HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL948522

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2008
Volume: 51
Issue: 13
First Page: 3720
Last Page: 3730
DOI: 10.1021/jm701549s

Standard Type	Standard Relation	Standard Value
LogD	=	1.44
LogD	=	2.09
LogD	=	0.64
LogD	=	1.55
LogD	=	1.99
LogD	=	2.24
LogD	=	1.83
LogD	=	1.56
LogD	=	1.61
LogD	=	2.15
LogD	=	3.49
LogD	=	1.25
LogD	=	1.31
LogD	=	2.1
LogD	=	1.34
LogD	=	1.32
LogD	=	2.41
LogD	=	1.52
LogD	=	1.32
LogD	=	1.23

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：BindingDB 靶标：N/A

External ID: BindingDB_2739_1

Protocol: N/A

Comment: Compounds with any of Ki, IC50, Kd, or EC50 activity value <= 10uM are labeled as "Active".
If multiple measurements are available for a given compound, it is labeled as "Active" if any of the measurements meet the criterion. Activity values are checked in the order of Ki, IC50, Kd, and EC50. The first entry that meets the above activity threshold is used to determine "Standard Type", "Standard Relation", and "PubChem Standard Value". Otherwise, the first non-empty entry will be used to set those values.

Standard Type	Standard Relation	PubChem Standard Value	Ki	IC50 Qualifier	IC50	Target Accession(s)	Ligand	Target
IC50		0.5			500	P09960	BDBM23971	Leukotriene A-4 hydrolase
IC50		120			120000	P00727	BDBM23973	Cytosol aminopeptidase
IC50		130			130000	Q01693	BDBM23973	Bacterial leucyl aminopeptidase
IC50		0.5			500	P15145	BDBM23973	Aminopeptidase N
IC50	>	1000		>	1000000	P09960	BDBM23973	Leukotriene A-4 hydrolase
IC50	>	1000		>	1000000	P00727	BDBM23974	Cytosol aminopeptidase
IC50	>	1000		>	1000000	Q01693	BDBM23974	Bacterial leucyl aminopeptidase
IC50		1800			1800000	P15145	BDBM23974	Aminopeptidase N
IC50	>	1000		>	1000000	P09960	BDBM23981	Leukotriene A-4 hydrolase
IC50	>	1000		>	1000000	P00727	BDBM23982	Cytosol aminopeptidase
IC50		500			500000	Q01693	BDBM23982	Bacterial leucyl aminopeptidase
IC50	>	1000		>	1000000	P15145	BDBM23982	Aminopeptidase N
IC50	>	1000		>	1000000	P09960	BDBM23985	Leukotriene A-4 hydrolase
IC50	>	1000		>	1000000	P00727	BDBM23986	Cytosol aminopeptidase
Ki		4	4000			Q01693	BDBM23986	Bacterial leucyl aminopeptidase
IC50	>	1000		>	1000000	P15145	BDBM23986	Aminopeptidase N
IC50	>	1000		>	1000000	P09960	BDBM23988	Leukotriene A-4 hydrolase
IC50	>	1000		>	1000000	P00727	BDBM23989	Cytosol aminopeptidase
IC50	>	1000		>	1000000	Q01693	BDBM23989	Bacterial leucyl aminopeptidase
IC50	>	1000		>	1000000	P15145	BDBM23989	Aminopeptidase N

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL949564

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2008
Volume: 51
Issue: 13
First Page: 3720
Last Page: 3730
DOI: 10.1021/jm701549s

Standard Type	Standard Relation	Standard Value
LogD	=	0.34
LogD	=	0.98
LogD	=	-0.48
LogD	=	-0.83
LogD	=	0.97
LogD	=	0.66
LogD	=	1.35
LogD	=	0.91
LogD	=	0.96
LogD	=	1.9
LogD	=	1.99
LogD	=	0
LogD	=	0.47
LogD	=	0.66
LogD	=	-0.89
LogD	=	-0.15
LogD	=	0.75
LogD	=	-0.15
LogD	=	-0.6
LogD	=	0.52

4385-35-7 靶点实验数据