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463-56-9 靶点实验数据

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:Carbonic anhydrase 13
External ID: CHEMBL841782
Protocol: N/A
Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem Lett
Year: 2004
Volume: 14
Issue: 21
First Page: 5435
Last Page: 5439
DOI: 10.1016/j.bmcl.2004.07.086

Target ChEMBL ID: CHEMBL2186
ChEMBL Target Name: Carbonic anhydrase XIII
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned
PubChem Standard ValueStandard TypeStandard RelationStandard ValueStandard UnitsData Validity Comment
3000Ki=3000000nMManually validated
5400Ki=5400000nMOutside typical range
2850Ki=2850000nMOutside typical range
21500Ki=21500000nMOutside typical range
740Ki=740000nMManually validated
140Ki=140000nMOutside typical range
36000Ki=36000000nMOutside typical range
5200Ki=5200000nMOutside typical range
60Ki=60000nM
3000Ki=3000000nMManually validated
45000Ki=45000000nMManually validated
5400Ki=5400000nMOutside typical range
5500Ki=5500000nMManually validated
12600Ki=12600000nMManually validated
75500Ki=75500000nMManually validated
0.25Ki=250nM
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:Carbonic anhydrase 2
External ID: CHEMBL1645695
Protocol: N/A
Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem Lett
Year: 2011
Volume: 21
Issue: 2
First Page: 710
Last Page: 714
DOI: 10.1016/j.bmcl.2010.11.124

Target ChEMBL ID: CHEMBL205
ChEMBL Target Name: Carbonic anhydrase II
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned
PubChem Standard ValueStandard TypeStandard RelationStandard ValueStandard UnitsData Validity Comment
0.05Ki=50nM
0.046Ki=46nM
0.002Ki=2nM
0.133Ki=133nM
0.08Ki=80nM
0.295Ki=295nM
0.019Ki=19nM
0.06Ki=60nM
0.07Ki=70nM
0.038Ki=38nM
0.008Ki=8nM
0.04Ki=40nM
0.06Ki=60nM
0.014Ki=14nM
0.012Ki=12nM
0.063Ki=63nM
0.17Ki=170nM
0.11Ki=110nM
0.24Ki=240nM
0.04Ki=40nM
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:Carbonic anhydrase 1
External ID: CHEMBL3815891
Protocol: N/A
Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2016
Volume: 24
Issue: 16
First Page: 3413
Last Page: 3417
DOI: 10.1016/j.bmc.2016.05.029

Target ChEMBL ID: CHEMBL261
ChEMBL Target Name: Carbonic anhydrase I
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned
PubChem Standard ValueStandard TypeStandard RelationStandard ValueStandard UnitsData Validity Comment
21Ki=21000nM
200Ki=200000nMOutside typical range
310Ki=310000nMOutside typical range
0.5Ki=500nM
31700Ki=31700000nMOutside typical range
1.2Ki=1200nM
63000Ki=63000000nMOutside typical range
25800Ki=25800000nMOutside typical range
15000Ki=15000000nMOutside typical range
12000Ki=12000000nMOutside typical range
200000Ki>200000000nMOutside typical range
8400Ki=8400000nMOutside typical range
18000Ki=18000000nMOutside typical range
0.7Ki=700nM
0.6Ki=600nM
7000Ki=7000000nMOutside typical range
8.7Ki=8700nM
4000Ki=4000000nMOutside typical range
6000Ki=6000000nMOutside typical range
300000Ki>300000000nMOutside typical range
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:Carbonic anhydrase 6
External ID: CHEMBL1645696
Protocol: N/A
Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem Lett
Year: 2011
Volume: 21
Issue: 2
First Page: 710
Last Page: 714
DOI: 10.1016/j.bmcl.2010.11.124

Target ChEMBL ID: CHEMBL3025
ChEMBL Target Name: Carbonic anhydrase VI
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned
PubChem Standard ValueStandard TypeStandard RelationStandard ValueStandard UnitsActivity CommentData Validity Comment
0.024Ki=24nM
0.055Ki=55nM
0.073Ki=73nM
0.887Ki=887nM
6.68Ki=6680nM
0.772Ki=772nM
0.74Ki=740nM
0.798Ki=798nM
1.024Ki=1024nM
0.079Ki=79nM
0.043Ki=43nM
4.68Ki=4680nM
0.096Ki=96nM
0.01Ki=10nM
0.011Ki=11nM
0.955Ki=955nM
4.8Ki=4800nM
1.097Ki=1097nM
0.941Ki=941nM
8.0E-4Ki=0.8nM
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:Sodium/iodide cotransporter
External ID: CHEMBL3880647
Protocol: N/A
Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Target ChEMBL ID: CHEMBL2331047
ChEMBL Target Name: Sodium/iodide cotransporter
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: SureChEMBL Patent Bioactivity Data
PubChem Standard ValueStandard TypeStandard RelationStandard ValueStandard UnitsData Validity Comment
0.75IC50=750nM
0.009IC50=9nM
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:Carbonic anhydrase
External ID: CHEMBL1645697
Protocol: N/A
Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem Lett
Year: 2011
Volume: 21
Issue: 2
First Page: 710
Last Page: 714
DOI: 10.1016/j.bmcl.2010.11.124

Target ChEMBL ID: CHEMBL1075028
ChEMBL Target Name: Alpha carbonic anhydrase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned
PubChem Standard ValueStandard TypeStandard RelationStandard ValueStandard UnitsData Validity Comment
0.0197Ki=19.7nM
0.0298Ki=29.8nM
0.0276Ki=27.6nM
0.435Ki=435nM
0.768Ki=768nM
0.553Ki=553nM
0.0919Ki=91.9nM
0.105Ki=105nM
0.0883Ki=88.3nM
0.431Ki=431nM
0.0394Ki=39.4nM
0.104Ki=104nM
0.0751Ki=75.1nM
0.0212Ki=21.2nM
0.016Ki=16nM
0.367Ki=367nM
0.0825Ki=82.5nM
0.0875Ki=87.5nM
0.364Ki=364nM
0.43Ki=430nM
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:Carbonic anhydrase
External ID: CHEMBL1645698
Protocol: N/A
Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem Lett
Year: 2011
Volume: 21
Issue: 2
First Page: 710
Last Page: 714
DOI: 10.1016/j.bmcl.2010.11.124

Target ChEMBL ID: CHEMBL1649055
ChEMBL Target Name: Carbonic anhydrase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned
PubChem Standard ValueStandard TypeStandard RelationStandard ValueStandard UnitsData Validity Comment
0.902Ki=902nM
0.661Ki=661nM
0.333Ki=333nM
0.607Ki=607nM
0.642Ki=642nM
0.675Ki=675nM
0.357Ki=357nM
0.361Ki=361nM
0.695Ki=695nM
0.079Ki=79nM
0.105Ki=105nM
0.54Ki=540nM
0.493Ki=493nM
0.132Ki=132nM
0.074Ki=74nM
0.481Ki=481nM
0.508Ki=508nM
0.551Ki=551nM
0.3Ki=300nM
0.415Ki=415nM
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:Carbonic anhydrase
External ID: CHEMBL876781
Protocol: N/A
Comment: Journal: Bioorg Med Chem Lett
Year: 2004
Volume: 14
Issue: 17
First Page: 4563
Last Page: 4567
DOI: 10.1016/j.bmcl.2004.06.073

Target ChEMBL ID: CHEMBL3932
ChEMBL Target Name: Carbonic anhydrase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned
PubChem Standard ValueStandard TypeStandard RelationStandard ValueStandard UnitsData Validity Comment
200000Ki>200000000nMOutside typical range
160000Ki=160000000nMOutside typical range
230Ki=230000nMOutside typical range
9600Ki=9600000nMOutside typical range
7000Ki=7000000nMOutside typical range
70Ki=70000nM
36500Ki=36500000nMOutside typical range
50Ki=50000nM
90Ki=90000nM
680Ki=680000nMOutside typical range
200000Ki>200000000nMOutside typical range
160000Ki=160000000nMOutside typical range
160000Ki=160000000nMOutside typical range
42000Ki=42000000nMOutside typical range
6700Ki=6700000nMOutside typical range
6800Ki=6800000nMOutside typical range
150Ki=150000nMOutside typical range
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:Carbonic anhydrase 7
External ID: CHEMBL860093
Protocol: N/A
Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2006
Volume: 16
Issue: 12
First Page: 3139
Last Page: 3143
DOI: 10.1016/j.bmcl.2006.03.078

Target ChEMBL ID: CHEMBL2326
ChEMBL Target Name: Carbonic anhydrase VII
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned
PubChem Standard ValueStandard TypeStandard RelationStandard ValueStandard UnitsData Validity Comment
6.8Ki=6800nM
190Ki=190000nMOutside typical range
9200Ki=9200000nMOutside typical range
1410Ki=1410000nMOutside typical range
12.5Ki=12500nM
1380Ki=1380000nMOutside typical range
270Ki=270000nMOutside typical range
160Ki=160000nMOutside typical range
1780Ki=1780000nMOutside typical range
7300Ki=7300000nMOutside typical range
15200Ki=15200000nMOutside typical range
1240Ki=1240000nMOutside typical range
1060Ki=1060000nMOutside typical range
1840Ki=1840000nMOutside typical range
1240Ki=1240000nMOutside typical range
250Ki=250000nMOutside typical range
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:N/A
External ID: CHEMBL3815894
Protocol: N/A
Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2016
Volume: 24
Issue: 16
First Page: 3413
Last Page: 3417
DOI: 10.1016/j.bmc.2016.05.029
PubChem Standard ValueStandard TypeStandard RelationStandard ValueStandard UnitsData Validity Comment
31Ki=31000nM
820Ki=820000nMOutside typical range
8Ki=8000nM
33Ki=33000nM
23Ki=23000nM
760Ki=760000nMOutside typical range
850Ki=850000nMOutside typical range
2960Ki=2960000nMOutside typical range
4640Ki=4640000nMOutside typical range
5130Ki=5130000nMOutside typical range
200000Ki>200000000nMOutside typical range
34100Ki=34100000nMOutside typical range
68Ki=68000nM
75Ki=75000nM
74Ki=74000nM
670Ki=670000nMOutside typical range
88Ki=88000nM
28000Ki=28000000nMOutside typical range
930Ki=930000nMOutside typical range
800Ki=800000nMOutside typical range
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:Carbonic anhydrase 2
External ID: CHEMBL839927
Protocol: N/A
Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2004
Volume: 14
Issue: 23
First Page: 5769
Last Page: 5773
DOI: 10.1016/j.bmcl.2004.09.063

Target ChEMBL ID: CHEMBL205
ChEMBL Target Name: Carbonic anhydrase II
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned
PubChem Standard ValueStandard TypeStandard RelationStandard ValueStandard UnitsData Validity Comment
1500Ki=1500000nMOutside typical range
200000Ki>200000000nMOutside typical range
85000Ki=85000000nMOutside typical range
73000Ki=73000000nMOutside typical range
63000Ki=63000000nMOutside typical range
89000Ki=89000000nMOutside typical range
30Ki=30000nM
40Ki=40000nM
63000Ki=63000000nMOutside typical range
200000Ki=200000000nMOutside typical range
300000Ki>300000000nMOutside typical range
26000Ki=26000000nMOutside typical range
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:N/A
External ID: CHEMBL3815893
Protocol: N/A
Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem
Year: 2016
Volume: 24
Issue: 16
First Page: 3413
Last Page: 3417
DOI: 10.1016/j.bmc.2016.05.029
PubChem Standard ValueStandard TypeStandard RelationStandard ValueStandard UnitsData Validity Comment
80Ki=80000nM
4100Ki=4100000nMOutside typical range
73Ki=73000nM
760Ki=760000nMOutside typical range
440Ki=440000nMOutside typical range
830Ki=830000nMOutside typical range
820Ki=820000nMOutside typical range
660Ki=660000nMOutside typical range
660Ki=660000nMOutside typical range
750Ki=750000nMOutside typical range
10100Ki=10100000nMOutside typical range
930Ki=930000nMOutside typical range
990Ki=990000nMOutside typical range
600Ki=600000nMOutside typical range
690Ki=690000nMOutside typical range
810Ki=810000nMOutside typical range
380Ki=380000nMOutside typical range
2410Ki=2410000nMOutside typical range
2700Ki=2700000nMOutside typical range
4080Ki=4080000nMOutside typical range
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:Carbonic anhydrase 2
External ID: CHEMBL3815892
Protocol: N/A
Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2016
Volume: 24
Issue: 16
First Page: 3413
Last Page: 3417
DOI: 10.1016/j.bmc.2016.05.029

Target ChEMBL ID: CHEMBL205
ChEMBL Target Name: Carbonic anhydrase II
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned
PubChem Standard ValueStandard TypeStandard RelationStandard ValueStandard UnitsData Validity Comment
390Ki=390000nMOutside typical range
1600Ki=1600000nMOutside typical range
1130Ki=1130000nMOutside typical range
20Ki=20000nM
49200Ki=49200000nMOutside typical range
1510Ki=1510000nMOutside typical range
200000Ki>200000000nMOutside typical range
48500Ki=48500000nMOutside typical range
73000Ki=73000000nMOutside typical range
85000Ki=85000000nMOutside typical range
200000Ki>200000000nMOutside typical range
63000Ki=63000000nMOutside typical range
89000Ki=89000000nMOutside typical range
30Ki=30000nM
40Ki=40000nM
35000Ki=35000000nMOutside typical range
8.8Ki=8800nM
63000Ki=63000000nMOutside typical range
200000Ki=200000000nMOutside typical range
300000Ki>300000000nMOutside typical range
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:Carbonic anhydrase 9
External ID: CHEMBL839931
Protocol: N/A
Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2004
Volume: 14
Issue: 23
First Page: 5769
Last Page: 5773
DOI: 10.1016/j.bmcl.2004.09.063

Target ChEMBL ID: CHEMBL3594
ChEMBL Target Name: Carbonic anhydrase IX
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned
PubChem Standard ValueStandard TypeStandard RelationStandard ValueStandard UnitsActivity CommentData Validity Comment
5Ki=5000nM
KinMNot Tested
13000Ki=13000000nMOutside typical range
KinMNot Tested
KinMNot Tested
KinMNot Tested
40Ki=40000nM
7Ki=7000nM
16000Ki=16000000nMOutside typical range
33000Ki=33000000nMOutside typical range
48000Ki=48000000nMOutside typical range
7000Ki=7000000nMOutside typical range
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:Carbonic anhydrase 4
External ID: CHEMBL839929
Protocol: N/A
Comment: Journal: Bioorg Med Chem Lett
Year: 2004
Volume: 14
Issue: 23
First Page: 5769
Last Page: 5773
DOI: 10.1016/j.bmcl.2004.09.063

Target ChEMBL ID: CHEMBL3729
ChEMBL Target Name: Carbonic anhydrase IV
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned
PubChem Standard ValueStandard TypeStandard RelationStandard ValueStandard UnitsData Validity Comment
70Ki=70000nM
80Ki=80000nM
39000Ki=39000000nMOutside typical range
58700Ki=58700000nMOutside typical range
3900Ki=3900000nMOutside typical range
770Ki=770000nMOutside typical range
70Ki=70000nM
90Ki=90000nM
80Ki=80000nM
5700Ki=5700000nMOutside typical range
30800Ki=30800000nMOutside typical range
13200Ki=13200000nMOutside typical range
610Ki=610000nMOutside typical range
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:Carbonic anhydrase 1
External ID: CHEMBL838843
Protocol: N/A
Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2004
Volume: 14
Issue: 21
First Page: 5435
Last Page: 5439
DOI: 10.1016/j.bmcl.2004.07.086

Target ChEMBL ID: CHEMBL261
ChEMBL Target Name: Carbonic anhydrase I
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned
PubChem Standard ValueStandard TypeStandard RelationStandard ValueStandard UnitsData Validity Comment
310Ki=310000nMOutside typical range
7000Ki=7000000nMOutside typical range
0.5Ki=500nM
31700Ki=31700000nMOutside typical range
1.2Ki=1200nM
63000Ki=63000000nMOutside typical range
15000Ki=15000000nMManually validated
8400Ki=8400000nMManually validated
18000Ki=18000000nMManually validated
0.7Ki=700nM
0.6Ki=600nM
4000Ki=4000000nMManually validated
6000Ki=6000000nMOutside typical range
300000Ki>300000000nMManually validated
300Ki=300000nMOutside typical range
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:Carbonic anhydrase 5B, mitochondrial
External ID: CHEMBL839467
Protocol: N/A
Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2004
Volume: 14
Issue: 21
First Page: 5435
Last Page: 5439
DOI: 10.1016/j.bmcl.2004.07.086

Target ChEMBL ID: CHEMBL2111457
ChEMBL Target Name: Carbonic anhydrase V
ChEMBL Target Type: PROTEIN FAMILY - Target is a group of closely related proteins
Relationship Type: D - Direct protein target assigned
Confidence: Multiple direct protein targets may be assigned
PubChem Standard ValueStandard TypeStandard RelationStandard ValueStandard UnitsData Validity Comment
8.4E-4Ki=0.84nMPotential transcription error
0.016Ki=16nMPotential transcription error
1.0E-5Ki=0.01nM
0.00743Ki=7.43nM
3.0E-4Ki=0.3nMPotential transcription error
0.68Ki=680nMPotential transcription error
95000Ki=95000000nMOutside typical range
16000Ki=16000000nMOutside typical range
65000Ki=65000000nMOutside typical range
20Ki=20000nM
2.0E-5Ki=0.02nMPotential transcription error
50000Ki=50000000nMOutside typical range
0.156Ki=156nMPotential transcription error
241000Ki=241000000nMOutside typical range
0.025Ki=25nMPotential transcription error
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:Carbonic anhydrase 1
External ID: CHEMBL3737169
Protocol: N/A
Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2015
Volume: 25
Issue: 23
First Page: 5485
Last Page: 5489
DOI: 10.1016/j.bmcl.2015.10.074

Target ChEMBL ID: CHEMBL261
ChEMBL Target Name: Carbonic anhydrase I
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned
PubChem Standard ValueStandard TypeStandard RelationStandard ValueStandard UnitsData Validity Comment
12Ki=12000nM
0.328Ki=328nM
50Ki=50000nM
58600Ki=58600000nMOutside typical range
0.056Ki=56nM
54Ki=54000nM
0.015Ki=15nM
0.031Ki=31nM
18.54Ki=18540nM
200Ki=200000nMOutside typical range
0.374Ki=374nM
310Ki=310000nMOutside typical range
0.5Ki=500nM
1.2Ki=1200nM
21Ki=21000nM
63000Ki=63000000nMOutside typical range
12000Ki=12000000nMOutside typical range
15000Ki=15000000nMOutside typical range
200000Ki>200000000nMOutside typical range
8400Ki=8400000nMOutside typical range
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:N/A
External ID: CHEMBL3737173
Protocol: N/A
Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem Lett
Year: 2015
Volume: 25
Issue: 23
First Page: 5485
Last Page: 5489
DOI: 10.1016/j.bmcl.2015.10.074
PubChem Standard ValueStandard TypeStandard RelationStandard ValueStandard UnitsData Validity Comment
0.511Ki=511nM
0.866Ki=866nM
0.866Ki=866nM
10Ki=10000nM
0.0529Ki=52.9nM
0.726Ki=726nM
0.0653Ki=65.3nM
0.385Ki=385nM
0.877Ki=877nM
950Ki=950000nMOutside typical range
0.0495Ki=49.5nM
9Ki=9000nM
790Ki=790000nMOutside typical range
850Ki=850000nMOutside typical range
77Ki=77000nM
670Ki=670000nMOutside typical range
730Ki=730000nMOutside typical range
1020Ki=1020000nMOutside typical range
200000Ki>200000000nMOutside typical range
820Ki=820000nMOutside typical range
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:Carbonic anhydrase 2
External ID: CHEMBL3737170
Protocol: N/A
Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2015
Volume: 25
Issue: 23
First Page: 5485
Last Page: 5489
DOI: 10.1016/j.bmcl.2015.10.074

Target ChEMBL ID: CHEMBL205
ChEMBL Target Name: Carbonic anhydrase II
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned
PubChem Standard ValueStandard TypeStandard RelationStandard ValueStandard UnitsData Validity Comment
0.04Ki=40nM
0.29Ki=290nM
0.021Ki=21nM
23100Ki=23100000nMOutside typical range
0.035Ki=35nM
0.043Ki=43nM
0.009Ki=9nM
0.015Ki=15nM
5.95Ki=5950nM
1600Ki=1600000nMOutside typical range
0.009Ki=9nM
1130Ki=1130000nMOutside typical range
20Ki=20000nM
1500Ki=1500000nMOutside typical range
390Ki=390000nMOutside typical range
200000Ki>200000000nMOutside typical range
85000Ki=85000000nMOutside typical range
73000Ki=73000000nMOutside typical range
200000Ki>200000000nMOutside typical range
63000Ki=63000000nMOutside typical range
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:Carbonic anhydrase
External ID: CHEMBL828021
Protocol: N/A
Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2004
Volume: 14
Issue: 17
First Page: 4563
Last Page: 4567
DOI: 10.1016/j.bmcl.2004.06.073

Target ChEMBL ID: CHEMBL3926
ChEMBL Target Name: Carbonic anhydrase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned
PubChem Standard ValueStandard TypeStandard RelationStandard ValueStandard UnitsData Validity Comment
520Ki=520000nMOutside typical range
103000Ki=103000000nMOutside typical range
7800Ki=7800000nMOutside typical range
700Ki=700000nMOutside typical range
27800Ki=27800000nMOutside typical range
55700Ki=55700000nMOutside typical range
950000Ki=950000000nMOutside typical range
44900Ki=44900000nMOutside typical range
9600Ki=9600000nMOutside typical range
44800Ki=44800000nMOutside typical range
330Ki=330000nMOutside typical range
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:Carbonic anhydrase 1
External ID: CHEMBL828816
Protocol: N/A
Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2004
Volume: 14
Issue: 17
First Page: 4563
Last Page: 4567
DOI: 10.1016/j.bmcl.2004.06.073

Target ChEMBL ID: CHEMBL261
ChEMBL Target Name: Carbonic anhydrase I
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned
PubChem Standard ValueStandard TypeStandard RelationStandard ValueStandard UnitsData Validity Comment
310Ki=310000nMOutside typical range
7000Ki=7000000nMOutside typical range
0.7Ki=700nM
0.5Ki=500nM
1.2Ki=1200nM
18000Ki=18000000nMOutside typical range
63000Ki=63000000nMOutside typical range
12000Ki=12000000nMOutside typical range
15000Ki=15000000nMOutside typical range
8400Ki=8400000nMOutside typical range
0.6Ki=600nM
4000Ki=4000000nMOutside typical range
6000Ki=6000000nMOutside typical range
300000Ki>300000000nMOutside typical range
300Ki=300000nMOutside typical range
31700Ki=31700000nMOutside typical range
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:Carbonic anhydrase 5B, mitochondrial
External ID: CHEMBL876687
Protocol: N/A
Comment: Journal: Bioorg Med Chem Lett
Year: 2004
Volume: 14
Issue: 23
First Page: 5769
Last Page: 5773
DOI: 10.1016/j.bmcl.2004.09.063

Target ChEMBL ID: CHEMBL2111457
ChEMBL Target Name: Carbonic anhydrase V
ChEMBL Target Type: PROTEIN FAMILY - Target is a group of closely related proteins
Relationship Type: D - Direct protein target assigned
Confidence: Multiple direct protein targets may be assigned
PubChem Standard ValueStandard TypeStandard RelationStandard ValueStandard UnitsData Validity Comment
300Ki=300000nMPotential transcription error
680000Ki=680000000nMPotential transcription error
82000Ki=82000000nMOutside typical range
95000Ki=95000000nMOutside typical range
16000Ki=16000000nMOutside typical range
65000Ki=65000000nMOutside typical range
20Ki=20000nM
20Ki=20000nMPotential transcription error
50000Ki=50000000nMOutside typical range
156000Ki=156000000nMPotential transcription error
241000Ki=241000000nMOutside typical range
25000Ki=25000000nMPotential transcription error
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:N/A
External ID: CHEMBL3815898
Protocol: N/A
Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem
Year: 2016
Volume: 24
Issue: 16
First Page: 3413
Last Page: 3417
DOI: 10.1016/j.bmc.2016.05.029
PubChem Standard ValueStandard TypeStandard RelationStandard ValueStandard UnitsData Validity Comment
86Ki=86000nM
9500Ki=9500000nMOutside typical range
54Ki=54000nM
5700Ki=5700000nMOutside typical range
79Ki=79000nM
20500Ki=20500000nMOutside typical range
200000Ki>200000000nMOutside typical range
15100Ki=15100000nMOutside typical range
5900Ki=5900000nMOutside typical range
6700Ki=6700000nMOutside typical range
200000Ki>200000000nMOutside typical range
9100Ki=9100000nMOutside typical range
200000Ki>200000000nMOutside typical range
7100Ki=7100000nMOutside typical range
21300Ki=21300000nMOutside typical range
8400Ki=8400000nMOutside typical range
7000Ki=7000000nMOutside typical range
7400Ki=7400000nMOutside typical range
8100Ki=8100000nMOutside typical range
8700Ki=8700000nMOutside typical range
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:Carbonic anhydrase 1
External ID: CHEMBL839657
Protocol: N/A
Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem Lett
Year: 2004
Volume: 14
Issue: 23
First Page: 5769
Last Page: 5773
DOI: 10.1016/j.bmcl.2004.09.063

Target ChEMBL ID: CHEMBL261
ChEMBL Target Name: Carbonic anhydrase I
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned
PubChem Standard ValueStandard TypeStandard RelationStandard ValueStandard UnitsData Validity Comment
300000Ki>300000000nMOutside typical range
300Ki=300000nMOutside typical range
200Ki=200000nMOutside typical range
7000Ki=7000000nMOutside typical range
0.6Ki=600nM
0.5Ki=500nM
300000Ki>300000000nMOutside typical range
4000Ki=4000000nMOutside typical range
300Ki=300000nMOutside typical range
15000Ki=15000000nMOutside typical range
8400Ki=8400000nMOutside typical range
18000Ki=18000000nMOutside typical range
0.7Ki=700nM
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:Carbonic anhydrase 2
External ID: CHEMBL875204
Protocol: N/A
Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2004
Volume: 14
Issue: 17
First Page: 4563
Last Page: 4567
DOI: 10.1016/j.bmcl.2004.06.073

Target ChEMBL ID: CHEMBL205
ChEMBL Target Name: Carbonic anhydrase II
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned
PubChem Standard ValueStandard TypeStandard RelationStandard ValueStandard UnitsData Validity Comment
1130Ki=1130000nMOutside typical range
35000Ki=35000000nMOutside typical range
30Ki=30000nM
20Ki=20000nM
1500Ki=1500000nMOutside typical range
89000Ki=89000000nMOutside typical range
200000Ki>200000000nMOutside typical range
85000Ki=85000000nMOutside typical range
73000Ki=73000000nMOutside typical range
63000Ki=63000000nMOutside typical range
40Ki=40000nM
63000Ki=63000000nMOutside typical range
200000Ki=200000000nMOutside typical range
300000Ki>300000000nMOutside typical range
26000Ki=26000000nMOutside typical range
49200Ki=49200000nMOutside typical range
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:Carbonic anhydrase 1
External ID: CHEMBL1645694
Protocol: N/A
Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem Lett
Year: 2011
Volume: 21
Issue: 2
First Page: 710
Last Page: 714
DOI: 10.1016/j.bmcl.2010.11.124

Target ChEMBL ID: CHEMBL261
ChEMBL Target Name: Carbonic anhydrase I
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned
PubChem Standard ValueStandard TypeStandard RelationStandard ValueStandard UnitsData Validity Comment
0.185Ki=185nM
0.164Ki=164nM
0.006Ki=6nM
23Ki=23000nM
0.055Ki=55nM
45.4Ki=45400nM
9.3Ki=9300nM
8.6Ki=8600nM
6Ki=6000nM
1.2Ki=1200nM
0.025Ki=25nM
6.5Ki=6500nM
8.3Ki=8300nM
0.05Ki=50nM
0.25Ki=250nM
5.8Ki=5800nM
25Ki=25000nM
9.8Ki=9800nM
25Ki=25000nM
12Ki=12000nM
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:N/A
External ID: CHEMBL3815900
Protocol: N/A
Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem
Year: 2016
Volume: 24
Issue: 16
First Page: 3413
Last Page: 3417
DOI: 10.1016/j.bmc.2016.05.029
PubChem Standard ValueStandard TypeStandard RelationStandard ValueStandard UnitsData Validity Comment
87Ki=87000nM
13100Ki=13100000nMOutside typical range
84Ki=84000nM
8400Ki=8400000nMOutside typical range
91Ki=91000nM
8700Ki=8700000nMOutside typical range
9600Ki=9600000nMOutside typical range
7300Ki=7300000nMOutside typical range
3000Ki=3000000nMOutside typical range
8200Ki=8200000nMOutside typical range
200000Ki>200000000nMOutside typical range
8700Ki=8700000nMOutside typical range
200000Ki>200000000nMOutside typical range
2600Ki=2600000nMOutside typical range
7900Ki=7900000nMOutside typical range
7800Ki=7800000nMOutside typical range
8800Ki=8800000nMOutside typical range
8700Ki=8700000nMOutside typical range
8800Ki=8800000nMOutside typical range
21300Ki=21300000nMOutside typical range
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:Carbonic anhydrase 2
External ID: CHEMBL838517
Protocol: N/A
Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2004
Volume: 14
Issue: 21
First Page: 5435
Last Page: 5439
DOI: 10.1016/j.bmcl.2004.07.086

Target ChEMBL ID: CHEMBL205
ChEMBL Target Name: Carbonic anhydrase II
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned
PubChem Standard ValueStandard TypeStandard RelationStandard ValueStandard UnitsData Validity Comment
1130Ki=1130000nMOutside typical range
35000Ki=35000000nMOutside typical range
20Ki=20000nM
49200Ki=49200000nMOutside typical range
1500Ki=1500000nMOutside typical range
200000Ki>200000000nMOutside typical range
73000Ki=73000000nMManually validated
63000Ki=63000000nMManually validated
89000Ki=89000000nMManually validated
30Ki=30000nM
40Ki=40000nM
63000Ki=63000000nMManually validated
200000Ki=200000000nMOutside typical range
300000Ki>300000000nMManually validated
26000Ki=26000000nMOutside typical range
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:Carbonic anhydrase 4
External ID: CHEMBL852354
Protocol: N/A
Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2004
Volume: 14
Issue: 17
First Page: 4563
Last Page: 4567
DOI: 10.1016/j.bmcl.2004.06.073

Target ChEMBL ID: CHEMBL3729
ChEMBL Target Name: Carbonic anhydrase IV
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned
Standard TypeStandard UnitsActivity Comment
KinMNot Determined
KinMNot Determined
KinMNot Determined
KinMNot Determined
KinMNot Determined
KinMNot Determined
KinMNot Determined
KinMNot Determined
KinMNot Determined
KinMNot Determined
KinMNot Determined
KinMNot Determined
KinMNot Determined