HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL4422715

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Med Chem
Year: 2019
Volume: 62
Issue: 3
First Page: 1096
Last Page: 1115
DOI: 10.1021/acs.jmedchem.8b00961

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
50	IC50	>	50000	nM
2.1	IC50	=	2100	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Glutaminase liver isoform, mitochondrial

External ID: CHEMBL4422720

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Med Chem
Year: 2019
Volume: 62
Issue: 3
First Page: 1096
Last Page: 1115
DOI: 10.1021/acs.jmedchem.8b00961

Target ChEMBL ID: CHEMBL4105730
ChEMBL Target Name: Glutaminase liver isoform, mitochondrial
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.28	IC50	=	280	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Prostaglandin G/H synthase 1

External ID: CHEMBL4709175

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Eur J Med Chem
Year: 2020
Volume: 204
First Page: 112620
Last Page: 112620
DOI: 10.1016/j.ejmech.2020.112620

Target ChEMBL ID: CHEMBL2949
ChEMBL Target Name: Cyclooxygenase-1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
4.5	IC50	=	4500	nM
1.07	IC50	=	1070	nM
2.38	IC50	=	2380	nM
18.92	IC50	=	18920	nM
5.42	IC50	=	5420	nM
6.11	IC50	=	6110	nM
2.65	IC50	=	2650	nM
1.07	IC50	=	1070	nM
15.78	IC50	=	15780	nM
3.38	IC50	=	3380	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Polyunsaturated fatty acid 5-lipoxygenase

External ID: CHEMBL4709178

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Eur J Med Chem
Year: 2020
Volume: 204
First Page: 112620
Last Page: 112620
DOI: 10.1016/j.ejmech.2020.112620

Target ChEMBL ID: CHEMBL215
ChEMBL Target Name: Arachidonate 5-lipoxygenase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
1.37	IC50	=	1370	nM
1.05	IC50	=	1050	nM
3.72	IC50	=	3720	nM
1.14	IC50	=	1140	nM
0.14	IC50	=	140	nM
1.09	IC50	=	1090	nM
0.17	IC50	=	170	nM
0.94	IC50	=	940	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Prostaglandin G/H synthase 2

External ID: CHEMBL4709176

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Eur J Med Chem
Year: 2020
Volume: 204
First Page: 112620
Last Page: 112620
DOI: 10.1016/j.ejmech.2020.112620

Target ChEMBL ID: CHEMBL230
ChEMBL Target Name: Cyclooxygenase-2
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
2.46	IC50	=	2460	nM
15.92	IC50	=	15920	nM
0.57	IC50	=	570	nM
2.74	IC50	=	2740	nM
1.9	IC50	=	1900	nM
8.97	IC50	=	8970	nM
4.65	IC50	=	4650	nM
4.81	IC50	=	4810	nM
2.71	IC50	=	2710	nM
0.55	IC50	=	550	nM
5.82	IC50	=	5820	nM
1.55	IC50	=	1550	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL4709177

Protocol: N/A

Comment: Journal: Eur J Med Chem
Year: 2020
Volume: 204
First Page: 112620
Last Page: 112620
DOI: 10.1016/j.ejmech.2020.112620

Standard Type	Standard Relation	Standard Value
Ratio IC50	=	2.38
Ratio IC50	=	0.79
Ratio IC50	=	1.83
Ratio IC50	=	0.87
Ratio IC50	=	9.96
Ratio IC50	=	0.28
Ratio IC50	=	1.17
Ratio IC50	=	1.27
Ratio IC50	=	1.95
Ratio IC50	=	3.47

5259-06-3 靶点实验数据