HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：BindingDB 靶标：N/A

External ID: BindingDB_6119_1

Protocol: N/A

Comment: Compounds with any of Ki, IC50, Kd, or EC50 activity value <= 10uM are labeled as "Active".
If multiple measurements are available for a given compound, it is labeled as "Active" if any of the measurements meet the criterion. Activity values are checked in the order of Ki, IC50, Kd, and EC50. The first entry that meets the above activity threshold is used to determine "Standard Type", "Standard Relation", and "PubChem Standard Value". Otherwise, the first non-empty entry will be used to set those values.

Standard Type	Standard Relation	PubChem Standard Value	IC50 Qualifier	IC50	Target Accession(s)	Ligand	Target
IC50		1.1		1100	P11509	BDBM12343	Cytochrome P450 2A6
IC50		133		133000	P11509	BDBM12344	Cytochrome P450 2A6
IC50		0.268		268	P11509	BDBM12345	Cytochrome P450 2A6
IC50		16.9		16900	P11509	BDBM12345	Cytochrome P450 2A6
IC50		28.3		28300	P11509	BDBM12347	Cytochrome P450 2A6
IC50		0.514		514	P11509	BDBM12348	Cytochrome P450 2A6
IC50		5.36		5360	P11509	BDBM12349	Cytochrome P450 2A6
IC50		0.622		622	P11509	BDBM12351	Cytochrome P450 2A6
IC50		1.37		1370	P11509	BDBM12355	Cytochrome P450 2A6
IC50		1.5		1500	P11509	BDBM12356	Cytochrome P450 2A6
IC50		1.51		1510	P11509	BDBM12357	Cytochrome P450 2A6
IC50		1.51		1510	P11509	BDBM12357	Cytochrome P450 2A6
IC50		1.85		1850	P11509	BDBM12358	Cytochrome P450 2A6
IC50		1.85		1850	P11509	BDBM12358	Cytochrome P450 2A6
IC50		26.3		26300	P11509	BDBM50004108	Cytochrome P450 2A6
IC50	>	400	>	400000	P11509	BDBM50035415	Cytochrome P450 2A6
IC50		0.97		970	P11509	BDBM50113851	Cytochrome P450 2A6
IC50		0.08		80	P11509	BDBM50113851	Cytochrome P450 2A6
IC50		0.97		970	P11509	BDBM50113851	Cytochrome P450 2A6
IC50		187		187000	P11509	BDBM50125053	Cytochrome P450 2A6

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Cytochrome P450 2A6

External ID: CHEMBL4422401

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Target ChEMBL ID: CHEMBL5282
ChEMBL Target Name: Cytochrome P450 2A6
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: SureChEMBL Patent Bioactivity Data

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
5.36	IC50	=	5360	nM
37.8	IC50	=	37800	nM
187	IC50	=	187000	nM	Outside typical range
118	IC50	=	118000	nM	Outside typical range
1.37	IC50	=	1370	nM
1.5	IC50	=	1500	nM
37.1	IC50	=	37100	nM
5.84	IC50	=	5840	nM
25	IC50	>	25000	nM
1.4	IC50	=	1400	nM
4.24	IC50	=	4240	nM
27.8	IC50	>=	27800	nM
30.4	IC50	=	30400	nM
16.5	IC50	=	16500	nM
58.9	IC50	=	58900	nM
165	IC50	=	165000	nM	Outside typical range
6.6	IC50	=	6600	nM
389	IC50	=	389000	nM	Outside typical range
408	IC50	=	408000	nM	Outside typical range
3.14	IC50	=	3140	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL4422402

Protocol: N/A

Comment: Data Source: SureChEMBL Patent Bioactivity Data

Standard Type	Standard Relation	Standard Value	Activity Comment
Ratio IC50	=	5
Ratio IC50			Not Determined
Ratio IC50			Not Determined
Ratio IC50			Not Determined
Ratio IC50			Not Determined
Ratio IC50			Not Determined
Ratio IC50			Not Determined
Ratio IC50	>=	40
Ratio IC50	=	93
Ratio IC50			Not Determined
Ratio IC50	=	20
Ratio IC50	<=	13
Ratio IC50			Not Determined
Ratio IC50			Not Determined
Ratio IC50			Not Determined
Ratio IC50	=	5
Ratio IC50			Not Determined
Ratio IC50	=	37
Ratio IC50			Not Determined
Ratio IC50	>	61

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Cytochrome P450 3A4

External ID: CHEMBL4422403

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Target ChEMBL ID: CHEMBL340
ChEMBL Target Name: Cytochrome P450 3A4
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: SureChEMBL Patent Bioactivity Data

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment	Data Validity Comment
	IC50				Not Determined
	IC50				Not Determined
	IC50				Not Determined
	IC50				Not Determined
55.9	IC50	=	55900	nM
140	IC50	=	140000	nM		Outside typical range
	IC50				Not Determined
114	IC50	=	114000	nM		Outside typical range
	IC50				Not Determined
12.98	IC50	=	12980	nM
400	IC50	>	400000	nM		Outside typical range
2.2	IC50	=	2200	nM
	IC50				Not Determined
84.23	IC50	=	84230	nM
	IC50				Not Determined
	IC50				Not Determined
400	IC50	>	400000	nM		Outside typical range
	IC50				Not Determined
	IC50				Not Determined
79.2	IC50	=	79200	nM

494-04-2 靶点实验数据