HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：DU-145

External ID: CHEMBL5049248

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2022
Volume: 65
Issue: 5.0
First Page: 3833
Last Page: 3848
DOI: 10.1021/acs.jmedchem.1c01367

Target ChEMBL ID: CHEMBL613508
ChEMBL Target Name: DU-145
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
190	IC50	=	190000	nM	Outside typical range
133	IC50	=	133000	nM	Outside typical range
61	IC50	=	61000	nM
187	IC50	=	187000	nM	Outside typical range
100	IC50	=	100000	nM
90	IC50	=	90000	nM
106	IC50	=	106000	nM	Outside typical range
71	IC50	=	71000	nM
200	IC50	>	200000	nM	Outside typical range
103	IC50	=	103000	nM	Outside typical range
84	IC50	=	84000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：LNCaP

External ID: CHEMBL5049247

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Med Chem
Year: 2022
Volume: 65
Issue: 5.0
First Page: 3833
Last Page: 3848
DOI: 10.1021/acs.jmedchem.1c01367

Target ChEMBL ID: CHEMBL612518
ChEMBL Target Name: LNCaP
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
73	IC50	=	73000	nM
137	IC50	=	137000	nM	Outside typical range
25	IC50	=	25000	nM
179	IC50	=	179000	nM	Outside typical range
31	IC50	=	31000	nM
10	IC50	=	10000	nM
61	IC50	=	61000	nM
50	IC50	=	50000	nM
172	IC50	=	172000	nM	Outside typical range
61	IC50	=	61000	nM
46	IC50	=	46000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：PC-3

External ID: CHEMBL5049246

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2022
Volume: 65
Issue: 5.0
First Page: 3833
Last Page: 3848
DOI: 10.1021/acs.jmedchem.1c01367

Target ChEMBL ID: CHEMBL390
ChEMBL Target Name: PC-3
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
200	IC50	>	200000	nM	Outside typical range
172	IC50	=	172000	nM	Outside typical range
47	IC50	=	47000	nM
200	IC50	>	200000	nM	Outside typical range
98	IC50	=	98000	nM
77	IC50	=	77000	nM
123	IC50	=	123000	nM	Outside typical range
75	IC50	=	75000	nM
200	IC50	>	200000	nM	Outside typical range
106	IC50	=	106000	nM	Outside typical range
84	IC50	=	84000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Aldehyde dehydrogenase 1A1

External ID: CHEMBL5049237

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2022
Volume: 65
Issue: 5.0
First Page: 3833
Last Page: 3848
DOI: 10.1021/acs.jmedchem.1c01367

Target ChEMBL ID: CHEMBL3577
ChEMBL Target Name: Aldehyde dehydrogenase 1A1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	69	%
Activity	=	3.14	%
Activity	=	17	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Aldehyde dehydrogenase, dimeric NADP-preferring

External ID: CHEMBL5049236

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Med Chem
Year: 2022
Volume: 65
Issue: 5.0
First Page: 3833
Last Page: 3848
DOI: 10.1021/acs.jmedchem.1c01367

Target ChEMBL ID: CHEMBL3578
ChEMBL Target Name: Aldehyde dehydrogenase dimeric NADP-preferring
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
1.61	IC50	=	1610	nM
13.7	IC50	=	13700	nM
64.1	IC50	=	64100	nM

374635-48-0 靶点实验数据