HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Nucleic Acid

External ID: CHEMBL875756

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 1986
Volume: 29
Issue: 7
First Page: 1321
Last Page: 1322
DOI: 10.1021/jm00157a040

Target ChEMBL ID: CHEMBL345
ChEMBL Target Name: Nucleic Acid
ChEMBL Target Type: NUCLEIC-ACID - Target is DNA, RNA or PNA
Relationship Type: M - Molecular target other than protein assigned
Confidence: Target assigned is molecular non-protein target

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.106	C50	=	106	nM
0.122	C50	=	122	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NON-PROTEIN TARGET

External ID: CHEMBL928072

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2008
Volume: 71
Issue: 2
First Page: 292
Last Page: 294
DOI: 10.1021/np070629g

Target ChEMBL ID: CHEMBL3879801
ChEMBL Target Name: NON-PROTEIN TARGET
ChEMBL Target Type: NON-MOLECULAR - Target has not been defined at a molecular level, only the non-molecular entity which is affected (e.g., organism, cell line etc)
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
IC50	=	0.13	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：NCGC 靶标：

External ID: SNCA-p-activity-luciferase

Protocol: PROTOCOL TABLE
SEQUENCE No. (e.g., 1, 2, 3, etc.); PARAMETER (e.g., Cells, Incubation, Reagent, etc.); VALUE; DESCRIPTION

1; Cells; 4 uL; Dispense 1500 HEK-293-SNCA-luc cells/well into Greiner 1536-well white / solid bottom tissue culture treated plate. The plate was covered with metal lids with gas-exchange holes.
2; Incubate; 24 hours; Incubate at 37C, 5% CO2, 95% RH.
3; Compounds; 23 nL; Compounds and controls were transferred via a Kalypsys Pin Tool (Wako USA) equipped with a 1536-slotted pin array. The plate was covered with metal lids with gas-exchange holes.
4; Incubate; 24 hours; Incubate at 37C, 5% CO2, 95% RH.
5; Dispense; 1 uL; Dispense Gly-Phe-7-amino-4-trifluoromethylcoumarin (GF-AFC, prepared at 125 uM in PBS) was added. The plate was covered with metal lids with gas-exchange holes.
6; Incubate; 30 min; Incubate at 37C, 5% CO2.
7; Detector; Fluorescence; Measure fluorescence with ViewLux microplate reader (PerkinElmer) equipped with 405/10 excitation and 540/25 emission filters.
8; Dispense; 3 uL; Dispense ONE-Glo (PerkinElmer) lucifase detection reagent was added to each well. Plates were covered with metal lids with gas-exchange holes.
9; Incubate; 15 min; Incubate at room temperature.
10; Detector; Luminescence; Measure luminescence with ViewLux microplate reader (PerkinElmer) equipped with clear filters.

NOTES (numbers refer to sequence above)
1; HEK-293-SNCA-luc were cultured and suspended in phenol-red free DMEM (4.5 g/L glucose, 25 mM HEPES, cat #21063 (Thermo)).
3; Compounds were added to the assay plate in an 11-point intra plate dose response, 1:3 titration in DMSO with a final concentration range of xxx - yyy uM. Vehicle-only plates, with DMSO being pin-transferred to every well, were inserted at the beginning of screening runs to confirm expected assay performance. Activity was normalized to wells containing medium only (-100% activity, full inhibition) and SNCA-luc cells treated with DMSO vehicle control (0% activity), contained on the same plate as test samples.
10; Signals were analyzed, and dose-response curves were fit using the Hill equation. Compounds in curve classes -1.1, -1.2, -2.1, -2.2 in the SNCA-luc assay were considered active. Compounds were eliminated from further consideration if also active (curve class -1.1, -1.2, -1.3, -1.4, -2.1, -2.2, -2.3, -2.4) in the GF-AFC cytotoxicity assay.

Comment: Disclaimer:
Although all reasonable efforts have been made to ensure the accuracy and reliability of the data, caution should be exercised when interpreting the results as artifacts are possible from nonspecific effects such as assay signal interference. The curve fitting and activity calls presented here are based on the NCATS analysis methods.

Compound Ranking:
1. Compounds are first classified as having full titration curves, partial modulation, partial curve (weaker actives), single point activity (at highest concentration only), or inactive. For this assay, apparent inhibitors are ranked higher than compounds that showed apparent activation.
2. For all inactive compounds, with a ratio activity curve class of 4, PUBCHEM_ACTIVITY_SCORE is 0. For all active compounds, a score range was given for each curve class type given above. Active compounds have PUBCHEM_ACTIVITY_SCORE between 40 and 100. For a ratio activity curve class = -1.1, score = 80+abs((log_ac50+4.5)*inf_activity/20). For ratio.curve_class == -1.2 && abs(ratio.max_response) > 6*10, score = 60+abs((log_ac50+4.5)*inf_activity/20). For ratio.curve_class == -2.1 || ( ratio.curve_class==-2.2 && abs(ratio.max_response) > 6*10), score = 40+abs((log_ac50+4.5)*inf_activity/20). For ratio.curve_class == -1.2 || ratio.curve_class == -2.2, score = 20+abs((log_ac50+4.5)*inf_activity/20). Inconclusive compounds, with a donor curve class other than 4, have PUBCHEM_ACTIVITY_SCORE of 10. Inconclusive compounds have PUBCHEM_ACTIVITY_SCORE between 1 and 39.

Phenotype	Potency	Efficacy	Curve_Description	Fit_LogAC50	Fit_HillSlope	Fit_R2	Fit_InfiniteActivity	Fit_ZeroActivity	Fit_CurveClass	Excluded_Points	Max_Response	Activity at 0.079 uM	Activity at 1.068 uM	Activity at 11.39 uM	Activity at 57.25 uM	Compound QC
Inactive				-6.75	4.9549	0.9727	0.0901	17.5	4	0 0 0 1	8.9408	15.9527	-1.5916	1.4969	8.9408	QC'd by Sytravon
Inactive				-5.3	4.095	0.9996	5.5	-7.7823	4	0 0 0 1	-11.1081	-7.5736	-7.7353	5.034	-11.1081	QC'd by Sytravon
Inactive				-5.15	4.9549	0.907	-15.9207	9.5	4	0 0 0 1	17.8725	5.2874	13.9021	-13.6839	17.8725	QC'd by Sytravon
Activator	35.4813	46.4095	Single point of activity	-4.45	2.5884	1	45.9404	-0.4691	3	1 0 0 0	35.593	40.1678	-0.3909	1.933	35.593	QC'd by Sytravon
Activator	39.8107	72.2646	Single point of activity	-4.4	4.9549	0.9515	68.1912	-4.0733	3	0 0 0 0	58.0117	5.8738	-9.2278	-8.5224	58.0117	QC'd by Sytravon
Activator	14.1254	45.3319	Partial curve; partial efficacy; poor fit	-4.85	2.4064	0.9982	40.7728	-4.5591	2.4	1 0 0 0	40.0933	-24.9557	-3.8845	11.5254	40.0933	QC'd by Sytravon
Inactive				-5.75	4.9549	0.9291	-20.6086	33.1545	4	1 0 0 0	-12.8464	45.4569	28.2161	-28.42	-12.8464	QC'd by Sytravon
Inactive				-4.35	4.9549	0.855	-24.2184	-0.5	4	0 0 0 0	-18.932	-3.6477	-2.409	4.988	-18.932	QC'd by Sytravon
Inactive				-4.7	3.6272	0.8625	15	-8.5523	4	0 0 0 0	14.477	-2.951	-13.7936	-5.9646	14.477	QC'd by Sytravon
Inactive				-6.7	4.9549	0.6637	3	-16.864	4	0 0 0 0	8.8169	-15.72	6.3794	-6.3599	8.8169	QC'd by Sytravon
Inactive				-4.75	2.4064	0.9999	21.5	-2.4101	4	1 0 0 0	20.2184	33.3778	-2.4251	3.5771	20.2184	QC'd by Sytravon
Inactive				-4.4	4.9549	0.8117	2.5	-8.345	4	0 0 0 0	1.096	-8.966	-5.5054	-11.1209	1.096	QC'd by Sytravon
Activator	39.8107	38.7945	Single point of activity	-4.4	4.9549	0.6241	41.7557	2.9612	3	0 0 0 0	36.2039	21.355	-6.3904	-4.5325	36.2039	QC'd by Sytravon
Inactive				-6.05	4.095	0.9994	-6.0518	20	4	0 0 0 1	20.5156	19.7377	1.4122	-6.2932	20.5156	QC'd by Sytravon
Inactive				-5.2	4.095	1	10.5	-10.1683	4	1 0 0 1	-15.9884	36.1362	-10.1402	8.7939	-15.9884	QC'd by Sytravon
Inactive				-6.5	1.3905	0.9999	-24.241	0.2745	4	0 0 0 1	-5.5981	-4.3546	-20.7587	-23.9509	-5.5981	QC'd by Sytravon
Inactive				-6.8	4.9549	0.711	-2.4459	21	4	0 0 0 0	-3.3453	17.3219	-9.9549	5.5495	-3.3453	QC'd by Sytravon
Activator	39.8107	47.809	Partial curve; partial efficacy; poor fit	-4.4	4.9549	0.5212	50.2399	2.4309	2.4	0 0 0 0	43.4722	30.2363	-10.9855	-11.5143	43.4722	QC'd by Sytravon
Activator	22.3872	75.5081	Partial curve; high efficacy; poor fit	-4.65	1.9673	0.9829	96.5324	21.0243	2.3	0 0 0 0	86.4985	26.0932	16.3365	36.2613	86.4985	QC'd by Sytravon
Inactive				-6.8	4.9549	0.7429	-1	-13.0738	4	0 0 0 0	1.8063	-11.3115	0.8702	-5.1757	1.8063	QC'd by Sytravon

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Malme-3M

External ID: CHEMBL708325

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 1994
Volume: 37
Issue: 14
First Page: 2190
Last Page: 2197
DOI: 10.1021/jm00040a011

Target ChEMBL ID: CHEMBL614021
ChEMBL Target Name: Malme-3M
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
8.87	GI50	=	8870	nM
1.99	GI50	=	1990	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：KB

External ID: CHEMBL928071

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2008
Volume: 71
Issue: 2
First Page: 292
Last Page: 294
DOI: 10.1021/np070629g

Target ChEMBL ID: CHEMBL398
ChEMBL Target Name: KB
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
IC50	=	0.41	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NCI-H187

External ID: CHEMBL928070

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2008
Volume: 71
Issue: 2
First Page: 292
Last Page: 294
DOI: 10.1021/np070629g

Target ChEMBL ID: CHEMBL2366276
ChEMBL Target Name: NCI-H187
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
IC50	=	0.52	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Vero

External ID: CHEMBL4368785

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: ACS Med Chem Lett
Year: 2019
Volume: 10
Issue: 10
First Page: 1400
Last Page: 1406
DOI: 10.1021/acsmedchemlett.9b00161

Target ChEMBL ID: CHEMBL391
ChEMBL Target Name: Vero
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.04	IC50	=	40	nM
12.4	IC50	=	12400	nM
1.87	IC50	=	1870	nM
0.07	IC50	=	70	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Salmon testes DNA

External ID: CHEMBL4828783

Protocol: N/A

Comment: Journal: J Nat Prod
Year: 2021
Volume: 84
Issue: 3.0
First Page: 750
Last Page: 761
DOI: 10.1021/acs.jnatprod.0c00946

Target ChEMBL ID: CHEMBL612408
ChEMBL Target Name: Salmon testes DNA
ChEMBL Target Type: NUCLEIC-ACID - Target is DNA, RNA or PNA
Relationship Type: M - Molecular target other than protein assigned
Confidence: Target assigned is molecular non-protein target

Standard Type	Activity Comment
Activity	Active
Activity	Active
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Homo sapiens

External ID: CHEMBL695426

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 1994
Volume: 37
Issue: 14
First Page: 2185
Last Page: 2189
DOI: 10.1021/jm00040a010

Target ChEMBL ID: CHEMBL372
ChEMBL Target Name: Homo sapiens
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
3.4	TGI	=	3400	nM
2.1	TGI	=	2100	nM
1	TGI	=	1000	nM
1.8	TGI	=	1800	nM
16	TGI	=	16000	nM
54	TGI	=	54000	nM
8.9	TGI	=	8900	nM
5.5	TGI	=	5500	nM
1	TGI	=	1000	nM
20	TGI	=	20000	nM
3.7	TGI	=	3700	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Homo sapiens

External ID: CHEMBL695427

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 1994
Volume: 37
Issue: 14
First Page: 2185
Last Page: 2189
DOI: 10.1021/jm00040a010

Target ChEMBL ID: CHEMBL372
ChEMBL Target Name: Homo sapiens
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
2.8	TGI	=	2800	nM
18	TGI	=	18000	nM
11	TGI	=	11000	nM
2.9	TGI	=	2900	nM
34	TGI	=	34000	nM
44	TGI	=	44000	nM
32	TGI	=	32000	nM
20	TGI	=	20000	nM
3.4	TGI	=	3400	nM
34	TGI	=	34000	nM
3.6	TGI	=	3600	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL4828782

Protocol: N/A

Comment: Journal: J Nat Prod
Year: 2021
Volume: 84
Issue: 3.0
First Page: 750
Last Page: 761
DOI: 10.1021/acs.jnatprod.0c00946

Standard Type	Standard Text Value
solubility	Soluble
solubility	Insoluble
solubility	Insoluble
solubility	Insoluble
solubility	Insoluble
solubility	Soluble
solubility	Soluble

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：KB

External ID: CHEMBL955283

Protocol: N/A

Comment: Journal: J Nat Prod
Year: 1982
Volume: 45
Issue: 4
First Page: 418
Last Page: 426
DOI: 10.1021/np50022a010

Target ChEMBL ID: CHEMBL398
ChEMBL Target Name: KB
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
ED50	=	4.3	ug ml-1
ED50	<	1	ug ml-1
ED50	=	2.3	ug ml-1
ED50	=	0.23	ug ml-1
ED50				Not Determined
ED50	=	0.36	ug ml-1
ED50	=	8.7	ug ml-1
ED50				Not Determined
ED50	=	3.9	ug ml-1
ED50	<	1	ug ml-1
ED50	<	0.25	ug ml-1
ED50	=	2.6	ug ml-1
ED50	=	10	ug ml-1
ED50	=	3.7	ug ml-1
ED50	>	100	ug ml-1
ED50	=	2.8	ug ml-1
ED50	=	0.013	ug ml-1
ED50	=	17	ug ml-1
ED50				Not Determined
ED50	=	8.9	ug ml-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Calcium/calmodulin-dependent protein kinase type II subunit gamma

External ID: CHEMBL3430795

Protocol: N/A

Comment: Journal: Proc Natl Acad Sci U S A
Year: 2007
Volume: 104
Issue: 51
First Page: 20523
Last Page: 20528
DOI: 10.1073/pnas.0708800104

Target ChEMBL ID: CHEMBL3829
ChEMBL Target Name: CaM kinase II gamma
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Thermal melting change	=	0	degrees C
Thermal melting change	=	-11.5	degrees C
Thermal melting change	=	0.4	degrees C
Thermal melting change	=	2.2	degrees C
Thermal melting change	=	2.9	degrees C
Thermal melting change	=	0	degrees C
Thermal melting change	=	4.9	degrees C
Thermal melting change	=	6.2	degrees C
Thermal melting change	=	5.2	degrees C
Thermal melting change	=	0.1	degrees C
Thermal melting change	=	0.1	degrees C
Thermal melting change	=	0.3	degrees C
Thermal melting change	=	0.3	degrees C
Thermal melting change	=	0.6	degrees C
Thermal melting change	=	-0.3	degrees C
Thermal melting change	=	1.6	degrees C
Thermal melting change	=	4.5	degrees C
Thermal melting change	=	0.1	degrees C
Thermal melting change	=	1.3	degrees C
Thermal melting change	=	0.4	degrees C

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：HepG2

External ID: CHEMBL3269592

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2014
Volume: 24
Issue: 10
First Page: 2244
Last Page: 2246
DOI: 10.1016/j.bmcl.2014.03.091

Target ChEMBL ID: CHEMBL395
ChEMBL Target Name: HepG2
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.2142	IC50	=	214.2	nM
0.0673	IC50	=	67.3	nM
0.0576	IC50	=	57.6	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Calcium/calmodulin-dependent protein kinase type IV

External ID: CHEMBL3430796

Protocol: N/A

Comment: Journal: Proc Natl Acad Sci U S A
Year: 2007
Volume: 104
Issue: 51
First Page: 20523
Last Page: 20528
DOI: 10.1073/pnas.0708800104

Target ChEMBL ID: CHEMBL2494
ChEMBL Target Name: CaM kinase IV
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Thermal melting change	=	0	degrees C
Thermal melting change	=	2.1	degrees C
Thermal melting change	=	0.4	degrees C
Thermal melting change	=	2.8	degrees C
Thermal melting change	=	1.1	degrees C
Thermal melting change	=	-0.8	degrees C
Thermal melting change	=	6.7	degrees C
Thermal melting change	=	3.3	degrees C
Thermal melting change	=	6	degrees C
Thermal melting change	=	0.2	degrees C
Thermal melting change	=	0.1	degrees C
Thermal melting change	=	0.2	degrees C
Thermal melting change	=	0.1	degrees C
Thermal melting change	=	0.2	degrees C
Thermal melting change	=	-0.2	degrees C
Thermal melting change	=	0.4	degrees C
Thermal melting change	=	4.8	degrees C
Thermal melting change	=	0	degrees C
Thermal melting change	=	4.2	degrees C
Thermal melting change	=	0.9	degrees C

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：KB

External ID: CHEMBL3269591

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2014
Volume: 24
Issue: 10
First Page: 2244
Last Page: 2246
DOI: 10.1016/j.bmcl.2014.03.091

Target ChEMBL ID: CHEMBL398
ChEMBL Target Name: KB
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.1605	IC50	=	160.5	nM
0.0862	IC50	=	86.2	nM
0.1074	IC50	=	107.4	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Calcium/calmodulin-dependent protein kinase type II subunit beta

External ID: CHEMBL3430793

Protocol: N/A

Comment: Journal: Proc Natl Acad Sci U S A
Year: 2007
Volume: 104
Issue: 51
First Page: 20523
Last Page: 20528
DOI: 10.1073/pnas.0708800104

Target ChEMBL ID: CHEMBL4121
ChEMBL Target Name: CaM kinase II beta
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Thermal melting change	=	0	degrees C
Thermal melting change	=	0.5	degrees C
Thermal melting change	=	0.8	degrees C
Thermal melting change	=	1.2	degrees C
Thermal melting change	=	0.9	degrees C
Thermal melting change	=	1.2	degrees C
Thermal melting change	=	2.9	degrees C
Thermal melting change	=	2.8	degrees C
Thermal melting change	=	2.2	degrees C
Thermal melting change	=	-0.2	degrees C
Thermal melting change	=	0.2	degrees C
Thermal melting change	=	0.3	degrees C
Thermal melting change	=	0.5	degrees C
Thermal melting change	=	0.1	degrees C
Thermal melting change	=	-0.5	degrees C
Thermal melting change	=	1	degrees C
Thermal melting change	=	1.3	degrees C
Thermal melting change	=	-0.1	degrees C
Thermal melting change	=	0.5	degrees C
Thermal melting change	=	1	degrees C

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：MCF7

External ID: CHEMBL3269594

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2014
Volume: 24
Issue: 10
First Page: 2244
Last Page: 2246
DOI: 10.1016/j.bmcl.2014.03.091

Target ChEMBL ID: CHEMBL387
ChEMBL Target Name: MCF7
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.269	IC50	>	269	nM
0.203	IC50	=	203	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Calcium/calmodulin-dependent protein kinase type II subunit delta

External ID: CHEMBL3430794

Protocol: N/A

Comment: Journal: Proc Natl Acad Sci U S A
Year: 2007
Volume: 104
Issue: 51
First Page: 20523
Last Page: 20528
DOI: 10.1073/pnas.0708800104

Target ChEMBL ID: CHEMBL2801
ChEMBL Target Name: CaM kinase II delta
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Thermal melting change	=	-0.3	degrees C
Thermal melting change	=	0.7	degrees C
Thermal melting change	=	0.4	degrees C
Thermal melting change	=	1	degrees C
Thermal melting change	=	1.1	degrees C
Thermal melting change	=	1.9	degrees C
Thermal melting change	=	2.7	degrees C
Thermal melting change	=	2.3	degrees C
Thermal melting change	=	2.3	degrees C
Thermal melting change	=	0.2	degrees C
Thermal melting change	=	-0.2	degrees C
Thermal melting change	=	0.1	degrees C
Thermal melting change	=	-0.3	degrees C
Thermal melting change	=	-0.1	degrees C
Thermal melting change	=	0.1	degrees C
Thermal melting change	=	-0.3	degrees C
Thermal melting change	=	1.2	degrees C
Thermal melting change	=	-0.5	degrees C
Thermal melting change	=	0.3	degrees C
Thermal melting change	=	0.6	degrees C

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NON-PROTEIN TARGET

External ID: CHEMBL3269593

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2014
Volume: 24
Issue: 10
First Page: 2244
Last Page: 2246
DOI: 10.1016/j.bmcl.2014.03.091

Target ChEMBL ID: CHEMBL3879801
ChEMBL Target Name: NON-PROTEIN TARGET
ChEMBL Target Type: NON-MOLECULAR - Target has not been defined at a molecular level, only the non-molecular entity which is affected (e.g., organism, cell line etc)
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.269	IC50	>	269	nM
0.269	IC50	>	269	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Cyclin-dependent kinase 6

External ID: CHEMBL3430799

Protocol: N/A

Comment: Journal: Proc Natl Acad Sci U S A
Year: 2007
Volume: 104
Issue: 51
First Page: 20523
Last Page: 20528
DOI: 10.1073/pnas.0708800104

Target ChEMBL ID: CHEMBL2508
ChEMBL Target Name: Cyclin-dependent kinase 6
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Thermal melting change	=	-0.1	degrees C
Thermal melting change	=	0.4	degrees C
Thermal melting change	=	0.4	degrees C
Thermal melting change	=	1.2	degrees C
Thermal melting change	=	0.4	degrees C
Thermal melting change	=	0.1	degrees C
Thermal melting change	=	1.9	degrees C
Thermal melting change	=	2	degrees C
Thermal melting change	=	2.1	degrees C
Thermal melting change	=	0.3	degrees C
Thermal melting change	=	0	degrees C
Thermal melting change	=	0.2	degrees C
Thermal melting change	=	0.5	degrees C
Thermal melting change	=	0.2	degrees C
Thermal melting change	=	0.9	degrees C
Thermal melting change	=	0.2	degrees C
Thermal melting change	=	0.4	degrees C
Thermal melting change	=	0.1	degrees C
Thermal melting change	=	0.4	degrees C
Thermal melting change	=	-0.4	degrees C

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Cyclin-dependent kinase-like 1

External ID: CHEMBL3430800

Protocol: N/A

Comment: Journal: Proc Natl Acad Sci U S A
Year: 2007
Volume: 104
Issue: 51
First Page: 20523
Last Page: 20528
DOI: 10.1073/pnas.0708800104

Target ChEMBL ID: CHEMBL5789
ChEMBL Target Name: Cyclin-dependent kinase-like 1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Thermal melting change	=	-0.4	degrees C
Thermal melting change	=	1.4	degrees C
Thermal melting change	=	-0.3	degrees C
Thermal melting change	=	0.6	degrees C
Thermal melting change	=	0.7	degrees C
Thermal melting change	=	-0.1	degrees C
Thermal melting change	=	1.6	degrees C
Thermal melting change	=	0.2	degrees C
Thermal melting change	=	0.5	degrees C
Thermal melting change	=	0.4	degrees C
Thermal melting change	=	0	degrees C
Thermal melting change	=	0.2	degrees C
Thermal melting change	=	0	degrees C
Thermal melting change	=	-0.2	degrees C
Thermal melting change	=	0	degrees C
Thermal melting change	=	0.7	degrees C
Thermal melting change	=	0.3	degrees C
Thermal melting change	=	-0.5	degrees C
Thermal melting change	=	2.7	degrees C
Thermal melting change	=	-0.3	degrees C

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Calcium/calmodulin-dependent protein kinase kinase 2

External ID: CHEMBL3430797

Protocol: N/A

Comment: Journal: Proc Natl Acad Sci U S A
Year: 2007
Volume: 104
Issue: 51
First Page: 20523
Last Page: 20528
DOI: 10.1073/pnas.0708800104

Target ChEMBL ID: CHEMBL5284
ChEMBL Target Name: CaM-kinase kinase beta
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Thermal melting change	=	0	degrees C
Thermal melting change	=	3	degrees C
Thermal melting change	=	-0.4	degrees C
Thermal melting change	=	-0.4	degrees C
Thermal melting change	=	2.6	degrees C
Thermal melting change	=	1.3	degrees C
Thermal melting change	=	5.5	degrees C
Thermal melting change	=	7.9	degrees C
Thermal melting change	=	6.8	degrees C
Thermal melting change	=	0.1	degrees C
Thermal melting change	=	-0.2	degrees C
Thermal melting change	=	0.3	degrees C
Thermal melting change	=	0.1	degrees C
Thermal melting change	=	-0.2	degrees C
Thermal melting change	=	-0.5	degrees C
Thermal melting change	=	1.3	degrees C
Thermal melting change	=	1.3	degrees C
Thermal melting change	=	-0.6	degrees C
Thermal melting change	=	3.3	degrees C
Thermal melting change	=	-1.2	degrees C

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Cyclin-dependent kinase 2

External ID: CHEMBL3430798

Protocol: N/A

Comment: Journal: Proc Natl Acad Sci U S A
Year: 2007
Volume: 104
Issue: 51
First Page: 20523
Last Page: 20528
DOI: 10.1073/pnas.0708800104

Target ChEMBL ID: CHEMBL301
ChEMBL Target Name: Cyclin-dependent kinase 2
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Thermal melting change	=	-0.1	degrees C
Thermal melting change	=	2.3	degrees C
Thermal melting change	=	0.3	degrees C
Thermal melting change	=	1.5	degrees C
Thermal melting change	=	1.7	degrees C
Thermal melting change	=	0.7	degrees C
Thermal melting change	=	5.3	degrees C
Thermal melting change	=	0.9	degrees C
Thermal melting change	=	-0.8	degrees C
Thermal melting change	=	-0.8	degrees C
Thermal melting change	=	0.4	degrees C
Thermal melting change	=	1.5	degrees C
Thermal melting change	=	-0.6	degrees C
Thermal melting change	=	0.4	degrees C
Thermal melting change	=	1.8	degrees C
Thermal melting change	=	1.6	degrees C
Thermal melting change	=	1.2	degrees C
Thermal melting change	=	0.5	degrees C
Thermal melting change	=	3.3	degrees C
Thermal melting change	=	0.3	degrees C

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Dual specificity protein kinase CLK2

External ID: CHEMBL3430803

Protocol: N/A

Comment: Journal: Proc Natl Acad Sci U S A
Year: 2007
Volume: 104
Issue: 51
First Page: 20523
Last Page: 20528
DOI: 10.1073/pnas.0708800104

Target ChEMBL ID: CHEMBL4225
ChEMBL Target Name: Dual specificity protein kinase CLK2
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Thermal melting change	=	0.2	degrees C
Thermal melting change	=	2.8	degrees C
Thermal melting change	=	0.7	degrees C
Thermal melting change	=	2.5	degrees C
Thermal melting change	=	4.1	degrees C
Thermal melting change	=	0.5	degrees C
Thermal melting change	=	4.9	degrees C
Thermal melting change	=	5.8	degrees C
Thermal melting change	=	5.9	degrees C
Thermal melting change	=	0.3	degrees C
Thermal melting change	=	0.1	degrees C
Thermal melting change	=	2.3	degrees C
Thermal melting change	=	0.3	degrees C
Thermal melting change	=	0.1	degrees C
Thermal melting change	=	0.1	degrees C
Thermal melting change	=	3.3	degrees C
Thermal melting change	=	3.6	degrees C
Thermal melting change	=	-0.1	degrees C
Thermal melting change	=	4.5	degrees C
Thermal melting change	=	-0.2	degrees C

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Dual specificity protein kinase CLK3

External ID: CHEMBL3430804

Protocol: N/A

Comment: Journal: Proc Natl Acad Sci U S A
Year: 2007
Volume: 104
Issue: 51
First Page: 20523
Last Page: 20528
DOI: 10.1073/pnas.0708800104

Target ChEMBL ID: CHEMBL4226
ChEMBL Target Name: Dual specificity protein kinase CLK3
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Thermal melting change	=	-0.1	degrees C
Thermal melting change	=	3.1	degrees C
Thermal melting change	=	0	degrees C
Thermal melting change	=	2.5	degrees C
Thermal melting change	=	2.7	degrees C
Thermal melting change	=	1	degrees C
Thermal melting change	=	5.4	degrees C
Thermal melting change	=	2.2	degrees C
Thermal melting change	=	2.1	degrees C
Thermal melting change	=	0.1	degrees C
Thermal melting change	=	-0.1	degrees C
Thermal melting change	=	0.8	degrees C
Thermal melting change	=	0.9	degrees C
Thermal melting change	=	-0.1	degrees C
Thermal melting change	=	0.1	degrees C
Thermal melting change	=	4.2	degrees C
Thermal melting change	=	2.4	degrees C
Thermal melting change	=	-0.1	degrees C
Thermal melting change	=	6.1	degrees C
Thermal melting change	=	-0.3	degrees C

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Serine/threonine-protein kinase Chk2

External ID: CHEMBL3430801

Protocol: N/A

Comment: Journal: Proc Natl Acad Sci U S A
Year: 2007
Volume: 104
Issue: 51
First Page: 20523
Last Page: 20528
DOI: 10.1073/pnas.0708800104

Target ChEMBL ID: CHEMBL2527
ChEMBL Target Name: Serine/threonine-protein kinase Chk2
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Thermal melting change	=	-0.5	degrees C
Thermal melting change	=	2.7	degrees C
Thermal melting change	=	-0.3	degrees C
Thermal melting change	=	2.6	degrees C
Thermal melting change	=	7.1	degrees C
Thermal melting change	=	1.6	degrees C
Thermal melting change	=	4.8	degrees C
Thermal melting change	=	10.3	degrees C
Thermal melting change	=	12.9	degrees C
Thermal melting change	=	0.1	degrees C
Thermal melting change	=	-0.6	degrees C
Thermal melting change	=	0	degrees C
Thermal melting change	=	0.4	degrees C
Thermal melting change	=	-0.2	degrees C
Thermal melting change	=	-0.4	degrees C
Thermal melting change	=	2	degrees C
Thermal melting change	=	14.1	degrees C
Thermal melting change	=	0.2	degrees C
Thermal melting change	=	7.5	degrees C
Thermal melting change	=	0.3	degrees C

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Dual specificity protein kinase CLK1

External ID: CHEMBL3430802

Protocol: N/A

Comment: Journal: Proc Natl Acad Sci U S A
Year: 2007
Volume: 104
Issue: 51
First Page: 20523
Last Page: 20528
DOI: 10.1073/pnas.0708800104

Target ChEMBL ID: CHEMBL4224
ChEMBL Target Name: Dual specificity protein kinase CLK1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Thermal melting change	=	-0.3	degrees C
Thermal melting change	=	3.9	degrees C
Thermal melting change	=	1.4	degrees C
Thermal melting change	=	4.1	degrees C
Thermal melting change	=	6.3	degrees C
Thermal melting change	=	1.1	degrees C
Thermal melting change	=	7.7	degrees C
Thermal melting change	=	6.6	degrees C
Thermal melting change	=	5.1	degrees C
Thermal melting change	=	1.3	degrees C
Thermal melting change	=	-0.2	degrees C
Thermal melting change	=	2.1	degrees C
Thermal melting change	=	-0.5	degrees C
Thermal melting change	=	0.8	degrees C
Thermal melting change	=	-1.2	degrees C
Thermal melting change	=	6.6	degrees C
Thermal melting change	=	4.3	degrees C
Thermal melting change	=	0.6	degrees C
Thermal melting change	=	5.5	degrees C
Thermal melting change	=	0.2	degrees C

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Casein kinase I isoform gamma-3

External ID: CHEMBL3430807

Protocol: N/A

Comment: Journal: Proc Natl Acad Sci U S A
Year: 2007
Volume: 104
Issue: 51
First Page: 20523
Last Page: 20528
DOI: 10.1073/pnas.0708800104

Target ChEMBL ID: CHEMBL5084
ChEMBL Target Name: Casein kinase I isoform gamma-3
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Thermal melting change	=	0.4	degrees C
Thermal melting change	=	0.7	degrees C
Thermal melting change	=	1.1	degrees C
Thermal melting change	=	0.7	degrees C
Thermal melting change	=	0.3	degrees C
Thermal melting change	=	1.6	degrees C
Thermal melting change	=	2.9	degrees C
Thermal melting change	=	3.8	degrees C
Thermal melting change	=	4.9	degrees C
Thermal melting change	=	2.4	degrees C
Thermal melting change	=	0	degrees C
Thermal melting change	=	0.9	degrees C
Thermal melting change	=	0.2	degrees C
Thermal melting change	=	1.1	degrees C
Thermal melting change	=	2.6	degrees C
Thermal melting change	=	0.7	degrees C
Thermal melting change	=	0.8	degrees C
Thermal melting change	=	0.4	degrees C
Thermal melting change	=	1.1	degrees C
Thermal melting change	=	0.4	degrees C

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Death-associated protein kinase 3

External ID: CHEMBL3430808

Protocol: N/A

Comment: Journal: Proc Natl Acad Sci U S A
Year: 2007
Volume: 104
Issue: 51
First Page: 20523
Last Page: 20528
DOI: 10.1073/pnas.0708800104

Target ChEMBL ID: CHEMBL2468
ChEMBL Target Name: Death-associated protein kinase 3
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Thermal melting change	=	-0.4	degrees C
Thermal melting change	=	3.5	degrees C
Thermal melting change	=	-0.1	degrees C
Thermal melting change	=	-0.2	degrees C
Thermal melting change	=	2.8	degrees C
Thermal melting change	=	0.5	degrees C
Thermal melting change	=	7.5	degrees C
Thermal melting change	=	5.9	degrees C
Thermal melting change	=	0.3	degrees C
Thermal melting change	=	0.8	degrees C
Thermal melting change	=	-0.1	degrees C
Thermal melting change	=	-0.1	degrees C
Thermal melting change	=	1.2	degrees C
Thermal melting change	=	0.9	degrees C
Thermal melting change	=	0.1	degrees C
Thermal melting change	=	4.3	degrees C
Thermal melting change	=	11.8	degrees C
Thermal melting change	=	-0.6	degrees C
Thermal melting change	=	3.4	degrees C
Thermal melting change	=	-0.2	degrees C

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Casein kinase I isoform gamma-1

External ID: CHEMBL3430805

Protocol: N/A

Comment: Journal: Proc Natl Acad Sci U S A
Year: 2007
Volume: 104
Issue: 51
First Page: 20523
Last Page: 20528
DOI: 10.1073/pnas.0708800104

Target ChEMBL ID: CHEMBL2426
ChEMBL Target Name: Casein kinase I gamma 1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Thermal melting change	=	0.8	degrees C
Thermal melting change	=	1.4	degrees C
Thermal melting change	=	0.7	degrees C
Thermal melting change	=	0.6	degrees C
Thermal melting change	=	1	degrees C
Thermal melting change	=	0.8	degrees C
Thermal melting change	=	3.2	degrees C
Thermal melting change	=	4.3	degrees C
Thermal melting change	=	4.5	degrees C
Thermal melting change	=	3	degrees C
Thermal melting change	=	0.1	degrees C
Thermal melting change	=	1.2	degrees C
Thermal melting change	=	0.5	degrees C
Thermal melting change	=	1	degrees C
Thermal melting change	=	3	degrees C
Thermal melting change	=	0.6	degrees C
Thermal melting change	=	0.5	degrees C
Thermal melting change	=	0.5	degrees C
Thermal melting change	=	2	degrees C
Thermal melting change	=	0.5	degrees C

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Casein kinase I isoform gamma-2

External ID: CHEMBL3430806

Protocol: N/A

Comment: Journal: Proc Natl Acad Sci U S A
Year: 2007
Volume: 104
Issue: 51
First Page: 20523
Last Page: 20528
DOI: 10.1073/pnas.0708800104

Target ChEMBL ID: CHEMBL2543
ChEMBL Target Name: Casein kinase I gamma 2
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Thermal melting change	=	0.7	degrees C
Thermal melting change	=	0.7	degrees C
Thermal melting change	=	0.5	degrees C
Thermal melting change	=	0.7	degrees C
Thermal melting change	=	0.5	degrees C
Thermal melting change	=	0.3	degrees C
Thermal melting change	=	2.4	degrees C
Thermal melting change	=	4	degrees C
Thermal melting change	=	4.9	degrees C
Thermal melting change	=	2	degrees C
Thermal melting change	=	0.5	degrees C
Thermal melting change	=	1.2	degrees C
Thermal melting change	=	-0.1	degrees C
Thermal melting change	=	0.8	degrees C
Thermal melting change	=	1.7	degrees C
Thermal melting change	=	0.2	degrees C
Thermal melting change	=	0.7	degrees C
Thermal melting change	=	0.4	degrees C
Thermal melting change	=	1.8	degrees C
Thermal melting change	=	0.2	degrees C

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Vero

External ID: CHEMBL3592236

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2015
Volume: 23
Issue: 13
First Page: 3472
Last Page: 3480
DOI: 10.1016/j.bmc.2015.04.036

Target ChEMBL ID: CHEMBL391
ChEMBL Target Name: Vero
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
50	IC50	>	50000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：A549

External ID: CHEMBL1219513

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2010
Volume: 18
Issue: 16
First Page: 5873
Last Page: 5884
DOI: 10.1016/j.bmc.2010.06.098

Target ChEMBL ID: CHEMBL392
ChEMBL Target Name: A549
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
4.9	IC50	=	4900	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：MCF7

External ID: CHEMBL1219512

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2010
Volume: 18
Issue: 16
First Page: 5873
Last Page: 5884
DOI: 10.1016/j.bmc.2010.06.098

Target ChEMBL ID: CHEMBL387
ChEMBL Target Name: MCF7
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
2.4	IC50	=	2400	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Calcium/calmodulin-dependent protein kinase type 1G

External ID: CHEMBL3430791

Protocol: N/A

Comment: Journal: Proc Natl Acad Sci U S A
Year: 2007
Volume: 104
Issue: 51
First Page: 20523
Last Page: 20528
DOI: 10.1073/pnas.0708800104

Target ChEMBL ID: CHEMBL5258
ChEMBL Target Name: CaM kinase I gamma
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Thermal melting change	=	-0.2	degrees C
Thermal melting change	=	0.9	degrees C
Thermal melting change	=	0.7	degrees C
Thermal melting change	=	1	degrees C
Thermal melting change	=	0.6	degrees C
Thermal melting change	=	-0.1	degrees C
Thermal melting change	=	2.7	degrees C
Thermal melting change	=	5.7	degrees C
Thermal melting change	=	7.3	degrees C
Thermal melting change	=	0.3	degrees C
Thermal melting change	=	0	degrees C
Thermal melting change	=	0	degrees C
Thermal melting change	=	0	degrees C
Thermal melting change	=	-0.1	degrees C
Thermal melting change	=	-0.2	degrees C
Thermal melting change	=	0.3	degrees C
Thermal melting change	=	1.9	degrees C
Thermal melting change	=	0.2	degrees C
Thermal melting change	=	0.5	degrees C
Thermal melting change	=	-0.1	degrees C

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Calcium/calmodulin-dependent protein kinase type II subunit alpha

External ID: CHEMBL3430792

Protocol: N/A

Comment: Journal: Proc Natl Acad Sci U S A
Year: 2007
Volume: 104
Issue: 51
First Page: 20523
Last Page: 20528
DOI: 10.1073/pnas.0708800104

Target ChEMBL ID: CHEMBL4147
ChEMBL Target Name: CaM kinase II alpha
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Thermal melting change	=	0.3	degrees C
Thermal melting change	=	0.5	degrees C
Thermal melting change	=	1	degrees C
Thermal melting change	=	3.3	degrees C
Thermal melting change	=	2.4	degrees C
Thermal melting change	=	0.8	degrees C
Thermal melting change	=	4.1	degrees C
Thermal melting change	=	5.7	degrees C
Thermal melting change	=	5	degrees C
Thermal melting change	=	0.4	degrees C
Thermal melting change	=	-0.3	degrees C
Thermal melting change	=	-0.1	degrees C
Thermal melting change	=	0	degrees C
Thermal melting change	=	0.4	degrees C
Thermal melting change	=	2.2	degrees C
Thermal melting change	=	2.2	degrees C
Thermal melting change	=	2.6	degrees C
Thermal melting change	=	-0.1	degrees C
Thermal melting change	=	0.5	degrees C
Thermal melting change	=	0.3	degrees C

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：5'-AMP-activated protein kinase catalytic subunit alpha-2

External ID: CHEMBL3430789

Protocol: N/A

Comment: Journal: Proc Natl Acad Sci U S A
Year: 2007
Volume: 104
Issue: 51
First Page: 20523
Last Page: 20528
DOI: 10.1073/pnas.0708800104

Target ChEMBL ID: CHEMBL2116
ChEMBL Target Name: AMP-activated protein kinase, alpha-2 subunit
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Thermal melting change	=	-0.9	degrees C
Thermal melting change	=	1.5	degrees C
Thermal melting change	=	-1	degrees C
Thermal melting change	=	1.2	degrees C
Thermal melting change	=	2.6	degrees C
Thermal melting change	=	1.6	degrees C
Thermal melting change	=	2.3	degrees C
Thermal melting change	=	7	degrees C
Thermal melting change	=	7.4	degrees C
Thermal melting change	=	0.4	degrees C
Thermal melting change	=	0.2	degrees C
Thermal melting change	=	0.4	degrees C
Thermal melting change	=	-0.6	degrees C
Thermal melting change	=	-0.7	degrees C
Thermal melting change	=	-0.4	degrees C
Thermal melting change	=	1.8	degrees C
Thermal melting change	=	6.4	degrees C
Thermal melting change	=	0.4	degrees C
Thermal melting change	=	0.3	degrees C
Thermal melting change	=	-0.9	degrees C

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Calcium/calmodulin-dependent protein kinase type 1D

External ID: CHEMBL3430790

Protocol: N/A

Comment: Journal: Proc Natl Acad Sci U S A
Year: 2007
Volume: 104
Issue: 51
First Page: 20523
Last Page: 20528
DOI: 10.1073/pnas.0708800104

Target ChEMBL ID: CHEMBL5073
ChEMBL Target Name: CaM kinase I delta
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Thermal melting change	=	-0.2	degrees C
Thermal melting change	=	1	degrees C
Thermal melting change	=	0.6	degrees C
Thermal melting change	=	0.6	degrees C
Thermal melting change	=	1.1	degrees C
Thermal melting change	=	0.7	degrees C
Thermal melting change	=	2.9	degrees C
Thermal melting change	=	2.6	degrees C
Thermal melting change	=	2.4	degrees C
Thermal melting change	=	-0.2	degrees C
Thermal melting change	=	-0.1	degrees C
Thermal melting change	=	0	degrees C
Thermal melting change	=	0.1	degrees C
Thermal melting change	=	-0.1	degrees C
Thermal melting change	=	0.2	degrees C
Thermal melting change	=	1.2	degrees C
Thermal melting change	=	3.6	degrees C
Thermal melting change	=	0.1	degrees C
Thermal melting change	=	0.7	degrees C
Thermal melting change	=	0.1	degrees C

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Serine/threonine-protein kinase pim-1

External ID: CHEMBL3430827

Protocol: N/A

Comment: Journal: Proc Natl Acad Sci U S A
Year: 2007
Volume: 104
Issue: 51
First Page: 20523
Last Page: 20528
DOI: 10.1073/pnas.0708800104

Target ChEMBL ID: CHEMBL2147
ChEMBL Target Name: Serine/threonine-protein kinase PIM1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Thermal melting change	=	-2.1	degrees C
Thermal melting change	=	3.7	degrees C
Thermal melting change	=	0.2	degrees C
Thermal melting change	=	5.9	degrees C
Thermal melting change	=	7	degrees C
Thermal melting change	=	3.3	degrees C
Thermal melting change	=	8.1	degrees C
Thermal melting change	=	2.9	degrees C
Thermal melting change	=	2.3	degrees C
Thermal melting change	=	-0.1	degrees C
Thermal melting change	=	-1	degrees C
Thermal melting change	=	-1	degrees C
Thermal melting change	=	0	degrees C
Thermal melting change	=	-1.4	degrees C
Thermal melting change	=	-1.2	degrees C
Thermal melting change	=	4.8	degrees C
Thermal melting change	=	3.7	degrees C
Thermal melting change	=	-0.2	degrees C
Thermal melting change	=	1.2	degrees C
Thermal melting change	=	-0.2	degrees C

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Serine/threonine-protein kinase pim-2

External ID: CHEMBL3430828

Protocol: N/A

Comment: Journal: Proc Natl Acad Sci U S A
Year: 2007
Volume: 104
Issue: 51
First Page: 20523
Last Page: 20528
DOI: 10.1073/pnas.0708800104

Target ChEMBL ID: CHEMBL4523
ChEMBL Target Name: Serine/threonine-protein kinase PIM2
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Thermal melting change	=	0	degrees C
Thermal melting change	=	3.8	degrees C
Thermal melting change	=	0.4	degrees C
Thermal melting change	=	4	degrees C
Thermal melting change	=	5.2	degrees C
Thermal melting change	=	3.1	degrees C
Thermal melting change	=	8.6	degrees C
Thermal melting change	=	2.3	degrees C
Thermal melting change	=	0	degrees C
Thermal melting change	=	0.2	degrees C
Thermal melting change	=	0.1	degrees C
Thermal melting change	=	0.3	degrees C
Thermal melting change	=	0	degrees C
Thermal melting change	=	0.8	degrees C
Thermal melting change	=	0.5	degrees C
Thermal melting change	=	7.1	degrees C
Thermal melting change	=	5.1	degrees C
Thermal melting change	=	-0.1	degrees C
Thermal melting change	=	-0.1	degrees C
Thermal melting change	=	-0.2	degrees C

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Cyclin-dependent kinase 16

External ID: CHEMBL3430825

Protocol: N/A

Comment: Journal: Proc Natl Acad Sci U S A
Year: 2007
Volume: 104
Issue: 51
First Page: 20523
Last Page: 20528
DOI: 10.1073/pnas.0708800104

Target ChEMBL ID: CHEMBL4597
ChEMBL Target Name: Serine/threonine-protein kinase PCTAIRE-1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Thermal melting change	=	-0.8	degrees C
Thermal melting change	=	1.2	degrees C
Thermal melting change	=	0.3	degrees C
Thermal melting change	=	1.7	degrees C
Thermal melting change	=	3	degrees C
Thermal melting change	=	-0.6	degrees C
Thermal melting change	=	1.8	degrees C
Thermal melting change	=	3.5	degrees C
Thermal melting change	=	-0.2	degrees C
Thermal melting change	=	0.5	degrees C
Thermal melting change	=	-0.6	degrees C
Thermal melting change	=	-0.1	degrees C
Thermal melting change	=	-0.4	degrees C
Thermal melting change	=	-0.4	degrees C
Thermal melting change	=	-0.9	degrees C
Thermal melting change	=	-0.4	degrees C
Thermal melting change	=	0	degrees C
Thermal melting change	=	-0.4	degrees C
Thermal melting change	=	8.1	degrees C
Thermal melting change	=	-0.4	degrees C

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：3-phosphoinositide-dependent protein kinase 1

External ID: CHEMBL3430826

Protocol: N/A

Comment: Journal: Proc Natl Acad Sci U S A
Year: 2007
Volume: 104
Issue: 51
First Page: 20523
Last Page: 20528
DOI: 10.1073/pnas.0708800104

Target ChEMBL ID: CHEMBL2534
ChEMBL Target Name: 3-phosphoinositide dependent protein kinase-1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Thermal melting change	=	-0.1	degrees C
Thermal melting change	=	-1.9	degrees C
Thermal melting change	=	-0.1	degrees C
Thermal melting change	=	0	degrees C
Thermal melting change	=	-0.2	degrees C
Thermal melting change	=	2.5	degrees C
Thermal melting change	=	1.1	degrees C
Thermal melting change	=	-0.7	degrees C
Thermal melting change	=	2.9	degrees C
Thermal melting change	=	-0.2	degrees C
Thermal melting change	=	0	degrees C
Thermal melting change	=	0.2	degrees C
Thermal melting change	=	0	degrees C
Thermal melting change	=	-1	degrees C
Thermal melting change	=	-0.1	degrees C
Thermal melting change	=	8.6	degrees C
Thermal melting change	=	-1.3	degrees C
Thermal melting change	=	0	degrees C
Thermal melting change	=	1.4	degrees C
Thermal melting change	=	0	degrees C

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Serine/threonine-protein kinase PLK4

External ID: CHEMBL3430831

Protocol: N/A

Comment: Journal: Proc Natl Acad Sci U S A
Year: 2007
Volume: 104
Issue: 51
First Page: 20523
Last Page: 20528
DOI: 10.1073/pnas.0708800104

Target ChEMBL ID: CHEMBL3788
ChEMBL Target Name: Serine/threonine-protein kinase PLK4
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Thermal melting change	=	0.7	degrees C
Thermal melting change	=	5.2	degrees C
Thermal melting change	=	0.1	degrees C
Thermal melting change	=	4.2	degrees C
Thermal melting change	=	3	degrees C
Thermal melting change	=	0.4	degrees C
Thermal melting change	=	7.4	degrees C
Thermal melting change	=	7.8	degrees C
Thermal melting change	=	1.6	degrees C
Thermal melting change	=	0.2	degrees C
Thermal melting change	=	0.2	degrees C
Thermal melting change	=	0.3	degrees C
Thermal melting change	=	-0.1	degrees C
Thermal melting change	=	1.1	degrees C
Thermal melting change	=	1.8	degrees C
Thermal melting change	=	3.3	degrees C
Thermal melting change	=	11.8	degrees C
Thermal melting change	=	0.2	degrees C
Thermal melting change	=	6.2	degrees C
Thermal melting change	=	-0.2	degrees C

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Lu1

External ID: CHEMBL979727

Protocol: N/A

Comment: Journal: J Nat Prod
Year: 2008
Volume: 71
Issue: 4
First Page: 655
Last Page: 663
DOI: 10.1021/np7007347

Target ChEMBL ID: CHEMBL613290
ChEMBL Target Name: Lu1
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
ED50	=	0.2	ug ml-1
ED50	>	5	ug ml-1
ED50	>	5	ug ml-1
ED50	>	5	ug ml-1
ED50	>	5	ug ml-1
ED50	>	5	ug ml-1
ED50	>	5	ug ml-1
ED50	=	3.1	ug ml-1
ED50	=	0.14	ug ml-1
ED50	>	5	ug ml-1
ED50	>	5	ug ml-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：cAMP-dependent protein kinase catalytic subunit alpha

External ID: CHEMBL3430832

Protocol: N/A

Comment: Journal: Proc Natl Acad Sci U S A
Year: 2007
Volume: 104
Issue: 51
First Page: 20523
Last Page: 20528
DOI: 10.1073/pnas.0708800104

Target ChEMBL ID: CHEMBL4101
ChEMBL Target Name: cAMP-dependent protein kinase alpha-catalytic subunit
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Thermal melting change	=	0	degrees C
Thermal melting change	=	1.7	degrees C
Thermal melting change	=	1.1	degrees C
Thermal melting change	=	1.4	degrees C
Thermal melting change	=	3.6	degrees C
Thermal melting change	=	2.1	degrees C
Thermal melting change	=	4.2	degrees C
Thermal melting change	=	2	degrees C
Thermal melting change	=	9.2	degrees C
Thermal melting change	=	0.7	degrees C
Thermal melting change	=	-0.1	degrees C
Thermal melting change	=	0.2	degrees C
Thermal melting change	=	0	degrees C
Thermal melting change	=	2.6	degrees C
Thermal melting change	=	1.6	degrees C
Thermal melting change	=	5.9	degrees C
Thermal melting change	=	2.6	degrees C
Thermal melting change	=	1.1	degrees C
Thermal melting change	=	6.5	degrees C
Thermal melting change	=	0.4	degrees C

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Serine/threonine-protein kinase pim-3

External ID: CHEMBL3430829

Protocol: N/A

Comment: Journal: Proc Natl Acad Sci U S A
Year: 2007
Volume: 104
Issue: 51
First Page: 20523
Last Page: 20528
DOI: 10.1073/pnas.0708800104

Target ChEMBL ID: CHEMBL5407
ChEMBL Target Name: Serine/threonine-protein kinase PIM3
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Thermal melting change	=	0	degrees C
Thermal melting change	=	4.6	degrees C
Thermal melting change	=	0.5	degrees C
Thermal melting change	=	6.3	degrees C
Thermal melting change	=	9.1	degrees C
Thermal melting change	=	3	degrees C
Thermal melting change	=	8.8	degrees C
Thermal melting change	=	4.7	degrees C
Thermal melting change	=	7.1	degrees C
Thermal melting change	=	0	degrees C
Thermal melting change	=	-0.1	degrees C
Thermal melting change	=	0.5	degrees C
Thermal melting change	=	-0.1	degrees C
Thermal melting change	=	1.3	degrees C
Thermal melting change	=	0.7	degrees C
Thermal melting change	=	1.3	degrees C
Thermal melting change	=	7.2	degrees C
Thermal melting change	=	0.5	degrees C
Thermal melting change	=	6.7	degrees C
Thermal melting change	=	0.3	degrees C

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Serine/threonine-protein kinase PLK1

External ID: CHEMBL3430830

Protocol: N/A

Comment: Journal: Proc Natl Acad Sci U S A
Year: 2007
Volume: 104
Issue: 51
First Page: 20523
Last Page: 20528
DOI: 10.1073/pnas.0708800104

Target ChEMBL ID: CHEMBL3024
ChEMBL Target Name: Serine/threonine-protein kinase PLK1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Thermal melting change	=	0.2	degrees C
Thermal melting change	=	2	degrees C
Thermal melting change	=	0.7	degrees C
Thermal melting change	=	0.6	degrees C
Thermal melting change	=	1	degrees C
Thermal melting change	=	1.4	degrees C
Thermal melting change	=	1.7	degrees C
Thermal melting change	=	0.5	degrees C
Thermal melting change	=	1.5	degrees C
Thermal melting change	=	0.1	degrees C
Thermal melting change	=	-0.9	degrees C
Thermal melting change	=	1	degrees C
Thermal melting change	=	1.6	degrees C
Thermal melting change	=	0.1	degrees C
Thermal melting change	=	-1.4	degrees C
Thermal melting change	=	3.9	degrees C
Thermal melting change	=	11.9	degrees C
Thermal melting change	=	0.1	degrees C
Thermal melting change	=	1	degrees C
Thermal melting change	=	1.3	degrees C

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NON-PROTEIN TARGET

External ID: CHEMBL979728

Protocol: N/A

Comment: Journal: J Nat Prod
Year: 2008
Volume: 71
Issue: 4
First Page: 655
Last Page: 663
DOI: 10.1021/np7007347

Target ChEMBL ID: CHEMBL3879801
ChEMBL Target Name: NON-PROTEIN TARGET
ChEMBL Target Type: NON-MOLECULAR - Target has not been defined at a molecular level, only the non-molecular entity which is affected (e.g., organism, cell line etc)
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
ED50	=	0.2	ug ml-1
ED50	>	5	ug ml-1
ED50	>	5	ug ml-1
ED50	>	5	ug ml-1
ED50	>	5	ug ml-1
ED50	>	5	ug ml-1
ED50	>	5	ug ml-1
ED50	>	5	ug ml-1
ED50	=	2.3	ug ml-1
ED50	>	5	ug ml-1
ED50	>	5	ug ml-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL1219514

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2010
Volume: 18
Issue: 16
First Page: 5873
Last Page: 5884
DOI: 10.1016/j.bmc.2010.06.098

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
10	IC50	>	10000	nM

519-23-3 靶点实验数据