HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Polyunsaturated fatty acid 5-lipoxygenase

External ID: CHEMBL3420867

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Eur. J. Med. Chem.
Year: 2015
Volume: 94
First Page: 132
Last Page: 139
DOI: 10.1016/j.ejmech.2015.02.042

Target ChEMBL ID: CHEMBL215
ChEMBL Target Name: Arachidonate 5-lipoxygenase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
4.7	IC50	=	4700	nM
10	IC50	>	10000	nM
1.7	IC50	=	1700	nM
0.49	IC50	=	490	nM
10	IC50	>	10000	nM
7.1	IC50	=	7100	nM
10	IC50	>	10000	nM
7.9	IC50	=	7900	nM
3.5	IC50	=	3500	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Polyunsaturated fatty acid lipoxygenase ALOX12

External ID: CHEMBL3420874

Protocol: N/A

Comment: Journal: Eur. J. Med. Chem.
Year: 2015
Volume: 94
First Page: 132
Last Page: 139
DOI: 10.1016/j.ejmech.2015.02.042

Target ChEMBL ID: CHEMBL3687
ChEMBL Target Name: Arachidonate 12-lipoxygenase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
Activity				Not Determined
Activity	=	0.91	%
Activity	=	74.9	%
Activity	=	84.3	%
Activity	=	138.4	%
Activity	=	73.2	%
Activity	=	160.8	%
Activity	=	90.6	%
Activity	=	137.5	%
Activity	=	58.8	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Macrophage-expressed gene 1 protein

External ID: CHEMBL3420871

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Eur. J. Med. Chem.
Year: 2015
Volume: 94
First Page: 132
Last Page: 139
DOI: 10.1016/j.ejmech.2015.02.042

Target ChEMBL ID: CHEMBL3414409
ChEMBL Target Name: Macrophage-expressed gene 1 protein
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.8	IC50	=	800	nM
0.9	IC50	=	900	nM
2.1	IC50	=	2100	nM
10	IC50	>	10000	nM
10	IC50	>	10000	nM
10	IC50	>	10000	nM
1	IC50	=	1000	nM
10	IC50	>	10000	nM
10	IC50	>	10000	nM
10	IC50	>	10000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Polyunsaturated fatty acid lipoxygenase ALOX15

External ID: CHEMBL3420872

Protocol: N/A

Comment: Journal: Eur. J. Med. Chem.
Year: 2015
Volume: 94
First Page: 132
Last Page: 139
DOI: 10.1016/j.ejmech.2015.02.042

Target ChEMBL ID: CHEMBL2903
ChEMBL Target Name: Arachidonate 15-lipoxygenase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
Activity				Not Determined
Activity	=	5.2	%
Activity	=	91.5	%
Activity	=	123.6	%
Activity	=	131.2	%
Activity	=	88.1	%
Activity	=	93.4	%
Activity	=	65.1	%
Activity	=	118.9	%
Activity	=	84.1	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Polyunsaturated fatty acid 5-lipoxygenase

External ID: CHEMBL3420629

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Eur. J. Med. Chem.
Year: 2015
Volume: 94
First Page: 132
Last Page: 139
DOI: 10.1016/j.ejmech.2015.02.042

Target ChEMBL ID: CHEMBL215
ChEMBL Target Name: Arachidonate 5-lipoxygenase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
2.5	IC50	=	2500	nM
4.3	IC50	=	4300	nM
0.6	IC50	=	600	nM
0.27	IC50	=	270	nM
10	IC50	>	10000	nM
2	IC50	=	2000	nM
10	IC50	>	10000	nM
3.4	IC50	=	3400	nM
10	IC50	>	10000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Polyunsaturated fatty acid 5-lipoxygenase

External ID: CHEMBL3420628

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Eur. J. Med. Chem.
Year: 2015
Volume: 94
First Page: 132
Last Page: 139
DOI: 10.1016/j.ejmech.2015.02.042

Target ChEMBL ID: CHEMBL215
ChEMBL Target Name: Arachidonate 5-lipoxygenase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.22	IC50	=	220	nM
0.23	IC50	=	230	nM
1.8	IC50	=	1800	nM
0.42	IC50	=	420	nM
4	IC50	=	4000	nM
0.18	IC50	=	180	nM
1.8	IC50	=	1800	nM
3.3	IC50	=	3300	nM
1.6	IC50	=	1600	nM

523-90-0 靶点实验数据