HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Cyclin-dependent kinase 2

External ID: CHEMBL1067148

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2010
Volume: 20
Issue: 4
First Page: 1384
Last Page: 1387
DOI: 10.1016/j.bmcl.2010.01.007

Target ChEMBL ID: CHEMBL301
ChEMBL Target Name: Cyclin-dependent kinase 2
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
50	IC50	>	50000	nM
50	IC50	>	50000	nM
50	IC50	>	50000	nM
50	IC50	>	50000	nM
20	IC50	>	20000	nM
1.2	IC50	=	1200	nM
13.4	IC50	=	13400	nM
18	IC50	=	18000	nM
30	IC50	>	30000	nM
2.9	IC50	=	2900	nM
0.035	IC50	=	35	nM
30	IC50	>	30000	nM
2.15	IC50	=	2150	nM
35	IC50	>	35000	nM
0.02	IC50	=	20	nM
20	IC50	>	20000	nM
15	IC50	=	15000	nM
20	IC50	>	20000	nM
50	IC50	>	50000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：HeLa

External ID: CHEMBL4181498

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem
Year: 2017
Volume: 25
Issue: 24
First Page: 6542
Last Page: 6553
DOI: 10.1016/j.bmc.2017.10.027

Target ChEMBL ID: CHEMBL399
ChEMBL Target Name: HeLa
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
200	IC50	>	200000	nM	Outside typical range
19.1	IC50	=	19100	nM
74.49	IC50	=	74490	nM
32.52	IC50	=	32520	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：KB

External ID: CHEMBL968125

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Nat. Prod.
Year: 2000
Volume: 63
Issue: 12
First Page: 1638
Last Page: 1640
DOI: 10.1021/np000144r

Target ChEMBL ID: CHEMBL398
ChEMBL Target Name: KB
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment	Data Validity Comment
	IC50				Not Determined
759	IC50	>	759000	nM		Outside typical range
764	IC50	>	764000	nM		Outside typical range
733	IC50	>	733000	nM		Outside typical range
338	IC50	>	338000	nM		Outside typical range
733	IC50	>	733000	nM		Outside typical range
733	IC50	>	733000	nM		Outside typical range
533	IC50	>	533000	nM		Outside typical range
74.3	IC50	=	74300	nM
42.5	IC50	=	42500	nM
586	IC50	>	586000	nM		Outside typical range
734	IC50	>	734000	nM		Outside typical range
685	IC50	>	685000	nM		Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：MGC-803

External ID: CHEMBL4181499

Protocol: N/A

Comment: Journal: Bioorg Med Chem
Year: 2017
Volume: 25
Issue: 24
First Page: 6542
Last Page: 6553
DOI: 10.1016/j.bmc.2017.10.027

Target ChEMBL ID: CHEMBL3706566
ChEMBL Target Name: MGC-803
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
200	IC50	>	200000	nM	Outside typical range
25.62	IC50	=	25620	nM
37.86	IC50	=	37860	nM
20.41	IC50	=	20410	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Plasmodium falciparum

External ID: CHEMBL953744

Protocol: N/A

Comment: Journal: J Nat Prod
Year: 1993
Volume: 56
Issue: 9
First Page: 1468
Last Page: 1478
DOI: 10.1021/np50099a005

Target ChEMBL ID: CHEMBL364
ChEMBL Target Name: Plasmodium falciparum
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
ED50	=	11.2	ng/ml
ED50	=	1.6	ng/ml
ED50	=	24.5	ng/ml
ED50	=	4470	ng/ml
ED50	>	10000	ng/ml
ED50	=	1900	ng/ml
ED50	>	10000	ng/ml
ED50	=	470	ng/ml
ED50	=	4010	ng/ml
ED50	=	2260	ng/ml
ED50	=	550	ng/ml
ED50	=	840	ng/ml
ED50	>	10000	ng/ml
ED50	=	1940	ng/ml
ED50	>	10000	ng/ml
ED50	=	1610	ng/ml
ED50	=	2270	ng/ml
ED50	=	1780	ng/ml
ED50	=	2550	ng/ml
ED50	=	1030	ng/ml

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Entamoeba histolytica

External ID: CHEMBL968124

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Nat. Prod.
Year: 2000
Volume: 63
Issue: 12
First Page: 1638
Last Page: 1640
DOI: 10.1021/np000144r

Target ChEMBL ID: CHEMBL612853
ChEMBL Target Name: Entamoeba histolytica
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment	Data Validity Comment
	IC50				Not Determined
56.2	IC50	=	56200	nM
76.4	IC50	=	76400	nM
147	IC50	=	147000	nM		Outside typical range
135	IC50	=	135000	nM		Outside typical range
90.6	IC50	=	90600	nM
147	IC50	>	147000	nM		Outside typical range
111	IC50	=	111000	nM		Outside typical range
51.2	IC50	=	51200	nM
	IC50				Not Determined
58.6	IC50	=	58600	nM
73.4	IC50	=	73400	nM
75.1	IC50	=	75100	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Plasmodium falciparum

External ID: CHEMBL4888485

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL364
ChEMBL Target Name: Plasmodium falciparum
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Data Source: MMV Malaria Hit Generation Library

Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
Z score	=	1.23
Inhibition	=	-8	%
Z score	=	1.2
Inhibition	=	-11	%	Outside typical range
Z score	=	-0.08
Inhibition	=	1	%
Z score	=	2.72
Inhibition	=	-24	%	Outside typical range
Z score	=	0.82
Inhibition	=	-5	%
Z score	=	1.48
Inhibition	=	-12	%	Outside typical range
Z score	=	-10.93
Inhibition	=	57	%
Z score	=	-0.31
Inhibition	=	2	%
Z score	=	1.21
Inhibition	=	-8	%
Z score	=	-1.25
Inhibition	=	7	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Plasmodium falciparum

External ID: CHEMBL953743

Protocol: N/A

Comment: Journal: J Nat Prod
Year: 1993
Volume: 56
Issue: 9
First Page: 1468
Last Page: 1478
DOI: 10.1021/np50099a005

Target ChEMBL ID: CHEMBL364
ChEMBL Target Name: Plasmodium falciparum
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
ED50	=	1.3	ng/ml
ED50	=	7.3	ng/ml
ED50	=	9.4	ng/ml
ED50	=	4050	ng/ml
ED50	>	10000	ng/ml
ED50	=	1290	ng/ml
ED50	>	10000	ng/ml
ED50	=	950	ng/ml
ED50	=	5800	ng/ml
ED50	=	2290	ng/ml
ED50	=	1610	ng/ml
ED50	=	2840	ng/ml
ED50	>	10000	ng/ml
ED50	=	2230	ng/ml
ED50	>	10000	ng/ml
ED50	=	2560	ng/ml
ED50	=	440	ng/ml
ED50	=	3150	ng/ml
ED50	=	1260	ng/ml
ED50	=	470	ng/ml

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Plasmodium falciparum

External ID: CHEMBL968123

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Nat Prod
Year: 2000
Volume: 63
Issue: 12
First Page: 1638
Last Page: 1640
DOI: 10.1021/np000144r

Target ChEMBL ID: CHEMBL364
ChEMBL Target Name: Plasmodium falciparum
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
0.2	IC50	=	200	nM
152	IC50	>	152000	nM	Outside typical range
95	IC50	>	95000	nM
24.1	IC50	=	24100	nM
5.08	IC50	=	5080	nM
22.3	IC50	=	22300	nM
37	IC50	=	37000	nM
107	IC50	>	107000	nM	Outside typical range
34.8	IC50	=	34800	nM
5.99	IC50	=	5990	nM
117	IC50	>	117000	nM	Outside typical range
207	IC50	=	207000	nM	Outside typical range
16.2	IC50	=	16200	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：HepG2

External ID: CHEMBL4181497

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem
Year: 2017
Volume: 25
Issue: 24
First Page: 6542
Last Page: 6553
DOI: 10.1016/j.bmc.2017.10.027

Target ChEMBL ID: CHEMBL395
ChEMBL Target Name: HepG2
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
200	IC50	>	200000	nM	Outside typical range
16.15	IC50	=	16150	nM
63.37	IC50	=	63370	nM
20.69	IC50	=	20690	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Entamoeba histolytica

External ID: CHEMBL3058937

Protocol: N/A

Comment: Journal: Med Chem Res
Year: 2012
Volume: 21
Issue: 9
First Page: 2501
Last Page: 2516
DOI: 10.1007/s00044-011-9767-1

Target ChEMBL ID: CHEMBL612853
ChEMBL Target Name: Entamoeba histolytica
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
IC50	=	12.7	ug.mL-1
IC50	=	114.3	ug.mL-1	Outside typical range
IC50	=	92.24	ug.mL-1	Outside typical range
IC50	=	81	ug.mL-1	Outside typical range
IC50	=	189.01	ug.mL-1	Outside typical range
IC50	=	7.93	ug.mL-1
IC50	=	17.8	ug.mL-1
IC50	=	12.7	ug.mL-1
IC50	=	6.89	ug.mL-1
IC50	=	0.00777	ug.mL-1
IC50	=	22.6	ug.mL-1
IC50	=	115.21	ug.mL-1	Outside typical range
IC50	=	158.67	ug.mL-1	Outside typical range
IC50	=	70.3	ug.mL-1	Outside typical range
IC50	=	0.306	ug.mL-1
IC50	=	16.6	ug.mL-1
IC50	=	23	ug.mL-1
IC50	=	14.8	ug.mL-1
IC50	=	0.14	ug.mL-1
IC50	=	105.3	ug.mL-1	Outside typical range

476-69-7 靶点实验数据