HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Cytochrome c oxidase subunit 1

External ID: CHEMBL2340535

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2013
Volume: 56
Issue: 8
First Page: 3296
Last Page: 3309
DOI: 10.1021/jm301900x

Target ChEMBL ID: CHEMBL6173
ChEMBL Target Name: Cytochrome c oxidase subunit 1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	60.2	%
Inhibition	<	1	%
Inhibition	<	1	%
Inhibition	<	1	%
Inhibition	<	1	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Polyunsaturated fatty acid 5-lipoxygenase

External ID: CHEMBL2340522

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2013
Volume: 56
Issue: 8
First Page: 3296
Last Page: 3309
DOI: 10.1021/jm301900x

Target ChEMBL ID: CHEMBL215
ChEMBL Target Name: Arachidonate 5-lipoxygenase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	95.9	%
Inhibition	<	1	%
Inhibition	=	39	%
Inhibition	=	8	%
Inhibition	=	30	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Polyunsaturated fatty acid 5-lipoxygenase

External ID: CHEMBL2340529

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2013
Volume: 56
Issue: 8
First Page: 3296
Last Page: 3309
DOI: 10.1021/jm301900x

Target ChEMBL ID: CHEMBL215
ChEMBL Target Name: Arachidonate 5-lipoxygenase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	80.6	%
Inhibition	<	1	%
Inhibition	<	1	%
Inhibition	<	1	%
Inhibition	<	1	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Prostaglandin E synthase

External ID: CHEMBL2340533

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2013
Volume: 56
Issue: 8
First Page: 3296
Last Page: 3309
DOI: 10.1021/jm301900x

Target ChEMBL ID: CHEMBL5658
ChEMBL Target Name: Prostaglandin E synthase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
9.6	IC50	=	9600	nM
7.5	IC50	=	7500	nM
0.002	IC50	=	2	nM
1.7	IC50	=	1700	nM
5.4	IC50	=	5400	nM
0.8	IC50	=	800	nM
3.6	IC50	=	3600	nM
3.1	IC50	=	3100	nM
0.0093	IC50	=	9.3	nM
0.057	IC50	=	57	nM
32.5	IC50	=	32500	nM
0.93	IC50	=	930	nM
5.1	IC50	=	5100	nM
0.17	IC50	=	170	nM
1.8	IC50	=	1800	nM
0.1	IC50	=	100	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Prostaglandin E synthase

External ID: CHEMBL2340532

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2013
Volume: 56
Issue: 8
First Page: 3296
Last Page: 3309
DOI: 10.1021/jm301900x

Target ChEMBL ID: CHEMBL5658
ChEMBL Target Name: Prostaglandin E synthase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
120	IC50	=	120000	nM	Outside typical range
200	IC50	=	200000	nM	Outside typical range
0.3	IC50	=	300	nM
66	IC50	=	66000	nM
200	IC50	=	200000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Cytochrome c oxidase subunit 2

External ID: CHEMBL2340531

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2013
Volume: 56
Issue: 8
First Page: 3296
Last Page: 3309
DOI: 10.1021/jm301900x

Target ChEMBL ID: CHEMBL6174
ChEMBL Target Name: Cytochrome c oxidase subunit 2
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	89.8	%
Inhibition	=	14.7	%
Inhibition	=	-2.2	%
Inhibition	<	1	%
Inhibition	=	17.3	%

493003-81-9 靶点实验数据