HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL631551

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2004
Volume: 47
Issue: 10
First Page: 2635
Last Page: 2644
DOI: 10.1021/jm030473r

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
T1/2				No hydrolysis obsd
T1/2	=	7.5	hr
T1/2	=	12.2	hr
T1/2				Not Tested
T1/2	>	100	hr

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NAD-dependent histone deacetylase SIR2

External ID: CHEMBL808739

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2004
Volume: 47
Issue: 10
First Page: 2635
Last Page: 2644
DOI: 10.1021/jm030473r

Target ChEMBL ID: CHEMBL3275
ChEMBL Target Name: NAD-dependent histone deacetylase SIR2
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
150	IC50	>=	150000	nM	Outside typical range
150	IC50	>=	150000	nM	Outside typical range
131	IC50	=	131000	nM	Outside typical range
150	IC50	>=	150000	nM	Outside typical range
150	IC50	>=	150000	nM	Outside typical range
150	IC50	>=	150000	nM	Outside typical range
52	IC50	=	52000	nM
25	IC50	=	25000	nM
128	IC50	=	128000	nM	Outside typical range
111	IC50	=	111000	nM	Outside typical range
65	IC50	=	65000	nM
89	IC50	=	89000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NAD-dependent histone deacetylase SIR2

External ID: CHEMBL808741

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2004
Volume: 47
Issue: 10
First Page: 2635
Last Page: 2644
DOI: 10.1021/jm030473r

Target ChEMBL ID: CHEMBL3275
ChEMBL Target Name: NAD-dependent histone deacetylase SIR2
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
150	MGC	>=	150	uM
11	MGC	=	11	uM
150	MGC	>=	150	uM
150	MGC	>=	150	uM
38	MGC	=	38	uM
5.4	MGC	=	5.4	uM
1.5	MGC	=	1.5	uM
0.69	MGC	=	0.69	uM
2.4	MGC	=	2.4	uM
4.9	MGC	=	4.9	uM

4352-63-0 靶点实验数据