washer. Subsequently, 5 L of biotinylated pre-miRNA substrate (500 nM final) was dispensed into the plate using a Multidrop Combi Reagent Dispenser (Thermo Scientific). Plates were then centrifuged for 1 min at 1,000 RPM (223 g), sealed with plate tape, and incubated overnight at 4 C. The following morning, plates were washed three times with 50 L of PB7, followed by the addition of 5 L of Dicer digest buffer (20 mM Tris, 12 mM NaCl, 2.5 mM MgCl2, 1 mM fresh DTT, and 4.5% DMSO) and centrifugation. Compounds (50 nL of 5 mM DMSO stock, 25 M final) were then added into the sample wells using a Sciclone (Caliper) liquid handler with V&P pintool; the same volume of DMSO was added to the control wells. The plates were incubated at 25 C for 15 min before addition of 5 L of digest buffer containing 217 g/nL Dicer (108 g/mL Dicer, 5% glycerol and 0.01% Triton X-100 final, excess with respect to pre-miRNA). For the positive control wells, digest buffer without Dicer was added. The plates were centrifuged again and resealed before being placed in a 37 C incubator for 5 h. After Dicer cleavage, plates were washed three times with 50 L of PB7. mTet-HRP in PB7 (10 L, 750 nM final) was then dispensed into each well. The plates were subsequently centrifuged, sealed, and incubated at 25 C for 2 h. Plates were then washed three times with 50 L of wash buffer (2 mM imidazole, 260 mM NaCl, 0.5 mM EDTA, 0.1% Tween-20, pH 7.0), followed by washing three additional times with 50 L of PB7. Finally, SuperSignal West Pico (25 L; Pierce) was added, the plates were incubated at 25 C for 5 min, and chemiluminescence signal was detected using a PHERAstar plate reader using LUM plus module (BMG Labtech).

Comment: The activity outcome is based on a Z-score (number of standard deviations from the negative control mean) of 3 or higher on at least 50% times that the sample was screened.

For instance, if the sample was screened in n=4 runs, it would be considered active only if it had a Z-score of 3 or above in at least 2 runs.

Z_SCORE
2.91
-0.56
0.61
2.15
0.54
-0.32
1.12
-0.07
0.61
1.55
-0.77
-0.76
-2.08
0.67
-0.35
0.17
-1.42
-0.64
-5.35
1.42

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL1021174

Protocol: N/A

Comment: Journal: Eur. J. Med. Chem.
Year: 2009
Volume: 44
Issue: 1
First Page: 54
Last Page: 62
DOI: 10.1016/j.ejmech.2008.03.015

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
400	CC50	>	400000	nM
400	CC50	>	400000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL5387605

Protocol: N/A

Comment: Journal: Eur J Med Chem
Year: 2023
Volume: 250
First Page: 115191
Last Page: 115191
DOI: 10.1016/j.ejmech.2023.115191

Standard Type	Standard Relation	Standard Value
Ratio IC50	=	11.42
Ratio IC50	=	2.07
Ratio IC50	=	9.89
Ratio IC50	=	1.16
Ratio IC50	=	2.52
Ratio IC50	=	2.81
Ratio IC50	=	32.02

Concentration uM	Data readout
33	55
33	63
33	65
33	63
33	61
33	62
33	61
33	58
33	71
33	61
33	64
33	83
33	158
33	84
33	104
33	60
33	62
33	59
33	58
33	59

Concentration uM	Data readout
33	55
33	63
33	65
33	63
33	61
33	62
33	61
33	58
33	71
33	61
33	64
33	83
33	158
33	84
33	104
33	60
33	62
33	59
33	58
33	59

52835-63-9 靶点实验数据

Concentration uM	Data readout
33	55
33	63
33	65
33	63
33	61
33	62
33	61
33	58
33	71
33	61
33	64
33	83
33	158
33	84
33	104
33	60
33	62
33	59
33	58
33	59