HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 1

External ID: CHEMBL3269991

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2014
Volume: 22
Issue: 10
First Page: 2867
Last Page: 2874
DOI: 10.1016/j.bmc.2014.03.041

Target ChEMBL ID: CHEMBL261
ChEMBL Target Name: Carbonic anhydrase I
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.012	Ki	=	12	nM
0.3	Ki	=	300	nM
0.0567	Ki	=	56.7	nM
0.08	Ki	=	80	nM
0.311	Ki	=	311	nM
7.46	Ki	=	7460	nM
1.04	Ki	=	1040	nM
7.45	Ki	=	7450	nM
1.29	Ki	=	1290	nM
0.1166	Ki	=	116.6	nM
0.266	Ki	=	266	nM
0.1164	Ki	=	116.4	nM
0.1895	Ki	=	189.5	nM
0.2283	Ki	=	228.3	nM
0.0503	Ki	=	50.3	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 2

External ID: CHEMBL3269990

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2014
Volume: 22
Issue: 10
First Page: 2867
Last Page: 2874
DOI: 10.1016/j.bmc.2014.03.041

Target ChEMBL ID: CHEMBL205
ChEMBL Target Name: Carbonic anhydrase II
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.25	Ki	=	250	nM
28	Ki	=	28000	nM
0.1232	Ki	=	123.2	nM
0.0111	Ki	=	11.1	nM
0.105	Ki	=	105	nM
0.78	Ki	=	780	nM
1.3	Ki	=	1300	nM
11.25	Ki	=	11250	nM
13.3	Ki	=	13300	nM
0.0214	Ki	=	21.4	nM
0.1845	Ki	=	184.5	nM
0.2005	Ki	=	200.5	nM
0.1425	Ki	=	142.5	nM
5.329	Ki	=	5329	nM
0.0086	Ki	=	8.6	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Cholinesterase

External ID: CHEMBL3879585

Protocol: N/A

Comment: Journal: Bioorg Med Chem
Year: 2017
Volume: 25
Issue: 4
First Page: 1471
Last Page: 1480
DOI: 10.1016/j.bmc.2017.01.010

Target ChEMBL ID: CHEMBL5763
ChEMBL Target Name: Cholinesterase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
386.9	IC50	=	386900	nM	Outside typical range
746.7	IC50	=	746700	nM	Outside typical range
291.5	IC50	=	291500	nM	Outside typical range
839	IC50	=	839000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3879586

Protocol: N/A

Comment: Journal: Bioorg Med Chem
Year: 2017
Volume: 25
Issue: 4
First Page: 1471
Last Page: 1480
DOI: 10.1016/j.bmc.2017.01.010

Standard Type	Standard Relation	Standard Value
Ratio IC50	=	381
Ratio IC50	=	39.71
Ratio IC50	=	29.25
Ratio IC50	=	32.73
Ratio IC50	=	39.77

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3269994

Protocol: N/A

Comment: Journal: Bioorg Med Chem
Year: 2014
Volume: 22
Issue: 10
First Page: 2867
Last Page: 2874
DOI: 10.1016/j.bmc.2014.03.041

Standard Type	Standard Text Value
solubility	soluble
solubility	soluble
solubility	soluble
solubility	soluble
solubility	soluble
solubility	soluble
solubility	soluble
solubility	soluble
solubility	soluble

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 2

External ID: CHEMBL1059274

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2009
Volume: 19
Issue: 21
First Page: 6014
Last Page: 6017
DOI: 10.1016/j.bmcl.2009.09.047

Target ChEMBL ID: CHEMBL205
ChEMBL Target Name: Carbonic anhydrase II
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.1415	Ki	=	141.5	nM
5.329	Ki	=	5329	nM
0.1425	Ki	=	142.5	nM
0.1305	Ki	=	130.5	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Acetylcholinesterase

External ID: CHEMBL3879584

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem
Year: 2017
Volume: 25
Issue: 4
First Page: 1471
Last Page: 1480
DOI: 10.1016/j.bmc.2017.01.010

Target ChEMBL ID: CHEMBL4078
ChEMBL Target Name: Acetylcholinesterase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
6	IC50	=	6000	nM
25.53	IC50	=	25530	nM
6.09	IC50	=	6090	nM
3.93	IC50	=	3930	nM

3939-41-1 靶点实验数据