HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL2449007

Protocol: N/A

Comment: Journal: Pharm Res
Year: 2013
DOI: 10.1007/s11095-013-1232-z

Standard Type	Standard Value	Activity Comment
pKa	8.11	Basic pKa
pKa	8.31	Basic pKa
pKa	6.01	Acidic pKa
pKa	4.42	Acidic pKa
pKa	6.16	Acidic pKa
pKa	8.62	Basic pKa
pKa	6.23	Acidic pKa
pKa	8.51	Basic pKa
pKa	9.51	Basic pKa
pKa	9.56	Basic pKa
pKa	9.51	Basic pKa
pKa	2.65	Acidic pKa
pKa	8.02	Basic pKa
pKa	9.54	Basic pKa
pKa	3.5	Acidic pKa
pKa	2.88	Acidic pKa
pKa	9.53	Basic pKa
pKa	3.52	Acidic pKa
pKa	7.9	Basic pKa
pKa	10.13	Basic pKa

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL875169

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1997
Volume: 40
Issue: 9
First Page: 1340
Last Page: 1346
DOI: 10.1021/jm960436i

Standard Type	Standard Relation	Standard Value
pKa1	=	8.79
pKa1	=	8.74
pKa1	=	8.88
pKa1	=	8.96
pKa1	=	7.73
pKa1	=	8.99
pKa1	=	8.84
pKa1	=	7.61
pKa1	=	8.18

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Pasteurella multocida

External ID: CHEMBL763912

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1997
Volume: 40
Issue: 9
First Page: 1340
Last Page: 1346
DOI: 10.1021/jm960436i

Target ChEMBL ID: CHEMBL614409
ChEMBL Target Name: Pasteurella multocida
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MIC	=	0.2	ug.mL-1
MIC	=	0.78	ug.mL-1
MIC	=	25	ug.mL-1
MIC	=	0.39	ug.mL-1
MIC	=	6.25	ug.mL-1
MIC	=	1.56	ug.mL-1
MIC	=	1.56	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：Southern Research Specialized Biocontainment Screening Center 靶标：cyclic AMP receptor protein [Vibrio cholerae O1 biovar El Tor str. N16961]

External ID: Vcholera_QS_Pilot

Protocol: Vibrio cholerae assay for pro-quorum sensing small molecules
One hundred and twenty five nl of test compound was dispensed to a dry assay plate (Corning 3571) with an Echo555. Then 5ul of LB was added to the plates with a Matrix/Thermo Wellmate. Bacterial inoculation was also done with a Wellmate. Twenty ul of a stationary phase culture of a quorum sensing reporter strain was dispensed to the assay plates. Plates were incubated at 30C for 6 hours then read using Luminescence mode with a 0.1 second integration time on a Perkin Elmer Envision.

Comment: Possible artifacts in the V. cholerae Quorum Sensing assay include, but are not limited to, compounds that inhibit light production or kill the bacteria (false negative) and compounds that precipitate.
Compounds with luminescence values greater than 1038 (mean+3 standard deviations) were considered to show sufficient activity in the primary screen to be considered for followup. However, for this pilot study, only 2 compounds were actually tested in the confirmatory assay. Compounds showing as active in the primary screen that have no conclusive confirmatory data are categorized as "inconclusive". Primary screen data are scored based on relative activity on a scale of 0-40. Confirmatory data are scored based on reative IC50 values in the range of 41-80.

Primary Screen LUM Value	Primary Screen Concentration	Primary Screen Concentration Unit
0	50	uM
0	50	uM
40	50	uM
40	50	uM
0	50	uM
0	50	uM
0	50	uM
0	50	uM
0	50	uM
40	50	uM
40	50	uM
0	50	uM
0	50	uM
0	50	uM
0	50	uM
40	50	uM
0	50	uM
0	50	uM
40	50	uM
40	50	uM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Escherichia coli

External ID: CHEMBL1247932

Protocol: N/A

Comment: Journal: Antimicrob. Agents Chemother.
Year: 2010
Volume: 54
Issue: 3
First Page: 1007
Last Page: 1015
DOI: 10.1128/aac.01126-09

Target ChEMBL ID: CHEMBL354
ChEMBL Target Name: Escherichia coli
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MIC	=	1	ug.mL-1
MIC	=	512	ug.mL-1
MIC	=	16	ug.mL-1
MIC	=	64	ug.mL-1
MIC	=	512	ug.mL-1
MIC	>	1024	ug.mL-1
MIC	=	4	ug.mL-1
MIC	>	1024	ug.mL-1
MIC	>	1024	ug.mL-1
MIC	=	16	ug.mL-1
MIC	>	512	ug.mL-1
MIC	=	16	ug.mL-1
MIC	=	32	ug.mL-1
MIC	>	1024	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Escherichia coli

External ID: CHEMBL1247931

Protocol: N/A

Comment: Journal: Antimicrob. Agents Chemother.
Year: 2010
Volume: 54
Issue: 3
First Page: 1007
Last Page: 1015
DOI: 10.1128/aac.01126-09

Target ChEMBL ID: CHEMBL354
ChEMBL Target Name: Escherichia coli
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MIC	=	0.25	ug.mL-1
MIC	=	128	ug.mL-1
MIC	=	32	ug.mL-1
MIC	=	64	ug.mL-1
MIC	=	512	ug.mL-1
MIC	=	1024	ug.mL-1
MIC	=	4	ug.mL-1
MIC	>	1024	ug.mL-1
MIC	>	1024	ug.mL-1
MIC	=	8	ug.mL-1
MIC	>	512	ug.mL-1
MIC	=	8	ug.mL-1
MIC	=	16	ug.mL-1
MIC	>	1024	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL630826

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1997
Volume: 40
Issue: 9
First Page: 1340
Last Page: 1346
DOI: 10.1021/jm960436i

Standard Type	Standard Relation	Standard Value
CLogP	=	-0.491
CLogP	=	1.826
CLogP	=	0.653
CLogP	=	0.355
CLogP	=	-0.786
CLogP	=	1.276
CLogP	=	0.596
CLogP	=	0.526
CLogP	=	2.502

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Escherichia coli

External ID: CHEMBL1247930

Protocol: N/A

Comment: Journal: Antimicrob. Agents Chemother.
Year: 2010
Volume: 54
Issue: 3
First Page: 1007
Last Page: 1015
DOI: 10.1128/aac.01126-09

Target ChEMBL ID: CHEMBL354
ChEMBL Target Name: Escherichia coli
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MIC	=	0.5	ug.mL-1
MIC	=	128	ug.mL-1
MIC	=	16	ug.mL-1
MIC	=	128	ug.mL-1
MIC	=	512	ug.mL-1
MIC	=	1024	ug.mL-1
MIC	=	4	ug.mL-1
MIC	>	1024	ug.mL-1
MIC	>	1024	ug.mL-1
MIC	=	8	ug.mL-1
MIC	>	512	ug.mL-1
MIC	=	8	ug.mL-1
MIC	=	32	ug.mL-1
MIC	>	1024	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Escherichia coli

External ID: CHEMBL1247929

Protocol: N/A

Comment: Journal: Antimicrob. Agents Chemother.
Year: 2010
Volume: 54
Issue: 3
First Page: 1007
Last Page: 1015
DOI: 10.1128/aac.01126-09

Target ChEMBL ID: CHEMBL354
ChEMBL Target Name: Escherichia coli
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MIC	=	0.004	ug.mL-1
MIC	=	8	ug.mL-1
MIC	=	4	ug.mL-1
MIC	=	2	ug.mL-1
MIC	=	8	ug.mL-1
MIC	=	16	ug.mL-1
MIC	=	0.5	ug.mL-1
MIC	>	1024	ug.mL-1
MIC	>	1024	ug.mL-1
MIC	=	4	ug.mL-1
MIC	=	8	ug.mL-1
MIC	=	1	ug.mL-1
MIC	=	4	ug.mL-1
MIC	=	64	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL633444

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1997
Volume: 40
Issue: 9
First Page: 1340
Last Page: 1346
DOI: 10.1021/jm960436i

Standard Type	Standard Relation	Standard Value
pCF	=	0.017
pCF	=	1.36
pCF	=	0.014
pCF	=	1.572
pCF	=	0.167
pCF	=	0.011
pCF	=	0.015
pCF	=	0.209
pCF	=	0.847

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：11908 靶标：N/A

External ID: RMI-FANCM-MM2

Protocol: FP HTS. Screening took place at the University of Wisconsin Small Molecule Screening and Synthesis Facility. A master mix of RMI core complex and F-MM2 (30 microL per well) was plated in black 384 shallow well plates (ThermoFisher, Waltham, MA), using a BioTek "MicroFlo Select" reagent dispenser. Compounds were added using a Beckman FX liquid handler; 0.33 microL of 10 mM stock was added for a final compound concentration of 33 microM. MM2 and cMM2 were each added to 4 wells of master mix per plate to a final concentration of 10 muM to serve as controls. Following compound addition, plates were covered, centrifuged briefly, and incubated for 20 minutes at room temperature. FP measurements were taking using a Tecan "Safire 2" microplate reader. Instrument settings were as follows: top read, EX 470, EM 525/20, G-factor 0.89947. A suitable gain was calculated from the first plate of each day. Z' scores for were calculated for each plate; plates with Z' scores <0.5 were rerun prior to analysis.

Comment:

Concentration uM	Data readout
33	55
33	63
33	65
33	63
33	61
33	62
33	61
33	58
33	71
33	61
33	64
33	83
33	158
33	84
33	104
33	60
33	62
33	59
33	58
33	59

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Homo sapiens

External ID: CHEMBL1027763

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2009
Volume: 52
Issue: 14
First Page: 4488
Last Page: 4495
DOI: 10.1021/jm9004658

Target ChEMBL ID: CHEMBL372
ChEMBL Target Name: Homo sapiens
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Vdss	=	0.62	L.kg-1
Vdss	=	2.6	L.kg-1
Vdss	=	2.38	L.kg-1
Vdss	=	1.03	L.kg-1
Vdss	=	0.77	L.kg-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mus musculus

External ID: CHEMBL722018

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1997
Volume: 40
Issue: 9
First Page: 1340
Last Page: 1346
DOI: 10.1021/jm960436i

Target ChEMBL ID: CHEMBL375
ChEMBL Target Name: Mus musculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
PD50	=	68	mg kg-1
PD50	=	16	mg kg-1
PD50	>	150	mg kg-1
PD50	=	86	mg kg-1
PD50	=	100	mg kg-1
PD50	>	150	mg kg-1
PD50	>	150	mg kg-1
PD50	=	100	mg kg-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Burkholderia pseudomallei

External ID: CHEMBL919475

Protocol: N/A

Comment: Journal: Antimicrob Agents Chemother
Year: 2007
Volume: 51
Issue: 2
First Page: 623
Last Page: 630
DOI: 10.1128/aac.01033-06

Target ChEMBL ID: CHEMBL3140323
ChEMBL Target Name: Burkholderia pseudomallei
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MIC	=	32	ug.mL-1
MIC	=	128	ug.mL-1
MIC	=	256	ug.mL-1
MIC	>	2000	ug.mL-1
MIC	=	1024	ug.mL-1
MIC	=	2	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL635403

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1997
Volume: 40
Issue: 9
First Page: 1340
Last Page: 1346
DOI: 10.1021/jm960436i

Standard Type	Standard Relation	Standard Value
CLogP	=	0
CLogP	=	0
CLogP	=	0
CLogP	=	1.18
CLogP	=	0
CLogP	=	0
CLogP	=	0
CLogP	=	0
CLogP	=	0

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL630700

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1997
Volume: 40
Issue: 9
First Page: 1340
Last Page: 1346
DOI: 10.1021/jm960436i

Standard Type	Standard Relation	Standard Value
pNF	=	1.407
pNF	=	3.41
pNF	=	1.494
pNF	=	4.12
pNF	=	0.497
pNF	=	1.601
pNF	=	1.455
pNF	=	0.419
pNF	=	3.007

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Burkholderia pseudomallei

External ID: CHEMBL919480

Protocol: N/A

Comment: Journal: Antimicrob Agents Chemother
Year: 2007
Volume: 51
Issue: 2
First Page: 623
Last Page: 630
DOI: 10.1128/aac.01033-06

Target ChEMBL ID: CHEMBL3140323
ChEMBL Target Name: Burkholderia pseudomallei
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MIC	=	32	ug.mL-1
MIC	=	32	ug.mL-1
MIC	=	128	ug.mL-1
MIC	=	256	ug.mL-1
MIC	=	1024	ug.mL-1
MIC	=	2	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Burkholderia pseudomallei

External ID: CHEMBL918917

Protocol: N/A

Comment: Journal: Antimicrob Agents Chemother
Year: 2007
Volume: 51
Issue: 2
First Page: 623
Last Page: 630
DOI: 10.1128/aac.01033-06

Target ChEMBL ID: CHEMBL3140323
ChEMBL Target Name: Burkholderia pseudomallei
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MIC	=	32	ug.mL-1
MIC	=	64	ug.mL-1
MIC	=	256	ug.mL-1
MIC	=	512	ug.mL-1
MIC	=	1024	ug.mL-1
MIC	=	2	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Burkholderia pseudomallei

External ID: CHEMBL918918

Protocol: N/A

Comment: Journal: Antimicrob Agents Chemother
Year: 2007
Volume: 51
Issue: 2
First Page: 623
Last Page: 630
DOI: 10.1128/aac.01033-06

Target ChEMBL ID: CHEMBL3140323
ChEMBL Target Name: Burkholderia pseudomallei
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MIC	=	32	ug.mL-1
MIC	=	64	ug.mL-1
MIC	=	256	ug.mL-1
MIC	=	512	ug.mL-1
MIC	=	1024	ug.mL-1
MIC	=	2	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Burkholderia pseudomallei

External ID: CHEMBL918919

Protocol: N/A

Comment: Journal: Antimicrob Agents Chemother
Year: 2007
Volume: 51
Issue: 2
First Page: 623
Last Page: 630
DOI: 10.1128/aac.01033-06

Target ChEMBL ID: CHEMBL3140323
ChEMBL Target Name: Burkholderia pseudomallei
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MIC	=	32	ug.mL-1
MIC	=	128	ug.mL-1
MIC	=	256	ug.mL-1
MIC	>	2000	ug.mL-1
MIC	=	1024	ug.mL-1
MIC	=	2	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Burkholderia pseudomallei

External ID: CHEMBL919476

Protocol: N/A

Comment: Journal: Antimicrob Agents Chemother
Year: 2007
Volume: 51
Issue: 2
First Page: 623
Last Page: 630
DOI: 10.1128/aac.01033-06

Target ChEMBL ID: CHEMBL3140323
ChEMBL Target Name: Burkholderia pseudomallei
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MIC	<	0.25	ug.mL-1
MIC	=	8	ug.mL-1
MIC	<	0.25	ug.mL-1
MIC	=	64	ug.mL-1
MIC	=	256	ug.mL-1
MIC	<	0.25	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Burkholderia pseudomallei

External ID: CHEMBL919477

Protocol: N/A

Comment: Journal: Antimicrob Agents Chemother
Year: 2007
Volume: 51
Issue: 2
First Page: 623
Last Page: 630
DOI: 10.1128/aac.01033-06

Target ChEMBL ID: CHEMBL3140323
ChEMBL Target Name: Burkholderia pseudomallei
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MIC	<	0.25	ug.mL-1
MIC	=	8	ug.mL-1
MIC	<	0.25	ug.mL-1
MIC	=	64	ug.mL-1
MIC	=	256	ug.mL-1
MIC	<	0.25	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Burkholderia pseudomallei

External ID: CHEMBL919478

Protocol: N/A

Comment: Journal: Antimicrob Agents Chemother
Year: 2007
Volume: 51
Issue: 2
First Page: 623
Last Page: 630
DOI: 10.1128/aac.01033-06

Target ChEMBL ID: CHEMBL3140323
ChEMBL Target Name: Burkholderia pseudomallei
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MIC	<	0.25	ug.mL-1
MIC	=	8	ug.mL-1
MIC	=	32	ug.mL-1
MIC	=	128	ug.mL-1
MIC	=	512	ug.mL-1
MIC	=	2	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Burkholderia pseudomallei

External ID: CHEMBL919479

Protocol: N/A

Comment: Journal: Antimicrob Agents Chemother
Year: 2007
Volume: 51
Issue: 2
First Page: 623
Last Page: 630
DOI: 10.1128/aac.01033-06

Target ChEMBL ID: CHEMBL3140323
ChEMBL Target Name: Burkholderia pseudomallei
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MIC	=	16	ug.mL-1
MIC	=	32	ug.mL-1
MIC	=	32	ug.mL-1
MIC	=	256	ug.mL-1
MIC	=	1024	ug.mL-1
MIC	=	2	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Oleandomycin glycosyltransferase

External ID: CHEMBL1226482

Protocol: N/A

Comment: Journal: Nat. Chem. Biol.
Year: 2007
Volume: 3
Issue: 10
First Page: 657
Last Page: 662
DOI: 10.1038/nchembio.2007.28

Target ChEMBL ID: CHEMBL3308957
ChEMBL Target Name: Oleandomycin glycosyltransferase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	26	nmol/min
Activity	=	24	nmol/min
Activity	=	84	nmol/min
Activity	=	3.6	nmol/min
Activity	=	28	nmol/min
Activity	=	0.62	nmol/min
Activity	=	1.14	nmol/min
Activity	=	13	nmol/min

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Burkholderia pseudomallei

External ID: CHEMBL918924

Protocol: N/A

Comment: Journal: Antimicrob Agents Chemother
Year: 2007
Volume: 51
Issue: 2
First Page: 623
Last Page: 630
DOI: 10.1128/aac.01033-06

Target ChEMBL ID: CHEMBL3140323
ChEMBL Target Name: Burkholderia pseudomallei
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MIC	=	32	ug.mL-1
MIC	=	128	ug.mL-1
MIC	=	256	ug.mL-1
MIC	>	2000	ug.mL-1
MIC	=	1024	ug.mL-1
MIC	=	2	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Oleandomycin glycosyltransferase

External ID: CHEMBL1226481

Protocol: N/A

Comment: Journal: Nat. Chem. Biol.
Year: 2007
Volume: 3
Issue: 10
First Page: 657
Last Page: 662
DOI: 10.1038/nchembio.2007.28

Target ChEMBL ID: CHEMBL3308957
ChEMBL Target Name: Oleandomycin glycosyltransferase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	14.1	nmol/min
Activity	=	8.5	nmol/min
Activity	=	5.4	nmol/min
Activity	=	0.16	nmol/min
Activity	=	15.3	nmol/min
Activity	=	0.01	nmol/min
Activity	=	0.33	nmol/min
Activity	=	70	nmol/min

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Burkholderia pseudomallei

External ID: CHEMBL918925

Protocol: N/A

Comment: Journal: Antimicrob Agents Chemother
Year: 2007
Volume: 51
Issue: 2
First Page: 623
Last Page: 630
DOI: 10.1128/aac.01033-06

Target ChEMBL ID: CHEMBL3140323
ChEMBL Target Name: Burkholderia pseudomallei
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MIC	=	32	ug.mL-1
MIC	=	128	ug.mL-1
MIC	=	256	ug.mL-1
MIC	>	2000	ug.mL-1
MIC	=	1024	ug.mL-1
MIC	=	2	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Oleandomycin glycosyltransferase

External ID: CHEMBL1226480

Protocol: N/A

Comment: Journal: Nat. Chem. Biol.
Year: 2007
Volume: 3
Issue: 10
First Page: 657
Last Page: 662
DOI: 10.1038/nchembio.2007.28

Target ChEMBL ID: CHEMBL3308957
ChEMBL Target Name: Oleandomycin glycosyltransferase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	8.8	nmol/min
Activity	=	5.5	nmol/min
Activity	=	6.3	nmol/min
Activity	=	0.08	nmol/min
Activity	=	23	nmol/min
Activity	=	0.022	nmol/min
Activity	=	0.49	nmol/min
Activity	=	1487	nmol/min

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Burkholderia pseudomallei

External ID: CHEMBL918926

Protocol: N/A

Comment: Journal: Antimicrob Agents Chemother
Year: 2007
Volume: 51
Issue: 2
First Page: 623
Last Page: 630
DOI: 10.1128/aac.01033-06

Target ChEMBL ID: CHEMBL3140323
ChEMBL Target Name: Burkholderia pseudomallei
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MIC	=	32	ug.mL-1
MIC	=	128	ug.mL-1
MIC	=	256	ug.mL-1
MIC	>	2000	ug.mL-1
MIC	=	1024	ug.mL-1
MIC	=	2	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Oleandomycin glycosyltransferase

External ID: CHEMBL1226479

Protocol: N/A

Comment: Journal: Nat. Chem. Biol.
Year: 2007
Volume: 3
Issue: 10
First Page: 657
Last Page: 662
DOI: 10.1038/nchembio.2007.28

Target ChEMBL ID: CHEMBL3308957
ChEMBL Target Name: Oleandomycin glycosyltransferase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	28.8	nmol/min
Activity	=	16	nmol/min
Activity	=	15.7	nmol/min
Activity	=	0.22	nmol/min
Activity	=	99.9	nmol/min
Activity	=	0.022	nmol/min
Activity	=	0.65	nmol/min
Activity	=	200	nmol/min

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Burkholderia pseudomallei

External ID: CHEMBL918927

Protocol: N/A

Comment: Journal: Antimicrob Agents Chemother
Year: 2007
Volume: 51
Issue: 2
First Page: 623
Last Page: 630
DOI: 10.1128/aac.01033-06

Target ChEMBL ID: CHEMBL3140323
ChEMBL Target Name: Burkholderia pseudomallei
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MIC	=	32	ug.mL-1
MIC	=	128	ug.mL-1
MIC	=	256	ug.mL-1
MIC	>	2000	ug.mL-1
MIC	=	1024	ug.mL-1
MIC	=	2	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Oleandomycin glycosyltransferase

External ID: CHEMBL1226478

Protocol: N/A

Comment: Journal: Nat. Chem. Biol.
Year: 2007
Volume: 3
Issue: 10
First Page: 657
Last Page: 662
DOI: 10.1038/nchembio.2007.28

Target ChEMBL ID: CHEMBL3308957
ChEMBL Target Name: Oleandomycin glycosyltransferase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
Activity	=	3.4	nmol/min
Activity	=	4.2	nmol/min
Activity	=	2.5	nmol/min
Activity				Not Determined
Activity	=	13.2	nmol/min
Activity	=	0.01	nmol/min
Activity	=	0.24	nmol/min
Activity	=	700	nmol/min

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Burkholderia pseudomallei

External ID: CHEMBL918920

Protocol: N/A

Comment: Journal: Antimicrob Agents Chemother
Year: 2007
Volume: 51
Issue: 2
First Page: 623
Last Page: 630
DOI: 10.1128/aac.01033-06

Target ChEMBL ID: CHEMBL3140323
ChEMBL Target Name: Burkholderia pseudomallei
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MIC	=	32	ug.mL-1
MIC	=	128	ug.mL-1
MIC	=	256	ug.mL-1
MIC	>	2000	ug.mL-1
MIC	=	1024	ug.mL-1
MIC	=	2	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Burkholderia pseudomallei

External ID: CHEMBL918921

Protocol: N/A

Comment: Journal: Antimicrob Agents Chemother
Year: 2007
Volume: 51
Issue: 2
First Page: 623
Last Page: 630
DOI: 10.1128/aac.01033-06

Target ChEMBL ID: CHEMBL3140323
ChEMBL Target Name: Burkholderia pseudomallei
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MIC	<	0.25	ug.mL-1
MIC	<	0.25	ug.mL-1
MIC	<	0.25	ug.mL-1
MIC	=	0.5	ug.mL-1
MIC	=	0.5	ug.mL-1
MIC	<	0.25	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Burkholderia pseudomallei

External ID: CHEMBL918922

Protocol: N/A

Comment: Journal: Antimicrob Agents Chemother
Year: 2007
Volume: 51
Issue: 2
First Page: 623
Last Page: 630
DOI: 10.1128/aac.01033-06

Target ChEMBL ID: CHEMBL3140323
ChEMBL Target Name: Burkholderia pseudomallei
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MIC	=	16	ug.mL-1
MIC	=	32	ug.mL-1
MIC	=	64	ug.mL-1
MIC	=	256	ug.mL-1
MIC	=	516	ug.mL-1
MIC	=	1	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Burkholderia pseudomallei

External ID: CHEMBL918923

Protocol: N/A

Comment: Journal: Antimicrob Agents Chemother
Year: 2007
Volume: 51
Issue: 2
First Page: 623
Last Page: 630
DOI: 10.1128/aac.01033-06

Target ChEMBL ID: CHEMBL3140323
ChEMBL Target Name: Burkholderia pseudomallei
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MIC	=	32	ug.mL-1
MIC	=	64	ug.mL-1
MIC	=	64	ug.mL-1
MIC	>	2000	ug.mL-1
MIC	=	1024	ug.mL-1
MIC	=	2	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Burkholderia pseudomallei

External ID: CHEMBL918932

Protocol: N/A

Comment: Journal: Antimicrob Agents Chemother
Year: 2007
Volume: 51
Issue: 2
First Page: 623
Last Page: 630
DOI: 10.1128/aac.01033-06

Target ChEMBL ID: CHEMBL3140323
ChEMBL Target Name: Burkholderia pseudomallei
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MIC	=	32	ug.mL-1
MIC	=	128	ug.mL-1
MIC	=	64	ug.mL-1
MIC	>	2000	ug.mL-1
MIC	=	1024	ug.mL-1
MIC	=	2	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Burkholderia pseudomallei

External ID: CHEMBL918933

Protocol: N/A

Comment: Journal: Antimicrob Agents Chemother
Year: 2007
Volume: 51
Issue: 2
First Page: 623
Last Page: 630
DOI: 10.1128/aac.01033-06

Target ChEMBL ID: CHEMBL3140323
ChEMBL Target Name: Burkholderia pseudomallei
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MIC	=	32	ug.mL-1
MIC	=	128	ug.mL-1
MIC	=	256	ug.mL-1
MIC	>	2000	ug.mL-1
MIC	=	1024	ug.mL-1
MIC	=	2	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Burkholderia pseudomallei

External ID: CHEMBL918934

Protocol: N/A

Comment: Journal: Antimicrob Agents Chemother
Year: 2007
Volume: 51
Issue: 2
First Page: 623
Last Page: 630
DOI: 10.1128/aac.01033-06

Target ChEMBL ID: CHEMBL3140323
ChEMBL Target Name: Burkholderia pseudomallei
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MIC	=	32	ug.mL-1
MIC	=	128	ug.mL-1
MIC	=	256	ug.mL-1
MIC	>	2000	ug.mL-1
MIC	=	1024	ug.mL-1
MIC	=	2	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL631358

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1997
Volume: 40
Issue: 9
First Page: 1340
Last Page: 1346
DOI: 10.1021/jm960436i

Standard Type	Standard Relation	Standard Value
LogD	=	0.85
LogD	=	0.61
LogD	=	1.58
LogD	=	-0.32
LogD	=	1.15
LogD	=	1.57
LogD	=	0.43
LogD	=	2.62
LogD	=	0.79

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Burkholderia pseudomallei

External ID: CHEMBL918935

Protocol: N/A

Comment: Journal: Antimicrob Agents Chemother
Year: 2007
Volume: 51
Issue: 2
First Page: 623
Last Page: 630
DOI: 10.1128/aac.01033-06

Target ChEMBL ID: CHEMBL3140323
ChEMBL Target Name: Burkholderia pseudomallei
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MIC	=	32	ug.mL-1
MIC	=	128	ug.mL-1
MIC	=	256	ug.mL-1
MIC	>	2000	ug.mL-1
MIC	=	1024	ug.mL-1
MIC	=	2	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Burkholderia pseudomallei

External ID: CHEMBL918928

Protocol: N/A

Comment: Journal: Antimicrob Agents Chemother
Year: 2007
Volume: 51
Issue: 2
First Page: 623
Last Page: 630
DOI: 10.1128/aac.01033-06

Target ChEMBL ID: CHEMBL3140323
ChEMBL Target Name: Burkholderia pseudomallei
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MIC	=	32	ug.mL-1
MIC	=	128	ug.mL-1
MIC	=	256	ug.mL-1
MIC	>	2000	ug.mL-1
MIC	=	1024	ug.mL-1
MIC	=	2	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Burkholderia pseudomallei

External ID: CHEMBL918929

Protocol: N/A

Comment: Journal: Antimicrob Agents Chemother
Year: 2007
Volume: 51
Issue: 2
First Page: 623
Last Page: 630
DOI: 10.1128/aac.01033-06

Target ChEMBL ID: CHEMBL3140323
ChEMBL Target Name: Burkholderia pseudomallei
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MIC	=	32	ug.mL-1
MIC	=	128	ug.mL-1
MIC	=	256	ug.mL-1
MIC	>	2000	ug.mL-1
MIC	=	1024	ug.mL-1
MIC	=	2	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL632771

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1997
Volume: 40
Issue: 9
First Page: 1340
Last Page: 1346
DOI: 10.1021/jm960436i

Standard Type	Standard Relation	Standard Value
CLogP	=	2.19
CLogP	=	4.02
CLogP	=	3.06
CLogP	=	3
CLogP	=	1.63
CLogP	=	3.16
CLogP	=	1.69
CLogP	=	3.04
CLogP	=	3.8

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Burkholderia pseudomallei

External ID: CHEMBL918930

Protocol: N/A

Comment: Journal: Antimicrob Agents Chemother
Year: 2007
Volume: 51
Issue: 2
First Page: 623
Last Page: 630
DOI: 10.1128/aac.01033-06

Target ChEMBL ID: CHEMBL3140323
ChEMBL Target Name: Burkholderia pseudomallei
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MIC	=	16	ug.mL-1
MIC	<	0.25	ug.mL-1
MIC	=	32	ug.mL-1
MIC	<	0.25	ug.mL-1
MIC	<	0.25	ug.mL-1
MIC	=	1	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Burkholderia pseudomallei

External ID: CHEMBL918931

Protocol: N/A

Comment: Journal: Antimicrob Agents Chemother
Year: 2007
Volume: 51
Issue: 2
First Page: 623
Last Page: 630
DOI: 10.1128/aac.01033-06

Target ChEMBL ID: CHEMBL3140323
ChEMBL Target Name: Burkholderia pseudomallei
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MIC	=	16	ug.mL-1
MIC	=	128	ug.mL-1
MIC	=	64	ug.mL-1
MIC	>	2000	ug.mL-1
MIC	=	1024	ug.mL-1
MIC	=	2	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Burkholderia pseudomallei

External ID: CHEMBL917956

Protocol: N/A

Comment: Journal: Antimicrob Agents Chemother
Year: 2007
Volume: 51
Issue: 2
First Page: 623
Last Page: 630
DOI: 10.1128/aac.01033-06

Target ChEMBL ID: CHEMBL3140323
ChEMBL Target Name: Burkholderia pseudomallei
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MIC	=	32	ug.mL-1
MIC	=	128	ug.mL-1
MIC	=	256	ug.mL-1
MIC	>	2000	ug.mL-1
MIC	=	1024	ug.mL-1
MIC	=	2	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Burkholderia pseudomallei

External ID: CHEMBL918938

Protocol: N/A

Comment: Journal: Antimicrob Agents Chemother
Year: 2007
Volume: 51
Issue: 2
First Page: 623
Last Page: 630
DOI: 10.1128/aac.01033-06

Target ChEMBL ID: CHEMBL3140323
ChEMBL Target Name: Burkholderia pseudomallei
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MIC	=	32	ug.mL-1
MIC	=	128	ug.mL-1
MIC	=	256	ug.mL-1
MIC	>	2000	ug.mL-1
MIC	=	1024	ug.mL-1
MIC	=	2	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Burkholderia pseudomallei

External ID: CHEMBL918939

Protocol: N/A

Comment: Journal: Antimicrob Agents Chemother
Year: 2007
Volume: 51
Issue: 2
First Page: 623
Last Page: 630
DOI: 10.1128/aac.01033-06

Target ChEMBL ID: CHEMBL3140323
ChEMBL Target Name: Burkholderia pseudomallei
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MIC	=	32	ug.mL-1
MIC	=	128	ug.mL-1
MIC	=	256	ug.mL-1
MIC	>	2000	ug.mL-1
MIC	=	1024	ug.mL-1
MIC	=	2	ug.mL-1

Primary Screen LUM Value	Primary Screen Concentration	Primary Screen Concentration Unit
0	50	uM
0	50	uM
40	50	uM
40	50	uM
0	50	uM
0	50	uM
0	50	uM
0	50	uM
0	50	uM
40	50	uM
40	50	uM
0	50	uM
0	50	uM
0	50	uM
0	50	uM
40	50	uM
0	50	uM
0	50	uM
40	50	uM
40	50	uM

Concentration uM	Data readout
33	55
33	63
33	65
33	63
33	61
33	62
33	61
33	58
33	71
33	61
33	64
33	83
33	158
33	84
33	104
33	60
33	62
33	59
33	58
33	59

Primary Screen LUM Value	Primary Screen Concentration	Primary Screen Concentration Unit
0	50	uM
0	50	uM
40	50	uM
40	50	uM
0	50	uM
0	50	uM
0	50	uM
0	50	uM
0	50	uM
40	50	uM
40	50	uM
0	50	uM
0	50	uM
0	50	uM
0	50	uM
40	50	uM
0	50	uM
0	50	uM
40	50	uM
40	50	uM

Concentration uM	Data readout
33	55
33	63
33	65
33	63
33	61
33	62
33	61
33	58
33	71
33	61
33	64
33	83
33	158
33	84
33	104
33	60
33	62
33	59
33	58
33	59

3922-90-5 靶点实验数据

Primary Screen LUM Value	Primary Screen Concentration	Primary Screen Concentration Unit
0	50	uM
0	50	uM
40	50	uM
40	50	uM
0	50	uM
0	50	uM
0	50	uM
0	50	uM
0	50	uM
40	50	uM
40	50	uM
0	50	uM
0	50	uM
0	50	uM
0	50	uM
40	50	uM
0	50	uM
0	50	uM
40	50	uM
40	50	uM

Concentration uM	Data readout
33	55
33	63
33	65
33	63
33	61
33	62
33	61
33	58
33	71
33	61
33	64
33	83
33	158
33	84
33	104
33	60
33	62
33	59
33	58
33	59