HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：A2780

External ID: CHEMBL2032599

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2012
Volume: 22
Issue: 12
First Page: 3866
Last Page: 3869
DOI: 10.1016/j.bmcl.2012.04.119

Target ChEMBL ID: CHEMBL614004
ChEMBL Target Name: A2780
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
92	IC50	=	92000	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM
85.2	IC50	=	85200	nM
80.8	IC50	=	80800	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：K562

External ID: CHEMBL2032597

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2012
Volume: 22
Issue: 12
First Page: 3866
Last Page: 3869
DOI: 10.1016/j.bmcl.2012.04.119

Target ChEMBL ID: CHEMBL385
ChEMBL Target Name: K562
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
34.7	IC50	=	34700	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM
16.7	IC50	=	16700	nM
29.8	IC50	=	29800	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：A2780

External ID: CHEMBL2032598

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2012
Volume: 22
Issue: 12
First Page: 3866
Last Page: 3869
DOI: 10.1016/j.bmcl.2012.04.119

Target ChEMBL ID: CHEMBL614004
ChEMBL Target Name: A2780
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
106	IC50	=	106000	nM	Outside typical range
100	IC50	>	100000	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM
82.4	IC50	=	82400	nM
89.7	IC50	=	89700	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mycobacterium tuberculosis

External ID: CHEMBL4400904

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Eur J Med Chem
Year: 2019
Volume: 165
First Page: 273
Last Page: 292
DOI: 10.1016/j.ejmech.2019.01.026

Target ChEMBL ID: CHEMBL360
ChEMBL Target Name: Mycobacterium tuberculosis
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
44.17	MIC	=	44170	nM
1.35	MIC	=	1350	nM
9.03	MIC	=	9030	nM
1.3	MIC	=	1300	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：BV-2

External ID: CHEMBL5587238

Protocol: N/A

Comment: Journal: J Nat Prod
Year: 2024
Volume: 87
Issue: 8
First Page: 1930
Last Page: 1940
DOI: 10.1021/acs.jnatprod.4c00334

Target ChEMBL ID: CHEMBL614781
ChEMBL Target Name: BV-2
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	>	98	%
Activity	>	98	%
Activity	>	98	%
Activity	>	98	%
Activity	>	98	%
Activity	>	98	%
Activity	>	98	%
Activity	>	98	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：BV-2

External ID: CHEMBL5587239

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Nat Prod
Year: 2024
Volume: 87
Issue: 8
First Page: 1930
Last Page: 1940
DOI: 10.1021/acs.jnatprod.4c00334

Target ChEMBL ID: CHEMBL614781
ChEMBL Target Name: BV-2
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
19.5	IC50	=	19500	nM
8.4	IC50	=	8400	nM
20	IC50	>	20000	nM
7.5	IC50	=	7500	nM
20	IC50	>	20000	nM
8.6	IC50	=	8600	nM
17.4	IC50	=	17400	nM
8	IC50	=	8000	nM
8.5	IC50	=	8500	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Escherichia coli

External ID: CHEMBL3602538

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2015
Volume: 25
Issue: 16
First Page: 3125
Last Page: 3128
DOI: 10.1016/j.bmcl.2015.06.010

Target ChEMBL ID: CHEMBL354
ChEMBL Target Name: Escherichia coli
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MIC	=	0.8	ug.mL-1
MIC	>	20	ug.mL-1
MIC	=	3.9	ug.mL-1
MIC	=	18.5	ug.mL-1
MIC	>	20	ug.mL-1
MIC	>	20	ug.mL-1
MIC	>	20	ug.mL-1
MIC	>	20	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Tryprostatin B synthase

External ID: CHEMBL1060345

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2009
Volume: 72
Issue: 1
First Page: 44
Last Page: 52
DOI: 10.1021/np800501m

Target ChEMBL ID: CHEMBL5635
ChEMBL Target Name: Brevianamide F prenyltransferase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value
Ratio	=	675

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Staphylococcus aureus

External ID: CHEMBL3602536

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2015
Volume: 25
Issue: 16
First Page: 3125
Last Page: 3128
DOI: 10.1016/j.bmcl.2015.06.010

Target ChEMBL ID: CHEMBL352
ChEMBL Target Name: Staphylococcus aureus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MIC	=	0.05	ug.mL-1
MIC	=	10.2	ug.mL-1
MIC	=	1.5	ug.mL-1
MIC	=	15.6	ug.mL-1
MIC	=	15.1	ug.mL-1
MIC	=	18.8	ug.mL-1
MIC	=	16.3	ug.mL-1
MIC	=	12.6	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Artemia salina

External ID: CHEMBL3050935

Protocol: N/A

Comment: Journal: J Agric Food Chem
Year: 2012
Volume: 60
Issue: 13
First Page: 3424
Last Page: 3431
DOI: 10.1021/jf300146n

Target ChEMBL ID: CHEMBL612341
ChEMBL Target Name: Artemia salina
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
LC50	>	100	ug.mL-1
LC50	=	44.8	ug.mL-1
LC50	>	100	ug.mL-1
LC50	>	100	ug.mL-1
LC50	=	40.5	ug.mL-1
LC50	=	52.7	ug.mL-1
LC50	>	100	ug.mL-1
LC50	=	73.7	ug.mL-1
LC50	<	1	ug.mL-1
LC50	>	100	ug.mL-1
LC50	=	66.1	ug.mL-1
LC50	=	83.7	ug.mL-1
LC50	>	100	ug.mL-1
LC50	>	100	ug.mL-1
LC50	>	100	ug.mL-1
LC50	>	100	ug.mL-1
LC50	>	100	ug.mL-1
LC50	>	100	ug.mL-1
LC50	=	73.2	ug.mL-1
LC50	=	80.8	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Bacillus subtilis

External ID: CHEMBL3602537

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2015
Volume: 25
Issue: 16
First Page: 3125
Last Page: 3128
DOI: 10.1016/j.bmcl.2015.06.010

Target ChEMBL ID: CHEMBL359
ChEMBL Target Name: Bacillus subtilis
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MIC	=	0.03	ug.mL-1
MIC	=	8.7	ug.mL-1
MIC	=	1.2	ug.mL-1
MIC	=	16	ug.mL-1
MIC	=	17.2	ug.mL-1
MIC	=	15.7	ug.mL-1
MIC	=	18.2	ug.mL-1
MIC	=	11.9	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Candida albicans

External ID: CHEMBL5113762

Protocol: N/A

Comment: Journal: Eur J Med Chem
Year: 2021
Volume: 209
First Page: 112945
Last Page: 112945
DOI: 10.1016/j.ejmech.2020.112945

Target ChEMBL ID: CHEMBL366
ChEMBL Target Name: Candida albicans
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
IZ	=	25	mm

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Broad substrate specificity ATP-binding cassette transporter ABCG2

External ID: CHEMBL3876145

Protocol: N/A

Comment: Journal: Bioorg Med Chem Lett
Year: 2016
Volume: 26
Issue: 24
First Page: 5843
Last Page: 5850
DOI: 10.1016/j.bmcl.2016.11.013

Target ChEMBL ID: CHEMBL5393
ChEMBL Target Name: ATP-binding cassette sub-family G member 2
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Units	Activity Comment
Inhibition	%
Inhibition	%
Inhibition	%	Active
Inhibition	%	Active
Inhibition	%
Inhibition	%	Active
Inhibition	%	Active
Inhibition	%	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Tryprostatin B synthase

External ID: CHEMBL1056998

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2009
Volume: 72
Issue: 1
First Page: 44
Last Page: 52
DOI: 10.1021/np800501m

Target ChEMBL ID: CHEMBL5635
ChEMBL Target Name: Brevianamide F prenyltransferase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Activity Comment
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Broad substrate specificity ATP-binding cassette transporter ABCG2

External ID: CHEMBL3876146

Protocol: N/A

Comment: Journal: Bioorg Med Chem Lett
Year: 2016
Volume: 26
Issue: 24
First Page: 5843
Last Page: 5850
DOI: 10.1016/j.bmcl.2016.11.013

Target ChEMBL ID: CHEMBL5393
ChEMBL Target Name: ATP-binding cassette sub-family G member 2
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Units	Activity Comment
Inhibition	%
Inhibition	%
Inhibition	%	Active
Inhibition	%	Active
Inhibition	%
Inhibition	%	Active
Inhibition	%	Active
Inhibition	%	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Tryprostatin B synthase

External ID: CHEMBL1056999

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2009
Volume: 72
Issue: 1
First Page: 44
Last Page: 52
DOI: 10.1021/np800501m

Target ChEMBL ID: CHEMBL5635
ChEMBL Target Name: Brevianamide F prenyltransferase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Activity Comment
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Tryprostatin B synthase

External ID: CHEMBL1056997

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2009
Volume: 72
Issue: 1
First Page: 44
Last Page: 52
DOI: 10.1021/np800501m

Target ChEMBL ID: CHEMBL5635
ChEMBL Target Name: Brevianamide F prenyltransferase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Activity Comment
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Staphylococcus aureus

External ID: CHEMBL5113761

Protocol: N/A

Comment: Journal: Eur J Med Chem
Year: 2021
Volume: 209
First Page: 112945
Last Page: 112945
DOI: 10.1016/j.ejmech.2020.112945

Target ChEMBL ID: CHEMBL352
ChEMBL Target Name: Staphylococcus aureus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
IZ	=	19	mm

38136-70-8 靶点实验数据