HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：P388

External ID: CHEMBL761526

Protocol: N/A

Comment: Journal: J Med Chem
Year: 1983
Volume: 26
Issue: 8
First Page: 1168
Last Page: 1173
DOI: 10.1021/jm00362a016

Target ChEMBL ID: CHEMBL389
ChEMBL Target Name: P388
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation
Survival time	=

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：P388

External ID: CHEMBL760322

Protocol: N/A

Comment: Journal: J Med Chem
Year: 1983
Volume: 26
Issue: 8
First Page: 1168
Last Page: 1173
DOI: 10.1021/jm00362a016

Target ChEMBL ID: CHEMBL389
ChEMBL Target Name: P388
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation
Mortality	=
Mortality	=
Mortality	=
Mortality	=
Mortality	=
Mortality	=
Mortality	=
Mortality	=
Mortality	=
Mortality	=

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：DTP/NCI 靶标：N/A

External ID: MCF7_OneDose

Protocol: NCI-60 Human Tumor Cell Lines Screen was performed using the standard one-dose NCI protocol, which is described in more detail at https://dtp.cancer.gov/discovery_development/nci-60/default.htm.

Compounds with GIPRCNT values below 10 were considered active. Activity score was based on GIPRCNT using the following formula:
max(-GIPRCNT/2 + 50, 0)
Score is 0 for GIPRCNT values of 100 or above, 50 for GIPRCNT values of 0, and 100 for GIPRCNT values of -100.

Comment: These data are a subset of the data from the NCI human tumor cell line screen. Compounds are identified by the NCI National Service Center (NSC) number, which is contained in the
PUBCHEM_EXT_DATASOURCE_REGID field. In the NCI cell line identification system, MCF7 is panel number 5, cell number 1. PANELCODE or PANELNAME identify the NCI-60 cell panel. PANELNBR does NOT identify the NCI-60 panel.

EXPID is the NCI internal tracking number for the experiment identifier, and PREFIX = 'S' for the NSCs submitted through the NCI Chemical Agents repository.

Substance concentration unit is indicated in the data table, using the following abbreviations: M = molar (M), u = micrograms/milliliter (microg/mL), V = volumetric fraction.

M_GIPRCNT represents the mean growth percent for that experiment, and N_GIPRCNT indicates the number of values for that NSC within an experiment, while STDEV_GIPRCNT is the standard deviation. Most NSCs are tested once per experiment, resulting in EXP_COUNT = 1.

EXPID	PREFIX	CONCENTRATION_UNIT	CONCENTRATION	PANELNBR	CELLNBR	PANELNAME	CELLNAME	PANELCODE	M_GIPRCNT	N_GIPRCNT	EXP_COUNT
2106OS49	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	88.231	1	1
2106OS49	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	87.1119	1	1
2106OS49	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	14.4371	1	1
2106OS49	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	89.7113	1	1
2106OS49	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	97.2463	1	1
2106OS49	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	90.0129	1	1
2106OS49	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	85.7031	1	1
2106OS49	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	30.8539	1	1
2106OS49	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	14.2896	1	1
2106OS49	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	85.8526	1	1
2106OS49	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	83.1036	1	1
2106OS49	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	84.2194	1	1
2106OS49	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	89.3237	1	1
2106OS49	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	85.6034	1	1
2106OS49	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	89.6643	1	1
2106OS52	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	91.2503	1	1
2106OS52	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	94.8714	1	1
2106OS52	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	93.7372	1	1
2106OS52	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	112.6132	1	1
2106OS52	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	73.375	1	1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：P388

External ID: CHEMBL760910

Protocol: N/A

Comment: Journal: J Med Chem
Year: 1983
Volume: 26
Issue: 8
First Page: 1168
Last Page: 1173
DOI: 10.1021/jm00362a016

Target ChEMBL ID: CHEMBL389
ChEMBL Target Name: P388
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation
Survival time	=

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：P388

External ID: CHEMBL761573

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1983
Volume: 26
Issue: 8
First Page: 1168
Last Page: 1173
DOI: 10.1021/jm00362a016

Target ChEMBL ID: CHEMBL389
ChEMBL Target Name: P388
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Weight change difference	=	-0.1	g
Weight change difference	=	-5.2	g
Weight change difference	=	-3.6	g
Weight change difference	=	-1.8	g
Weight change difference	=	-0.7	g
Weight change difference	=	-0.1	g
Weight change difference	=	0.5	g
Weight change difference	=	-0.7	g
Weight change difference	=	-0.1	g
Weight change difference	=	-2.9	g
Weight change difference	=	-0.9	g
Weight change difference	=	-1.5	g
Weight change difference	=	-2.1	g
Weight change difference	=	-1.1	g
Weight change difference	=	-1.1	g
Weight change difference	=	-0.3	g
Weight change difference	=	0	g
Weight change difference	=	-2.5	g
Weight change difference	=	-2.8	g
Weight change difference	=	-1.4	g

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：P388

External ID: CHEMBL756335

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1983
Volume: 26
Issue: 8
First Page: 1168
Last Page: 1173
DOI: 10.1021/jm00362a016

Target ChEMBL ID: CHEMBL389
ChEMBL Target Name: P388
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
T/C	=	93	%
T/C	=	165	%
T/C	=	200	%
T/C	=	159	%
T/C	=	128	%
T/C	=	120	%
T/C	=	107	%
T/C	=	125	%
T/C	=	111	%
T/C	=	106	%
T/C	=	151	%
T/C	=	144	%
T/C	=	126	%
T/C	=	116	%
T/C	=	104	%
T/C	=	100	%
T/C	=	104	%
T/C	=	134	%
T/C	=	133	%
T/C	=	100	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：P388

External ID: CHEMBL758396

Protocol: N/A

Comment: Journal: J Med Chem
Year: 1983
Volume: 26
Issue: 8
First Page: 1168
Last Page: 1173
DOI: 10.1021/jm00362a016

Target ChEMBL ID: CHEMBL389
ChEMBL Target Name: P388
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation
Mortality	=
Mortality	=
Mortality	=
Mortality	=
Mortality	=
Mortality	=
Mortality	=

Standard Type	Standard Relation	Standard Value	Standard Units
T/C	=	93	%
T/C	=	165	%
T/C	=	200	%
T/C	=	159	%
T/C	=	128	%
T/C	=	120	%
T/C	=	107	%
T/C	=	125	%
T/C	=	111	%
T/C	=	106	%
T/C	=	151	%
T/C	=	144	%
T/C	=	126	%
T/C	=	116	%
T/C	=	104	%
T/C	=	100	%
T/C	=	104	%
T/C	=	134	%
T/C	=	133	%
T/C	=	100	%

Standard Type	Standard Relation	Standard Value	Standard Units
T/C	=	93	%
T/C	=	165	%
T/C	=	200	%
T/C	=	159	%
T/C	=	128	%
T/C	=	120	%
T/C	=	107	%
T/C	=	125	%
T/C	=	111	%
T/C	=	106	%
T/C	=	151	%
T/C	=	144	%
T/C	=	126	%
T/C	=	116	%
T/C	=	104	%
T/C	=	100	%
T/C	=	104	%
T/C	=	134	%
T/C	=	133	%
T/C	=	100	%

4239-12-7 靶点实验数据

Standard Type	Standard Relation	Standard Value	Standard Units
T/C	=	93	%
T/C	=	165	%
T/C	=	200	%
T/C	=	159	%
T/C	=	128	%
T/C	=	120	%
T/C	=	107	%
T/C	=	125	%
T/C	=	111	%
T/C	=	106	%
T/C	=	151	%
T/C	=	144	%
T/C	=	126	%
T/C	=	116	%
T/C	=	104	%
T/C	=	100	%
T/C	=	104	%
T/C	=	134	%
T/C	=	133	%
T/C	=	100	%