HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Bromodomain adjacent to zinc finger domain protein 2B

External ID: CHEMBL3111108

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2013
Volume: 56
Issue: 24
First Page: 10183
Last Page: 10187
DOI: 10.1021/jm401582c

Target ChEMBL ID: CHEMBL1741220
ChEMBL Target Name: Bromodomain adjacent to zinc finger domain protein 2B
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Units	Activity Comment
Inhibition	%	Active
Inhibition	%	Active
Inhibition	%	Active
Inhibition	%	Active
Inhibition	%	Active
Inhibition	%	Active
Inhibition	%	Active
Inhibition	%	Active
Inhibition	%	Active
Inhibition	%	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Bromodomain adjacent to zinc finger domain protein 2B

External ID: CHEMBL3111109

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2013
Volume: 56
Issue: 24
First Page: 10183
Last Page: 10187
DOI: 10.1021/jm401582c

Target ChEMBL ID: CHEMBL1741220
ChEMBL Target Name: Bromodomain adjacent to zinc finger domain protein 2B
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Units	Activity Comment
Inhibition	%	Active
Inhibition	%	Active
Inhibition	%	Active
Inhibition	%	Active
Inhibition	%	Active
Inhibition	%	Active
Inhibition	%	Active
Inhibition	%	Active
Inhibition	%	Active
Inhibition	%	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL2444679

Protocol: N/A

Comment: Journal: ACS Med. Chem. Lett.
Year: 2013
Volume: 4
Issue: 10
First Page: 904
Last Page: 908
DOI: 10.1021/ml400239a

Standard Type	Standard Relation	Standard Value	Standard Units
T1/2	=	0.125	hr
T1/2	=	0.195	hr
T1/2	=	0.05167	hr
T1/2	=	0.03	hr
T1/2	=	0.2283	hr

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Bromodomain adjacent to zinc finger domain protein 2B

External ID: CHEMBL3111110

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2013
Volume: 56
Issue: 24
First Page: 10183
Last Page: 10187
DOI: 10.1021/jm401582c

Target ChEMBL ID: CHEMBL1741220
ChEMBL Target Name: Bromodomain adjacent to zinc finger domain protein 2B
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Units	Activity Comment
Inhibition	%	Active
Inhibition	%	Active
Inhibition	%	Active
Inhibition	%	Active
Inhibition	%	Active
Inhibition	%	Active
Inhibition	%	Active
Inhibition	%	Active
Inhibition	%	Active
Inhibition	%	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Bromodomain adjacent to zinc finger domain protein 2B

External ID: CHEMBL3111112

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2013
Volume: 56
Issue: 24
First Page: 10183
Last Page: 10187
DOI: 10.1021/jm401582c

Target ChEMBL ID: CHEMBL1741220
ChEMBL Target Name: Bromodomain adjacent to zinc finger domain protein 2B
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
109	IC50	=	109000	nM
37	IC50	=	37000	nM
1094	IC50	=	1094000	nM
241	IC50	=	241000	nM
476	IC50	=	476000	nM
495	IC50	=	495000	nM
38	IC50	=	38000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Bromodomain adjacent to zinc finger domain protein 2B

External ID: CHEMBL3111113

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2013
Volume: 56
Issue: 24
First Page: 10183
Last Page: 10187
DOI: 10.1021/jm401582c

Target ChEMBL ID: CHEMBL1741220
ChEMBL Target Name: Bromodomain adjacent to zinc finger domain protein 2B
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Activity Comment
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Bromodomain adjacent to zinc finger domain protein 2B

External ID: CHEMBL3111114

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2013
Volume: 56
Issue: 24
First Page: 10183
Last Page: 10187
DOI: 10.1021/jm401582c

Target ChEMBL ID: CHEMBL1741220
ChEMBL Target Name: Bromodomain adjacent to zinc finger domain protein 2B
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Activity Comment
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Bromodomain adjacent to zinc finger domain protein 2B

External ID: CHEMBL3111115

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2013
Volume: 56
Issue: 24
First Page: 10183
Last Page: 10187
DOI: 10.1021/jm401582c

Target ChEMBL ID: CHEMBL1741220
ChEMBL Target Name: Bromodomain adjacent to zinc finger domain protein 2B
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Activity Comment
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mycobacterium tuberculosis variant bovis

External ID: CHEMBL5099097

Protocol: N/A

Comment: Journal: Bioorg Med Chem
Year: 2022
Volume: 74
First Page: 117046
Last Page: 117046
DOI: 10.1016/j.bmc.2022.117046

Target ChEMBL ID: CHEMBL613086
ChEMBL Target Name: Mycobacterium tuberculosis variant bovis
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
700	MIC50	=	700000	nM
3200	MIC50	=	3200000	nM
1700	MIC50	=	1700000	nM
2700	MIC50	=	2700000	nM
700	MIC50	=	700000	nM
5000	MIC50	>	5000000	nM
4000	MIC50	>	4000000	nM
5000	MIC50	>	5000000	nM
2700	MIC50	=	2700000	nM
5000	MIC50	>	5000000	nM
4000	MIC50	>	4000000	nM
1400	MIC50	=	1400000	nM
3000	MIC50	>	3000000	nM
4000	MIC50	>	4000000	nM
2500	MIC50	>	2500000	nM
1500	MIC50	=	1500000	nM
700	MIC50	=	700000	nM
4000	MIC50	>	4000000	nM
3500	MIC50	=	3500000	nM
700	MIC50	=	700000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL2444676

Protocol: N/A

Comment: Journal: ACS Med. Chem. Lett.
Year: 2013
Volume: 4
Issue: 10
First Page: 904
Last Page: 908
DOI: 10.1021/ml400239a

Standard Type	Standard Relation	Standard Value	Standard Units
T1/2	=	0.025	hr
T1/2	=	0.04167	hr
T1/2	=	0.09667	hr
T1/2	=	0.07167	hr
T1/2	=	0.04333	hr
T1/2	=	0.1533	hr
T1/2	=	0.05167	hr
T1/2	=	0.035	hr
T1/2	=	0.025	hr
T1/2	=	0.1067	hr
T1/2	=	0.03667	hr

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：DTP/NCI 靶标：N/A

External ID: MCF7_OneDose

Protocol: NCI-60 Human Tumor Cell Lines Screen was performed using the standard one-dose NCI protocol, which is described in more detail at https://dtp.cancer.gov/discovery_development/nci-60/default.htm.

Compounds with GIPRCNT values below 10 were considered active. Activity score was based on GIPRCNT using the following formula:
max(-GIPRCNT/2 + 50, 0)
Score is 0 for GIPRCNT values of 100 or above, 50 for GIPRCNT values of 0, and 100 for GIPRCNT values of -100.

Comment: These data are a subset of the data from the NCI human tumor cell line screen. Compounds are identified by the NCI National Service Center (NSC) number, which is contained in the
PUBCHEM_EXT_DATASOURCE_REGID field. In the NCI cell line identification system, MCF7 is panel number 5, cell number 1. PANELCODE or PANELNAME identify the NCI-60 cell panel. PANELNBR does NOT identify the NCI-60 panel.

EXPID is the NCI internal tracking number for the experiment identifier, and PREFIX = 'S' for the NSCs submitted through the NCI Chemical Agents repository.

Substance concentration unit is indicated in the data table, using the following abbreviations: M = molar (M), u = micrograms/milliliter (microg/mL), V = volumetric fraction.

M_GIPRCNT represents the mean growth percent for that experiment, and N_GIPRCNT indicates the number of values for that NSC within an experiment, while STDEV_GIPRCNT is the standard deviation. Most NSCs are tested once per experiment, resulting in EXP_COUNT = 1.

EXPID	PREFIX	CONCENTRATION_UNIT	CONCENTRATION	PANELNBR	CELLNBR	PANELNAME	CELLNAME	PANELCODE	M_GIPRCNT	N_GIPRCNT	EXP_COUNT
2106OS49	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	88.231	1	1
2106OS49	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	87.1119	1	1
2106OS49	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	14.4371	1	1
2106OS49	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	89.7113	1	1
2106OS49	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	97.2463	1	1
2106OS49	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	90.0129	1	1
2106OS49	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	85.7031	1	1
2106OS49	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	30.8539	1	1
2106OS49	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	14.2896	1	1
2106OS49	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	85.8526	1	1
2106OS49	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	83.1036	1	1
2106OS49	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	84.2194	1	1
2106OS49	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	89.3237	1	1
2106OS49	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	85.6034	1	1
2106OS49	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	89.6643	1	1
2106OS52	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	91.2503	1	1
2106OS52	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	94.8714	1	1
2106OS52	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	93.7372	1	1
2106OS52	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	112.6132	1	1
2106OS52	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	73.375	1	1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：DTP/NCI 靶标：N/A

External ID: IGROV1_OneDose

Protocol: NCI-60 Human Tumor Cell Lines Screen was performed using the standard one-dose NCI protocol, which is described in more detail at https://dtp.cancer.gov/discovery_development/nci-60/default.htm.

Compounds with GIPRCNT values below 10 were considered active. Activity score was based on GIPRCNT using the following formula:
max(-GIPRCNT/2 + 50, 0)
Score is 0 for GIPRCNT values of 100 or above, 50 for GIPRCNT values of 0, and 100 for GIPRCNT values of -100.

Comment: These data are a subset of the data from the NCI human tumor cell line screen. Compounds are identified by the NCI National Service Center (NSC) number, which is contained in the
PUBCHEM_EXT_DATASOURCE_REGID field. In the NCI cell line identification system, IGROV1 is panel number 6, cell number 10. PANELCODE or PANELNAME identify the NCI-60 cell panel. PANELNBR does NOT identify the NCI-60 panel.

EXPID is the NCI internal tracking number for the experiment identifier, and PREFIX = 'S' for the NSCs submitted through the NCI Chemical Agents repository.

Substance concentration unit is indicated in the data table, using the following abbreviations: M = molar (M), u = micrograms/milliliter (microg/mL), V = volumetric fraction.

M_GIPRCNT represents the mean growth percent for that experiment, and N_GIPRCNT indicates the number of values for that NSC within an experiment, while STDEV_GIPRCNT is the standard deviation. Most NSCs are tested once per experiment, resulting in EXP_COUNT = 1.

EXPID	PREFIX	CONCENTRATION_UNIT	CONCENTRATION	PANELNBR	CELLNBR	PANELNAME	CELLNAME	PANELCODE	M_GIPRCNT	N_GIPRCNT	EXP_COUNT
0809OS51	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	89.6274	1	1
0810OS71	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	94.0185	1	1
0810OS71	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	77.1805	1	1
0810OS71	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	76.1686	1	1
0810OS71	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	82.5618	1	1
0810OS71	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	88.7561	1	1
0810OS71	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	83.5845	1	1
0810OS71	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	92.7497	1	1
0810OS71	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	70.9555	1	1
0810OS71	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	58.7306	1	1
0810OS71	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	72.6041	1	1
0810OS71	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	90.3839	1	1
0810OS71	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	110.2345	1	1
0810OS71	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	97.6538	1	1
0810OS71	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	93.7697	1	1
0810OS71	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	56.4618	1	1
0810OS71	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	80.8893	1	1
0810OS71	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	79.078	1	1
0810OS71	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	-20.3008	1	1
0810OS71	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	72.0949	1	1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Bromodomain adjacent to zinc finger domain protein 2B

External ID: CHEMBL3111106

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2013
Volume: 56
Issue: 24
First Page: 10183
Last Page: 10187
DOI: 10.1021/jm401582c

Target ChEMBL ID: CHEMBL1741220
ChEMBL Target Name: Bromodomain adjacent to zinc finger domain protein 2B
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
17	Kd	=	17000	nM

4604-72-2 靶点实验数据