HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Oxysterols receptor LXR-alpha

External ID: CHEMBL712591

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2001
Volume: 44
Issue: 6
First Page: 886
Last Page: 897
DOI: 10.1021/jm0004749

Target ChEMBL ID: CHEMBL2808
ChEMBL Target Name: LXR-alpha
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Standard Type	Standard Relation	Standard Value
RE	<	0.1
RE	=	0.2
RE	=	1.1
RE	=	0.7
RE	=	0.85
RE	=	1
RE	=	1.4
RE	=	1
RE	=	0.35
RE	=	0.85
RE	=	1
RE	=	0.3
RE	=	1
RE	<	0.1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL2423076

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2013
Volume: 21
Issue: 17
First Page: 5297
Last Page: 5309
DOI: 10.1016/j.bmc.2013.06.022

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
2.3	EC50	=	2300	nM
9.7	EC50	=	9700	nM
9.7	EC50	=	9700	nM
8.5	EC50	=	8500	nM
2.3	EC50	=	2300	nM
2	EC50	=	2000	nM
2.8	EC50	=	2800	nM
1.8	EC50	=	1800	nM
8.5	EC50	=	8500	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Steroidogenic acute regulatory protein, mitochondrial

External ID: CHEMBL2033281

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2012
Volume: 22
Issue: 12
First Page: 4139
Last Page: 4143
DOI: 10.1016/j.bmcl.2012.04.058

Target ChEMBL ID: CHEMBL2029195
ChEMBL Target Name: Steroidogenic acute regulatory protein, mitochondrial
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
Inhibition				Not Active
Inhibition				Not Active
Inhibition	=	50	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Oxysterols receptor LXR-alpha

External ID: CHEMBL710255

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2001
Volume: 44
Issue: 6
First Page: 886
Last Page: 897
DOI: 10.1021/jm0004749

Target ChEMBL ID: CHEMBL2808
ChEMBL Target Name: LXR-alpha
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
5.9	EC50	=	5900	nM
0.325	EC50	=	325	nM
0.18	EC50	=	180	nM
0.17	EC50	=	170	nM
0.67	EC50	=	670	nM
0.22	EC50	=	220	nM
0.46	EC50	=	460	nM
0.25	EC50	=	250	nM
0.47	EC50	=	470	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Ephrin type-A receptor 2

External ID: CHEMBL3738294

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Eur. J. Med. Chem.
Year: 2015
Volume: 103
First Page: 312
Last Page: 324
DOI: 10.1016/j.ejmech.2015.08.048

Target ChEMBL ID: CHEMBL2068
ChEMBL Target Name: Ephrin type-A receptor 2
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
6.30957	IC50	=	6309.57	nM
8.91251	IC50	=	8912.51	nM
6.0256	IC50	=	6025.6	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NPC1-like intracellular cholesterol transporter 1

External ID: CHEMBL3362444

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2014
Volume: 24
Issue: 15
First Page: 3480
Last Page: 3485
DOI: 10.1016/j.bmcl.2014.05.064

Target ChEMBL ID: CHEMBL2027
ChEMBL Target Name: Niemann-Pick C1-like protein 1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Activity Comment
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active

5255-17-4 靶点实验数据