HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Vascular endothelial growth factor receptor 3

External ID: CHEMBL835746

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2004
Volume: 47
Issue: 22
First Page: 5367
Last Page: 5380
DOI: 10.1021/jm030594r

Target ChEMBL ID: CHEMBL2095227
ChEMBL Target Name: Vascular endothelial growth factor receptor
ChEMBL Target Type: PROTEIN FAMILY - Target is a group of closely related proteins
Relationship Type: D - Direct protein target assigned
Confidence: Multiple direct protein targets may be assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
1.4	IC50	=	1400	nM
2	IC50	=	2000	nM
0.91	IC50	=	910	nM
1.4	IC50	=	1400	nM
16	IC50	=	16000	nM
0.61	IC50	=	610	nM
0.63	IC50	=	630	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：HCT-116

External ID: CHEMBL826550

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2004
Volume: 47
Issue: 22
First Page: 5367
Last Page: 5380
DOI: 10.1021/jm030594r

Target ChEMBL ID: CHEMBL394
ChEMBL Target Name: HCT-116
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	10.72	mm
Inhibition	=	8.77	mm

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：L1210

External ID: CHEMBL826531

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2004
Volume: 47
Issue: 22
First Page: 5367
Last Page: 5380
DOI: 10.1021/jm030594r

Target ChEMBL ID: CHEMBL386
ChEMBL Target Name: L1210
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	5.85	mm
Inhibition	=	6.5	mm

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NON-PROTEIN TARGET

External ID: CHEMBL825732

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2004
Volume: 47
Issue: 22
First Page: 5367
Last Page: 5380
DOI: 10.1021/jm030594r

Target ChEMBL ID: CHEMBL3879801
ChEMBL Target Name: NON-PROTEIN TARGET
ChEMBL Target Type: NON-MOLECULAR - Target has not been defined at a molecular level, only the non-molecular entity which is affected (e.g., organism, cell line etc)
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	0	mm

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL850275

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2004
Volume: 47
Issue: 22
First Page: 5367
Last Page: 5380
DOI: 10.1021/jm030594r

Standard Type	Standard Relation	Standard Value
CLogP	=	3.8
CLogP	=	4.4
CLogP	=	3.1
CLogP	=	2.3

36965-16-9 靶点实验数据