前往化源商城

3758-71-2 靶点实验数据

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:G-protein coupled bile acid receptor 1
External ID: CHEMBL949257
Protocol: N/A
Comment: Journal: J. Med. Chem.
Year: 2008
Volume: 51
Issue: 6
First Page: 1831
Last Page: 1841
DOI: 10.1021/jm7015864

Target ChEMBL ID: CHEMBL5409
ChEMBL Target Name: G-protein coupled bile acid receptor 1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned
Standard TypeStandard RelationStandard ValueStandard Units
Efficacy=98%
Efficacy=11%
Efficacy=77%
Efficacy=92%
Efficacy=75%
Efficacy=72%
Efficacy=103%
Efficacy=101%
Efficacy=104%
Efficacy=101%
Efficacy=105%
Efficacy=83%
Efficacy=87%
Efficacy=94.4%
Efficacy=79.7%
Efficacy=114%
Efficacy=102%
Efficacy=74.9%
Efficacy=79%
Efficacy=102%
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:G-protein coupled bile acid receptor 1
External ID: CHEMBL949256
Protocol: N/A
Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2008
Volume: 51
Issue: 6
First Page: 1831
Last Page: 1841
DOI: 10.1021/jm7015864

Target ChEMBL ID: CHEMBL5409
ChEMBL Target Name: G-protein coupled bile acid receptor 1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned
PubChem Standard ValueStandard TypeStandard RelationStandard ValueStandard UnitsData Validity Comment
3.76EC50=3760nM
3.33EC50=3330nM
7.01EC50=7010nM
0.77EC50=770nM
1.25EC50=1250nM
1.92EC50=1920nM
0.58EC50=580nM
6.71EC50=6710nM
127EC50=127000nMOutside typical range
2.29EC50=2290nM
3.2EC50=3200nM
100EC50>100000nM
31.6EC50=31600nM
10.4EC50=10400nM
0.25EC50=250nM
36.4EC50=36400nM
2.62EC50=2620nM
0.29EC50=290nM
0.36EC50=360nM
0.85EC50=850nM