HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Albumin

External ID: CHEMBL810806

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1988
Volume: 31
Issue: 10
First Page: 1923
Last Page: 1933
DOI: 10.1021/jm00118a010

Target ChEMBL ID: CHEMBL3728
ChEMBL Target Name: Serum albumin
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Standard Type	Standard Relation	Standard Value
Log 1/C	=	3.32
Log 1/C	=	3.4
Log 1/C	=	4.07
Log 1/C	=	3.58
Log 1/C	=	3.23
Log 1/C	=	3
Log 1/C	=	4.91
Log 1/C	=	3.68
Log 1/C	=	4
Log 1/C	=	3.7
Log 1/C	=	3.15
Log 1/C	=	4.66
Log 1/C	=	4.3
Log 1/C	=	2.92
Log 1/C	=	4.52
Log 1/C	=	4.4
Log 1/C	=	3.54
Log 1/C	=	3.26
Log 1/C	=	4.22
Log 1/C	=	2.94

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL635387

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1988
Volume: 31
Issue: 10
First Page: 1923
Last Page: 1933
DOI: 10.1021/jm00118a010

Standard Type	Standard Relation	Standard Value
LogP	=	1.46
LogP	=	1.34
LogP	=	2.14
LogP	=	1.85
LogP	=	1.56
LogP	=	1.58
LogP	=	3.3
LogP	=	1.83
LogP	=	2.11
LogP	=	1.94
LogP	=	0.8
LogP	=	3.3
LogP	=	2.5
LogP	=	0.95
LogP	=	2.95
LogP	=	2.91
LogP	=	1.58
LogP	=	1.7
LogP	=	2.4
LogP	=	1.17

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：L1210

External ID: CHEMBL914537

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2005
Volume: 48
Issue: 23
First Page: 7234
Last Page: 7242
DOI: 10.1021/jm050567w

Target ChEMBL ID: CHEMBL386
ChEMBL Target Name: L1210
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	<	15	%
Activity	<	15	%
Activity	<	15	%
Activity	<	15	%
Activity	<	15	%
Activity	<	15	%
Activity	<	15	%
Activity	<	15	%
Activity	<	15	%
Activity	<	15	%
Activity	<	15	%
Activity	<	15	%
Activity	<	15	%
Activity	<	15	%
Activity	<	15	%
Activity	<	15	%
Activity	<	15	%
Activity	<	15	%
Activity	<	15	%
Activity	<	15	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL991844

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2008
Volume: 51
Issue: 15
First Page: 4359
Last Page: 4369
DOI: 10.1021/jm800219f

Standard Type	Standard Relation	Standard Value
pKa	=	4.62
pKa	=	4.76
pKa	=	5.17
pKa	=	10.7
pKa	=	4.2
pKa	=	10.7
pKa	=	10.7
pKa	=	4.87
pKa	=	9.99
pKa	=	16
pKa	=	4.85
pKa	=	11.1
pKa	=	4.65
pKa	=	8.9
pKa	=	9.89
pKa	=	9.29
pKa	=	3.58
pKa	=	3.79
pKa	=	3.87
pKa	=	4.14

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：L1210

External ID: CHEMBL914538

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2005
Volume: 48
Issue: 23
First Page: 7234
Last Page: 7242
DOI: 10.1021/jm050567w

Target ChEMBL ID: CHEMBL386
ChEMBL Target Name: L1210
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value
log(1/ID50)	=	1.25
log(1/ID50)	=	1.1
log(1/ID50)	=	1
log(1/ID50)	=	-0.2
log(1/ID50)	=	0.79
log(1/ID50)	=	0.02
log(1/ID50)	=	2.41
log(1/ID50)	=	0.11
log(1/ID50)	=	0.79
log(1/ID50)	=	2.29
log(1/ID50)	=	2.38
log(1/ID50)	=	1.9
log(1/ID50)	=	2.09
log(1/ID50)	=	0.74
log(1/ID50)	=	0.45
log(1/ID50)	=	1.87
log(1/ID50)	=	1.31
log(1/ID50)	=	1.11
log(1/ID50)	=	0.82
log(1/ID50)	=	0.1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL876466

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2005
Volume: 48
Issue: 9
First Page: 3269
Last Page: 3279
DOI: 10.1021/jm048980b

Standard Type	Standard Relation	Standard Value
Log PNalk	=	0.03
Log PNalk	=	0.98
Log PNalk	=	0.73
Log PNalk	=	3.6
Log PNalk	=	-0.38
Log PNalk	=	1.3
Log PNalk	=	-0.3
Log PNalk	=	-1.6
Log PNalk	=	1.37
Log PNalk	=	-1.28
Log PNalk	=	-0.92
Log PNalk	=	1.75
Log PNalk	=	-2.28
Log PNalk	=	-0.6
Log PNalk	=	0.52
Log PNalk	=	-2.75
Log PNalk	=	3.1
Log PNalk	=	-2.15
Log PNalk	=	-0.99
Log PNalk	=	-1.22

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：L1210

External ID: CHEMBL914539

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2005
Volume: 48
Issue: 23
First Page: 7234
Last Page: 7242
DOI: 10.1021/jm050567w

Target ChEMBL ID: CHEMBL386
ChEMBL Target Name: L1210
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
log(1/ID50)	=	4.59	-
log(1/ID50)	=	3.45	-
log(1/ID50)	=	3.34	-
log(1/ID50)	=	3.27	-
log(1/ID50)	=	3.48	-
log(1/ID50)	=	3.73	-
log(1/ID50)	=	3.85	-
log(1/ID50)	=	3.46	-
log(1/ID50)	=	2.7	-
log(1/ID50)	=	5.16	-
log(1/ID50)	=	3.75	-
log(1/ID50)	=	3.26	-
log(1/ID50)	=	4.24	-
log(1/ID50)	=	3.5	-
log(1/ID50)	=	3.02	-
log(1/ID50)	=	3.73	-
log(1/ID50)	=	3.04	-
log(1/ID50)	=	3.8	-
log(1/ID50)	=	3.85	-
log(1/ID50)	=	4.04	-

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3256050

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1977
Volume: 20
Issue: 8
First Page: 1071
Last Page: 1081
DOI: 10.1021/jm00218a017

Standard Type	Standard Relation	Standard Value
LogP	=	-0.83
LogP	=	0.64
LogP	=	1.16
LogP	=	1.09
LogP	=	1.3
LogP	=	0.9
LogP	=	1.81
LogP	=	1.46
LogP	=	2
LogP	=	1.34
LogP	=	2.99
LogP	=	2.84
LogP	=	2.27
LogP	=	0.82
LogP	=	1.85
LogP	=	1.56
LogP	=	1.58
LogP	=	2.69
LogP	=	1.48
LogP	=	2.13

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3256053

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1977
Volume: 20
Issue: 8
First Page: 1071
Last Page: 1081
DOI: 10.1021/jm00218a017

Standard Type	Standard Relation	Standard Value
LogP	=	0.96
LogP	=	1.3
LogP	=	1.64
LogP	=	1.04
LogP	=	1.84
LogP	=	2.16
LogP	=	1.84
LogP	=	2.72
LogP	=	2.8
LogP	=	1.28
LogP	=	2.24
LogP	=	1.56
LogP	=	1.69
LogP	=	2.46
LogP	=	2.61
LogP	=	2.41

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL633693

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1988
Volume: 31
Issue: 10
First Page: 1923
Last Page: 1933
DOI: 10.1021/jm00118a010

Standard Type	Standard Relation	Standard Value
Log k' w	=	1.251
Log k' w	=	1.004
Log k' w	=	2.014
Log k' w	=	1.633
Log k' w	=	1.279
Log k' w	=	1.359
Log k' w	=	3.191
Log k' w	=	1.855
Log k' w	=	2.006
Log k' w	=	1.759
Log k' w	=	0.544
Log k' w	=	3.092
Log k' w	=	2.391
Log k' w	=	0.603
Log k' w	=	2.847
Log k' w	=	2.795
Log k' w	=	1.254
Log k' w	=	1.557
Log k' w	=	2.228
Log k' w	=	1.014

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL938588

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2009
Volume: 17
Issue: 2
First Page: 896
Last Page: 904
DOI: 10.1016/j.bmc.2008.11.040

Standard Type	Standard Relation	Standard Value
log Ks	=	2.33
log Ks	=	2.76
log Ks	=	1.76
log Ks	=	1.78
log Ks	=	1.97
log Ks	=	2.52
log Ks	=	3.28
log Ks	=	2.71
log Ks	=	3.22
log Ks	=	1.78
log Ks	=	3.01
log Ks	=	3.07
log Ks	=	3.08
log Ks	=	1.98
log Ks	=	2.32
log Ks	=	2.2
log Ks	=	2.67
log Ks	=	2.69
log Ks	=	1.73
log Ks	=	1.97

372-20-3 靶点实验数据