HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Thioredoxin reductase

External ID: CHEMBL869602

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2006
Volume: 16
Issue: 8
First Page: 2283
Last Page: 2292
DOI: 10.1016/j.bmcl.2006.01.027

Target ChEMBL ID: CHEMBL4547
ChEMBL Target Name: Thioredoxin reductase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
40	IC50	=	40000	nM
2	IC50	=	2000	nM
30	IC50	=	30000	nM
10	IC50	=	10000	nM
2	IC50	=	2000	nM
20	IC50	=	20000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Thioredoxin reductase 3

External ID: CHEMBL869603

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2006
Volume: 16
Issue: 8
First Page: 2283
Last Page: 2292
DOI: 10.1016/j.bmcl.2006.01.027

Target ChEMBL ID: CHEMBL2096978
ChEMBL Target Name: Thioredoxin reductase
ChEMBL Target Type: PROTEIN FAMILY - Target is a group of closely related proteins
Relationship Type: D - Direct protein target assigned
Confidence: Multiple direct protein targets may be assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
200	IC50	>	200000	nM	Outside typical range
140	IC50	=	140000	nM	Outside typical range
200	IC50	>	200000	nM	Outside typical range
200	IC50	>	200000	nM	Outside typical range
80	IC50	=	80000	nM
50	IC50	=	50000	nM
150	IC50	>	150000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL861196

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2006
Volume: 16
Issue: 8
First Page: 2283
Last Page: 2292
DOI: 10.1016/j.bmcl.2006.01.027

Standard Type	Standard Relation	Standard Value
Ratio IC50	=	12
Ratio IC50	=	9
Ratio IC50	=	0.2
Ratio IC50	>	5
Ratio IC50	=	70
Ratio IC50	>	6
Ratio IC50	=	25
Ratio IC50	>	7
Ratio IC50	=	8

401-99-0 靶点实验数据