HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：BV-2

External ID: CHEMBL3583454

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2014
Volume: 25
Issue: 1
First Page: 53
Last Page: 58
DOI: 10.1016/j.bmcl.2014.11.015

Target ChEMBL ID: CHEMBL614781
ChEMBL Target Name: BV-2
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
100	IC50	>	100000	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM
3.54	IC50	=	3540	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM
45.67	IC50	=	45670	nM
28.51	IC50	=	28510	nM
50.85	IC50	=	50850	nM
14.13	IC50	=	14130	nM
100	IC50	>	100000	nM
5.98	IC50	=	5980	nM
100	IC50	>	100000	nM
87.67	IC50	=	87670	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM
78.83	IC50	=	78830	nM
22.69	IC50	=	22690	nM
100	IC50	>	100000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Cytochrome P450 1A1

External ID: CHEMBL4675252

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem
Year: 2018
Volume: 26
Issue: 23-24
First Page: 6076
Last Page: 6086
DOI: 10.1016/j.bmc.2018.11.013

Target ChEMBL ID: CHEMBL2231
ChEMBL Target Name: Cytochrome P450 1A1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
4.4	IC50	=	4400	nM
0.02	IC50	=	20	nM
6.4	IC50	=	6400	nM
0.49	IC50	=	490	nM
0.24	IC50	=	240	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3583455

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2014
Volume: 25
Issue: 1
First Page: 53
Last Page: 58
DOI: 10.1016/j.bmcl.2014.11.015

Standard Type	Activity Comment
Activity	Non-toxic
Activity	Non-toxic
Activity	Non-toxic
Activity	Non-toxic
Activity	Non-toxic
Activity	Non-toxic
Activity	Non-toxic
Activity	Non-toxic
Activity	Non-toxic
Activity	Non-toxic
Activity	Non-toxic
Activity	Non-toxic
Activity	Non-toxic
Activity	Non-toxic
Activity	Non-toxic
Activity	Non-toxic
Activity	Non-toxic
Activity	Non-toxic
Activity	Non-toxic
Activity	Non-toxic

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Cytochrome P450 1B1

External ID: CHEMBL4675251

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem
Year: 2018
Volume: 26
Issue: 23-24
First Page: 6076
Last Page: 6086
DOI: 10.1016/j.bmc.2018.11.013

Target ChEMBL ID: CHEMBL4878
ChEMBL Target Name: Cytochrome P450 1B1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
4.5	IC50	=	4500	nM
1.06	IC50	=	1060	nM
6.8	IC50	=	6800	nM
5.7	IC50	=	5700	nM
1.2	IC50	=	1200	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Cytochrome P450 1A1

External ID: CHEMBL4675254

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem
Year: 2018
Volume: 26
Issue: 23-24
First Page: 6076
Last Page: 6086
DOI: 10.1016/j.bmc.2018.11.013

Target ChEMBL ID: CHEMBL2231
ChEMBL Target Name: Cytochrome P450 1A1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
2.4	IC50	=	2400	nM
0.071	IC50	=	71	nM
8.2	IC50	=	8200	nM
0.28	IC50	=	280	nM
0.69	IC50	=	690	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Cytochrome P450 1B1

External ID: CHEMBL4675253

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem
Year: 2018
Volume: 26
Issue: 23-24
First Page: 6076
Last Page: 6086
DOI: 10.1016/j.bmc.2018.11.013

Target ChEMBL ID: CHEMBL4878
ChEMBL Target Name: Cytochrome P450 1B1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
3.9	IC50	=	3900	nM
0.95	IC50	=	950	nM
3.4	IC50	=	3400	nM
20	IC50	>	20000	nM
3.8	IC50	=	3800	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL1038573

Protocol: N/A

Comment: Journal: Bioorg Med Chem
Year: 2009
Volume: 17
Issue: 14
First Page: 5170
Last Page: 5175
DOI: 10.1016/j.bmc.2009.05.051

Standard Type	Standard Relation	Standard Value	Standard Units
IC50	=	28.7	%
IC50	=	4.4	%
IC50	=	26.3	%
IC50	=	36.5	%
IC50	=	21.4	%
IC50	=	8.6	%
IC50	=	22.8	%
IC50	=	19.7	%
IC50	=	18.4	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：MCF7

External ID: CHEMBL4675236

Protocol: N/A

Comment: Journal: Bioorg Med Chem
Year: 2018
Volume: 26
Issue: 23-24
First Page: 6076
Last Page: 6086
DOI: 10.1016/j.bmc.2018.11.013

Target ChEMBL ID: CHEMBL387
ChEMBL Target Name: MCF7
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	24.1	%
Activity	=	7.1	%
Activity	=	6.7	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：MCF7

External ID: CHEMBL4675235

Protocol: N/A

Comment: Journal: Bioorg Med Chem
Year: 2018
Volume: 26
Issue: 23-24
First Page: 6076
Last Page: 6086
DOI: 10.1016/j.bmc.2018.11.013

Target ChEMBL ID: CHEMBL387
ChEMBL Target Name: MCF7
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	20.5	%
Activity	=	9.2	%
Activity	=	8.3	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：MCF7

External ID: CHEMBL4675238

Protocol: N/A

Comment: Journal: Bioorg Med Chem
Year: 2018
Volume: 26
Issue: 23-24
First Page: 6076
Last Page: 6086
DOI: 10.1016/j.bmc.2018.11.013

Target ChEMBL ID: CHEMBL387
ChEMBL Target Name: MCF7
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Active
Activity	Active
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：MCF7

External ID: CHEMBL4675237

Protocol: N/A

Comment: Journal: Bioorg Med Chem
Year: 2018
Volume: 26
Issue: 23-24
First Page: 6076
Last Page: 6086
DOI: 10.1016/j.bmc.2018.11.013

Target ChEMBL ID: CHEMBL387
ChEMBL Target Name: MCF7
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	55.4	%
Activity	=	81	%
Activity	=	83.8	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL1038575

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2009
Volume: 17
Issue: 14
First Page: 5170
Last Page: 5175
DOI: 10.1016/j.bmc.2009.05.051

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
SC50				Not Active
SC50				Not Active
SC50				Not Active
SC50				Not Active
SC50				Not Active
SC50				Not Active
SC50				Not Active
SC50				Not Active
SC50	=	2.4	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL4675228

Protocol: N/A

Comment: Journal: Bioorg Med Chem
Year: 2018
Volume: 26
Issue: 23-24
First Page: 6076
Last Page: 6086
DOI: 10.1016/j.bmc.2018.11.013

Standard Type	Standard Relation	Standard Value
Ratio IC50	=	13

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL4675227

Protocol: N/A

Comment: Journal: Bioorg Med Chem
Year: 2018
Volume: 26
Issue: 23-24
First Page: 6076
Last Page: 6086
DOI: 10.1016/j.bmc.2018.11.013

Standard Type	Standard Relation	Standard Value
Ratio IC50	=	52

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Cytochrome P450 1A1

External ID: CHEMBL4675230

Protocol: N/A

Comment: Journal: Bioorg Med Chem
Year: 2018
Volume: 26
Issue: 23-24
First Page: 6076
Last Page: 6086
DOI: 10.1016/j.bmc.2018.11.013

Target ChEMBL ID: CHEMBL2231
ChEMBL Target Name: Cytochrome P450 1A1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	100	%
Activity	=	100	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL4675229

Protocol: N/A

Comment: Journal: Bioorg Med Chem
Year: 2018
Volume: 26
Issue: 23-24
First Page: 6076
Last Page: 6086
DOI: 10.1016/j.bmc.2018.11.013

Standard Type	Standard Relation	Standard Value
Ratio IC50	=	19.5
Ratio IC50	=	53

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：MCF7

External ID: CHEMBL4675234

Protocol: N/A

Comment: Journal: Bioorg Med Chem
Year: 2018
Volume: 26
Issue: 23-24
First Page: 6076
Last Page: 6086
DOI: 10.1016/j.bmc.2018.11.013

Target ChEMBL ID: CHEMBL387
ChEMBL Target Name: MCF7
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	60	%
Activity	=	60	%

481-99-2 靶点实验数据