HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 4

External ID: CHEMBL659048

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2003
Volume: 46
Issue: 11
First Page: 2187
Last Page: 2196
DOI: 10.1021/jm021123s

Target ChEMBL ID: CHEMBL281
ChEMBL Target Name: Carbonic anhydrase IV
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.38	Ki	=	380	nM
0.013	Ki	=	13	nM
0.066	Ki	=	66	nM
0.18	Ki	=	180	nM
0.036	Ki	=	36	nM
0.07	Ki	=	70	nM
0.32	Ki	=	320	nM
3	Ki	=	3000	nM
0.004	Ki	=	4	nM
0.0046	Ki	=	4.6	nM
0.0042	Ki	=	4.2	nM
0.165	Ki	=	165	nM
0.0025	Ki	=	2.5	nM
0.002	Ki	=	2	nM
0.0045	Ki	=	4.5	nM
0.095	Ki	=	95	nM
0.043	Ki	=	43	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：BindingDB 靶标：N/A

External ID: BindingDB_1469_1

Protocol: N/A

Comment: Compounds with any of Ki, IC50, Kd, or EC50 activity value <= 10uM are labeled as "Active".
If multiple measurements are available for a given compound, it is labeled as "Active" if any of the measurements meet the criterion. Activity values are checked in the order of Ki, IC50, Kd, and EC50. The first entry that meets the above activity threshold is used to determine "Standard Type", "Standard Relation", and "PubChem Standard Value". Otherwise, the first non-empty entry will be used to set those values.

Standard Type	PubChem Standard Value	Ki	Target Accession(s)	Ligand	Target
Ki	0.54	540	Q95323	BDBM10868	Carbonic anhydrase 4
Ki	0.041	41	Q16790	BDBM10868	Carbonic anhydrase 9
Ki	4.2	4200	P00915	BDBM11596	Carbonic anhydrase 1
Ki	0.029	29	P00918	BDBM11596	Carbonic anhydrase 2
Ki	0.105	105	Q95323	BDBM11596	Carbonic anhydrase 4
Ki	0.213	213	Q16790	BDBM11596	Carbonic anhydrase 9
Ki	28	28000	P00915	BDBM10857	Carbonic anhydrase 1
Ki	0.3	300	P00918	BDBM10857	Carbonic anhydrase 2
Ki	3	3000	Q95323	BDBM10857	Carbonic anhydrase 4
Ki	0.294	294	Q16790	BDBM10857	Carbonic anhydrase 9
Ki	8.3	8300	P00915	BDBM10862	Carbonic anhydrase 1
Ki	0.06	60	P00918	BDBM10862	Carbonic anhydrase 2
Ki	0.18	180	Q95323	BDBM10862	Carbonic anhydrase 4
Ki	0.245	245	Q16790	BDBM10862	Carbonic anhydrase 9
Ki	9.8	9800	P00915	BDBM10863	Carbonic anhydrase 1
Ki	0.11	110	P00918	BDBM10863	Carbonic anhydrase 2
Ki	0.32	320	Q95323	BDBM10863	Carbonic anhydrase 4
Ki	0.264	264	Q16790	BDBM10863	Carbonic anhydrase 9
Ki	6.5	6500	P00915	BDBM10864	Carbonic anhydrase 1
Ki	0.04	40	P00918	BDBM10864	Carbonic anhydrase 2

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 9

External ID: CHEMBL657042

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2003
Volume: 46
Issue: 11
First Page: 2187
Last Page: 2196
DOI: 10.1021/jm021123s

Target ChEMBL ID: CHEMBL3594
ChEMBL Target Name: Carbonic anhydrase IX
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.05	Ki	=	50	nM
0.034	Ki	=	34	nM
0.269	Ki	=	269	nM
0.245	Ki	=	245	nM
0.027	Ki	=	27	nM
0.025	Ki	=	25	nM
0.264	Ki	=	264	nM
0.294	Ki	=	294	nM
0.079	Ki	=	79	nM
0.078	Ki	=	78	nM
0.071	Ki	=	71	nM
0.027	Ki	=	27	nM
0.046	Ki	=	46	nM
0.213	Ki	=	213	nM
0.027	Ki	=	27	nM
0.012	Ki	=	12	nM
0.052	Ki	=	52	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 2

External ID: CHEMBL657145

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2003
Volume: 46
Issue: 11
First Page: 2187
Last Page: 2196
DOI: 10.1021/jm021123s

Target ChEMBL ID: CHEMBL205
ChEMBL Target Name: Carbonic anhydrase II
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.038	Ki	=	38	nM
0.008	Ki	=	8	nM
0.04	Ki	=	40	nM
0.06	Ki	=	60	nM
0.014	Ki	=	14	nM
0.012	Ki	=	12	nM
0.11	Ki	=	110	nM
0.3	Ki	=	300	nM
0.0012	Ki	=	1.2	nM
0.0015	Ki	=	1.5	nM
0.0013	Ki	=	1.3	nM
0.05	Ki	=	50	nM
8.0E-4	Ki	=	0.8	nM
6.0E-4	Ki	=	0.6	nM
0.0017	Ki	=	1.7	nM
0.032	Ki	=	32	nM
0.009	Ki	=	9	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 1

External ID: CHEMBL657820

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2003
Volume: 46
Issue: 11
First Page: 2187
Last Page: 2196
DOI: 10.1021/jm021123s

Target ChEMBL ID: CHEMBL261
ChEMBL Target Name: Carbonic anhydrase I
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
1.2	Ki	=	1200	nM
0.025	Ki	=	25	nM
6.5	Ki	=	6500	nM
8.3	Ki	=	8300	nM
0.05	Ki	=	50	nM
0.25	Ki	=	250	nM
9.8	Ki	=	9800	nM
28	Ki	=	28000	nM
0.0057	Ki	=	5.7	nM
0.005	Ki	=	5	nM
0.0054	Ki	=	5.4	nM
7	Ki	=	7000	nM
0.0031	Ki	=	3.1	nM
0.0013	Ki	=	1.3	nM
0.0052	Ki	=	5.2	nM
3.8	Ki	=	3800	nM
50	Ki	=	50000	nM

402-22-2 靶点实验数据