HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：24565 靶标：N/A

External ID: ERK5 transcriptional activity-HTS

Protocol: Stable cells plated on a 384-well plate (2500 cells/well) were treated with test compounds at the concentration of 5 muM for 18 hrs. The level of luciferase activity was assayed using a
Luciferase kit (Promega corporation, Madison, WI) and a series of positive and negative control compounds were used as references.

Comment:

Luciferase activity (AU)
104
108
64
28
100
152
176
52
124
44
60
60
32
96
60
144
28
64
84
44

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Solute carrier organic anion transporter family member 1B3

External ID: CHEMBL3039491

Protocol: N/A

Comment: Journal: Mol Pharmacol
Year: 2013
Volume: 83
Issue: 6
First Page: 1257
Last Page: 1267
DOI: 10.1124/mol.112.084152

Target ChEMBL ID: CHEMBL1743121
ChEMBL Target Name: Solute carrier organic anion transporter family member 1B3
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
Inhibition	=	89.51	%
Inhibition	=	81.71	%
Inhibition	=	65.47	%
Inhibition	=	50.32	%
Inhibition	=	112.43	%
Inhibition	=	99.94	%
Inhibition	=	101.75	%
Inhibition	=	98.72	%
Inhibition	=	104.08	%
Inhibition	=	114.2	%
Inhibition	=	97.5	%
Inhibition	=	120.61	%
Inhibition	=	45.56	%
Inhibition	=	105.72	%
Inhibition	=	107.28	%
Inhibition	=	93.09	%
Inhibition	=	84.51	%
Inhibition	=	155.79	%	Outside typical range
Inhibition	=	97.26	%
Inhibition	=	72.91	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：A549

External ID: CHEMBL3122539

Protocol: N/A

Comment: Journal: Bioorg Med Chem
Year: 2014
Volume: 22
Issue: 6
First Page: 1889
Last Page: 1898
DOI: 10.1016/j.bmc.2014.01.052

Target ChEMBL ID: CHEMBL392
ChEMBL Target Name: A549
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
ED50	=	0.11	ug ml-1
ED50	=	0.0027	ug ml-1
ED50	>	20	ug ml-1
ED50	=	0.0092	ug ml-1
ED50	=	0.07	ug ml-1
ED50	=	0.08	ug ml-1
ED50	=	0.59	ug ml-1
ED50	=	0.14	ug ml-1
ED50	=	0.12	ug ml-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NON-PROTEIN TARGET

External ID: CHEMBL1176132

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2010
Volume: 73
Issue: 7
First Page: 1214
Last Page: 1222
DOI: 10.1021/np9005212

Target ChEMBL ID: CHEMBL3879801
ChEMBL Target Name: NON-PROTEIN TARGET
ChEMBL Target Type: NON-MOLECULAR - Target has not been defined at a molecular level, only the non-molecular entity which is affected (e.g., organism, cell line etc)
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value
Ratio	=	8.7
Ratio	=	20
Ratio	=	8
Ratio	=	10
Ratio	=	9
Ratio	=	24
Ratio	=	65

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Endothelial PAS domain-containing protein 1

External ID: CHEMBL1058696

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2009
Volume: 72
Issue: 5
First Page: 805
Last Page: 812
DOI: 10.1021/np8006342

Target ChEMBL ID: CHEMBL2221345
ChEMBL Target Name: Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha
ChEMBL Target Type: PROTEIN FAMILY - Target is a group of closely related proteins
Relationship Type: D - Direct protein target assigned
Confidence: Multiple direct protein targets may be assigned

Standard Type	Activity Comment
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NON-PROTEIN TARGET

External ID: CHEMBL3122936

Protocol: N/A

Comment: Journal: Bioorg Med Chem
Year: 2014
Volume: 22
Issue: 6
First Page: 1889
Last Page: 1898
DOI: 10.1016/j.bmc.2014.01.052

Target ChEMBL ID: CHEMBL3879801
ChEMBL Target Name: NON-PROTEIN TARGET
ChEMBL Target Type: NON-MOLECULAR - Target has not been defined at a molecular level, only the non-molecular entity which is affected (e.g., organism, cell line etc)
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
ED50	=	0.69	ug ml-1
ED50	=	0.013	ug ml-1
GI				Not Active
ED50	=	0.018	ug ml-1
ED50	=	0.18	ug ml-1
ED50	=	0.32	ug ml-1
ED50	=	5.1	ug ml-1
ED50	=	3	ug ml-1
ED50	=	1.7	ug ml-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NON-PROTEIN TARGET

External ID: CHEMBL1176131

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2010
Volume: 73
Issue: 7
First Page: 1214
Last Page: 1222
DOI: 10.1021/np9005212

Target ChEMBL ID: CHEMBL3879801
ChEMBL Target Name: NON-PROTEIN TARGET
ChEMBL Target Type: NON-MOLECULAR - Target has not been defined at a molecular level, only the non-molecular entity which is affected (e.g., organism, cell line etc)
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value
Ratio	=	9
Ratio	=	20
Ratio	=	10
Ratio	=	50
Ratio	=	20
Ratio	=	20
Ratio	=	20
Ratio	=	6.3

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：HT-29

External ID: CHEMBL1100180

Protocol: N/A

Comment: Journal: J Nat Prod
Year: 2009
Volume: 72
Issue: 11
First Page: 1969
Last Page: 1974
DOI: 10.1021/np900210m

Target ChEMBL ID: CHEMBL384
ChEMBL Target Name: HT-29
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Survival	=	58	%
Survival	=	22	%
Survival	=	28	%
Survival	=	18	%
Survival	=	20	%
Survival	=	40	%
Survival	=	81	%
Survival	=	19	%
Survival	=	24	%
Survival	=	24	%
Survival	=	20	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：KB

External ID: CHEMBL3122937

Protocol: N/A

Comment: Journal: Bioorg Med Chem
Year: 2014
Volume: 22
Issue: 6
First Page: 1889
Last Page: 1898
DOI: 10.1016/j.bmc.2014.01.052

Target ChEMBL ID: CHEMBL398
ChEMBL Target Name: KB
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
ED50	=	0.61	ug ml-1
ED50	=	0.014	ug ml-1
ED50	=	0.044	ug ml-1
ED50	=	0.2	ug ml-1
ED50	=	0.3	ug ml-1
ED50	=	5.3	ug ml-1
ED50	=	2.7	ug ml-1
ED50	=	1.5	ug ml-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NON-PROTEIN TARGET

External ID: CHEMBL1176130

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2010
Volume: 73
Issue: 7
First Page: 1214
Last Page: 1222
DOI: 10.1021/np9005212

Target ChEMBL ID: CHEMBL3879801
ChEMBL Target Name: NON-PROTEIN TARGET
ChEMBL Target Type: NON-MOLECULAR - Target has not been defined at a molecular level, only the non-molecular entity which is affected (e.g., organism, cell line etc)
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	240	%
Activity	=	249	%
Activity	=	300	%
Activity	=	300	%
Activity	=	292	%
Activity	=	464	%
Activity	=	408	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Endothelial PAS domain-containing protein 1

External ID: CHEMBL1058694

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2009
Volume: 72
Issue: 5
First Page: 805
Last Page: 812
DOI: 10.1021/np8006342

Target ChEMBL ID: CHEMBL2221345
ChEMBL Target Name: Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha
ChEMBL Target Type: PROTEIN FAMILY - Target is a group of closely related proteins
Relationship Type: D - Direct protein target assigned
Confidence: Multiple direct protein targets may be assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	77	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：HCT-116

External ID: CHEMBL1100179

Protocol: N/A

Comment: Journal: J Nat Prod
Year: 2009
Volume: 72
Issue: 11
First Page: 1969
Last Page: 1974
DOI: 10.1021/np900210m

Target ChEMBL ID: CHEMBL394
ChEMBL Target Name: HCT-116
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Survival	=	21	%
Survival	=	4	%
Survival	=	4	%
Survival	=	1	%
Survival	=	3	%
Survival	=	5	%
Survival	=	63	%
Survival	=	3	%
Survival	=	4	%
Survival	=	3	%
Survival	=	3	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NON-PROTEIN TARGET

External ID: CHEMBL1176129

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2010
Volume: 73
Issue: 7
First Page: 1214
Last Page: 1222
DOI: 10.1021/np9005212

Target ChEMBL ID: CHEMBL3879801
ChEMBL Target Name: NON-PROTEIN TARGET
ChEMBL Target Type: NON-MOLECULAR - Target has not been defined at a molecular level, only the non-molecular entity which is affected (e.g., organism, cell line etc)
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	165	%
Activity	=	775	%
Activity	=	467	%
Activity	=	300	%
Activity	=	443	%
Activity	=	660	%
Activity	=	121	%
Activity	=	205	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Endothelial PAS domain-containing protein 1

External ID: CHEMBL1058695

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2009
Volume: 72
Issue: 5
First Page: 805
Last Page: 812
DOI: 10.1021/np8006342

Target ChEMBL ID: CHEMBL2221345
ChEMBL Target Name: Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha
ChEMBL Target Type: PROTEIN FAMILY - Target is a group of closely related proteins
Relationship Type: D - Direct protein target assigned
Confidence: Multiple direct protein targets may be assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	50	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NON-PROTEIN TARGET

External ID: CHEMBL1100178

Protocol: N/A

Comment: Journal: J Nat Prod
Year: 2009
Volume: 72
Issue: 11
First Page: 1969
Last Page: 1974
DOI: 10.1021/np900210m

Target ChEMBL ID: CHEMBL3879801
ChEMBL Target Name: NON-PROTEIN TARGET
ChEMBL Target Type: NON-MOLECULAR - Target has not been defined at a molecular level, only the non-molecular entity which is affected (e.g., organism, cell line etc)
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Survival	=	3	%
Survival	=	3	%
Survival	=	2	%
Survival	=	3	%
Survival	=	1	%
Survival	=	2	%
Survival	=	54	%
Survival	=	2	%
Survival	=	1	%
Survival	=	2	%
Survival	=	2	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NON-PROTEIN TARGET

External ID: CHEMBL1176128

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Nat. Prod.
Year: 2010
Volume: 73
Issue: 7
First Page: 1214
Last Page: 1222
DOI: 10.1021/np9005212

Target ChEMBL ID: CHEMBL3879801
ChEMBL Target Name: NON-PROTEIN TARGET
ChEMBL Target Type: NON-MOLECULAR - Target has not been defined at a molecular level, only the non-molecular entity which is affected (e.g., organism, cell line etc)
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.083	Activity	=	0.083	uM
0.075	Activity	=	0.075	uM
4	Activity	=	4	uM
0.25	Activity	=	0.25	uM
2	Activity	=	2	uM
0.3	Activity	=	0.3	uM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：U-251

External ID: CHEMBL1058692

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2009
Volume: 72
Issue: 5
First Page: 805
Last Page: 812
DOI: 10.1021/np8006342

Target ChEMBL ID: CHEMBL615022
ChEMBL Target Name: U-251
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Non-toxic
Activity	Non-toxic
Activity	Non-toxic
Activity	Non-toxic

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NON-PROTEIN TARGET

External ID: CHEMBL1176127

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Nat. Prod.
Year: 2010
Volume: 73
Issue: 7
First Page: 1214
Last Page: 1222
DOI: 10.1021/np9005212

Target ChEMBL ID: CHEMBL3879801
ChEMBL Target Name: NON-PROTEIN TARGET
ChEMBL Target Type: NON-MOLECULAR - Target has not been defined at a molecular level, only the non-molecular entity which is affected (e.g., organism, cell line etc)
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.1	Activity	=	0.1	uM
0.38	Activity	=	0.38	uM
2.75	Activity	=	2.75	uM
0.25	Activity	=	0.25	uM
0.05	Activity	=	0.05	uM
0.25	Activity	=	0.25	uM
0.1	Activity	=	0.1	uM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：U-251

External ID: CHEMBL1058693

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2009
Volume: 72
Issue: 5
First Page: 805
Last Page: 812
DOI: 10.1021/np8006342

Target ChEMBL ID: CHEMBL615022
ChEMBL Target Name: U-251
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Non-toxic
Activity	Non-toxic
Activity	Non-toxic
Activity	Non-toxic

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NON-PROTEIN TARGET

External ID: CHEMBL2421294

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2013
Volume: 76
Issue: 9
First Page: 1771
Last Page: 1780
DOI: 10.1021/np4005147

Target ChEMBL ID: CHEMBL3879801
ChEMBL Target Name: NON-PROTEIN TARGET
ChEMBL Target Type: NON-MOLECULAR - Target has not been defined at a molecular level, only the non-molecular entity which is affected (e.g., organism, cell line etc)
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	82.4	%
Inhibition	=	82.1	%
Inhibition	=	76.9	%
Inhibition	=	67.9	%
Inhibition	=	75.7	%
Inhibition	=	34.3	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Endothelial PAS domain-containing protein 1

External ID: CHEMBL1058690

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Nat. Prod.
Year: 2009
Volume: 72
Issue: 5
First Page: 805
Last Page: 812
DOI: 10.1021/np8006342

Target ChEMBL ID: CHEMBL2221345
ChEMBL Target Name: Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha
ChEMBL Target Type: PROTEIN FAMILY - Target is a group of closely related proteins
Relationship Type: D - Direct protein target assigned
Confidence: Multiple direct protein targets may be assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.04	EC50	=	40	nM
0.12	EC50	=	120	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Endothelial PAS domain-containing protein 1

External ID: CHEMBL1058691

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2009
Volume: 72
Issue: 5
First Page: 805
Last Page: 812
DOI: 10.1021/np8006342

Target ChEMBL ID: CHEMBL2221345
ChEMBL Target Name: Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha
ChEMBL Target Type: PROTEIN FAMILY - Target is a group of closely related proteins
Relationship Type: D - Direct protein target assigned
Confidence: Multiple direct protein targets may be assigned

Standard Type	Activity Comment
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：U-251

External ID: CHEMBL1059454

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2009
Volume: 72
Issue: 5
First Page: 805
Last Page: 812
DOI: 10.1021/np8006342

Target ChEMBL ID: CHEMBL615022
ChEMBL Target Name: U-251
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：U-251

External ID: CHEMBL1059455

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2009
Volume: 72
Issue: 5
First Page: 805
Last Page: 812
DOI: 10.1021/np8006342

Target ChEMBL ID: CHEMBL615022
ChEMBL Target Name: U-251
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NON-PROTEIN TARGET

External ID: CHEMBL1100186

Protocol: N/A

Comment: Journal: J Nat Prod
Year: 2009
Volume: 72
Issue: 11
First Page: 1969
Last Page: 1974
DOI: 10.1021/np900210m

Target ChEMBL ID: CHEMBL3879801
ChEMBL Target Name: NON-PROTEIN TARGET
ChEMBL Target Type: NON-MOLECULAR - Target has not been defined at a molecular level, only the non-molecular entity which is affected (e.g., organism, cell line etc)
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value
Activity	=	1.71
Activity	=	0.21
Activity	=	0.03
Activity	=	1
Activity	=	0.38

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：U-251

External ID: CHEMBL1059452

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2009
Volume: 72
Issue: 5
First Page: 805
Last Page: 812
DOI: 10.1021/np8006342

Target ChEMBL ID: CHEMBL615022
ChEMBL Target Name: U-251
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Not Active
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：HCT-116

External ID: CHEMBL1100185

Protocol: N/A

Comment: Journal: J Nat Prod
Year: 2009
Volume: 72
Issue: 11
First Page: 1969
Last Page: 1974
DOI: 10.1021/np900210m

Target ChEMBL ID: CHEMBL394
ChEMBL Target Name: HCT-116
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value
Activity	=	2.74
Activity	=	0.22
Activity	=	0.04
Activity	=	1
Activity	=	0.3

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：U-251

External ID: CHEMBL1059453

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2009
Volume: 72
Issue: 5
First Page: 805
Last Page: 812
DOI: 10.1021/np8006342

Target ChEMBL ID: CHEMBL615022
ChEMBL Target Name: U-251
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：HT-29

External ID: CHEMBL1100184

Protocol: N/A

Comment: Journal: J Nat Prod
Year: 2009
Volume: 72
Issue: 11
First Page: 1969
Last Page: 1974
DOI: 10.1021/np900210m

Target ChEMBL ID: CHEMBL384
ChEMBL Target Name: HT-29
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value
Activity	=	2.91
Activity	=	0.39
Activity	=	0.39
Activity	=	1
Activity	=	0.31

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：U-251

External ID: CHEMBL1058698

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2009
Volume: 72
Issue: 5
First Page: 805
Last Page: 812
DOI: 10.1021/np8006342

Target ChEMBL ID: CHEMBL615022
ChEMBL Target Name: U-251
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：U-251

External ID: CHEMBL1058699

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2009
Volume: 72
Issue: 5
First Page: 805
Last Page: 812
DOI: 10.1021/np8006342

Target ChEMBL ID: CHEMBL615022
ChEMBL Target Name: U-251
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Saccharomyces cerevisiae

External ID: CHEMBL966059

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 1993
Volume: 56
Issue: 9
First Page: 1451
Last Page: 1458
DOI: 10.1021/np50099a003

Target ChEMBL ID: CHEMBL361
ChEMBL Target Name: Saccharomyces cerevisiae
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：SK-MEL-2

External ID: CHEMBL3122532

Protocol: N/A

Comment: Journal: Bioorg Med Chem
Year: 2014
Volume: 22
Issue: 6
First Page: 1889
Last Page: 1898
DOI: 10.1016/j.bmc.2014.01.052

Target ChEMBL ID: CHEMBL614917
ChEMBL Target Name: SK-MEL-2
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
ED50	=	0.13	ug ml-1
ED50	=	0.0013	ug ml-1
GI				Not Active
ED50	=	0.015	ug ml-1
ED50	=	0.42	ug ml-1
ED50	=	0.62	ug ml-1
ED50	=	0.41	ug ml-1
ED50	=	0.57	ug ml-1
ED50	=	0.16	ug ml-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NON-PROTEIN TARGET

External ID: CHEMBL3122533

Protocol: N/A

Comment: Journal: Bioorg Med Chem
Year: 2014
Volume: 22
Issue: 6
First Page: 1889
Last Page: 1898
DOI: 10.1016/j.bmc.2014.01.052

Target ChEMBL ID: CHEMBL3879801
ChEMBL Target Name: NON-PROTEIN TARGET
ChEMBL Target Type: NON-MOLECULAR - Target has not been defined at a molecular level, only the non-molecular entity which is affected (e.g., organism, cell line etc)
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
ED50	=	0.51	ug ml-1
ED50	=	0.0014	ug ml-1
ED50	=	0.044	ug ml-1
ED50	=	0.2	ug ml-1
ED50	=	0.18	ug ml-1
ED50	=	4.5	ug ml-1
ED50	=	6.4	ug ml-1
ED50	=	0.94	ug ml-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：CAKI-1

External ID: CHEMBL3122534

Protocol: N/A

Comment: Journal: Bioorg Med Chem
Year: 2014
Volume: 22
Issue: 6
First Page: 1889
Last Page: 1898
DOI: 10.1016/j.bmc.2014.01.052

Target ChEMBL ID: CHEMBL614067
ChEMBL Target Name: CAKI-1
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
ED50	=	0.14	ug ml-1
ED50	=	0.0031	ug ml-1
GI				Not Active
ED50	=	0.014	ug ml-1
ED50	=	0.071	ug ml-1
ED50	=	0.073	ug ml-1
ED50	=	1.3	ug ml-1
ED50	=	0.67	ug ml-1
ED50	=	0.51	ug ml-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：1A9

External ID: CHEMBL3122535

Protocol: N/A

Comment: Journal: Bioorg Med Chem
Year: 2014
Volume: 22
Issue: 6
First Page: 1889
Last Page: 1898
DOI: 10.1016/j.bmc.2014.01.052

Target ChEMBL ID: CHEMBL614075
ChEMBL Target Name: 1A9
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
ED50	=	0.15	ug ml-1
ED50	=	0.03	ug ml-1
GI				Not Active
ED50	=	0.012	ug ml-1
ED50	=	0.072	ug ml-1
ED50	=	0.076	ug ml-1
ED50	=	0.12	ug ml-1
ED50	=	0.66	ug ml-1
ED50	=	0.53	ug ml-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：PC-3

External ID: CHEMBL3122536

Protocol: N/A

Comment: Journal: Bioorg Med Chem
Year: 2014
Volume: 22
Issue: 6
First Page: 1889
Last Page: 1898
DOI: 10.1016/j.bmc.2014.01.052

Target ChEMBL ID: CHEMBL390
ChEMBL Target Name: PC-3
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
ED50	=	0.17	ug ml-1
ED50	=	0.094	ug ml-1
GI				Not Active
ED50	=	0.018	ug ml-1
ED50	=	0.095	ug ml-1
ED50	=	0.11	ug ml-1
ED50	=	1.2	ug ml-1
ED50	=	0.81	ug ml-1
ED50	=	0.6	ug ml-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NON-PROTEIN TARGET

External ID: CHEMBL3122537

Protocol: N/A

Comment: Journal: Bioorg Med Chem
Year: 2014
Volume: 22
Issue: 6
First Page: 1889
Last Page: 1898
DOI: 10.1016/j.bmc.2014.01.052

Target ChEMBL ID: CHEMBL3879801
ChEMBL Target Name: NON-PROTEIN TARGET
ChEMBL Target Type: NON-MOLECULAR - Target has not been defined at a molecular level, only the non-molecular entity which is affected (e.g., organism, cell line etc)
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
ED50	=	0.72	ug ml-1
ED50	=	0.014	ug ml-1
ED50	=	0.054	ug ml-1
ED50	=	0.4	ug ml-1
ED50	=	0.37	ug ml-1
ED50	=	4.6	ug ml-1
ED50	=	2.9	ug ml-1
ED50	=	1.9	ug ml-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：MCF7

External ID: CHEMBL3122538

Protocol: N/A

Comment: Journal: Bioorg Med Chem
Year: 2014
Volume: 22
Issue: 6
First Page: 1889
Last Page: 1898
DOI: 10.1016/j.bmc.2014.01.052

Target ChEMBL ID: CHEMBL387
ChEMBL Target Name: MCF7
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
ED50	=	0.38	ug ml-1
ED50	=	0.0065	ug ml-1
ED50	>	20	ug ml-1
ED50	=	0.015	ug ml-1
ED50	=	0.15	ug ml-1
ED50	=	0.19	ug ml-1
ED50	=	1.3	ug ml-1
ED50	=	0.69	ug ml-1
ED50	=	0.58	ug ml-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Solute carrier organic anion transporter family member 1B1

External ID: CHEMBL3039488

Protocol: N/A

Comment: Journal: Mol Pharmacol
Year: 2013
Volume: 83
Issue: 6
First Page: 1257
Last Page: 1267
DOI: 10.1124/mol.112.084152

Target ChEMBL ID: CHEMBL1697668
ChEMBL Target Name: Solute carrier organic anion transporter family member 1B1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	65.85	%
Inhibition	=	63.37	%
Inhibition	=	75.25	%
Inhibition	=	97.38	%
Inhibition	=	105.26	%
Inhibition	=	97.94	%
Inhibition	=	105.32	%
Inhibition	=	99.4	%
Inhibition	=	101.01	%
Inhibition	=	86.27	%
Inhibition	=	80.06	%
Inhibition	=	89.01	%
Inhibition	=	120.91	%
Inhibition	=	102.46	%
Inhibition	=	101.26	%
Inhibition	=	90.74	%
Inhibition	=	113.76	%
Inhibition	=	82.92	%
Inhibition	=	126.2	%
Inhibition	=	116.63	%

508-75-8 靶点实验数据