HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 2

External ID: CHEMBL2045715

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Eur. J. Med. Chem.
Year: 2012
Volume: 54
First Page: 423
Last Page: 428
DOI: 10.1016/j.ejmech.2012.05.025

Target ChEMBL ID: CHEMBL205
ChEMBL Target Name: Carbonic anhydrase II
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
34.56	Ki	=	34560	nM
69.12	Ki	=	69120	nM
35.45	Ki	=	35450	nM
34.62	Ki	=	34620	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 4

External ID: CHEMBL2045823

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Eur. J. Med. Chem.
Year: 2012
Volume: 54
First Page: 423
Last Page: 428
DOI: 10.1016/j.ejmech.2012.05.025

Target ChEMBL ID: CHEMBL3729
ChEMBL Target Name: Carbonic anhydrase IV
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
6.48	Ki	=	6480	nM
7.64	Ki	=	7640	nM
17.48	Ki	=	17480	nM
1.84	Ki	=	1840	nM
46.35	Ki	=	46350	nM
48.73	Ki	=	48730	nM
32.72	Ki	=	32720	nM
30.78	Ki	=	30780	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：HCT-116

External ID: CHEMBL965891

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Nat. Prod.
Year: 2004
Volume: 67
Issue: 9
First Page: 1445
Last Page: 1449
DOI: 10.1021/np0305268

Target ChEMBL ID: CHEMBL394
ChEMBL Target Name: HCT-116
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
14.1	IC50	=	14100	nM
	IC50				Not Determined
1.32	IC50	=	1320	nM
	IC50				Not Determined
21.4	IC50	=	21400	nM
	IC50				Not Determined
	IC50				Not Determined

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 1

External ID: CHEMBL2045714

Protocol: N/A

Comment: Journal: Eur. J. Med. Chem.
Year: 2012
Volume: 54
First Page: 423
Last Page: 428
DOI: 10.1016/j.ejmech.2012.05.025

Target ChEMBL ID: CHEMBL261
ChEMBL Target Name: Carbonic anhydrase I
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
43.51	Ki	=	43510	nM
537.311	Ki	=	537311	nM	Outside typical range
93.42	Ki	=	93420	nM
41.36	Ki	=	41360	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 6

External ID: CHEMBL2045824

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Eur. J. Med. Chem.
Year: 2012
Volume: 54
First Page: 423
Last Page: 428
DOI: 10.1016/j.ejmech.2012.05.025

Target ChEMBL ID: CHEMBL3025
ChEMBL Target Name: Carbonic anhydrase VI
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
13.692	Ki	=	13692	nM
29.138	Ki	=	29138	nM
3.41	Ki	=	3410	nM
29.67	Ki	=	29670	nM
382.473	Ki	=	382473	nM	Outside typical range
45.36	Ki	=	45360	nM
28.17	Ki	=	28170	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：DLD-1

External ID: CHEMBL965890

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Nat. Prod.
Year: 2004
Volume: 67
Issue: 9
First Page: 1445
Last Page: 1449
DOI: 10.1021/np0305268

Target ChEMBL ID: CHEMBL614285
ChEMBL Target Name: DLD-1
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
14.6	IC50	=	14600	nM
27.9	IC50	=	27900	nM
12.4	IC50	=	12400	nM
30.9	IC50	=	30900	nM
15	IC50	=	15000	nM
35.3	IC50	=	35300	nM
26.3	IC50	=	26300	nM

488-47-1 靶点实验数据