HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3829311

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2016
Volume: 24
Issue: 18
First Page: 4464
Last Page: 4469
DOI: 10.1016/j.bmc.2016.07.043

Standard Type	Standard Relation	Standard Value
Ratio IC50	=	0.28
Ratio IC50	=	4.63

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Platelet

External ID: CHEMBL987624

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 1996
Volume: 59
Issue: 5
First Page: 531
Last Page: 534
DOI: 10.1021/np960354x

Target ChEMBL ID: CHEMBL4296519
ChEMBL Target Name: Platelet
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	39.2	%
Activity	=	0	%
Activity	=	13.8	%
Activity	=	49.7	%
Activity	=	75.5	%
Activity	=	81.2	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Cholinesterase

External ID: CHEMBL3828921

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2016
Volume: 24
Issue: 18
First Page: 4464
Last Page: 4469
DOI: 10.1016/j.bmc.2016.07.043

Target ChEMBL ID: CHEMBL5763
ChEMBL Target Name: Cholinesterase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	84.07	%
Inhibition	=	22.58	%
Inhibition	=	50.95	%
Inhibition	=	83.87	%
Inhibition	=	95.18	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Acetylcholinesterase

External ID: CHEMBL3828922

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2016
Volume: 24
Issue: 18
First Page: 4464
Last Page: 4469
DOI: 10.1016/j.bmc.2016.07.043

Target ChEMBL ID: CHEMBL4078
ChEMBL Target Name: Acetylcholinesterase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment	Data Validity Comment
	IC50				Not Determined
201.52	IC50	=	201520	nM		Outside typical range
	IC50				Not Determined
	IC50				Not Determined
	IC50				Not Determined

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Plasmodium falciparum

External ID: CHEMBL991087

Protocol: N/A

Comment: Journal: J Nat Prod
Year: 1996
Volume: 59
Issue: 6
First Page: 576
Last Page: 580
DOI: 10.1021/np960195h

Target ChEMBL ID: CHEMBL364
ChEMBL Target Name: Plasmodium falciparum
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
IC50	=	0.0518	ug.mL-1
IC50	=	0.001	ug.mL-1
IC50	=	0.0388	ug.mL-1
IC50	=	1.47	ug.mL-1
IC50	=	3.65	ug.mL-1
IC50	=	1.68	ug.mL-1
IC50	=	2.83	ug.mL-1
IC50	=	2.53	ug.mL-1
IC50	=	2.7	ug.mL-1
IC50	=	0.904	ug.mL-1
IC50	=	1.9	ug.mL-1
IC50	=	3.81	ug.mL-1
IC50	=	3.1	ug.mL-1
IC50	=	0.0022	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Cholinesterase

External ID: CHEMBL3829309

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2016
Volume: 24
Issue: 18
First Page: 4464
Last Page: 4469
DOI: 10.1016/j.bmc.2016.07.043

Target ChEMBL ID: CHEMBL5763
ChEMBL Target Name: Cholinesterase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
218.81	IC50	=	218810	nM	Outside typical range
166.69	IC50	=	166690	nM	Outside typical range
19.34	IC50	=	19340	nM
288.34	IC50	=	288340	nM	Outside typical range
3.95	IC50	=	3950	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3829310

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2016
Volume: 24
Issue: 18
First Page: 4464
Last Page: 4469
DOI: 10.1016/j.bmc.2016.07.043

Standard Type	Standard Relation	Standard Value
Ratio IC50	=	3.63
Ratio IC50	=	0.22

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mycobacterium tuberculosis

External ID: CHEMBL3387322

Protocol: N/A

Comment: Journal: J Nat Prod
Year: 2014
Volume: 77
Issue: 12
First Page: 2711
Last Page: 2715
DOI: 10.1021/np500538c

Target ChEMBL ID: CHEMBL360
ChEMBL Target Name: Mycobacterium tuberculosis
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MIC	=	0.63	ug.mL-1
MIC	=	32	ug.mL-1
MIC	=	0.15	ug.mL-1
MIC	=	0.83	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Platelet

External ID: CHEMBL987621

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 1996
Volume: 59
Issue: 5
First Page: 531
Last Page: 534
DOI: 10.1021/np960354x

Target ChEMBL ID: CHEMBL4296519
ChEMBL Target Name: Platelet
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	58.7	%
Activity	=	70.2	%
Activity	=	73.6	%
Activity	=	30.4	%
Activity	=	69.7	%
Activity	=	92.2	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Aorta

External ID: CHEMBL990266

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 1996
Volume: 59
Issue: 5
First Page: 531
Last Page: 534
DOI: 10.1021/np960354x

Target ChEMBL ID: CHEMBL613606
ChEMBL Target Name: Aorta
ChEMBL Target Type: TISSUE - Target is a healthy or diseased tissue
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	109.3	%
Activity	=	109.9	%
Activity	=	107.8	%
Activity	=	71.2	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Platelet

External ID: CHEMBL987627

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 1996
Volume: 59
Issue: 5
First Page: 531
Last Page: 534
DOI: 10.1021/np960354x

Target ChEMBL ID: CHEMBL4296519
ChEMBL Target Name: Platelet
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	84.2	%
Activity	=	69.7	%
Activity	=	24.8	%
Activity	=	24.7	%
Activity	=	83.4	%
Activity	=	81.4	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Platelet

External ID: CHEMBL988443

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 1996
Volume: 59
Issue: 5
First Page: 531
Last Page: 534
DOI: 10.1021/np960354x

Target ChEMBL ID: CHEMBL4296519
ChEMBL Target Name: Platelet
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	85.9	%
Activity	=	72.7	%
Activity	=	75.7	%
Activity	=	86.4	%
Activity	=	57.8	%
Activity	=	92.5	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Aorta

External ID: CHEMBL991114

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 1996
Volume: 59
Issue: 5
First Page: 531
Last Page: 534
DOI: 10.1021/np960354x

Target ChEMBL ID: CHEMBL613606
ChEMBL Target Name: Aorta
ChEMBL Target Type: TISSUE - Target is a healthy or diseased tissue
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	110.5	%
Activity	=	93.7	%
Activity	=	95.7	%
Activity	=	105.7	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Aorta

External ID: CHEMBL991110

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 1996
Volume: 59
Issue: 5
First Page: 531
Last Page: 534
DOI: 10.1021/np960354x

Target ChEMBL ID: CHEMBL613606
ChEMBL Target Name: Aorta
ChEMBL Target Type: TISSUE - Target is a healthy or diseased tissue
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	100	%
Activity	=	100	%
Activity	=	103	%
Activity	=	121.9	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Acetylcholinesterase

External ID: CHEMBL3828920

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2016
Volume: 24
Issue: 18
First Page: 4464
Last Page: 4469
DOI: 10.1016/j.bmc.2016.07.043

Target ChEMBL ID: CHEMBL4078
ChEMBL Target Name: Acetylcholinesterase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	52.96	%
Inhibition	=	17.51	%
Inhibition	=	38.79	%
Inhibition	=	2.06	%
Inhibition	=	31.58	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：D(2) dopamine receptor

External ID: CHEMBL5527121

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Med Chem
Year: 2024
Volume: 67
Issue: 15
First Page: 12463
Last Page: 12484
DOI: 10.1021/acs.jmedchem.4c00537

Target ChEMBL ID: CHEMBL217
ChEMBL Target Name: D(2) dopamine receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.22	IC50	=	220	nM
0.32	IC50	=	320	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mus musculus

External ID: CHEMBL978611

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 1979
Volume: 42
Issue: 4
First Page: 399
Last Page: 406
DOI: 10.1021/np50004a007

Target ChEMBL ID: CHEMBL375
ChEMBL Target Name: Mus musculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：D(1A) dopamine receptor

External ID: CHEMBL5527120

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Med Chem
Year: 2024
Volume: 67
Issue: 15
First Page: 12463
Last Page: 12484
DOI: 10.1021/acs.jmedchem.4c00537

Target ChEMBL ID: CHEMBL2056
ChEMBL Target Name: D(1A) dopamine receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.1	IC50	=	100	nM
0.08	IC50	=	80	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Cholinesterase

External ID: CHEMBL3064683

Protocol: N/A

Comment: Journal: Med Chem Res
Year: 2009
Volume: 18
Issue: 3
First Page: 231
Last Page: 241
DOI: 10.1007/s00044-008-9122-3

Target ChEMBL ID: CHEMBL5763
ChEMBL Target Name: Cholinesterase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
Inhibition				Not Determined
Inhibition	=	5.2	%
Inhibition				Not Determined
Inhibition				Not Determined
Inhibition	=	0	%
Inhibition	=	0	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Cholinesterase

External ID: CHEMBL3064684

Protocol: N/A

Comment: Journal: Med Chem Res
Year: 2009
Volume: 18
Issue: 3
First Page: 231
Last Page: 241
DOI: 10.1007/s00044-008-9122-3

Target ChEMBL ID: CHEMBL5763
ChEMBL Target Name: Cholinesterase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
Inhibition				Not Determined
Inhibition	=	17.4	%
Inhibition				Not Determined
Inhibition				Not Determined
Inhibition	=	1.7	%
Inhibition	=	18	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Plasmodium falciparum

External ID: CHEMBL953743

Protocol: N/A

Comment: Journal: J Nat Prod
Year: 1993
Volume: 56
Issue: 9
First Page: 1468
Last Page: 1478
DOI: 10.1021/np50099a005

Target ChEMBL ID: CHEMBL364
ChEMBL Target Name: Plasmodium falciparum
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
ED50	=	1.3	ng/ml
ED50	=	7.3	ng/ml
ED50	=	9.4	ng/ml
ED50	=	4050	ng/ml
ED50	>	10000	ng/ml
ED50	=	1290	ng/ml
ED50	>	10000	ng/ml
ED50	=	950	ng/ml
ED50	=	5800	ng/ml
ED50	=	2290	ng/ml
ED50	=	1610	ng/ml
ED50	=	2840	ng/ml
ED50	>	10000	ng/ml
ED50	=	2230	ng/ml
ED50	>	10000	ng/ml
ED50	=	2560	ng/ml
ED50	=	440	ng/ml
ED50	=	3150	ng/ml
ED50	=	1260	ng/ml
ED50	=	470	ng/ml

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Acetylcholinesterase

External ID: CHEMBL3064685

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Med Chem Res
Year: 2009
Volume: 18
Issue: 3
First Page: 231
Last Page: 241
DOI: 10.1007/s00044-008-9122-3

Target ChEMBL ID: CHEMBL4078
ChEMBL Target Name: Acetylcholinesterase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
10.7	IC50	=	10700	nM
5.5	IC50	=	5500	nM
	IC50				Not Determined
	IC50				Not Determined
	IC50				Not Determined
	IC50				Not Determined
7	IC50	=	7000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mus musculus

External ID: CHEMBL978612

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 1979
Volume: 42
Issue: 4
First Page: 399
Last Page: 406
DOI: 10.1021/np50004a007

Target ChEMBL ID: CHEMBL375
ChEMBL Target Name: Mus musculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Acetylcholinesterase

External ID: CHEMBL3064686

Protocol: N/A

Comment: Journal: Med Chem Res
Year: 2009
Volume: 18
Issue: 3
First Page: 231
Last Page: 241
DOI: 10.1007/s00044-008-9122-3

Target ChEMBL ID: CHEMBL4078
ChEMBL Target Name: Acetylcholinesterase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
Inhibition				Not Determined
Inhibition	=	9	%
Inhibition	=	2.3	%
Inhibition				Not Determined
Inhibition				Not Determined
Inhibition	=	5.9	%
Inhibition	=	53	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Acetylcholinesterase

External ID: CHEMBL3064687

Protocol: N/A

Comment: Journal: Med Chem Res
Year: 2009
Volume: 18
Issue: 3
First Page: 231
Last Page: 241
DOI: 10.1007/s00044-008-9122-3

Target ChEMBL ID: CHEMBL4078
ChEMBL Target Name: Acetylcholinesterase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	0.6	%
Inhibition	=	11.4	%
Inhibition	=	29.9	%
Inhibition	=	57.2	%
Inhibition	=	20.2	%
Inhibition	=	5.7	%
Inhibition	=	85.1	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Rattus norvegicus

External ID: CHEMBL978619

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 1979
Volume: 42
Issue: 4
First Page: 399
Last Page: 406
DOI: 10.1021/np50004a007

Target ChEMBL ID: CHEMBL376
ChEMBL Target Name: Rattus norvegicus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	1.1	degrees C

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Rattus norvegicus

External ID: CHEMBL978618

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 1979
Volume: 42
Issue: 4
First Page: 399
Last Page: 406
DOI: 10.1021/np50004a007

Target ChEMBL ID: CHEMBL376
ChEMBL Target Name: Rattus norvegicus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	0.69	degrees C

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Rattus norvegicus

External ID: CHEMBL978621

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 1979
Volume: 42
Issue: 4
First Page: 399
Last Page: 406
DOI: 10.1021/np50004a007

Target ChEMBL ID: CHEMBL376
ChEMBL Target Name: Rattus norvegicus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	11.9	s

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Rattus norvegicus

External ID: CHEMBL978620

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 1979
Volume: 42
Issue: 4
First Page: 399
Last Page: 406
DOI: 10.1021/np50004a007

Target ChEMBL ID: CHEMBL376
ChEMBL Target Name: Rattus norvegicus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	7.8	s

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mus musculus

External ID: CHEMBL978615

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 1979
Volume: 42
Issue: 4
First Page: 399
Last Page: 406
DOI: 10.1021/np50004a007

Target ChEMBL ID: CHEMBL375
ChEMBL Target Name: Mus musculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	23.7	min

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mus musculus

External ID: CHEMBL978614

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 1979
Volume: 42
Issue: 4
First Page: 399
Last Page: 406
DOI: 10.1021/np50004a007

Target ChEMBL ID: CHEMBL375
ChEMBL Target Name: Mus musculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	56.2	min

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Plasmodium falciparum

External ID: CHEMBL953744

Protocol: N/A

Comment: Journal: J Nat Prod
Year: 1993
Volume: 56
Issue: 9
First Page: 1468
Last Page: 1478
DOI: 10.1021/np50099a005

Target ChEMBL ID: CHEMBL364
ChEMBL Target Name: Plasmodium falciparum
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
ED50	=	11.2	ng/ml
ED50	=	1.6	ng/ml
ED50	=	24.5	ng/ml
ED50	=	4470	ng/ml
ED50	>	10000	ng/ml
ED50	=	1900	ng/ml
ED50	>	10000	ng/ml
ED50	=	470	ng/ml
ED50	=	4010	ng/ml
ED50	=	2260	ng/ml
ED50	=	550	ng/ml
ED50	=	840	ng/ml
ED50	>	10000	ng/ml
ED50	=	1940	ng/ml
ED50	>	10000	ng/ml
ED50	=	1610	ng/ml
ED50	=	2270	ng/ml
ED50	=	1780	ng/ml
ED50	=	2550	ng/ml
ED50	=	1030	ng/ml

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Rattus norvegicus

External ID: CHEMBL978617

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 1979
Volume: 42
Issue: 4
First Page: 399
Last Page: 406
DOI: 10.1021/np50004a007

Target ChEMBL ID: CHEMBL376
ChEMBL Target Name: Rattus norvegicus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	0.36	degrees C

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mus musculus

External ID: CHEMBL978616

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 1979
Volume: 42
Issue: 4
First Page: 399
Last Page: 406
DOI: 10.1021/np50004a007

Target ChEMBL ID: CHEMBL375
ChEMBL Target Name: Mus musculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Hepatitis B virus

External ID: CHEMBL899339

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2007
Volume: 17
Issue: 19
First Page: 5316
Last Page: 5320
DOI: 10.1016/j.bmcl.2007.08.027

Target ChEMBL ID: CHEMBL613497
ChEMBL Target Name: Hepatitis B virus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
2980	IC50	>	2980000	nM	Outside typical range
3291	IC50	>	3291000	nM	Outside typical range
3854	IC50	>	3854000	nM	Outside typical range
4180	IC50	>	4180000	nM	Outside typical range
2994	IC50	>	2994000	nM	Outside typical range
3615	IC50	>	3615000	nM	Outside typical range
4114	IC50	>	4114000	nM	Outside typical range
3684	IC50	>	3684000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL899340

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2007
Volume: 17
Issue: 19
First Page: 5316
Last Page: 5320
DOI: 10.1016/j.bmcl.2007.08.027

Standard Type	Standard Relation	Standard Value
Ratio CC50/IC50	=	2.56
Ratio CC50/IC50	>	1.31
Ratio CC50/IC50	=	1.67
Ratio CC50/IC50	=	4.13
Ratio CC50/IC50	=	1.19
Ratio CC50/IC50	<	1
Ratio CC50/IC50	<	1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL899336

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2007
Volume: 17
Issue: 19
First Page: 5316
Last Page: 5320
DOI: 10.1016/j.bmcl.2007.08.027

Standard Type	Standard Relation	Standard Value
Ratio CC50/IC50	=	1.16
Ratio CC50/IC50	<	1
Ratio CC50/IC50	<	1
Ratio CC50/IC50	<	1
Ratio CC50/IC50	<	1
Ratio CC50/IC50	<	1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Plasmodium falciparum

External ID: CHEMBL991086

Protocol: N/A

Comment: Journal: J Nat Prod
Year: 1996
Volume: 59
Issue: 6
First Page: 576
Last Page: 580
DOI: 10.1021/np960195h

Target ChEMBL ID: CHEMBL364
ChEMBL Target Name: Plasmodium falciparum
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
IC50	=	0.0034	ug.mL-1
IC50	=	0.0043	ug.mL-1
IC50	=	0.0157	ug.mL-1
IC50	=	2.13	ug.mL-1
IC50	=	5.8	ug.mL-1
IC50	=	1.24	ug.mL-1
IC50	=	1.9	ug.mL-1
IC50	=	3.9	ug.mL-1
IC50	=	7.15	ug.mL-1
IC50	=	0.668	ug.mL-1
IC50	=	1.99	ug.mL-1
IC50	=	2.73	ug.mL-1
IC50	=	4.1	ug.mL-1
IC50	=	0.0041	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Hoplobatrachus tigerinus

External ID: CHEMBL966615

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 1979
Volume: 42
Issue: 4
First Page: 399
Last Page: 406
DOI: 10.1021/np50004a007

Target ChEMBL ID: CHEMBL613201
ChEMBL Target Name: Hoplobatrachus tigerinus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Rattus norvegicus

External ID: CHEMBL966614

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 1979
Volume: 42
Issue: 4
First Page: 399
Last Page: 406
DOI: 10.1021/np50004a007

Target ChEMBL ID: CHEMBL376
ChEMBL Target Name: Rattus norvegicus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	60	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NON-PROTEIN TARGET

External ID: CHEMBL899337

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2007
Volume: 17
Issue: 19
First Page: 5316
Last Page: 5320
DOI: 10.1016/j.bmcl.2007.08.027

Target ChEMBL ID: CHEMBL3879801
ChEMBL Target Name: NON-PROTEIN TARGET
ChEMBL Target Type: NON-MOLECULAR - Target has not been defined at a molecular level, only the non-molecular entity which is affected (e.g., organism, cell line etc)
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
2989	CC50	>	2989000	nM
2193	CC50	=	2193000	nM
1859	CC50	=	1859000	nM
50	CC50	=	50000	nM
1909	CC50	=	1909000	nM
3615	CC50	>	3615000	nM
4114	CC50	>	4114000	nM
3684	CC50	>	3684000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Hepatitis B virus

External ID: CHEMBL899338

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2007
Volume: 17
Issue: 19
First Page: 5316
Last Page: 5320
DOI: 10.1016/j.bmcl.2007.08.027

Target ChEMBL ID: CHEMBL613497
ChEMBL Target Name: Hepatitis B virus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
2989	IC50	>	2989000	nM	Outside typical range
1312	IC50	=	1312000	nM	Outside typical range
450	IC50	=	450000	nM	Outside typical range
42	IC50	=	42000	nM
2143	IC50	=	2143000	nM	Outside typical range
3615	IC50	>	3615000	nM	Outside typical range
4114	IC50	>	4114000	nM	Outside typical range
3684	IC50	>	3684000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mus musculus

External ID: CHEMBL966616

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 1979
Volume: 42
Issue: 4
First Page: 399
Last Page: 406
DOI: 10.1021/np50004a007

Target ChEMBL ID: CHEMBL375
ChEMBL Target Name: Mus musculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
LD50	=	56	mg.kg-1

485-19-8 靶点实验数据