HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Rhodopsin

External ID: CHEMBL1769973

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2011
Volume: 74
Issue: 3
First Page: 383
Last Page: 390
DOI: 10.1021/np100744v

Target ChEMBL ID: CHEMBL5739
ChEMBL Target Name: Rhodopsin
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
Activity	=	104	%
Activity	=	100	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Aldo-keto reductase family 1 member B10

External ID: CHEMBL921558

Protocol: N/A

Comment: Journal: Proc. Natl. Acad. Sci. U.S.A.
Year: 2007
Volume: 104
Issue: 52
First Page: 20764
Last Page: 20769
DOI: 10.1073/pnas.0705659105

Target ChEMBL ID: CHEMBL5983
ChEMBL Target Name: Aldo-keto reductase family 1 member B10
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
Kcat/Km	=	3500	/mM/min
Kcat/Km	=	4.9	/mM/min
Kcat/Km				Not Determined

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Aldo-keto reductase family 1 member B10

External ID: CHEMBL921554

Protocol: N/A

Comment: Journal: Proc. Natl. Acad. Sci. U.S.A.
Year: 2007
Volume: 104
Issue: 52
First Page: 20764
Last Page: 20769
DOI: 10.1073/pnas.0705659105

Target ChEMBL ID: CHEMBL5983
ChEMBL Target Name: Aldo-keto reductase family 1 member B10
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Kcat/Km	=	13100	/mM/min
Kcat/Km	=	7	/mM/min
Kcat/Km	=	1300	/mM/min

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Aldo-keto reductase family 1 member B10

External ID: CHEMBL921556

Protocol: N/A

Comment: Journal: Proc. Natl. Acad. Sci. U.S.A.
Year: 2007
Volume: 104
Issue: 52
First Page: 20764
Last Page: 20769
DOI: 10.1073/pnas.0705659105

Target ChEMBL ID: CHEMBL5983
ChEMBL Target Name: Aldo-keto reductase family 1 member B10
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Kcat/Km	=	12700	/mM/min
Kcat/Km	=	7	/mM/min
Kcat/Km	=	1800	/mM/min

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Aldo-keto reductase family 1 member B1

External ID: CHEMBL921550

Protocol: N/A

Comment: Journal: Proc. Natl. Acad. Sci. U.S.A.
Year: 2007
Volume: 104
Issue: 52
First Page: 20764
Last Page: 20769
DOI: 10.1073/pnas.0705659105

Target ChEMBL ID: CHEMBL1900
ChEMBL Target Name: Aldose reductase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Kcat/Km	=	320	/mM/min
Kcat/Km	=	660	/mM/min
Kcat/Km	=	1500	/mM/min

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：HEK293

External ID: CHEMBL1251197

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2010
Volume: 18
Issue: 19
First Page: 7022
Last Page: 7028
DOI: 10.1016/j.bmc.2010.08.014

Target ChEMBL ID: CHEMBL614818
ChEMBL Target Name: HEK293
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Dose-dependent effect
Activity	Dose-dependent effect

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：HEK293

External ID: CHEMBL1251196

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2010
Volume: 18
Issue: 19
First Page: 7022
Last Page: 7028
DOI: 10.1016/j.bmc.2010.08.014

Target ChEMBL ID: CHEMBL614818
ChEMBL Target Name: HEK293
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
100	CC50	>	100000	nM
49	CC50	=	49000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Aldo-keto reductase family 1 member B10

External ID: CHEMBL921552

Protocol: N/A

Comment: Journal: Proc. Natl. Acad. Sci. U.S.A.
Year: 2007
Volume: 104
Issue: 52
First Page: 20764
Last Page: 20769
DOI: 10.1073/pnas.0705659105

Target ChEMBL ID: CHEMBL5983
ChEMBL Target Name: Aldo-keto reductase family 1 member B10
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Kcat/Km	=	45000	/mM/min
Kcat/Km	=	6	/mM/min
Kcat/Km	=	1300	/mM/min

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Rhodopsin

External ID: CHEMBL1251195

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2010
Volume: 18
Issue: 19
First Page: 7022
Last Page: 7028
DOI: 10.1016/j.bmc.2010.08.014

Target ChEMBL ID: CHEMBL4296308
ChEMBL Target Name: Rhodopsin
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Activity Comment
Activity	Active
Activity	Active

514-85-2 靶点实验数据