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405-85-6 靶点实验数据

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:Nuclear receptor subfamily 4 group A member 2
External ID: CHEMBL5392237
Protocol: N/A
Comment: Journal: J Med Chem
Year: 2023
Volume: 66
Issue: 22
First Page: 15362
Last Page: 15369
DOI: 10.1021/acs.jmedchem.3c01467

Target ChEMBL ID: CHEMBL5002
ChEMBL Target Name: Nuclear receptor subfamily 4 group A member 2
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned
Standard TypeStandard RelationStandard ValueStandard Units
Emax=144%
Emax=130%
Emax=166%
Emax=169%
Emax=151%
Emax=142%
Emax=140%
Emax=169%
Emax=177%
Emax=165%
Emax=290%
Emax=161%
Emax=145%
Emax=132%
Emax=186%
Emax=159%
Emax=200%
Emax=230%
Emax=220%
Emax=160%
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:Nuclear receptor subfamily 4 group A member 2
External ID: CHEMBL5392236
Protocol: N/A
Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Med Chem
Year: 2023
Volume: 66
Issue: 22
First Page: 15362
Last Page: 15369
DOI: 10.1021/acs.jmedchem.3c01467

Target ChEMBL ID: CHEMBL5002
ChEMBL Target Name: Nuclear receptor subfamily 4 group A member 2
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned
PubChem Standard ValueStandard TypeStandard RelationStandard ValueStandard UnitsActivity CommentData Validity Comment
3EC50=3000nM
12EC50=12000nM
8EC50=8000nM
0.05EC50=50nM
134EC50=134000nMOutside typical range
0.12EC50=120nM
6EC50=6000nM
1EC50=1000nM
0.97EC50=970nM
EC50Not Determined(Insoluble)
6EC50=6000nM
0.09EC50=90nM
0.52EC50=520nM
0.11EC50=110nM
0.5EC50=500nM
76EC50=76000nM
19EC50=19000nM
7EC50=7000nM