HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：2-amino-3-carboxymuconate-6-semialdehyde decarboxylase

External ID: CHEMBL4775522

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2021
Volume: 64
Issue: 1.0
First Page: 797
Last Page: 811
DOI: 10.1021/acs.jmedchem.0c01762

Target ChEMBL ID: CHEMBL4105941
ChEMBL Target Name: 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	100	%
Activity	=	95	%
Activity	=	75.4	%
Activity	=	78.2	%
Activity	=	76	%
Activity	=	88.9	%
Activity	=	99.6	%
Activity	=	6.9	%
Activity	=	82.7	%
Activity	=	98.7	%
Activity	=	85.1	%
Activity	=	97	%
Activity	=	83.4	%
Activity	=	77	%
Activity	=	5.1	%
Activity	=	6	%
Activity	=	73.3	%
Activity	=	5.3	%
Activity	=	78.6	%
Activity	=	75.9	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：2-amino-3-carboxymuconate-6-semialdehyde decarboxylase

External ID: CHEMBL4775521

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2021
Volume: 64
Issue: 1.0
First Page: 797
Last Page: 811
DOI: 10.1021/acs.jmedchem.0c01762

Target ChEMBL ID: CHEMBL4105941
ChEMBL Target Name: 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
Activity				Not Determined
Activity	=	5.03	%
Activity	=	24.6	%
Activity	=	21.8	%
Activity	=	24	%
Activity	=	11.1	%
Activity	=	0.43	%
Activity	=	93.1	%
Activity	=	17.4	%
Activity	=	1.29	%
Activity	=	14.9	%
Activity	=	2.98	%
Activity	=	16.6	%
Activity	=	23	%
Activity	=	94.9	%
Activity	=	94	%
Activity	=	26.7	%
Activity	=	94.7	%
Activity	=	21.4	%
Activity	=	24.1	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Rattus norvegicus

External ID: CHEMBL3252206

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1978
Volume: 21
Issue: 11
First Page: 1093
Last Page: 1100
DOI: 10.1021/jm00209a001

Target ChEMBL ID: CHEMBL376
ChEMBL Target Name: Rattus norvegicus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
ED50	=	89	mg.kg-1
ED50	=	77	mg.kg-1
ED50	=	9.8	mg.kg-1
ED50	=	54	mg.kg-1
ED50	=	14	mg.kg-1
ED50	=	20	mg.kg-1
ED50	=	130	mg.kg-1
ED50	=	120	mg.kg-1
ED50	=	150	mg.kg-1
ED50	=	27	mg.kg-1
ED50	=	155	mg.kg-1
ED50	=	24	mg.kg-1
ED50	=	90	mg.kg-1
ED50	=	170	mg.kg-1
ED50	=	25	mg.kg-1
ED50	=	40	mg.kg-1
ED50	=	76	mg.kg-1
ED50	=	20	mg.kg-1
ED50	=	50	mg.kg-1
ED50	=	60	mg.kg-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：2-amino-3-carboxymuconate-6-semialdehyde decarboxylase

External ID: CHEMBL4775525

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Med Chem
Year: 2021
Volume: 64
Issue: 1.0
First Page: 797
Last Page: 811
DOI: 10.1021/acs.jmedchem.0c01762

Target ChEMBL ID: CHEMBL4105941
ChEMBL Target Name: 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
3.29	IC50	=	3290	nM
88	IC50	=	88000	nM
1.32	IC50	=	1320	nM
44.1	IC50	=	44100	nM
20.1	IC50	=	20100	nM
4.61	IC50	=	4610	nM
47.9	IC50	=	47900	nM
27.1	IC50	=	27100	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Tyrosine-protein phosphatase non-receptor type 1

External ID: CHEMBL1011840

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2009
Volume: 17
Issue: 7
First Page: 2658
Last Page: 2672
DOI: 10.1016/j.bmc.2009.02.060

Target ChEMBL ID: CHEMBL335
ChEMBL Target Name: Protein-tyrosine phosphatase 1B
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	5	%
Inhibition	=	10	%
Inhibition	=	20	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Low molecular weight phosphotyrosine protein phosphatase

External ID: CHEMBL1011838

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2009
Volume: 17
Issue: 7
First Page: 2658
Last Page: 2672
DOI: 10.1016/j.bmc.2009.02.060

Target ChEMBL ID: CHEMBL4903
ChEMBL Target Name: Low molecular weight phosphotyrosine protein phosphatase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Units
Inhibition	=	%
Inhibition	=	%
Inhibition	=	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Low molecular weight phosphotyrosine protein phosphatase

External ID: CHEMBL1011839

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2009
Volume: 17
Issue: 7
First Page: 2658
Last Page: 2672
DOI: 10.1016/j.bmc.2009.02.060

Target ChEMBL ID: CHEMBL4903
ChEMBL Target Name: Low molecular weight phosphotyrosine protein phosphatase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Units
Inhibition	=	%
Inhibition	=	%
Inhibition	=	%

4482-27-3 靶点实验数据