HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Indoleamine 2,3-dioxygenase 1

External ID: CHEMBL2150236

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2012
Volume: 55
Issue: 11
First Page: 5270
Last Page: 5290
DOI: 10.1021/jm300260v

Target ChEMBL ID: CHEMBL4685
ChEMBL Target Name: Indoleamine 2,3-dioxygenase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Units	Activity Comment
Inhibition	%	Active
Inhibition	%	Active
Inhibition	%	Active
Inhibition	%	Active
Inhibition	%	Active
Inhibition	%	Active
Inhibition	%	Active
Inhibition	%	Active
Inhibition	%	Active
Inhibition	%	Active
Inhibition	%	Active
Inhibition	%	Active
Inhibition	%	Active
Inhibition	%	Active
Inhibition	%	Active
Inhibition	%	Active
Inhibition	%	Active
Inhibition	%	Active
Inhibition	%	Active
Inhibition	%	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Methionine aminopeptidase 2

External ID: CHEMBL872187

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2005
Volume: 48
Issue: 18
First Page: 5644
Last Page: 5647
DOI: 10.1021/jm050408c

Target ChEMBL ID: CHEMBL3922
ChEMBL Target Name: Methionine aminopeptidase 2
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.112	Ki	=	112	nM
0.15	Ki	=	150	nM
0.03	Ki	=	30	nM
1	Ki	>	1000	nM
0.337	Ki	=	337	nM
0.003	Ki	=	3	nM
0.001	Ki	=	1	nM
0.3	Ki	=	300	nM
0.28	Ki	=	280	nM
0.016	Ki	=	16	nM
0.004	Ki	=	4	nM
0.041	Ki	=	41	nM
0.006	Ki	=	6	nM
0.26	Ki	=	260	nM
1	Ki	>	1000	nM
0.006	Ki	=	6	nM
0.003	Ki	=	3	nM
0.008	Ki	=	8	nM
0.018	Ki	=	18	nM
0.013	Ki	=	13	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：BindingDB 靶标：N/A

External ID: BindingDB_2153_1

Protocol: N/A

Comment: Compounds with any of Ki, IC50, Kd, or EC50 activity value <= 10uM are labeled as "Active".
If multiple measurements are available for a given compound, it is labeled as "Active" if any of the measurements meet the criterion. Activity values are checked in the order of Ki, IC50, Kd, and EC50. The first entry that meets the above activity threshold is used to determine "Standard Type", "Standard Relation", and "PubChem Standard Value". Otherwise, the first non-empty entry will be used to set those values.

Standard Type	Standard Relation	PubChem Standard Value	Ki Qualifier	Ki	Target Accession(s)	Ligand	Target
Ki		0.052		52	P50579	BDBM17449	Methionine aminopeptidase 2
Ki		0.28		280	P50579	BDBM17450	Methionine aminopeptidase 2
Ki		0.112		112	P50579	BDBM17452	Methionine aminopeptidase 2
Ki	>	1	>	1000	P50579	BDBM17454	Methionine aminopeptidase 2
Ki		0.03		30	P50579	BDBM17455	Methionine aminopeptidase 2
Ki	>	1	>	1000	P50579	BDBM17456	Methionine aminopeptidase 2
Ki		0.337		337	P50579	BDBM17458	Methionine aminopeptidase 2
Ki		0.003		3	P50579	BDBM17460	Methionine aminopeptidase 2
Ki		0.001		1	P50579	BDBM17461	Methionine aminopeptidase 2
Ki		0.018		18	P50579	BDBM17462	Methionine aminopeptidase 2
Ki		0.3		300	P50579	BDBM17463	Methionine aminopeptidase 2
Ki		0.029		29	P50579	BDBM17465	Methionine aminopeptidase 2
Ki		0.016		16	P50579	BDBM17466	Methionine aminopeptidase 2
Ki		0.004		4	P50579	BDBM17467	Methionine aminopeptidase 2
Ki		0.013		13	P50579	BDBM17469	Methionine aminopeptidase 2
Ki		0.041		41	P50579	BDBM17470	Methionine aminopeptidase 2
Ki		0.26		260	P50579	BDBM17471	Methionine aminopeptidase 2
Ki	>	1	>	1000	P50579	BDBM17472	Methionine aminopeptidase 2
Ki		0.006		6	P50579	BDBM17473	Methionine aminopeptidase 2
Ki		0.003		3	P50579	BDBM17474	Methionine aminopeptidase 2

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Indoleamine 2,3-dioxygenase 1

External ID: CHEMBL2150124

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2012
Volume: 55
Issue: 11
First Page: 5270
Last Page: 5290
DOI: 10.1021/jm300260v

Target ChEMBL ID: CHEMBL4685
ChEMBL Target Name: Indoleamine 2,3-dioxygenase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment	Data Validity Comment
39	IC50	=	39000	nM
310	IC50	=	310000	nM		Outside typical range
1500	IC50	=	1500000	nM		Outside typical range
2	IC50	=	2000	nM
530	IC50	=	530000	nM		Outside typical range
1000	IC50	=	1000000	nM		Outside typical range
85	IC50	=	85000	nM
22	IC50	=	22000	nM
	IC50				Not Determined
	IC50				Not Determined
32	IC50	=	32000	nM
6.4	IC50	=	6400	nM
190	IC50	=	190000	nM		Outside typical range
15	IC50	=	15000	nM
1300	IC50	=	1300000	nM		Outside typical range
23	IC50	=	23000	nM
60	IC50	=	60000	nM
1800	IC50	=	1800000	nM		Outside typical range
1200	IC50	=	1200000	nM		Outside typical range
47	IC50	=	47000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Indoleamine 2,3-dioxygenase 1

External ID: CHEMBL2150230

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2012
Volume: 55
Issue: 11
First Page: 5270
Last Page: 5290
DOI: 10.1021/jm300260v

Target ChEMBL ID: CHEMBL1075294
ChEMBL Target Name: Indoleamine 2,3-dioxygenase 1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
1.3	IC50	=	1300	nM
4	IC50	=	4000	nM
0.023	IC50	=	23	nM
0.12	IC50	=	120	nM
0.1	IC50	=	100	nM
100	IC50	>	100000	nM
1.5	IC50	=	1500	nM
0.034	IC50	=	34	nM
2.1	IC50	=	2100	nM
0.022	IC50	=	22	nM
1.7	IC50	=	1700	nM
1.7	IC50	=	1700	nM
0.12	IC50	=	120	nM
1.1	IC50	=	1100	nM
20	IC50	=	20000	nM
0.05	IC50	=	50	nM
0.63	IC50	=	630	nM
0.06	IC50	=	60	nM
0.002	IC50	=	2	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Indoleamine 2,3-dioxygenase 1

External ID: CHEMBL2150231

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2012
Volume: 55
Issue: 11
First Page: 5270
Last Page: 5290
DOI: 10.1021/jm300260v

Target ChEMBL ID: CHEMBL4685
ChEMBL Target Name: Indoleamine 2,3-dioxygenase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
100	IC50	>	100000	nM
100	IC50	>	100000	nM
0.94	IC50	=	940	nM
7	IC50	=	7000	nM
0.06	IC50	=	60	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM
2.6	IC50	=	2600	nM
100	IC50	>	100000	nM
1.7	IC50	=	1700	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM
14	IC50	=	14000	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM
2.9	IC50	=	2900	nM
70	IC50	=	70000	nM
3.5	IC50	=	3500	nM
0.08	IC50	=	80	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：HepG2

External ID: CHEMBL2150234

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2012
Volume: 55
Issue: 11
First Page: 5270
Last Page: 5290
DOI: 10.1021/jm300260v

Target ChEMBL ID: CHEMBL395
ChEMBL Target Name: HepG2
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
100	LD50	>	100	uM
100	LD50	>	100	uM
100	LD50	>	100	uM
100	LD50	>	100	uM
100	LD50	>	100	uM
100	LD50	>	100	uM
100	LD50	>	100	uM
100	LD50	>	100	uM
100	LD50	>	100	uM
100	LD50	>	100	uM
100	LD50	>	100	uM
100	LD50	>	100	uM
100	LD50	>	100	uM
100	LD50	>	100	uM
100	LD50	>	100	uM
100	LD50	>	100	uM
100	LD50	>	100	uM
100	LD50	>	100	uM
100	LD50	>	100	uM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL2150235

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2012
Volume: 55
Issue: 11
First Page: 5270
Last Page: 5290
DOI: 10.1021/jm300260v

Standard Type	Standard Relation	Standard Value
Ratio IC50	=	77
Ratio IC50	=	77
Ratio IC50	=	77
Ratio IC50	=	77
Ratio IC50	=	77
Ratio IC50	=	77
Ratio IC50	=	77
Ratio IC50	=	77
Ratio IC50	=	77
Ratio IC50	=	77
Ratio IC50	=	77
Ratio IC50	=	77
Ratio IC50	=	77
Ratio IC50	=	77
Ratio IC50	=	77
Ratio IC50	=	77
Ratio IC50	=	77
Ratio IC50	=	77
Ratio IC50	=	77
Ratio IC50	=	77

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Tryptophan 2,3-dioxygenase

External ID: CHEMBL2150232

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2012
Volume: 55
Issue: 11
First Page: 5270
Last Page: 5290
DOI: 10.1021/jm300260v

Target ChEMBL ID: CHEMBL1075307
ChEMBL Target Name: Tryptophan 2,3-dioxygenase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
100	IC50	>	100000	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM
60	IC50	=	60000	nM
17	IC50	=	17000	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Tryptophan 2,3-dioxygenase

External ID: CHEMBL2150233

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2012
Volume: 55
Issue: 11
First Page: 5270
Last Page: 5290
DOI: 10.1021/jm300260v

Target ChEMBL ID: CHEMBL2140
ChEMBL Target Name: Tryptophan 2,3-dioxygenase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
100	IC50	>	100000	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM
70	IC50	=	70000	nM
28	IC50	=	28000	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM

369363-54-2 靶点实验数据