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51145-79-0 靶点实验数据

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:Aldo-keto reductase family 1 member B1
External ID: CHEMBL981183
Protocol: N/A
Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2008
Volume: 16
Issue: 15
First Page: 7470
Last Page: 7476
DOI: 10.1016/j.bmc.2008.06.004

Target ChEMBL ID: CHEMBL2622
ChEMBL Target Name: Aldose reductase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned
PubChem Standard ValueStandard TypeStandard RelationStandard ValueStandard UnitsData Validity Comment
0.07762IC50=77.62nM
0.0389IC50=38.9nM
1.41254IC50=1412.54nM
0.23988IC50=239.88nM
1000IC50=1000000nMOutside typical range
18.6209IC50=18620.87nM
0.03236IC50=32.36nM
6.76083IC50=6760.83nM
0.02799IC50=27.99nM
0.34834IC50=348.34nM
0.20417IC50=204.17nM
0.81283IC50=812.83nM
5.24807IC50=5248.07nM
0.25119IC50=251.19nM
0.26915IC50=269.15nM
0.28184IC50=281.84nM
0.302IC50=302nM
0.40738IC50=407.38nM
0.85114IC50=851.14nM
1.20226IC50=1202.26nM
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:Polyunsaturated fatty acid 5-lipoxygenase
External ID: CHEMBL619911
Protocol: N/A
Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 1986
Volume: 29
Issue: 11
First Page: 2256
Last Page: 2262
DOI: 10.1021/jm00161a021

Target ChEMBL ID: CHEMBL312
ChEMBL Target Name: Arachidonate 5-lipoxygenase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned
PubChem Standard ValueStandard TypeStandard RelationStandard ValueStandard Units
0.015IC50=15nM
0.022IC50=22nM