HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NON-PROTEIN TARGET

External ID: CHEMBL847246

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 1997
Volume: 7
Issue: 21
First Page: 2781
Last Page: 2786
DOI: 10.1016/S0960-894X(97)10072-5

Target ChEMBL ID: CHEMBL3879801
ChEMBL Target Name: NON-PROTEIN TARGET
ChEMBL Target Type: NON-MOLECULAR - Target has not been defined at a molecular level, only the non-molecular entity which is affected (e.g., organism, cell line etc)
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value
Ratio	>	2187
Ratio	>	284
Ratio	=	53
Ratio	>	43
Ratio	>	4885
Ratio	>	3333

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NON-PROTEIN TARGET

External ID: CHEMBL999159

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 1998
Volume: 61
Issue: 11
First Page: 1447
Last Page: 1451
DOI: 10.1021/np980136z

Target ChEMBL ID: CHEMBL3879801
ChEMBL Target Name: NON-PROTEIN TARGET
ChEMBL Target Type: NON-MOLECULAR - Target has not been defined at a molecular level, only the non-molecular entity which is affected (e.g., organism, cell line etc)
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
125	Activity	>	125	uM
13	Activity	=	13	uM
25	Activity	>	25	uM
120	Activity	=	120	uM
200	Activity	=	200	uM
52	Activity	=	52	uM
122	Activity	=	122	uM
200	Activity	>	200	uM
37	Activity	=	37	uM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Human alphaherpesvirus 1

External ID: CHEMBL999158

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Nat Prod
Year: 1998
Volume: 61
Issue: 11
First Page: 1447
Last Page: 1451
DOI: 10.1021/np980136z

Target ChEMBL ID: CHEMBL377
ChEMBL Target Name: Human alphaherpesvirus 1
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.5	Activity	=	500	nM
13	Activity	=	13	uM
0.038	Activity	=	38	nM
0.36	Activity	=	360	nM
0.05	Activity	=	50	nM
17	Activity	=	17	uM
49	Activity	=	49	uM
0.25	Activity	=	250	nM
12	Activity	=	12	uM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3231043

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Med Chem
Year: 1979
Volume: 22
Issue: 3
First Page: 215
Last Page: 221
DOI: 10.1021/jm00189a001

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.5	ID50	=	0.5	uM
1	ID50	=	1	uM
0.8	ID50	=	0.8	uM
10	ID50	=	10	uM
5	ID50	=	5	uM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：P388

External ID: CHEMBL1025843

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Nat. Prod.
Year: 1995
Volume: 58
Issue: 6
First Page: 870
Last Page: 877
DOI: 10.1021/np50120a008

Target ChEMBL ID: CHEMBL389
ChEMBL Target Name: P388
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.1	IC50	=	100	nM
0.6	IC50	=	600	nM
0.06	IC50	=	60	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：HT-29

External ID: CHEMBL2166893

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2012
Volume: 55
Issue: 15
First Page: 6724
Last Page: 6737
DOI: 10.1021/jm2017573

Target ChEMBL ID: CHEMBL384
ChEMBL Target Name: HT-29
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
2.62	GI50	=	2620	nM
11.4	GI50	=	11400	nM
1.73	GI50	=	1730	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：A549

External ID: CHEMBL619517

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2004
Volume: 14
Issue: 5
First Page: 1283
Last Page: 1286
DOI: 10.1016/j.bmcl.2003.12.039

Target ChEMBL ID: CHEMBL392
ChEMBL Target Name: A549
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.019	IC50	=	19	nM
0.188	IC50	=	188	nM
0.454	IC50	=	454	nM
0.048	IC50	=	48	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：A549

External ID: CHEMBL2166892

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2012
Volume: 55
Issue: 15
First Page: 6724
Last Page: 6737
DOI: 10.1021/jm2017573

Target ChEMBL ID: CHEMBL392
ChEMBL Target Name: A549
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
3.32	GI50	=	3320	nM
6.21	GI50	=	6210	nM
1.15	GI50	=	1150	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mus musculus

External ID: CHEMBL735757

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 1997
Volume: 7
Issue: 21
First Page: 2781
Last Page: 2786
DOI: 10.1016/S0960-894X(97)10072-5

Target ChEMBL ID: CHEMBL375
ChEMBL Target Name: Mus musculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
IC50	<	0.128	ug.mL-1
IC50	=	0.229	ug.mL-1
IC50	=	0.0518	ug.mL-1
IC50	=	0.585	ug.mL-1
IC50	=	0.00563	ug.mL-1
IC50	<	0.00855	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：P388

External ID: CHEMBL758432

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2004
Volume: 14
Issue: 5
First Page: 1283
Last Page: 1286
DOI: 10.1016/j.bmcl.2003.12.039

Target ChEMBL ID: CHEMBL389
ChEMBL Target Name: P388
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.019	IC50	=	19	nM
0.188	IC50	=	188	nM
0.454	IC50	=	454	nM
0.024	IC50	=	24	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NON-PROTEIN TARGET

External ID: CHEMBL848562

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 1997
Volume: 7
Issue: 21
First Page: 2781
Last Page: 2786
DOI: 10.1016/S0960-894X(97)10072-5

Target ChEMBL ID: CHEMBL3879801
ChEMBL Target Name: NON-PROTEIN TARGET
ChEMBL Target Type: NON-MOLECULAR - Target has not been defined at a molecular level, only the non-molecular entity which is affected (e.g., organism, cell line etc)
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Cytotoxicity	=	280	ug ml-1
Cytotoxicity	>	65	ug ml-1
Cytotoxicity	=	2.75	ug ml-1
Cytotoxicity	>	25	ug ml-1
Cytotoxicity	>	27.5	ug ml-1
Cytotoxicity	>	28.5	ug ml-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL1002665

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 1998
Volume: 61
Issue: 11
First Page: 1447
Last Page: 1451
DOI: 10.1021/np980136z

Standard Type	Standard Relation	Standard Value
TI	=	6000
TI	=	15
TI	=	75
TI	=	250
TI	=	1
TI	=	667
TI	=	333
TI	=	4000
TI	=	3
TI	=	1.2

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：A549

External ID: CHEMBL1025844

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Nat. Prod.
Year: 1995
Volume: 58
Issue: 6
First Page: 870
Last Page: 877
DOI: 10.1021/np50120a008

Target ChEMBL ID: CHEMBL392
ChEMBL Target Name: A549
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.13	IC50	=	130	nM
0.6	IC50	=	600	nM
0.06	IC50	=	60	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：HT-29

External ID: CHEMBL1025845

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Nat. Prod.
Year: 1995
Volume: 58
Issue: 6
First Page: 870
Last Page: 877
DOI: 10.1021/np50120a008

Target ChEMBL ID: CHEMBL384
ChEMBL Target Name: HT-29
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.06	IC50	=	60	nM
1.2	IC50	=	1200	nM
1.2	IC50	=	1200	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NON-PROTEIN TARGET

External ID: CHEMBL840451

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1996
Volume: 39
Issue: 14
First Page: 2865
Last Page: 2868
DOI: 10.1021/jm960023h

Target ChEMBL ID: CHEMBL3879801
ChEMBL Target Name: NON-PROTEIN TARGET
ChEMBL Target Type: NON-MOLECULAR - Target has not been defined at a molecular level, only the non-molecular entity which is affected (e.g., organism, cell line etc)
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value
Selectivity index	>	2190
Selectivity index	>	284
Selectivity index	=	53
Selectivity index	=	4097
Selectivity index	>	2
Selectivity index	>	2085
Selectivity index	>	2586

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL747813

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1996
Volume: 39
Issue: 14
First Page: 2865
Last Page: 2868
DOI: 10.1021/jm960023h

Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
IC50	>	65	ug.mL-1	Outside typical range
IC50	=	2.75	ug.mL-1
IC50	=	11.5	ug.mL-1
IC50	>	25	ug.mL-1
IC50	=	19.7	ug.mL-1
IC50	=	12.8	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mus musculus

External ID: CHEMBL823975

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1996
Volume: 39
Issue: 14
First Page: 2865
Last Page: 2868
DOI: 10.1021/jm960023h

Target ChEMBL ID: CHEMBL375
ChEMBL Target Name: Mus musculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
IC50	=	0.299	ug.mL-1
IC50	=	0.00281	ug.mL-1
IC50	=	11.8	ug.mL-1
IC50	<	0.00945	ug.mL-1
IC50	<	0.00495	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：HT-29

External ID: CHEMBL692404

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2004
Volume: 14
Issue: 5
First Page: 1283
Last Page: 1286
DOI: 10.1016/j.bmcl.2003.12.039

Target ChEMBL ID: CHEMBL384
ChEMBL Target Name: HT-29
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.019	IC50	=	19	nM
0.188	IC50	=	188	nM
0.454	IC50	=	454	nM
0.048	IC50	=	48	nM

4375-07-9 靶点实验数据