HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：RAW264.7

External ID: CHEMBL5226936

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Eur J Med Chem
Year: 2021
Volume: 213
First Page: 113165
Last Page: 113165
DOI: 10.1016/j.ejmech.2021.113165

Target ChEMBL ID: CHEMBL612557
ChEMBL Target Name: RAW264.7
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
3.4	IC50	=	3400	nM
9.1	IC50	=	9100	nM
0.8	IC50	=	800	nM
2.4	IC50	=	2400	nM
12	IC50	=	12000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：D(1A) dopamine receptor

External ID: CHEMBL944160

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2007
Volume: 50
Issue: 2
First Page: 171
Last Page: 181
DOI: 10.1021/jm060959i

Target ChEMBL ID: CHEMBL265
ChEMBL Target Name: Dopamine D1 receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
1.72	IC50	=	1720	nM
0.92	Ki	=	920	nM
0.38	Ki	=	380	nM
1.3	IC50	=	1300	nM
0.97	IC50	=	970	nM
10	IC50	>	10000	nM
0.73	Ki	=	730	nM
0.049	Ki	=	49	nM
68	IC50	=	68000	nM
4.8	IC50	=	4800	nM
17.2	IC50	=	17200	nM
100	IC50	>	100000	nM
63	IC50	=	63000	nM
0.17	Ki	=	170	nM
10	Ki	>	10000	nM
50	IC50	=	50000	nM
1	IC50	=	1000	nM
0.06	IC50	=	60	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：D(2) dopamine receptor

External ID: CHEMBL944161

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2007
Volume: 50
Issue: 2
First Page: 171
Last Page: 181
DOI: 10.1021/jm060959i

Target ChEMBL ID: CHEMBL339
ChEMBL Target Name: Dopamine D2 receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
100	Ki	>	100000	nM
7.0E-5	IC50	=	0.07	nM
1.07	Ki	=	1070	nM
7.1E-5	IC50	=	0.071	nM
8.9E-4	IC50	=	0.89	nM
0.0055	IC50	=	5.5	nM
0.01	Ki	=	10	nM
0.74	Ki	=	740	nM
19	IC50	=	19000	nM
27	IC50	=	27000	nM
2.8	IC50	=	2800	nM
100	IC50	>	100000	nM
0.5	IC50	=	500	nM
0.0037	Ki	=	3.7	nM
0.039	Ki	=	39	nM
2	IC50	=	2000	nM
1.5	IC50	=	1500	nM
0.03	IC50	=	30	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Sodium-dependent dopamine transporter

External ID: CHEMBL944162

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2007
Volume: 50
Issue: 2
First Page: 171
Last Page: 181
DOI: 10.1021/jm060959i

Target ChEMBL ID: CHEMBL338
ChEMBL Target Name: Dopamine transporter
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
8.1	IC50	=	8100	nM
40	IC50	=	40000	nM
32	IC50	=	32000	nM
100	IC50	>	100000	nM
41	IC50	=	41000	nM
57	IC50	=	57000	nM
86	IC50	=	86000	nM
10	IC50	>	10000	nM
100	IC50	>	100000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3868893

Protocol: N/A

Comment: Journal: J Nat Prod
Year: 2016
Volume: 79
Issue: 8
First Page: 2083
Last Page: 2088
DOI: 10.1021/acs.jnatprod.6b00409

Standard Type	Standard Units	Activity Comment
Inhibition	%	Dose-dependent effect

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3868894

Protocol: N/A

Comment: Journal: J Nat Prod
Year: 2016
Volume: 79
Issue: 8
First Page: 2083
Last Page: 2088
DOI: 10.1021/acs.jnatprod.6b00409

Standard Type	Standard Units	Activity Comment
Inhibition	%	Dose-dependent effect

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：RAW264.7

External ID: CHEMBL4812826

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Nat Prod
Year: 2021
Volume: 84
Issue: 5.0
First Page: 1598
Last Page: 1606
DOI: 10.1021/acs.jnatprod.1c00146

Target ChEMBL ID: CHEMBL612557
ChEMBL Target Name: RAW264.7
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
50	IC50	>	50000	nM
50	IC50	>	50000	nM
50	IC50	>	50000	nM
50	IC50	>	50000	nM
50	IC50	>	50000	nM
35.5	IC50	=	35500	nM
21.6	IC50	=	21600	nM
50	IC50	>	50000	nM
34.2	IC50	=	34200	nM
50	IC50	>	50000	nM
50	IC50	>	50000	nM
7.3	IC50	=	7300	nM
50	IC50	>	50000	nM
50	IC50	>	50000	nM
50	IC50	>	50000	nM
50	IC50	>	50000	nM
50	IC50	>	50000	nM
50	IC50	>	50000	nM
50	IC50	>	50000	nM
50	IC50	>	50000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3868895

Protocol: N/A

Comment: Journal: J Nat Prod
Year: 2016
Volume: 79
Issue: 8
First Page: 2083
Last Page: 2088
DOI: 10.1021/acs.jnatprod.6b00409

Standard Type	Standard Units
Inhibition	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Aspergillus niger

External ID: CHEMBL1114915

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2009
Volume: 72
Issue: 11
First Page: 1949
Last Page: 1953
DOI: 10.1021/np900572g

Target ChEMBL ID: CHEMBL358
ChEMBL Target Name: Aspergillus niger
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MIC	=	25	ug.mL-1
MIC	=	25	ug.mL-1
MIC	=	50	ug.mL-1
MIC	=	188	ug.mL-1
MIC	=	100	ug.mL-1
MIC	=	38	ug.mL-1
MIC	=	150	ug.mL-1
MIC	=	250	ug.mL-1
MIC	=	12	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Saccharomyces cerevisiae

External ID: CHEMBL1114914

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2009
Volume: 72
Issue: 11
First Page: 1949
Last Page: 1953
DOI: 10.1021/np900572g

Target ChEMBL ID: CHEMBL361
ChEMBL Target Name: Saccharomyces cerevisiae
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MIC	=	25	ug.mL-1
MIC	=	12	ug.mL-1
MIC	=	25	ug.mL-1
MIC	=	47	ug.mL-1
MIC	=	50	ug.mL-1
MIC	=	38	ug.mL-1
MIC	=	150	ug.mL-1
MIC	=	63	ug.mL-1
MIC	=	12	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mycolicibacterium smegmatis

External ID: CHEMBL1114913

Protocol: N/A

Comment: Journal: J Nat Prod
Year: 2009
Volume: 72
Issue: 11
First Page: 1949
Last Page: 1953
DOI: 10.1021/np900572g

Target ChEMBL ID: CHEMBL613088
ChEMBL Target Name: Mycolicibacterium smegmatis
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MIC	=	12	ug.mL-1
MIC	=	0.2	ug.mL-1
MIC	=	25	ug.mL-1
MIC	=	94	ug.mL-1
MIC	=	50	ug.mL-1
MIC	=	38	ug.mL-1
MIC	=	75	ug.mL-1
MIC	=	31	ug.mL-1
MIC	=	12	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Micrococcus luteus

External ID: CHEMBL1114912

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2009
Volume: 72
Issue: 11
First Page: 1949
Last Page: 1953
DOI: 10.1021/np900572g

Target ChEMBL ID: CHEMBL614421
ChEMBL Target Name: Micrococcus luteus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MIC	=	6.3	ug.mL-1
MIC	=	0.1	ug.mL-1
MIC	=	25	ug.mL-1
MIC	=	94	ug.mL-1
MIC	=	50	ug.mL-1
MIC	=	150	ug.mL-1
MIC	=	150	ug.mL-1
MIC	=	125	ug.mL-1
MIC	=	50	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Protein tyrosine phosphatase receptor type C-associated protein

External ID: CHEMBL812682

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 1995
Volume: 5
Issue: 14
First Page: 1519
Last Page: 1522
DOI: 10.1016/0960-894X(95)00250-W

Target ChEMBL ID: CHEMBL4806
ChEMBL Target Name: Protein tyrosine phosphatase receptor type C-associated protein
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
88	IC50	=	88000	nM
17	IC50	=	17000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mycobacterium tuberculosis

External ID: CHEMBL5262775

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Eur J Med Chem
Year: 2017
Volume: 137
First Page: 504
Last Page: 544
DOI: 10.1016/j.ejmech.2017.06.005

Target ChEMBL ID: CHEMBL360
ChEMBL Target Name: Mycobacterium tuberculosis
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
	MIC	=	4	ug.mL-1
0.35	MIC	=	350	nM
17	MIC	=	17000	nM
	MIC	=	6	ug.mL-1
	MIC	=	6.25	ug.mL-1
	MIC	=	0.015	ug.mL-1
	MIC	=	6	ug.mL-1
	MIC	=	169.9	ug.mL-1
	MIC	=	14.3	ug.mL-1
	MIC	=	50	ug.mL-1
	MIC	=	50	ug.mL-1
	MIC	=	24.5	ug.mL-1
	MIC	=	100	ug.mL-1
	MIC	=	50	ug.mL-1
	MIC	=	0.02	ug.mL-1
	MIC	=	6.25	ug.mL-1
	MIC	=	6.25	ug.mL-1
7	MIC	=	7000	nM
21	MIC	=	21000	nM
58.8	MIC	=	58800	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3868882

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Nat Prod
Year: 2016
Volume: 79
Issue: 8
First Page: 2083
Last Page: 2088
DOI: 10.1021/acs.jnatprod.6b00409

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
8.7	IC50	=	8700	nM
0.6	IC50	=	600	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：HEK293

External ID: CHEMBL3868884

Protocol: N/A

Comment: Journal: J Nat Prod
Year: 2016
Volume: 79
Issue: 8
First Page: 2083
Last Page: 2088
DOI: 10.1021/acs.jnatprod.6b00409

Target ChEMBL ID: CHEMBL614818
ChEMBL Target Name: HEK293
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type
Activity
Activity

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：SF-268

External ID: CHEMBL1117575

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Nat. Prod.
Year: 2009
Volume: 72
Issue: 11
First Page: 1949
Last Page: 1953
DOI: 10.1021/np900572g

Target ChEMBL ID: CHEMBL613977
ChEMBL Target Name: SF-268
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
10	IC50	>	10000	nM
10	IC50	>	10000	nM
10	IC50	>	10000	nM
	Activity				Not Active
10	IC50	=	10000	nM
10	IC50	=	10000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NCI-H460

External ID: CHEMBL1117574

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Nat. Prod.
Year: 2009
Volume: 72
Issue: 11
First Page: 1949
Last Page: 1953
DOI: 10.1021/np900572g

Target ChEMBL ID: CHEMBL396
ChEMBL Target Name: NCI-H460
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
10	IC50	>	10000	nM
10	IC50	>	10000	nM
10	IC50	>	10000	nM
	Activity				Not Active
10	IC50	=	10000	nM
10	IC50	=	10000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：MCF7

External ID: CHEMBL1117573

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Nat. Prod.
Year: 2009
Volume: 72
Issue: 11
First Page: 1949
Last Page: 1953
DOI: 10.1021/np900572g

Target ChEMBL ID: CHEMBL387
ChEMBL Target Name: MCF7
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
10	IC50	>	10000	nM
10	IC50	>	10000	nM
10	IC50	>	10000	nM
	Activity				Not Active
10	IC50	=	10000	nM
10	IC50	=	10000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：KB

External ID: CHEMBL1114916

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Nat. Prod.
Year: 2009
Volume: 72
Issue: 11
First Page: 1949
Last Page: 1953
DOI: 10.1021/np900572g

Target ChEMBL ID: CHEMBL398
ChEMBL Target Name: KB
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
10	IC50	>	10000	nM
10	IC50	>	10000	nM
10	IC50	>	10000	nM
	Activity				Not Active
10	IC50	=	10000	nM
10	IC50	=	10000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Acetylcholinesterase

External ID: CHEMBL1272767

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Nat. Prod.
Year: 2010
Volume: 73
Issue: 10
First Page: 1632
Last Page: 1635
DOI: 10.1021/np100247r

Target ChEMBL ID: CHEMBL4078
ChEMBL Target Name: Acetylcholinesterase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
150	IC50	>	150000	nM	Outside typical range
8.4	IC50	=	8400	nM
0.4	IC50	=	400	nM
97.6	IC50	=	97600	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3868892

Protocol: N/A

Comment: Journal: J Nat Prod
Year: 2016
Volume: 79
Issue: 8
First Page: 2083
Last Page: 2088
DOI: 10.1021/acs.jnatprod.6b00409

Standard Type	Standard Units	Activity Comment
Inhibition	%	Dose-dependent effect

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NON-PROTEIN TARGET

External ID: CHEMBL3868887

Protocol: N/A

Comment: Journal: J Nat Prod
Year: 2016
Volume: 79
Issue: 8
First Page: 2083
Last Page: 2088
DOI: 10.1021/acs.jnatprod.6b00409

Target ChEMBL ID: CHEMBL3879801
ChEMBL Target Name: NON-PROTEIN TARGET
ChEMBL Target Type: NON-MOLECULAR - Target has not been defined at a molecular level, only the non-molecular entity which is affected (e.g., organism, cell line etc)
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Non-Toxic
Activity	Non-Toxic

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Neuronal acetylcholine receptor subunit alpha-3

External ID: CHEMBL2340264

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2013
Volume: 76
Issue: 2
First Page: 243
Last Page: 249
DOI: 10.1021/np3007414

Target ChEMBL ID: CHEMBL1907594
ChEMBL Target Name: Neuronal acetylcholine receptor; alpha3/beta4
ChEMBL Target Type: PROTEIN COMPLEX - Target is a defined protein complex, consisting of multiple subunits
Relationship Type: D - Direct protein target assigned
Confidence: Direct protein complex subunits assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	88.3	%
Inhibition	=	19.3	%
Inhibition	=	54	%
Inhibition	=	14	%
Inhibition	=	58.2	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Neuronal acetylcholine receptor subunit alpha-4

External ID: CHEMBL2340263

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2013
Volume: 76
Issue: 2
First Page: 243
Last Page: 249
DOI: 10.1021/np3007414

Target ChEMBL ID: CHEMBL1907589
ChEMBL Target Name: Neuronal acetylcholine receptor; alpha4/beta2
ChEMBL Target Type: PROTEIN COMPLEX - Target is a defined protein complex, consisting of multiple subunits
Relationship Type: D - Direct protein target assigned
Confidence: Direct protein complex subunits assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	91.8	%
Inhibition	=	13.3	%
Inhibition	=	61	%
Inhibition	=	21.8	%
Inhibition	=	74	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：HT-29

External ID: CHEMBL2340267

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Nat. Prod.
Year: 2013
Volume: 76
Issue: 2
First Page: 243
Last Page: 249
DOI: 10.1021/np3007414

Target ChEMBL ID: CHEMBL384
ChEMBL Target Name: HT-29
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
10	IC50	>	10000	nM
10	IC50	>	10000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：RAW264.7

External ID: CHEMBL4812827

Protocol: N/A

Comment: Journal: J Nat Prod
Year: 2021
Volume: 84
Issue: 5.0
First Page: 1598
Last Page: 1606
DOI: 10.1021/acs.jnatprod.1c00146

Target ChEMBL ID: CHEMBL612557
ChEMBL Target Name: RAW264.7
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Toxic
Activity	Non-Toxic
Activity	Non-Toxic
Activity	Non-Toxic
Activity	Non-Toxic
Activity	Toxic

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL4629203

Protocol: N/A

Comment: Journal: Bioorg Med Chem
Year: 2020
Volume: 28
Issue: 10
First Page: 115462
Last Page: 115462
DOI: 10.1016/j.bmc.2020.115462

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
154.5	IC50	=	154500	nM	Outside typical range
83.5	IC50	=	83500	nM
11.3	IC50	=	11300	nM
57.9	IC50	=	57900	nM
38.3	IC50	=	38300	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Staphylococcus aureus

External ID: CHEMBL997464

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2002
Volume: 65
Issue: 6
First Page: 856
Last Page: 859
DOI: 10.1021/np0200717

Target ChEMBL ID: CHEMBL352
ChEMBL Target Name: Staphylococcus aureus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
IC50	=	0.07	ug.mL-1
MIC	=	0.39	ug.mL-1
IC50	=	2	ug.mL-1
MIC	=	3.13	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Cryptococcus neoformans

External ID: CHEMBL997463

Protocol: N/A

Comment: Journal: J Nat Prod
Year: 2002
Volume: 65
Issue: 6
First Page: 856
Last Page: 859
DOI: 10.1021/np0200717

Target ChEMBL ID: CHEMBL365
ChEMBL Target Name: Cryptococcus neoformans
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MIC	=	0.63	ug.mL-1
IC50	=	0.3	ug.mL-1
MIC	=	12.5	ug.mL-1
IC50	=	2	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Staphylococcus aureus

External ID: CHEMBL997465

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2002
Volume: 65
Issue: 6
First Page: 856
Last Page: 859
DOI: 10.1021/np0200717

Target ChEMBL ID: CHEMBL352
ChEMBL Target Name: Staphylococcus aureus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MIC	=	3.13	ug.mL-1
IC50	=	0.1	ug.mL-1
MIC	=	3.13	ug.mL-1
IC50	=	2	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Candida albicans

External ID: CHEMBL997461

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2002
Volume: 65
Issue: 6
First Page: 856
Last Page: 859
DOI: 10.1021/np0200717

Target ChEMBL ID: CHEMBL366
ChEMBL Target Name: Candida albicans
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
IC50	=	0.06	ug.mL-1
MIC	=	0.31	ug.mL-1
IC50	=	3.5	ug.mL-1
MIC	=	6.25	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：KB

External ID: CHEMBL1032619

Protocol: N/A

Comment: Journal: J Nat Prod
Year: 1982
Volume: 45
Issue: 1
First Page: 102
Last Page: 102
DOI: 10.1021/np50019a011

Target ChEMBL ID: CHEMBL398
ChEMBL Target Name: KB
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
ED50	=	3.1	ug ml-1
ED50	>	10	ug ml-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NON-PROTEIN TARGET

External ID: CHEMBL1010352

Protocol: N/A

Comment: Journal: J Nat Prod
Year: 1987
Volume: 50
Issue: 5
First Page: 891
Last Page: 896
DOI: 10.1021/np50053a020

Target ChEMBL ID: CHEMBL3879801
ChEMBL Target Name: NON-PROTEIN TARGET
ChEMBL Target Type: NON-MOLECULAR - Target has not been defined at a molecular level, only the non-molecular entity which is affected (e.g., organism, cell line etc)
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
ED50	=	1.6	ug ml-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Vero

External ID: CHEMBL979424

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Nat. Prod.
Year: 1998
Volume: 61
Issue: 4
First Page: 480
Last Page: 484
DOI: 10.1021/np970382v

Target ChEMBL ID: CHEMBL391
ChEMBL Target Name: Vero
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
250	MTC	=	250	uM
20	MTC	=	20	uM
62	MTC	=	62	uM
15	MTC	=	15	uM
125	MTC	=	125	uM
31	MTC	=	31	uM
62	MTC	=	62	uM
5	MTC	=	5	uM
125	MTC	=	125	uM
7	MTC	=	7	uM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Poliovirus 2

External ID: CHEMBL979423

Protocol: N/A

Comment: Journal: J Nat Prod
Year: 1998
Volume: 61
Issue: 4
First Page: 480
Last Page: 484
DOI: 10.1021/np970382v

Target ChEMBL ID: CHEMBL613752
ChEMBL Target Name: Poliovirus 2
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Activity Comment
Activity			Not Determined
Activity			Not Determined
Activity			Not Determined
Activity			Not Determined
Activity			Not Determined
Activity	=	1
Activity	=	1
Activity			Not Determined
Activity			Not Determined
Activity			Not Determined

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Vero

External ID: CHEMBL979420

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Nat. Prod.
Year: 1998
Volume: 61
Issue: 4
First Page: 480
Last Page: 484
DOI: 10.1021/np970382v

Target ChEMBL ID: CHEMBL391
ChEMBL Target Name: Vero
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
500	CC50	=	500000	nM
25	CC50	=	25000	nM
68	CC50	=	68000	nM
28	CC50	=	28000	nM
250	CC50	=	250000	nM
47	CC50	=	47000	nM
107	CC50	=	107000	nM
7	CC50	=	7000	nM
435	CC50	=	435000	nM
9	CC50	=	9000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Pancreatic triacylglycerol lipase

External ID: CHEMBL2394359

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2013
Volume: 23
Issue: 12
First Page: 3604
Last Page: 3608
DOI: 10.1016/j.bmcl.2013.04.013

Target ChEMBL ID: CHEMBL1687677
ChEMBL Target Name: Pancreatic triacylglycerol lipase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Units	Activity Comment
Inhibition	%	Active
Inhibition	%	Active
Inhibition	%	Active
Inhibition	%	Active
Inhibition	%	Active
Inhibition	%	Active
Inhibition	%	Active
Inhibition	%	Active
Inhibition	%	Active
Inhibition	%	Not Active
Inhibition	%	Active
Inhibition	%	Not Active
Inhibition	%	Active
Inhibition	%	Not Active
Inhibition	%	Not Active
Inhibition	%	Active
Inhibition	%	Not Active
Inhibition	%	Active
Inhibition	%	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：3T3-L1

External ID: CHEMBL2394358

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2013
Volume: 23
Issue: 12
First Page: 3604
Last Page: 3608
DOI: 10.1016/j.bmcl.2013.04.013

Target ChEMBL ID: CHEMBL614510
ChEMBL Target Name: 3T3-L1
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Not Active
Activity	Not Active
Activity	Active
Activity	Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Active
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Poliovirus 2

External ID: CHEMBL979426

Protocol: N/A

Comment: Journal: J Nat Prod
Year: 1998
Volume: 61
Issue: 4
First Page: 480
Last Page: 484
DOI: 10.1021/np970382v

Target ChEMBL ID: CHEMBL613752
ChEMBL Target Name: Poliovirus 2
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Activity Comment
Activity			Not Determined
Activity			Not Determined
Activity			Not Determined
Activity			Not Determined
Activity			Not Determined
Activity	=	1.5
Activity	=	1.5
Activity			Not Determined
Activity			Not Determined
Activity			Not Determined

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Poliovirus 2

External ID: CHEMBL979428

Protocol: N/A

Comment: Journal: J Nat Prod
Year: 1998
Volume: 61
Issue: 4
First Page: 480
Last Page: 484
DOI: 10.1021/np970382v

Target ChEMBL ID: CHEMBL613752
ChEMBL Target Name: Poliovirus 2
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Activity Comment
Activity			Not Determined
Activity			Not Determined
Activity			Not Determined
Activity			Not Determined
Activity			Not Determined
Activity	=	1.5
Activity	=	2.5
Activity			Not Determined
Activity			Not Determined
Activity			Not Determined

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mycobacterium tuberculosis

External ID: CHEMBL2209267

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Eur. J. Med. Chem.
Year: 2012
Volume: 49
First Page: 1
Last Page: 23
DOI: 10.1016/j.ejmech.2011.12.029

Target ChEMBL ID: CHEMBL360
ChEMBL Target Name: Mycobacterium tuberculosis
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
	MIC	=	50	ug.mL-1
	MIC	=	50	ug.mL-1
4.1	MIC	=	4100	nM
11.3	MIC	=	11300	nM
6.75	MIC	=	6750	nM
20.7	MIC	=	20700	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NON-PROTEIN TARGET

External ID: CHEMBL992035

Protocol: N/A

Comment: Journal: J Nat Prod
Year: 1989
Volume: 52
Issue: 3
First Page: 463
Last Page: 477
DOI: 10.1021/np50063a002

Target ChEMBL ID: CHEMBL3879801
ChEMBL Target Name: NON-PROTEIN TARGET
ChEMBL Target Type: NON-MOLECULAR - Target has not been defined at a molecular level, only the non-molecular entity which is affected (e.g., organism, cell line etc)
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
Activity				Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NON-PROTEIN TARGET

External ID: CHEMBL992034

Protocol: N/A

Comment: Journal: J Nat Prod
Year: 1989
Volume: 52
Issue: 3
First Page: 463
Last Page: 477
DOI: 10.1021/np50063a002

Target ChEMBL ID: CHEMBL3879801
ChEMBL Target Name: NON-PROTEIN TARGET
ChEMBL Target Type: NON-MOLECULAR - Target has not been defined at a molecular level, only the non-molecular entity which is affected (e.g., organism, cell line etc)
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
Activity				Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：BV-2

External ID: CHEMBL4835534

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Nat Prod
Year: 2021
Volume: 84
Issue: 4.0
First Page: 1316
Last Page: 1325
DOI: 10.1021/acs.jnatprod.1c00055

Target ChEMBL ID: CHEMBL614781
ChEMBL Target Name: BV-2
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
50	IC50	>	50000	nM
37	IC50	=	37000	nM
50	IC50	>	50000	nM
50	IC50	>	50000	nM
50	IC50	>	50000	nM
45	IC50	=	45000	nM
22	IC50	=	22000	nM
21	IC50	=	21000	nM
15	IC50	=	15000	nM
50	IC50	>	50000	nM
50	IC50	>	50000	nM
50	IC50	>	50000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：BV-2

External ID: CHEMBL4835533

Protocol: N/A

Comment: Journal: J Nat Prod
Year: 2021
Volume: 84
Issue: 4.0
First Page: 1316
Last Page: 1325
DOI: 10.1021/acs.jnatprod.1c00055

Target ChEMBL ID: CHEMBL614781
ChEMBL Target Name: BV-2
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Non-Toxic
Activity	Non-Toxic
Activity	Non-Toxic
Activity	Non-Toxic
Activity	Non-Toxic
Activity	Non-Toxic

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Artemia

External ID: CHEMBL992033

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 1989
Volume: 52
Issue: 3
First Page: 463
Last Page: 477
DOI: 10.1021/np50063a002

Target ChEMBL ID: CHEMBL613459
ChEMBL Target Name: Artemia
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
LC50	=	1.1	ug.mL-1
LC50	=	0.87	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Leishmania guyanensis

External ID: CHEMBL972239

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Nat. Prod.
Year: 2006
Volume: 69
Issue: 2
First Page: 292
Last Page: 294
DOI: 10.1021/np050422s

Target ChEMBL ID: CHEMBL612793
ChEMBL Target Name: Leishmania guyanensis
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
437.5	IC50	=	437500	nM	Outside typical range
613	IC50	>	613000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Leishmania braziliensis

External ID: CHEMBL973186

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Nat. Prod.
Year: 2006
Volume: 69
Issue: 2
First Page: 292
Last Page: 294
DOI: 10.1021/np050422s

Target ChEMBL ID: CHEMBL612878
ChEMBL Target Name: Leishmania braziliensis
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
252.7	IC50	=	252700	nM	Outside typical range
34.8	IC50	=	34800	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Enterococcus hirae

External ID: CHEMBL1117536

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2009
Volume: 72
Issue: 8
First Page: 1516
Last Page: 1519
DOI: 10.1021/np800788n

Target ChEMBL ID: CHEMBL614623
ChEMBL Target Name: Enterococcus hirae
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MIC	=	120	ug.mL-1
MIC	=	600	ug.mL-1

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
250	MTC	=	250	uM
20	MTC	=	20	uM
62	MTC	=	62	uM
15	MTC	=	15	uM
125	MTC	=	125	uM
31	MTC	=	31	uM
62	MTC	=	62	uM
5	MTC	=	5	uM
125	MTC	=	125	uM
7	MTC	=	7	uM

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
250	MTC	=	250	uM
20	MTC	=	20	uM
62	MTC	=	62	uM
15	MTC	=	15	uM
125	MTC	=	125	uM
31	MTC	=	31	uM
62	MTC	=	62	uM
5	MTC	=	5	uM
125	MTC	=	125	uM
7	MTC	=	7	uM

475-75-2 靶点实验数据

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
250	MTC	=	250	uM
20	MTC	=	20	uM
62	MTC	=	62	uM
15	MTC	=	15	uM
125	MTC	=	125	uM
31	MTC	=	31	uM
62	MTC	=	62	uM
5	MTC	=	5	uM
125	MTC	=	125	uM
7	MTC	=	7	uM