HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 12

External ID: CHEMBL3129538

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2014
Volume: 22
Issue: 6
First Page: 1821
Last Page: 1831
DOI: 10.1016/j.bmc.2014.01.056

Target ChEMBL ID: CHEMBL3242
ChEMBL Target Name: Carbonic anhydrase XII
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
50	Ki	>	50000	nM
1.78	Ki	=	1780	nM
2.52	Ki	=	2520	nM
2.76	Ki	=	2760	nM
0.97	Ki	=	970	nM
0.24	Ki	=	240	nM
0.71	Ki	=	710	nM
1.31	Ki	=	1310	nM
2.01	Ki	=	2010	nM
0.57	Ki	=	570	nM
0.24	Ki	=	240	nM
0.0419	Ki	=	41.9	nM
0.0765	Ki	=	76.5	nM
0.25	Ki	=	250	nM
0.15	Ki	=	150	nM
0.0246	Ki	=	24.6	nM
0.094	Ki	=	94	nM
0.0281	Ki	=	28.1	nM
0.21	Ki	=	210	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 9

External ID: CHEMBL3129539

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2014
Volume: 22
Issue: 6
First Page: 1821
Last Page: 1831
DOI: 10.1016/j.bmc.2014.01.056

Target ChEMBL ID: CHEMBL3594
ChEMBL Target Name: Carbonic anhydrase IX
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.4	Ki	=	400	nM
50	Ki	>	50000	nM
50	Ki	>	50000	nM
0.39	Ki	=	390	nM
50	Ki	>	50000	nM
0.27	Ki	=	270	nM
0.29	Ki	=	290	nM
50	Ki	>	50000	nM
50	Ki	>	50000	nM
0.21	Ki	=	210	nM
0.31	Ki	=	310	nM
0.31	Ki	=	310	nM
0.33	Ki	=	330	nM
50	Ki	>	50000	nM
0.24	Ki	=	240	nM
0.011	Ki	=	11	nM
0.14	Ki	=	140	nM
0.091	Ki	=	91	nM
0.097	Ki	=	97	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 1

External ID: CHEMBL3129540

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2014
Volume: 22
Issue: 6
First Page: 1821
Last Page: 1831
DOI: 10.1016/j.bmc.2014.01.056

Target ChEMBL ID: CHEMBL261
ChEMBL Target Name: Carbonic anhydrase I
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
50	Ki	>	50000	nM
50	Ki	>	50000	nM
50	Ki	>	50000	nM
50	Ki	>	50000	nM
50	Ki	>	50000	nM
50	Ki	>	50000	nM
50	Ki	>	50000	nM
50	Ki	>	50000	nM
50	Ki	>	50000	nM
50	Ki	>	50000	nM
50	Ki	>	50000	nM
50	Ki	>	50000	nM
50	Ki	>	50000	nM
50	Ki	>	50000	nM
50	Ki	>	50000	nM
50	Ki	>	50000	nM
50	Ki	>	50000	nM
50	Ki	>	50000	nM
50	Ki	>	50000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 2

External ID: CHEMBL3129541

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2014
Volume: 22
Issue: 6
First Page: 1821
Last Page: 1831
DOI: 10.1016/j.bmc.2014.01.056

Target ChEMBL ID: CHEMBL205
ChEMBL Target Name: Carbonic anhydrase II
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
2.6	Ki	=	2600	nM
50	Ki	>	50000	nM
50	Ki	>	50000	nM
50	Ki	>	50000	nM
50	Ki	>	50000	nM
0.0414	Ki	=	41.4	nM
50	Ki	>	50000	nM
0.46	Ki	=	460	nM
50	Ki	>	50000	nM
0.158	Ki	=	158	nM
50	Ki	>	50000	nM
50	Ki	>	50000	nM
2.21	Ki	=	2210	nM
50	Ki	>	50000	nM
0.0476	Ki	=	47.6	nM
0.0391	Ki	=	39.1	nM
0.086	Ki	=	86	nM
0.0409	Ki	=	40.9	nM
0.0367	Ki	=	36.7	nM

41335-48-2 靶点实验数据