HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Glycogen synthase kinase-3 beta

External ID: CHEMBL920549

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2005
Volume: 48
Issue: 23
First Page: 7103
Last Page: 7112
DOI: 10.1021/jm040895g

Target ChEMBL ID: CHEMBL2095188
ChEMBL Target Name: Glycogen synthase kinase-3
ChEMBL Target Type: PROTEIN FAMILY - Target is a group of closely related proteins
Relationship Type: H - Homologous protein target assigned
Confidence: Multiple homologous protein targets may be assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
2	IC50	=	2000	nM
5	IC50	=	5000	nM
10	IC50	=	10000	nM
5	IC50	=	5000	nM
1	IC50	=	1000	nM
3	IC50	=	3000	nM
2.5	IC50	=	2500	nM
2	IC50	=	2000	nM
3	IC50	=	3000	nM
3	IC50	=	3000	nM
3	IC50	=	3000	nM
12	IC50	=	12000	nM
100	IC50	>	100000	nM
50	IC50	>	50000	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM
100	IC50	=	100000	nM
100	IC50	=	100000	nM
100	IC50	=	100000	nM
100	IC50	=	100000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：BindingDB 靶标：N/A

External ID: BindingDB_985_1

Protocol: N/A

Comment: Compounds with any of Ki, IC50, Kd, or EC50 activity value <= 10uM are labeled as "Active".
If multiple measurements are available for a given compound, it is labeled as "Active" if any of the measurements meet the criterion. Activity values are checked in the order of Ki, IC50, Kd, and EC50. The first entry that meets the above activity threshold is used to determine "Standard Type", "Standard Relation", and "PubChem Standard Value". Otherwise, the first non-empty entry will be used to set those values.

Standard Type	PubChem Standard Value	IC50	Target Accession(s)	Ligand	Target
IC50	7	7000	G1T8E2	BDBM7782	Glycogen synthase kinase-3 beta [7-25]
IC50	2	2000	G1T8E2	BDBM7784	Glycogen synthase kinase-3 beta [7-25]
IC50	4	4000	G1T8E2	BDBM7789	Glycogen synthase kinase-3 beta [7-25]
IC50	10	10000	G1T8E2	BDBM7798	Glycogen synthase kinase-3 beta [7-25]
IC50	75	75000	G1T8E2	BDBM7799	Glycogen synthase kinase-3 beta [7-25]

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Glycogen synthase kinase-3 beta

External ID: CHEMBL684978

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2002
Volume: 45
Issue: 6
First Page: 1292
Last Page: 1299
DOI: 10.1021/jm011020u

Target ChEMBL ID: CHEMBL262
ChEMBL Target Name: Glycogen synthase kinase-3 beta
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
10	IC50	=	10000	nM
2	IC50	=	2000	nM
5	IC50	=	5000	nM
10	IC50	=	10000	nM

410074-61-2 靶点实验数据