HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Monoglyceride lipase

External ID: CHEMBL944311

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2008
Volume: 51
Issue: 22
First Page: 7057
Last Page: 7060
DOI: 10.1021/jm801051t

Target ChEMBL ID: CHEMBL4191
ChEMBL Target Name: Monoglyceride lipase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
100	IC50	=	100000	nM
38	IC50	=	38000	nM
19	IC50	=	19000	nM
7.9	IC50	=	7900	nM
31	IC50	=	31000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Subtilisin Carlsberg

External ID: CHEMBL808805

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem Lett
Year: 1996
Volume: 6
Issue: 21
First Page: 2501
Last Page: 2506
DOI: 10.1016/0960-894X(96)00466-0

Target ChEMBL ID: CHEMBL4299
ChEMBL Target Name: Subtilisin
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
257	Ki	=	257000	nM	Outside typical range
8	Ki	=	8000	nM
180	Ki	=	180000	nM	Outside typical range
75	Ki	=	75000	nM
100	Ki	=	100000	nM
120	Ki	=	120000	nM	Outside typical range
19	Ki	=	19000	nM
58	Ki	=	58000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Beta-lactamase TEM

External ID: CHEMBL771484

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 1994
Volume: 4
Issue: 10
First Page: 1229
Last Page: 1234
DOI: 10.1016/S0960-894X(01)80336-X

Target ChEMBL ID: CHEMBL2065
ChEMBL Target Name: Beta-lactamase TEM
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
83	Ki	=	83000	nM
28	Ki	=	28000	nM
43	Ki	=	43000	nM
29.8	Ki	=	29800	nM
49	Ki	=	49000	nM
58	Ki	=	58000	nM
101	Ki	=	101000	nM	Outside typical range
121	Ki	=	121000	nM	Outside typical range
670	Ki	=	670000	nM	Outside typical range
141	Ki	=	141000	nM	Outside typical range
106	Ki	=	106000	nM	Outside typical range
3700	Ki	=	3700000	nM	Outside typical range
491	Ki	=	491000	nM	Outside typical range
83	Ki	=	83000	nM
50	Ki	=	50000	nM
44	Ki	=	44000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL801818

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem Lett
Year: 1996
Volume: 6
Issue: 21
First Page: 2507
Last Page: 2512
DOI: 10.1016/0960-894X(96)00467-2

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
820	Ki	=	820000	nM	Outside typical range
139	Ki	=	139000	nM	Outside typical range
123	Ki	=	123000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL801133

Protocol: N/A

Comment: Journal: Bioorg Med Chem Lett
Year: 1996
Volume: 6
Issue: 21
First Page: 2507
Last Page: 2512
DOI: 10.1016/0960-894X(96)00467-2

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
290	Ki	=	290000	nM	Outside typical range
176	Ki	=	176000	nM	Outside typical range
146	Ki	=	146000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL801132

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem Lett
Year: 1996
Volume: 6
Issue: 21
First Page: 2507
Last Page: 2512
DOI: 10.1016/0960-894X(96)00467-2

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
178	Ki	=	178000	nM	Outside typical range
127	Ki	=	127000	nM	Outside typical range
108	Ki	=	108000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL801131

Protocol: N/A

Comment: Journal: Bioorg Med Chem Lett
Year: 1996
Volume: 6
Issue: 21
First Page: 2507
Last Page: 2512
DOI: 10.1016/0960-894X(96)00467-2

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
241	Ki	=	241000	nM	Outside typical range
204	Ki	=	204000	nM	Outside typical range
155	Ki	=	155000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL801820

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem Lett
Year: 1996
Volume: 6
Issue: 21
First Page: 2507
Last Page: 2512
DOI: 10.1016/0960-894X(96)00467-2

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
801	Ki	=	801000	nM	Outside typical range
150	Ki	=	150000	nM	Outside typical range
141	Ki	=	141000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Subtilisin BL

External ID: CHEMBL801819

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem Lett
Year: 1996
Volume: 6
Issue: 21
First Page: 2501
Last Page: 2506
DOI: 10.1016/0960-894X(96)00466-0

Target ChEMBL ID: CHEMBL4258
ChEMBL Target Name: Subtilisin
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
801	Ki	=	801000	nM	Outside typical range
27	Ki	=	27000	nM
577	Ki	=	577000	nM	Outside typical range
150	Ki	=	150000	nM	Outside typical range
141	Ki	=	141000	nM	Outside typical range
1584	Ki	=	1584000	nM	Outside typical range
325	Ki	=	325000	nM	Outside typical range
802	Ki	=	802000	nM	Outside typical range
986	Ki	=	986000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：BindingDB 靶标：N/A

External ID: BindingDB_2926_1

Protocol: N/A

Comment: Compounds with any of Ki, IC50, Kd, or EC50 activity value <= 10uM are labeled as "Active".
If multiple measurements are available for a given compound, it is labeled as "Active" if any of the measurements meet the criterion. Activity values are checked in the order of Ki, IC50, Kd, and EC50. The first entry that meets the above activity threshold is used to determine "Standard Type", "Standard Relation", and "PubChem Standard Value". Otherwise, the first non-empty entry will be used to set those values.

Standard Type	PubChem Standard Value	IC50	Target Accession(s)	Ligand	Target
IC50	38	38000	Q99685	BDBM26124	Monoglyceride lipase
IC50	1.6	1600	P97612	BDBM26125	Fatty-acid amide hydrolase 1 [30-579]
IC50	0.13	130	P97612	BDBM26126	Fatty-acid amide hydrolase 1 [30-579]
IC50	71	71000	Q99685	BDBM26126	Monoglyceride lipase
IC50	1.9	1900	P97612	BDBM26127	Fatty-acid amide hydrolase 1 [30-579]
IC50	1.5	1500	P97612	BDBM26128	Fatty-acid amide hydrolase 1 [30-579]
IC50	0.036	36	P97612	BDBM26129	Fatty-acid amide hydrolase 1 [30-579]
IC50	20	20000	Q99685	BDBM26129	Monoglyceride lipase
IC50	0.21	210	P97612	BDBM26130	Fatty-acid amide hydrolase 1 [30-579]
IC50	0.29	290	P97612	BDBM26131	Fatty-acid amide hydrolase 1 [30-579]
IC50	0.021	21	P97612	BDBM26132	Fatty-acid amide hydrolase 1 [30-579]
IC50	19	19000	Q99685	BDBM26132	Monoglyceride lipase
IC50	2	2000	P97612	BDBM26133	Fatty-acid amide hydrolase 1 [30-579]
IC50	0.0091	9.1	P97612	BDBM26134	Fatty-acid amide hydrolase 1 [30-579]
IC50	7.9	7900	Q99685	BDBM26134	Monoglyceride lipase
IC50	0.71	710	P97612	BDBM26135	Fatty-acid amide hydrolase 1 [30-579]
IC50	68	68000	P97612	BDBM26136	Fatty-acid amide hydrolase 1 [30-579]
IC50	110	110000	P97612	BDBM26137	Fatty-acid amide hydrolase 1 [30-579]
IC50	13	13000	P97612	BDBM26138	Fatty-acid amide hydrolase 1 [30-579]
IC50	0.15	150	P97612	BDBM26139	Fatty-acid amide hydrolase 1 [30-579]

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Subtilisin BL

External ID: CHEMBL708726

Protocol: N/A

Comment: Journal: Bioorg Med Chem Lett
Year: 1996
Volume: 6
Issue: 21
First Page: 2501
Last Page: 2506
DOI: 10.1016/0960-894X(96)00466-0

Target ChEMBL ID: CHEMBL4258
ChEMBL Target Name: Subtilisin
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
241	Ki	=	241000	nM	Outside typical range
38	Ki	=	38000	nM
757	Ki	=	757000	nM	Outside typical range
204	Ki	=	204000	nM	Outside typical range
155	Ki	=	155000	nM	Outside typical range
1000	Ki	>	1000000	nM	Outside typical range
233	Ki	=	233000	nM	Outside typical range
847	Ki	=	847000	nM	Outside typical range
314	Ki	=	314000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Fatty-acid amide hydrolase 1

External ID: CHEMBL944310

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2008
Volume: 51
Issue: 22
First Page: 7057
Last Page: 7060
DOI: 10.1021/jm801051t

Target ChEMBL ID: CHEMBL3229
ChEMBL Target Name: Anandamide amidohydrolase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
2.6	IC50	=	2600	nM
0.15	IC50	=	150	nM
0.21	IC50	=	210	nM
0.036	IC50	=	36	nM
1.5	IC50	=	1500	nM
0.33	IC50	=	330	nM
0.08	IC50	=	80	nM
68	IC50	=	68000	nM
13	IC50	=	13000	nM
0.12	IC50	=	120	nM
1.6	IC50	=	1600	nM
1.9	IC50	=	1900	nM
0.29	IC50	=	290	nM
0.021	IC50	=	21	nM
0.0091	IC50	=	9.1	nM
0.71	IC50	=	710	nM
110	IC50	=	110000	nM	Outside typical range
10	IC50	=	10000	nM
0.014	IC50	=	14	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Escherichia coli

External ID: CHEMBL5117444

Protocol: N/A

Comment: Journal: Eur J Med Chem
Year: 2022
Volume: 240
First Page: 114571
Last Page: 114571
DOI: 10.1016/j.ejmech.2022.114571

Target ChEMBL ID: CHEMBL354
ChEMBL Target Name: Escherichia coli
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
IZ	=	29.7	mm
IZ	=	27.8	mm
IZ	=	32.2	mm
IZ	=	32	mm
IZ	=	21.7	mm
IZ	=	30.5	mm
IZ	=	19.9	mm
IZ	=	29.6	mm
IZ	=	29.3	mm
IZ	=	25.5	mm
IZ	=	20.9	mm
IZ	=	25.2	mm
IZ	=	26.9	mm
IZ	=	25.2	mm

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Subtilisin BL

External ID: CHEMBL708727

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem Lett
Year: 1996
Volume: 6
Issue: 21
First Page: 2501
Last Page: 2506
DOI: 10.1016/0960-894X(96)00466-0

Target ChEMBL ID: CHEMBL4258
ChEMBL Target Name: Subtilisin
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
95	Ki	=	95000	nM
15	Ki	=	15000	nM
310	Ki	=	310000	nM	Outside typical range
73	Ki	=	73000	nM
96	Ki	=	96000	nM
1000	Ki	>	1000000	nM	Outside typical range
110	Ki	=	110000	nM	Outside typical range
2100	Ki	=	2100000	nM	Outside typical range
219	Ki	=	219000	nM	Outside typical range

5122-95-2 靶点实验数据