HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Histone acetyltransferase RTT109

External ID: CHEMBL3419141

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2015
Volume: 58
Issue: 5
First Page: 2091
Last Page: 2113
DOI: 10.1021/jm5019093

Target ChEMBL ID: CHEMBL3414417
ChEMBL Target Name: Histone acetyltransferase RTT109
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Standard Type	Activity Comment
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3419578

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2015
Volume: 58
Issue: 5
First Page: 2091
Last Page: 2113
DOI: 10.1021/jm5019093

Standard Type	Activity Comment
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Active
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Activity	Active
Activity	Not Active
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Activity	Not Active
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Activity	Not Active
Activity	Not Active
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Histone acetyltransferase RTT109

External ID: CHEMBL3419142

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2015
Volume: 58
Issue: 5
First Page: 2091
Last Page: 2113
DOI: 10.1021/jm5019093

Target ChEMBL ID: CHEMBL3414417
ChEMBL Target Name: Histone acetyltransferase RTT109
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Standard Type	Activity Comment
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Histone acetyltransferase RTT109

External ID: CHEMBL3419139

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2015
Volume: 58
Issue: 5
First Page: 2091
Last Page: 2113
DOI: 10.1021/jm5019093

Target ChEMBL ID: CHEMBL3414417
ChEMBL Target Name: Histone acetyltransferase RTT109
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
17	IC50	=	17000	nM
6.3	IC50	=	6300	nM
3	IC50	=	3000	nM
6	IC50	=	6000	nM
9.2	IC50	=	9200	nM
6.1	IC50	=	6100	nM
	IC50				Not Active
1.5	IC50	=	1500	nM
3	IC50	=	3000	nM
15	IC50	=	15000	nM
	IC50				Not Active
2.7	IC50	=	2700	nM
14	IC50	=	14000	nM
5.3	IC50	=	5300	nM
21	IC50	=	21000	nM
4.6	IC50	=	4600	nM
3.6	IC50	=	3600	nM
1.4	IC50	=	1400	nM
2	IC50	=	2000	nM
0.91	IC50	=	910	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Histone acetyltransferase RTT109

External ID: CHEMBL3419140

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2015
Volume: 58
Issue: 5
First Page: 2091
Last Page: 2113
DOI: 10.1021/jm5019093

Target ChEMBL ID: CHEMBL3414417
ChEMBL Target Name: Histone acetyltransferase RTT109
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
8	IC50	=	8000	nM
7.8	IC50	=	7800	nM
8.4	IC50	=	8400	nM
10	IC50	=	10000	nM
	IC50				Not Active
5.5	IC50	=	5500	nM
9.7	IC50	=	9700	nM
12	IC50	=	12000	nM
	IC50				Not Active
10	IC50	=	10000	nM
12	IC50	=	12000	nM
4.6	IC50	=	4600	nM
9.9	IC50	=	9900	nM
22	IC50	=	22000	nM
11	IC50	=	11000	nM
5.9	IC50	=	5900	nM
13	IC50	=	13000	nM
5.5	IC50	=	5500	nM
	IC50				Not Active
12	IC50	=	12000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3419553

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2015
Volume: 58
Issue: 5
First Page: 2091
Last Page: 2113
DOI: 10.1021/jm5019093

Standard Type	Activity Comment
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
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Activity	Not Active
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Activity	Not Active
Activity	Not Active
Activity	Not Active
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Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3419143

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2015
Volume: 58
Issue: 5
First Page: 2091
Last Page: 2113
DOI: 10.1021/jm5019093

Standard Type	Activity Comment
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
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Activity	Not Active
Activity	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3419144

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2015
Volume: 58
Issue: 5
First Page: 2091
Last Page: 2113
DOI: 10.1021/jm5019093

Standard Type	Activity Comment
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
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488804-46-2 靶点实验数据