HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NON-PROTEIN TARGET

External ID: CHEMBL3370107

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2014
Volume: 24
Issue: 16
First Page: 3797
Last Page: 3801
DOI: 10.1016/j.bmcl.2014.06.067

Target ChEMBL ID: CHEMBL3879801
ChEMBL Target Name: NON-PROTEIN TARGET
ChEMBL Target Type: NON-MOLECULAR - Target has not been defined at a molecular level, only the non-molecular entity which is affected (e.g., organism, cell line etc)
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Units	Activity Comment
Inhibition	%	Not Active
Inhibition	%	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：K562

External ID: CHEMBL3370108

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2014
Volume: 24
Issue: 16
First Page: 3797
Last Page: 3801
DOI: 10.1016/j.bmcl.2014.06.067

Target ChEMBL ID: CHEMBL385
ChEMBL Target Name: K562
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Not Active
Activity	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Histone deacetylase 5

External ID: CHEMBL3370105

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2014
Volume: 24
Issue: 16
First Page: 3797
Last Page: 3801
DOI: 10.1016/j.bmcl.2014.06.067

Target ChEMBL ID: CHEMBL2093865
ChEMBL Target Name: Histone deacetylase
ChEMBL Target Type: PROTEIN FAMILY - Target is a group of closely related proteins
Relationship Type: D - Direct protein target assigned
Confidence: Multiple direct protein targets may be assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	80	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NON-PROTEIN TARGET

External ID: CHEMBL3370106

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2014
Volume: 24
Issue: 16
First Page: 3797
Last Page: 3801
DOI: 10.1016/j.bmcl.2014.06.067

Target ChEMBL ID: CHEMBL3879801
ChEMBL Target Name: NON-PROTEIN TARGET
ChEMBL Target Type: NON-MOLECULAR - Target has not been defined at a molecular level, only the non-molecular entity which is affected (e.g., organism, cell line etc)
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Units	Activity Comment
Inhibition	%	Active
Inhibition	%	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Trichophyton rubrum

External ID: CHEMBL3075363

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Med Chem Res
Year: 2013
Volume: 22
Issue: 11
First Page: 5129
Last Page: 5140
DOI: 10.1007/s00044-013-0484-9

Target ChEMBL ID: CHEMBL612649
ChEMBL Target Name: Trichophyton rubrum
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
600	MIC	=	600000	nM
3720	MIC	=	3720000	nM
920	MIC	=	920000	nM
6160	MIC	=	6160000	nM
830	MIC	=	830000	nM
770	MIC	=	770000	nM
	MIC				Not Active
3080	MIC	=	3080000	nM
2600	MIC	=	2600000	nM
160	MIC	=	160000	nM
730	MIC	=	730000	nM
8990	MIC	=	8990000	nM
	MIC				Not Active
990	MIC	=	990000	nM
350	MIC	=	350000	nM
	MIC				Not Active
	MIC				Not Active
810	MIC	=	810000	nM
1700	MIC	=	1700000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Aspergillus parasiticus

External ID: CHEMBL3074439

Protocol: N/A

Comment: Journal: Med Chem Res
Year: 2013
Volume: 22
Issue: 11
First Page: 5129
Last Page: 5140
DOI: 10.1007/s00044-013-0484-9

Target ChEMBL ID: CHEMBL613814
ChEMBL Target Name: Aspergillus parasiticus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment	Data Validity Comment
1200	MIC	=	1200000	nM
14900	MIC	=	14900000	nM		Outside typical range
1830	MIC	=	1830000	nM
	MIC				Not Active
3330	MIC	=	3330000	nM
3080	MIC	=	3080000	nM
	MIC				Not Active
	MIC				Not Active
2600	MIC	=	2600000	nM
2550	MIC	=	2550000	nM
	MIC				Not Active
	MIC				Not Active
	MIC				Not Active
1990	MIC	=	1990000	nM
710	MIC	=	710000	nM
	MIC				Not Active
	MIC				Not Active
	MIC				Not Active
1700	MIC	=	1700000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Aspergillus sydowii

External ID: CHEMBL3074438

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Med Chem Res
Year: 2013
Volume: 22
Issue: 11
First Page: 5129
Last Page: 5140
DOI: 10.1007/s00044-013-0484-9

Target ChEMBL ID: CHEMBL2367171
ChEMBL Target Name: Aspergillus sydowii
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
2400	MIC	=	2400000	nM
3720	MIC	=	3720000	nM
1830	MIC	=	1830000	nM
	MIC				Not Active
3330	MIC	=	3330000	nM
3080	MIC	=	3080000	nM
	MIC				Not Active
	MIC				Not Active
5200	MIC	=	5200000	nM
5100	MIC	=	5100000	nM
	MIC				Not Active
4500	MIC	=	4500000	nM
	MIC				Not Active
1990	MIC	=	1990000	nM
350	MIC	=	350000	nM
	MIC				Not Active
	MIC				Not Active
	MIC				Not Active
850	MIC	=	850000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Pichia kudriavzevii

External ID: CHEMBL3074441

Protocol: N/A

Comment: Journal: Med Chem Res
Year: 2013
Volume: 22
Issue: 11
First Page: 5129
Last Page: 5140
DOI: 10.1007/s00044-013-0484-9

Target ChEMBL ID: CHEMBL612841
ChEMBL Target Name: Pichia kudriavzevii
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
1200	MIC	=	1200000	nM
3720	MIC	=	3720000	nM
3670	MIC	=	3670000	nM
6160	MIC	=	6160000	nM
830	MIC	=	830000	nM
770	MIC	=	770000	nM
6740	MIC	=	6740000	nM
	MIC				Not Active
2600	MIC	=	2600000	nM
2550	MIC	=	2550000	nM
730	MIC	=	730000	nM
8990	MIC	=	8990000	nM
	MIC				Not Active
490	MIC	=	490000	nM
350	MIC	=	350000	nM
	MIC				Not Active
	MIC				Not Active
1620	MIC	=	1620000	nM
1700	MIC	=	1700000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Human immunodeficiency virus 1

External ID: CHEMBL949642

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2001
Volume: 64
Issue: 10
First Page: 1278
Last Page: 1281
DOI: 10.1021/np010211x

Target ChEMBL ID: CHEMBL378
ChEMBL Target Name: Human immunodeficiency virus 1
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
EC50				Not Active
EC50	=	0.00289	ug.mL-1
EC50	=	0.22	ug.mL-1
EC50				Not Active
EC50				Not Active
EC50				Not Active
EC50	=	2.19	ug.mL-1
EC50	=	2.7	ug.mL-1
EC50	<	0.1	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Aspergillus niger

External ID: CHEMBL3074440

Protocol: N/A

Comment: Journal: Med Chem Res
Year: 2013
Volume: 22
Issue: 11
First Page: 5129
Last Page: 5140
DOI: 10.1007/s00044-013-0484-9

Target ChEMBL ID: CHEMBL358
ChEMBL Target Name: Aspergillus niger
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
4800	MIC	=	4800000	nM
7450	MIC	=	7450000	nM
7340	MIC	=	7340000	nM
	MIC				Not Active
3330	MIC	=	3330000	nM
3080	MIC	=	3080000	nM
	MIC				Not Active
	MIC				Not Active
5200	MIC	=	5200000	nM
5100	MIC	=	5100000	nM
	MIC				Not Active
	MIC				Not Active
	MIC				Not Active
990	MIC	=	990000	nM
1420	MIC	=	1420000	nM
	MIC				Not Active
	MIC				Not Active
	MIC				Not Active
1700	MIC	=	1700000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：H9

External ID: CHEMBL949641

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2001
Volume: 64
Issue: 10
First Page: 1278
Last Page: 1281
DOI: 10.1021/np010211x

Target ChEMBL ID: CHEMBL614806
ChEMBL Target Name: H9
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
IC50	>	100	ug.mL-1	Outside typical range
IC50	=	500	ug.mL-1	Outside typical range
IC50	=	1.8	ug.mL-1
IC50	=	0.205	ug.mL-1
IC50	=	2.14	ug.mL-1
IC50	=	18.8	ug.mL-1
IC50	=	18.9	ug.mL-1
IC50	=	22.1	ug.mL-1
IC50	=	18.6	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：NIAID 靶标：N/A

External ID: HIV Cellular Data

Protocol: N/A

Comment: N/A

Species	Strain	AssayMeth	CellType	CellType2	Target	Mutations	EC50Mod	EC50	EC50Unit	ECOtherPct	ECOtherPctUnit	ECOtherConc	ECOtherConcUnit	ToxAssayMeth	CC50Mod	CC50	CC50Unit	TIMod	TI	Comments	Reference	Citation	Other Information
HIV-1	LAI	RT	HuT TK+	HuT 78	Reverse transcriptase		<	1	uM	100	%	1	uM	MTT	>	10	uM	>	10	HuT TK+=HuT 78 CELLS EXPRESSING HSV-1 THYMIDINE KINASE; MEASUREMENT WAS MADE ON DAY10 POSTINFECTION AT 10 TCID50	9281520	USE OF HERPES SIMPLEX VIRUS THYMIDINE KINASE TO IMPROVE THE ANTIVIRAL ACTIVITY OF ZIDOVUDINE. Virology 1997, 235, 398-405.
HIV-1	MN	RT	HuT TK+	HuT 78	Reverse transcriptase		<	0.3	uM	76.74	%	0.3	uM	MTT	>	10	uM	>	33.3	HuT TK+=HuT 78 CELLS EXPRESSING HSV-1 THYMIDINE KINASE; MEASUREMENT WAS MADE ON DAY14 POSTINFECTION AT 10 TCID50	9281520	USE OF HERPES SIMPLEX VIRUS THYMIDINE KINASE TO IMPROVE THE ANTIVIRAL ACTIVITY OF ZIDOVUDINE. Virology 1997, 235, 398-405.
HIV-1	MN	RT	HuT TK+	HuT 78	Reverse transcriptase		<	0.3	uM	69	%	0.3	uM	MTT	>	10	uM	>	33.3	HuT TK+=HuT 78 CELLS EXPRESSING HSV-1 THYMIDINE KINASE; MEASUREMENT WAS MADE ON DAY14 POSTINFECTION AT 100 TCID50	9281520	USE OF HERPES SIMPLEX VIRUS THYMIDINE KINASE TO IMPROVE THE ANTIVIRAL ACTIVITY OF ZIDOVUDINE. Virology 1997, 235, 398-405.
R5; CLINICAL ISOLATE	1(JSL)	P24	PBMC		Reverse transcriptase	MDR		0.07	uM	90	%	1	uM	MTT	>	100	uM	>	1428	HIV-1(JSL) WAS ISOLATED FROM PATIENTS WHO RECEIVED ANTIRETROVIRAL THERAPY FOR A LONG PERIOD AND WHOSE VIRUS ACQUIRED A NUMBER OF MUTATIONS IN THE RT- AND PR-ENCODING GENES; DETAILS OF MUTATIONS NOT GIVEN	15280474	SPIRODIKETOPIPERAZINE-BASED CCR5 INHIBITOR WHICH PRESERVES CC-CHEMOKINE/CCR5 INTERACTIONS AND EXERTS POTENT ACTIVITY AGAINST R5 HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 IN VITRO. Journal of Virology 2004, 78(16), 8654-8662.	ECOtherConcMod:>
HIV-1	NL4-3	LUCIFERASE	1G5 T		Reverse transcriptase		<	1	uM	99	%	1	uM	TRYPAN BLUE	>	1	uM	>	1	ASSAY WAS CONDUCTED ON DAY 3 POST-INFECTION	16725040	INHIBITION OF HIGHLY PRODUCTIVE HIV-1 INFECTION IN T CELLS, PRIMARY HUMAN MACROPHAGES, MICROGLIA, AND ASTROCYTES BY SARGASSUM FUSIFORME. AIDS Research and Therapy 2006, 3(1), 15 PP.	CCOtherPct:6 \| CCOtherPctUnit:% \| CCOtherConc:1 \| CCOtherConcUnit:uM
HIV-1	NL4-3	LUCIFERASE	1G5 T		Reverse transcriptase		<	1	uM	99	%	1	uM	TRYPAN BLUE	>	1	uM	>	1	ASSAY WAS CONDUCTED ON DAY 5 POST-INFECTION	16725040	INHIBITION OF HIGHLY PRODUCTIVE HIV-1 INFECTION IN T CELLS, PRIMARY HUMAN MACROPHAGES, MICROGLIA, AND ASTROCYTES BY SARGASSUM FUSIFORME. AIDS Research and Therapy 2006, 3(1), 15 PP.	CCOtherPct:7 \| CCOtherPctUnit:% \| CCOtherConc:1 \| CCOtherConcUnit:uM
HIV-1	NL4-3	LUCIFERASE	1G5 T		Reverse transcriptase		<	1	uM	99	%	1	uM	TRYPAN BLUE	>	1	uM	>	1	ASSAY WAS CONDUCTED ON DAY 7 POST-INFECTION	16725040	INHIBITION OF HIGHLY PRODUCTIVE HIV-1 INFECTION IN T CELLS, PRIMARY HUMAN MACROPHAGES, MICROGLIA, AND ASTROCYTES BY SARGASSUM FUSIFORME. AIDS Research and Therapy 2006, 3(1), 15 PP.	CCOtherPct:3 \| CCOtherPctUnit:% \| CCOtherConc:1 \| CCOtherConcUnit:uM
HIV-1	LAV	RT	U1(THF-.alpha. STIM)	U1	Tumor necrosis factor alpha		~	30	ug/mL	70	%	50	ug/mL		>	50	ug/mL	>	1.66	CHRONICALLY HIV-1 INFECTED PROMONOCYTE CELL LINE	8327469	THALIDOMIDE INHIBITS THE REPLICATION OF HUMAN IMMUNODEFICIENCY VIRUS TYPE 1. Proceedings of the National Academy of Sciences of the United States of America 1993, 90, 5974-5978.	CCOtherPct:0 \| CCOtherPctUnit:% \| CCOtherConc:50 \| CCOtherConcUnit:ug/mL
HIV-1	BaL	P24 (DAY 18)	MACROPHAGES(GM-CSF)	Macrophage	Ribonucleotide reductase		<	10	uM	75	%	10	uM		>	1000	uM	>	10	MAXIMAL P24 EXPRESSION AT DAY 18	7973634	HYDROXYUREA AS AN INHIBITOR OF HUMAN IMMUNODEFICIENCY VIRUS-TYPE 1 REPLICATION. Science 1994, 266(5186), 801-805.	CCOtherPct:0 \| CCOtherPctUnit:% \| CCOtherConc:1000 \| CCOtherConcUnit:uM
HIV-1	BaL	P24 (DAY 18)	MACROPHAGES(GM-CSF)	Macrophage	Ribonucleotide reductase		<	10	uM	38	%	2	uM		>	1000	uM	>	10	MAXIMAL P24 EXPRESSION AT DAY 18	7973634	HYDROXYUREA AS AN INHIBITOR OF HUMAN IMMUNODEFICIENCY VIRUS-TYPE 1 REPLICATION. Science 1994, 266(5186), 801-805.	CCOtherPct:0 \| CCOtherPctUnit:% \| CCOtherConc:1000 \| CCOtherConcUnit:uM
HIV-1	BaL	P24 (DAY 18)	MACROPHAGES(GM-CSF)	Macrophage	Ribonucleotide reductase		<	10	uM	99	%	50	uM		>	1000	uM	>	10	MAXIMAL P24 EXPRESSION AT DAY 18	7973634	HYDROXYUREA AS AN INHIBITOR OF HUMAN IMMUNODEFICIENCY VIRUS-TYPE 1 REPLICATION. Science 1994, 266(5186), 801-805.	ECOtherPctMod:> \| CCOtherPct:0 \| CCOtherPctUnit:% \| CCOtherConc:1000 \| CCOtherConcUnit:uM
HIV-1	IIIB	RT	HT4(R116; AZT RESISTANT CELLS)	HT4	Reverse transcriptase		~	0.01	uM	70	%	0.01	uM		~`	1	uM	~	100	FLOXURIDINE APPEARS TO POTENTIATE AZT ACTIVITY AND ALSO HAVE SOME ANTI-HIV ACTIVITY IN AZT RESISTANT CELL LINES	8827211	USE OF FLOXURIDINE TO MODULATE THE ANTIVIRAL ACTIVITY OF ZIDOVUDINE. AIDS Research and Human Retroviruses 1996, 12(11), 965-968.	ECOtherPctMod:~ \| CCOtherPct:35 \| CCOtherPctUnit:% \| CCOtherConc:.1 \| CCOtherConcUnit:uM
HIV-1	1	.beta.GAL AS A MEASURE OF TAT-MEDIATED TRANSACTIVATION	HeLa H12(HIV-1 LTR-Laz, TAT)	HeLa	Tat:TAR/LTR		<	0.1	uM	52	%	0.1	uM	TRYPAN BLUE	>	100	uM	>	1000	DRUG AND RECOMBINANT TAT WERE INTRODUCED INTO CELLS THROUGH ELECTROPORATION	9561563	CURCUMIN AND CURCUMIN DERIVATIVES INHIBIT TAT-MEDIATED TRANSACTIVATION OF TYPE 1 HUMAN IMMUNODEFICIENCY VIRUS LONG TERMINAL REPEAT. Research in Virology 1998, 149(1), 43-52.
HIV-1	1	.beta.GAL AS A MEASURE OF TAT-MEDIATED TRANSACTIVATION	HeLa H12(HIV-1 LTR-Laz, TAT)	HeLa	Tat:TAR/LTR		<	0.01	uM	78	%	0.01	uM	TRYPAN BLUE	>	100	uM	>	10000	DRUG AND RECOMBINANT TAT WERE INTRODUCED INTO CELLS THROUGH ELECTROPORATION	9561563	CURCUMIN AND CURCUMIN DERIVATIVES INHIBIT TAT-MEDIATED TRANSACTIVATION OF TYPE 1 HUMAN IMMUNODEFICIENCY VIRUS LONG TERMINAL REPEAT. Research in Virology 1998, 149(1), 43-52.
HIV-1	IIIB	SYNCYT FORM	MOLT-4/H9(HIV-1(IIIB))	MOLT-4	gp120		<	1	uM	95	%	10	uM		-100	10	uM	>	10	CHRONICALLY INFECTED H9 CELLS	9343823	TRIAZINE DYES INHIBIT HIV-1 ENTRY BY BINDING TO ENVELOPE GLYCOPROTEINS. Microbiology and Immunology 1997, 41(9), 717-724.	CCOtherPct:30 \| CCOtherPctUnit:% \| CCOtherConc:10 \| CCOtherConcUnit:uM
HIV-1	1	.beta.GAL AS A MEASURE OF TAT-MEDIATED TRANSACTIVATION	HeLa H12(HIV-1 LTR-Laz, TAT)	HeLa	Tat:TAR/LTR		<	0.01	uM	75	%	0.01	uM	TRYPAN BLUE	>	100	uM	>	10000	DRUG AND RECOMBINANT TAT WERE INTRODUCED INTO CELLS THROUGH ELECTROPORATION	9561563	CURCUMIN AND CURCUMIN DERIVATIVES INHIBIT TAT-MEDIATED TRANSACTIVATION OF TYPE 1 HUMAN IMMUNODEFICIENCY VIRUS LONG TERMINAL REPEAT. Research in Virology 1998, 149(1), 43-52.
HIV-1	1	P24	MT-4		Integrase		<	0.25	uM	95	%	0.25	uM	MICROSCOPIC EXAMINATION	>	20	uM	>	80	IN THE PRESENCE OF 50% NHS	16554152	A SERIES OF 5-AMINOSUBSTITUTED 4-FLUOROBENZYL-8-HYDROXY-[1,6]NAPHTHYRIDINE-7-CARBOXAMIDE HIV-1 INTEGRASE INHIBITORS. Bioorganic & Medical Chemistry Letters 2006, 16(11), 2900-2904.	ECOtherPctMod:>
HIV-1	1	P24	MT-4		Integrase		<	0.103	uM	95	%	0.103	uM	MICROSCOPIC EXAMINATION	>	20	uM	>	194	IN THE PRESENCE OF 10% FBS	16554152	A SERIES OF 5-AMINOSUBSTITUTED 4-FLUOROBENZYL-8-HYDROXY-[1,6]NAPHTHYRIDINE-7-CARBOXAMIDE HIV-1 INTEGRASE INHIBITORS. Bioorganic & Medical Chemistry Letters 2006, 16(11), 2900-2904.	ECOtherPctMod:>
HIV-1	NL4-3	RT	MT-4		Reverse transcriptase		<	1	uM	100	%	1	uM	WST-8	>	1	uM	>	1	MEASUREMENTS WERE MADE ON DAY 4, 6 AND 8 POST INFECTION	15371436	POLYARGININE INHIBITS GP160 PROCESSING BY FURIN AND SUPPRESSES PRODUCTIVE HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 INFECTION. The Journal of Biological Chemistry 2004, 279(47), 49055-49063.
HIV-1	LAI	RT	HuT 78		Reverse transcriptase		<	1	uM	57.14	%	1	uM	MTT	>	10	uM	>	10	MEASUREMENT WAS MADE ON DAY10 POSTINFECTION AT 10 TCID50	9281520	USE OF HERPES SIMPLEX VIRUS THYMIDINE KINASE TO IMPROVE THE ANTIVIRAL ACTIVITY OF ZIDOVUDINE. Virology 1997, 235, 398-405.

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Enterobacter cloacae

External ID: CHEMBL3074443

Protocol: N/A

Comment: Journal: Med Chem Res
Year: 2013
Volume: 22
Issue: 11
First Page: 5129
Last Page: 5140
DOI: 10.1007/s00044-013-0484-9

Target ChEMBL ID: CHEMBL349
ChEMBL Target Name: Enterobacter cloacae
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment	Data Validity Comment
9600	MIC	=	9600000	nM
7450	MIC	=	7450000	nM
14690	MIC	=	14690000	nM		Outside typical range
5700	MIC	=	5700000	nM
	MIC				Not Active
3330	MIC	=	3330000	nM
3080	MIC	=	3080000	nM
	MIC				Not Active
	MIC				Not Active
10400	MIC	=	10400000	nM		Outside typical range
10190	MIC	=	10190000	nM		Outside typical range
	MIC				Not Active
	MIC				Not Active
11410	MIC	=	11410000	nM		Outside typical range
990	MIC	=	990000	nM
1420	MIC	=	1420000	nM
	MIC				Not Active
10460	MIC	=	10460000	nM		Outside typical range
810	MIC	=	810000	nM
	MIC				Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Candida albicans

External ID: CHEMBL3074442

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Med Chem Res
Year: 2013
Volume: 22
Issue: 11
First Page: 5129
Last Page: 5140
DOI: 10.1007/s00044-013-0484-9

Target ChEMBL ID: CHEMBL366
ChEMBL Target Name: Candida albicans
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
600	MIC	=	600000	nM
3720	MIC	=	3720000	nM
3670	MIC	=	3670000	nM
6160	MIC	=	6160000	nM
830	MIC	=	830000	nM
770	MIC	=	770000	nM
6740	MIC	=	6740000	nM
	MIC				Not Active
2600	MIC	=	2600000	nM
2550	MIC	=	2550000	nM
730	MIC	=	730000	nM
8990	MIC	=	8990000	nM
	MIC				Not Active
990	MIC	=	990000	nM
350	MIC	=	350000	nM
	MIC				Not Active
	MIC				Not Active
810	MIC	=	810000	nM
1700	MIC	=	1700000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL949643

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2001
Volume: 64
Issue: 10
First Page: 1278
Last Page: 1281
DOI: 10.1021/np010211x

Standard Type	Standard Relation	Standard Value	Activity Comment
Ratio IC50/EC50			Not Active
Ratio IC50/EC50	=	173000
Ratio IC50/EC50	=	8
Ratio IC50/EC50			Not Active
Ratio IC50/EC50			Not Active
Ratio IC50/EC50			Not Active
Ratio IC50/EC50	=	8.62
Ratio IC50/EC50	=	8.17
Ratio IC50/EC50	>	186

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL965954

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2002
Volume: 65
Issue: 9
First Page: 1278
Last Page: 1282
DOI: 10.1021/np0202475

Standard Type	Standard Relation	Standard Value	Standard Units
IC50	=	2.3	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Quinone oxidoreductase

External ID: CHEMBL961907

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2002
Volume: 65
Issue: 9
First Page: 1278
Last Page: 1282
DOI: 10.1021/np0202475

Target ChEMBL ID: CHEMBL4332
ChEMBL Target Name: Quinone oxidoreductase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
CD	=	9.5	ug ml-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：PBMC

External ID: CHEMBL3370104

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2014
Volume: 24
Issue: 16
First Page: 3797
Last Page: 3801
DOI: 10.1016/j.bmcl.2014.06.067

Target ChEMBL ID: CHEMBL613107
ChEMBL Target Name: PBMC
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Non-toxic
Activity	Non-toxic

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：K562

External ID: CHEMBL3370101

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2014
Volume: 24
Issue: 16
First Page: 3797
Last Page: 3801
DOI: 10.1016/j.bmcl.2014.06.067

Target ChEMBL ID: CHEMBL385
ChEMBL Target Name: K562
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Units	Activity Comment
Inhibition	%	Not Active
Inhibition	%	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Klebsiella pneumoniae

External ID: CHEMBL3074445

Protocol: N/A

Comment: Journal: Med Chem Res
Year: 2013
Volume: 22
Issue: 11
First Page: 5129
Last Page: 5140
DOI: 10.1007/s00044-013-0484-9

Target ChEMBL ID: CHEMBL350
ChEMBL Target Name: Klebsiella pneumoniae
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment	Data Validity Comment
	MIC				Not Active
7450	MIC	=	7450000	nM
14690	MIC	=	14690000	nM		Outside typical range
5700	MIC	=	5700000	nM
	MIC				Not Active
3330	MIC	=	3330000	nM
3080	MIC	=	3080000	nM
	MIC				Not Active
	MIC				Not Active
10400	MIC	=	10400000	nM		Outside typical range
10190	MIC	=	10190000	nM		Outside typical range
	MIC				Not Active
	MIC				Not Active
	MIC				Not Active
990	MIC	=	990000	nM
1420	MIC	=	1420000	nM
	MIC				Not Active
10460	MIC	=	10460000	nM		Outside typical range
810	MIC	=	810000	nM
	MIC				Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Pseudomonas aeruginosa

External ID: CHEMBL3074444

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Med Chem Res
Year: 2013
Volume: 22
Issue: 11
First Page: 5129
Last Page: 5140
DOI: 10.1007/s00044-013-0484-9

Target ChEMBL ID: CHEMBL348
ChEMBL Target Name: Pseudomonas aeruginosa
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
	MIC				Not Active
7450	MIC	=	7450000	nM
	MIC				Not Active
2800	MIC	=	2800000	nM
	MIC				Not Active
830	MIC	=	830000	nM
770	MIC	=	770000	nM
	MIC				Not Active
	MIC				Not Active
2600	MIC	=	2600000	nM
2550	MIC	=	2550000	nM
	MIC				Not Active
	MIC				Not Active
	MIC				Not Active
250	MIC	=	250000	nM
350	MIC	=	350000	nM
	MIC				Not Active
2610	MIC	=	2610000	nM
810	MIC	=	810000	nM
	MIC				Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Burkholderia cepacia

External ID: CHEMBL3074447

Protocol: N/A

Comment: Journal: Med Chem Res
Year: 2013
Volume: 22
Issue: 11
First Page: 5129
Last Page: 5140
DOI: 10.1007/s00044-013-0484-9

Target ChEMBL ID: CHEMBL612499
ChEMBL Target Name: Burkholderia cepacia
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment	Data Validity Comment
	MIC				Not Active
14900	MIC	=	14900000	nM		Outside typical range
14690	MIC	=	14690000	nM		Outside typical range
5700	MIC	=	5700000	nM
	MIC				Not Active
	MIC				Not Active
	MIC				Not Active
	MIC				Not Active
	MIC				Not Active
5200	MIC	=	5200000	nM
5100	MIC	=	5100000	nM
730	MIC	=	730000	nM
	MIC				Not Active
	MIC				Not Active
490	MIC	=	490000	nM
710	MIC	=	710000	nM
	MIC				Not Active
2610	MIC	=	2610000	nM
810	MIC	=	810000	nM
1700	MIC	=	1700000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Escherichia coli

External ID: CHEMBL3074446

Protocol: N/A

Comment: Journal: Med Chem Res
Year: 2013
Volume: 22
Issue: 11
First Page: 5129
Last Page: 5140
DOI: 10.1007/s00044-013-0484-9

Target ChEMBL ID: CHEMBL354
ChEMBL Target Name: Escherichia coli
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment	Data Validity Comment
	MIC				Not Active
7450	MIC	=	7450000	nM
14690	MIC	=	14690000	nM		Outside typical range
80	MIC	=	80000	nM
	MIC				Not Active
3330	MIC	=	3330000	nM
3080	MIC	=	3080000	nM
	MIC				Not Active
	MIC				Not Active
10400	MIC	=	10400000	nM		Outside typical range
10190	MIC	=	10190000	nM		Outside typical range
	MIC				Not Active
	MIC				Not Active
	MIC				Not Active
1990	MIC	=	1990000	nM
2840	MIC	=	2840000	nM
	MIC				Not Active
2610	MIC	=	2610000	nM
810	MIC	=	810000	nM
	MIC				Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Bacillus subtilis

External ID: CHEMBL3074449

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Med Chem Res
Year: 2013
Volume: 22
Issue: 11
First Page: 5129
Last Page: 5140
DOI: 10.1007/s00044-013-0484-9

Target ChEMBL ID: CHEMBL359
ChEMBL Target Name: Bacillus subtilis
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment	Data Validity Comment
	MIC				Not Active
7450	MIC	=	7450000	nM
14690	MIC	=	14690000	nM		Outside typical range
10	MIC	=	10000	nM
	MIC				Not Active
6660	MIC	=	6660000	nM
6160	MIC	=	6160000	nM
	MIC				Not Active
	MIC				Not Active
5200	MIC	=	5200000	nM
5100	MIC	=	5100000	nM
730	MIC	=	730000	nM
	MIC				Not Active
	MIC				Not Active
1990	MIC	=	1990000	nM
2840	MIC	=	2840000	nM
	MIC				Not Active
2610	MIC	=	2610000	nM
400	MIC	=	400000	nM
850	MIC	=	850000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Micrococcus luteus

External ID: CHEMBL3074448

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Med Chem Res
Year: 2013
Volume: 22
Issue: 11
First Page: 5129
Last Page: 5140
DOI: 10.1007/s00044-013-0484-9

Target ChEMBL ID: CHEMBL614421
ChEMBL Target Name: Micrococcus luteus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment	Data Validity Comment
	MIC				Not Active
7450	MIC	=	7450000	nM
	MIC				Not Active
10	MIC	=	10000	nM
	MIC				Not Active
3330	MIC	=	3330000	nM
3080	MIC	=	3080000	nM
	MIC				Not Active
	MIC				Not Active
2600	MIC	=	2600000	nM
2550	MIC	=	2550000	nM
730	MIC	=	730000	nM
2250	MIC	=	2250000	nM
11410	MIC	=	11410000	nM		Outside typical range
990	MIC	=	990000	nM
2840	MIC	=	2840000	nM
	MIC				Not Active
2610	MIC	=	2610000	nM
200	MIC	=	200000	nM
850	MIC	=	850000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Staphylococcus aureus

External ID: CHEMBL3074450

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Med Chem Res
Year: 2013
Volume: 22
Issue: 11
First Page: 5129
Last Page: 5140
DOI: 10.1007/s00044-013-0484-9

Target ChEMBL ID: CHEMBL352
ChEMBL Target Name: Staphylococcus aureus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment	Data Validity Comment
	MIC				Not Active
14900	MIC	=	14900000	nM		Outside typical range
1830	MIC	=	1830000	nM
10	MIC	=	10000	nM
	MIC				Not Active
3330	MIC	=	3330000	nM
3080	MIC	=	3080000	nM
	MIC				Not Active
	MIC				Not Active
5200	MIC	=	5200000	nM
5100	MIC	=	5100000	nM
730	MIC	=	730000	nM
	MIC				Not Active
	MIC				Not Active
1990	MIC	=	1990000	nM
2840	MIC	=	2840000	nM
	MIC				Not Active
10460	MIC	=	10460000	nM		Outside typical range
200	MIC	=	200000	nM
850	MIC	=	850000	nM

4497-40-9 靶点实验数据