HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Neuronal acetylcholine receptor subunit alpha-4

External ID: CHEMBL3057495

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Med Chem Res
Year: 2005
Volume: 14
Issue: 5
First Page: 241
Last Page: 259
DOI: 10.1007/s00044-005-0137-8

Target ChEMBL ID: CHEMBL1907589
ChEMBL Target Name: Neuronal acetylcholine receptor; alpha4/beta2
ChEMBL Target Type: PROTEIN COMPLEX - Target is a defined protein complex, consisting of multiple subunits
Relationship Type: D - Direct protein target assigned
Confidence: Direct protein complex subunits assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
	Inhibition			%	Dose-dependent effect
11.2	Ki	=	11200	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Neuronal acetylcholine receptor subunit alpha-4

External ID: CHEMBL3057496

Protocol: N/A

Comment: Journal: Med Chem Res
Year: 2005
Volume: 14
Issue: 5
First Page: 241
Last Page: 259
DOI: 10.1007/s00044-005-0137-8

Target ChEMBL ID: CHEMBL1907596
ChEMBL Target Name: Neuronal acetylcholine receptor; alpha4/beta2
ChEMBL Target Type: PROTEIN COMPLEX - Target is a defined protein complex, consisting of multiple subunits
Relationship Type: D - Direct protein target assigned
Confidence: Direct protein complex subunits assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	95	%
Inhibition	=	84	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Neuronal acetylcholine receptor subunit alpha-7

External ID: CHEMBL748018

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2002
Volume: 12
Issue: 22
First Page: 3321
Last Page: 3324
DOI: 10.1016/s0960-894x(02)00740-0

Target ChEMBL ID: CHEMBL2094110
ChEMBL Target Name: Neuronal acetylcholine receptor
ChEMBL Target Type: PROTEIN COMPLEX GROUP - Target is a poorly defined protein complex, where subunit composition is unclear (e.g., GABA-A receptor)
Relationship Type: H - Homologous protein target assigned
Confidence: Multiple homologous protein targets may be assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.14	Ki	=	140	nM
0.015	Ki	=	15	nM
1.0E-4	Ki	=	0.1	nM
0.22	Ki	=	220	nM
0.016	Ki	=	16	nM
0.0072	Ki	=	7.2	nM
0.0059	Ki	=	5.9	nM
0.031	Ki	=	31	nM

497948-84-2 靶点实验数据