HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：5-hydroxytryptamine receptor 7

External ID: CHEMBL3584688

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Nat. Prod.
Year: 2015
Volume: 78
Issue: 4
First Page: 722
Last Page: 729
DOI: 10.1021/np500893h

Target ChEMBL ID: CHEMBL3155
ChEMBL Target Name: Serotonin 7 (5-HT7) receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.069	Ki	=	69	nM
0.015	Ki	=	15	nM
0.024	Ki	=	24	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Rattus norvegicus

External ID: CHEMBL944151

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2007
Volume: 50
Issue: 2
First Page: 171
Last Page: 181
DOI: 10.1021/jm060959i

Target ChEMBL ID: CHEMBL376
ChEMBL Target Name: Rattus norvegicus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	50	%
Activity	=	25	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Rattus norvegicus

External ID: CHEMBL944152

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2007
Volume: 50
Issue: 2
First Page: 171
Last Page: 181
DOI: 10.1021/jm060959i

Target ChEMBL ID: CHEMBL376
ChEMBL Target Name: Rattus norvegicus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	50	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL5142995

Protocol: N/A

Comment: Journal: J Nat Prod
Year: 2022
Volume: 85
Issue: 9.0
First Page: 2149
Last Page: 2158
DOI: 10.1021/acs.jnatprod.2c00365

Standard Type	Standard Relation	Standard Value
Ratio Ki	=	0.4

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：5-hydroxytryptamine receptor 1A

External ID: CHEMBL3584692

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Nat. Prod.
Year: 2015
Volume: 78
Issue: 4
First Page: 722
Last Page: 729
DOI: 10.1021/np500893h

Target ChEMBL ID: CHEMBL214
ChEMBL Target Name: Serotonin 1a (5-HT1a) receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.506	Ki	=	506	nM
0.153	Ki	=	153	nM
0.179	Ki	=	179	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL916517

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2007
Volume: 15
Issue: 2
First Page: 988
Last Page: 996
DOI: 10.1016/j.bmc.2006.10.034

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
100	CC50	>	100000	nM
8.12	CC50	=	8120	nM
100	CC50	>	100000	nM
3.91	CC50	=	3910	nM
16.2	CC50	=	16200	nM
24.7	CC50	=	24700	nM
100	CC50	>	100000	nM
11.1	CC50	=	11100	nM
9.41	CC50	=	9410	nM
32.3	CC50	=	32300	nM
4.39	CC50	=	4390	nM
100	CC50	>	100000	nM
100	CC50	>	100000	nM
100	CC50	>	100000	nM
100	CC50	>	100000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL5142996

Protocol: N/A

Comment: Journal: J Nat Prod
Year: 2022
Volume: 85
Issue: 9.0
First Page: 2149
Last Page: 2158
DOI: 10.1021/acs.jnatprod.2c00365

Standard Type	Standard Relation	Standard Value
Ratio Ki	=	8.1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：T-cell

External ID: CHEMBL916518

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem
Year: 2007
Volume: 15
Issue: 2
First Page: 988
Last Page: 996
DOI: 10.1016/j.bmc.2006.10.034

Target ChEMBL ID: CHEMBL614309
ChEMBL Target Name: T-cell
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
100	IC50	>	100000	nM
0.798	IC50	=	798	nM
100	IC50	>	100000	nM
0.795	IC50	=	795	nM
4.16	IC50	=	4160	nM
10	IC50	=	10000	nM
100	IC50	>	100000	nM
6.96	IC50	=	6960	nM
2.29	IC50	=	2290	nM
3.58	IC50	=	3580	nM
0.81	IC50	=	810	nM
100	IC50	>	100000	nM
44.8	IC50	=	44800	nM
24	IC50	=	24000	nM
100	IC50	>	100000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：B-cell

External ID: CHEMBL916519

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem
Year: 2007
Volume: 15
Issue: 2
First Page: 988
Last Page: 996
DOI: 10.1016/j.bmc.2006.10.034

Target ChEMBL ID: CHEMBL614701
ChEMBL Target Name: B-cell
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
100	IC50	>	100000	nM
1.3	IC50	=	1300	nM
100	IC50	>	100000	nM
6.72	IC50	=	6720	nM
7.29	IC50	=	7290	nM
3.96	IC50	=	3960	nM
100	IC50	>	100000	nM
7.11	IC50	=	7110	nM
1.98	IC50	=	1980	nM
2.15	IC50	=	2150	nM
0.56	IC50	=	560	nM
100	IC50	>	100000	nM
79.6	IC50	=	79600	nM
29.6	IC50	=	29600	nM
100	IC50	>	100000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：5-hydroxytryptamine receptor 2A

External ID: CHEMBL5142991

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Nat Prod
Year: 2022
Volume: 85
Issue: 9.0
First Page: 2149
Last Page: 2158
DOI: 10.1021/acs.jnatprod.2c00365

Target ChEMBL ID: CHEMBL224
ChEMBL Target Name: Serotonin 2a (5-HT2a) receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
0.268	Ki	=	268	nM
0.239	Ki	=	239	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：5-hydroxytryptamine receptor 2B

External ID: CHEMBL5142992

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Nat Prod
Year: 2022
Volume: 85
Issue: 9.0
First Page: 2149
Last Page: 2158
DOI: 10.1021/acs.jnatprod.2c00365

Target ChEMBL ID: CHEMBL1833
ChEMBL Target Name: Serotonin 2b (5-HT2b) receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.056	Ki	=	56	nM
0.057	Ki	=	57	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Neuraminidase

External ID: CHEMBL3386732

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem
Year: 2014
Volume: 22
Issue: 21
First Page: 6047
Last Page: 6052
DOI: 10.1016/j.bmc.2014.09.004

Target ChEMBL ID: CHEMBL3559643
ChEMBL Target Name: Neuraminidase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment	Data Validity Comment
76.3	IC50	=	76300	nM
32.2	IC50	=	32200	nM
	IC50				Not Determined
29.8	IC50	=	29800	nM
100.2	IC50	=	100200	nM		Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3582631

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2015
Volume: 78
Issue: 4
First Page: 722
Last Page: 729
DOI: 10.1021/np500893h

Standard Type	Standard Relation	Standard Value
Ratio Ki	=	4
Ratio Ki	=	16

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：5-hydroxytryptamine receptor 2C

External ID: CHEMBL5142993

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Nat Prod
Year: 2022
Volume: 85
Issue: 9.0
First Page: 2149
Last Page: 2158
DOI: 10.1021/acs.jnatprod.2c00365

Target ChEMBL ID: CHEMBL225
ChEMBL Target Name: Serotonin 2c (5-HT2c) receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.45	Ki	=	450	nM
0.504	Ki	=	504	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3582632

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2015
Volume: 78
Issue: 4
First Page: 722
Last Page: 729
DOI: 10.1021/np500893h

Standard Type	Standard Relation	Standard Value
Ratio Ki	=	22

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Serotonin 2 receptors; 5-HT2a & 5-HT2c

External ID: CHEMBL5142994

Protocol: N/A

Comment: Journal: J Nat Prod
Year: 2022
Volume: 85
Issue: 9.0
First Page: 2149
Last Page: 2158
DOI: 10.1021/acs.jnatprod.2c00365

Target ChEMBL ID: CHEMBL2096662
ChEMBL Target Name: Serotonin 2 receptors; 5-HT2a & 5-HT2c
ChEMBL Target Type: SELECTIVITY GROUP - Target is a pair of proteins for which the selectivity has been assessed
Relationship Type: D - Direct protein target assigned
Confidence: Multiple direct protein targets may be assigned

Standard Type	Standard Relation	Standard Value
Ratio Ki	=	2.9

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：D(1A) dopamine receptor

External ID: CHEMBL944160

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2007
Volume: 50
Issue: 2
First Page: 171
Last Page: 181
DOI: 10.1021/jm060959i

Target ChEMBL ID: CHEMBL265
ChEMBL Target Name: Dopamine D1 receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
1.72	IC50	=	1720	nM
0.92	Ki	=	920	nM
0.38	Ki	=	380	nM
1.3	IC50	=	1300	nM
0.97	IC50	=	970	nM
10	IC50	>	10000	nM
0.73	Ki	=	730	nM
0.049	Ki	=	49	nM
68	IC50	=	68000	nM
4.8	IC50	=	4800	nM
17.2	IC50	=	17200	nM
100	IC50	>	100000	nM
63	IC50	=	63000	nM
0.17	Ki	=	170	nM
10	Ki	>	10000	nM
50	IC50	=	50000	nM
1	IC50	=	1000	nM
0.06	IC50	=	60	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Rattus norvegicus

External ID: CHEMBL944153

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2007
Volume: 50
Issue: 2
First Page: 171
Last Page: 181
DOI: 10.1021/jm060959i

Target ChEMBL ID: CHEMBL376
ChEMBL Target Name: Rattus norvegicus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	50	%
Activity	=	50	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Rattus norvegicus

External ID: CHEMBL944154

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2007
Volume: 50
Issue: 2
First Page: 171
Last Page: 181
DOI: 10.1021/jm060959i

Target ChEMBL ID: CHEMBL376
ChEMBL Target Name: Rattus norvegicus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	50	%
Activity	=	50	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Multidrug resistance-associated protein 1

External ID: CHEMBL4191981

Protocol: N/A

Comment: Journal: Eur J Med Chem
Year: 2017
Volume: 138
First Page: 273
Last Page: 292
DOI: 10.1016/j.ejmech.2017.06.047

Target ChEMBL ID: CHEMBL3004
ChEMBL Target Name: Multidrug resistance-associated protein 1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value
FC	=	22

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL4191980

Protocol: N/A

Comment: Journal: Eur J Med Chem
Year: 2017
Volume: 138
First Page: 273
Last Page: 292
DOI: 10.1016/j.ejmech.2017.06.047

Standard Type	Standard Relation	Standard Value
FC	=	7

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL4191983

Protocol: N/A

Comment: Journal: Eur J Med Chem
Year: 2017
Volume: 138
First Page: 273
Last Page: 292
DOI: 10.1016/j.ejmech.2017.06.047

Standard Type	Standard Relation	Standard Value
FC	=	32
FC	=	7
FC	=	20

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：D(2) dopamine receptor

External ID: CHEMBL944161

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2007
Volume: 50
Issue: 2
First Page: 171
Last Page: 181
DOI: 10.1021/jm060959i

Target ChEMBL ID: CHEMBL339
ChEMBL Target Name: Dopamine D2 receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
100	Ki	>	100000	nM
7.0E-5	IC50	=	0.07	nM
1.07	Ki	=	1070	nM
7.1E-5	IC50	=	0.071	nM
8.9E-4	IC50	=	0.89	nM
0.0055	IC50	=	5.5	nM
0.01	Ki	=	10	nM
0.74	Ki	=	740	nM
19	IC50	=	19000	nM
27	IC50	=	27000	nM
2.8	IC50	=	2800	nM
100	IC50	>	100000	nM
0.5	IC50	=	500	nM
0.0037	Ki	=	3.7	nM
0.039	Ki	=	39	nM
2	IC50	=	2000	nM
1.5	IC50	=	1500	nM
0.03	IC50	=	30	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL981213

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2008
Volume: 16
Issue: 15
First Page: 7457
Last Page: 7461
DOI: 10.1016/j.bmc.2008.06.010

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	44.3	%
Activity	=	3.6	%
Activity	=	6.1	%
Activity	=	69.6	%
Activity	=	1.6	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL981212

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2008
Volume: 16
Issue: 15
First Page: 7457
Last Page: 7461
DOI: 10.1016/j.bmc.2008.06.010

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	36.7	%
Activity	=	3.3	%
Activity	=	4.5	%
Activity	=	69	%
Activity	=	1.4	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL981214

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2008
Volume: 16
Issue: 15
First Page: 7457
Last Page: 7461
DOI: 10.1016/j.bmc.2008.06.010

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
105	CC50	=	105000	nM
112	CC50	=	112000	nM
152	CC50	=	152000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL981209

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2008
Volume: 16
Issue: 15
First Page: 7457
Last Page: 7461
DOI: 10.1016/j.bmc.2008.06.010

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	21	%
Activity	=	2.2	%
Activity	=	3.7	%
Activity	=	26.5	%
Activity	=	1.1	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL981208

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2008
Volume: 16
Issue: 15
First Page: 7457
Last Page: 7461
DOI: 10.1016/j.bmc.2008.06.010

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	13.8	%
Activity	=	2.4	%
Activity	=	2.9	%
Activity	=	17.2	%
Activity	=	1.2	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL981211

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2008
Volume: 16
Issue: 15
First Page: 7457
Last Page: 7461
DOI: 10.1016/j.bmc.2008.06.010

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	25.1	%
Activity	=	2.7	%
Activity	=	4.7	%
Activity	=	31.9	%
Activity	=	1.3	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL981210

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2008
Volume: 16
Issue: 15
First Page: 7457
Last Page: 7461
DOI: 10.1016/j.bmc.2008.06.010

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	12	%
Activity	=	2.1	%
Activity	=	2.1	%
Activity	=	16.1	%
Activity	=	0.8	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL992730

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2008
Volume: 16
Issue: 15
First Page: 7457
Last Page: 7461
DOI: 10.1016/j.bmc.2008.06.010

Standard Type	Standard Relation	Standard Value
Ratio CC50/IC50	=	12.5
Ratio CC50/IC50	=	5.5
Ratio CC50/IC50	=	20.8

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL992733

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2008
Volume: 16
Issue: 15
First Page: 7457
Last Page: 7461
DOI: 10.1016/j.bmc.2008.06.010

Standard Type	Standard Relation	Standard Value
Ratio CC50/IC50	=	19.2
Ratio CC50/IC50	=	1.9
Ratio CC50/IC50	=	104

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL981217

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2008
Volume: 16
Issue: 15
First Page: 7457
Last Page: 7461
DOI: 10.1016/j.bmc.2008.06.010

Standard Type	Standard Relation	Standard Value
Ratio CC50/IC50	=	12.5
Ratio CC50/IC50	=	1.9
Ratio CC50/IC50	=	43.3

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Staphylococcus aureus

External ID: CHEMBL966378

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2000
Volume: 63
Issue: 8
First Page: 1146
Last Page: 1149
DOI: 10.1021/np990639k

Target ChEMBL ID: CHEMBL352
ChEMBL Target Name: Staphylococcus aureus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Neuraminidase

External ID: CHEMBL3386731

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem
Year: 2014
Volume: 22
Issue: 21
First Page: 6047
Last Page: 6052
DOI: 10.1016/j.bmc.2014.09.004

Target ChEMBL ID: CHEMBL3559643
ChEMBL Target Name: Neuraminidase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
66.2	IC50	=	66200	nM
38.5	IC50	=	38500	nM
	IC50				Not Determined
33.1	IC50	=	33100	nM
80.5	IC50	=	80500	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3386730

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem
Year: 2014
Volume: 22
Issue: 21
First Page: 6047
Last Page: 6052
DOI: 10.1016/j.bmc.2014.09.004

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
13.5	IC50	=	13500	nM
	IC50				Not Determined
12.8	IC50	=	12800	nM
41.3	IC50	=	41300	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：5-hydroxytryptamine receptor 2A

External ID: CHEMBL3584693

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Nat. Prod.
Year: 2015
Volume: 78
Issue: 4
First Page: 722
Last Page: 729
DOI: 10.1021/np500893h

Target ChEMBL ID: CHEMBL224
ChEMBL Target Name: Serotonin 2a (5-HT2a) receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.818	Ki	=	818	nM
0.268	Ki	=	268	nM
0.239	Ki	=	239	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL992735

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2008
Volume: 16
Issue: 15
First Page: 7457
Last Page: 7461
DOI: 10.1016/j.bmc.2008.06.010

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
12	IC50	=	12000	nM
28	IC50	=	28000	nM
15	IC50	=	15000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：rhinovirus B14

External ID: CHEMBL992734

Protocol: N/A

Comment: Journal: Bioorg Med Chem
Year: 2008
Volume: 16
Issue: 15
First Page: 7457
Last Page: 7461
DOI: 10.1016/j.bmc.2008.06.010

Target ChEMBL ID: CHEMBL613759
ChEMBL Target Name: rhinovirus B14
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
113	CC50	=	113000	nM
125	CC50	=	125000	nM
155	CC50	=	155000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL992736

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2008
Volume: 16
Issue: 15
First Page: 7457
Last Page: 7461
DOI: 10.1016/j.bmc.2008.06.010

Standard Type	Standard Relation	Standard Value
Ratio CC50/IC50	=	14
Ratio CC50/IC50	=	8.3
Ratio CC50/IC50	=	170

475-81-0 靶点实验数据