HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3096849

Protocol: N/A

Comment: Journal: Eur. J. Med. Chem.
Year: 2013
Volume: 70
First Page: 831
Last Page: 845
DOI: 10.1016/j.ejmech.2013.10.029

Standard Type	Standard Relation	Standard Value
LogP	=	-0.822
LogP	=	-2.322
LogP	=	-2.486
LogP	=	-3.12
LogP	=	-0.845
LogP	=	-2.179
LogP	=	-1.102
LogP	=	-1.348
LogP	=	-1.372
LogP	=	-1.216
LogP	=	0.018
LogP	=	-2.322
LogP	=	-2.072
LogP	=	-0.503
LogP	=	-3.125
LogP	=	-1.512
LogP	=	-1.788
LogP	=	-1.459
LogP	=	-2.072
LogP	=	-1.949

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mycobacterium tuberculosis

External ID: CHEMBL3282117

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Med Chem
Year: 1976
Volume: 19
Issue: 4
First Page: 483
Last Page: 492
DOI: 10.1021/jm00226a007

Target ChEMBL ID: CHEMBL360
ChEMBL Target Name: Mycobacterium tuberculosis
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
	log(1/MIC)	=	-2.415
616	MIC	=	616000	nM
	log(1/MIC)	=	-2.79
717	MIC	=	717000	nM
	log(1/MIC)	=	-2.856
254	MIC	=	254000	nM
	log(1/MIC)	=	-2.404
50	MIC	=	50000	nM
	log(1/MIC)	=	-2.653
450	MIC	=	450000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mycobacterium tuberculosis

External ID: CHEMBL3267866

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Eur J Med Chem
Year: 2014
Volume: 81
First Page: 119
Last Page: 138
DOI: 10.1016/j.ejmech.2014.04.077

Target ChEMBL ID: CHEMBL360
ChEMBL Target Name: Mycobacterium tuberculosis
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
9.859	MIC	=	9859	nM
1323.01	MIC	=	1323014	nM
0.245	MIC	=	245	nM
3.93	MIC	=	3930	nM
8.61	MIC	=	8610	nM
10.819	MIC	=	10819	nM
717	MIC	=	717000	nM
254	MIC	=	254000	nM
50	MIC	=	50000	nM
0.097	MIC	=	97	nM
2.29	MIC	=	2290	nM
44.65	MIC	=	44650	nM
1.26	MIC	=	1260	nM
4.61	MIC	=	4610	nM
10.974	MIC	=	10974	nM
21.983	MIC	=	21983	nM
0.95	MIC	=	950	nM
0.346	MIC	=	346	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mycobacterium tuberculosis

External ID: CHEMBL749419

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2004
Volume: 47
Issue: 15
First Page: 3755
Last Page: 3764
DOI: 10.1021/jm049913k

Target ChEMBL ID: CHEMBL360
ChEMBL Target Name: Mycobacterium tuberculosis
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value
pMIC	=	4.2
pMIC	=	0.22
pMIC	=	0.22
pMIC	=	3.22
pMIC	=	3.4
pMIC	=	3.22
pMIC	=	1.1
pMIC	=	1.4
pMIC	=	1.92
pMIC	=	1.92
pMIC	=	2.7
pMIC	=	1.52
pMIC	=	2
pMIC	=	2.82
pMIC	=	1.92
pMIC	=	1.52
pMIC	=	1.82
pMIC	=	2.52
pMIC	=	3.82
pMIC	=	2.7

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3281876

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1976
Volume: 19
Issue: 4
First Page: 483
Last Page: 492
DOI: 10.1021/jm00226a007

Standard Type	Standard Relation	Standard Value
Rm	=	0.372
Rm	=	0.42
Rm	=	0.866
Rm	=	1.383
Rm	=	1.643

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mycobacterium tuberculosis

External ID: CHEMBL3096846

Protocol: N/A

Comment: Journal: Eur. J. Med. Chem.
Year: 2013
Volume: 70
First Page: 831
Last Page: 845
DOI: 10.1016/j.ejmech.2013.10.029

Target ChEMBL ID: CHEMBL360
ChEMBL Target Name: Mycobacterium tuberculosis
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
log(1/MIC)	=	0	-
log(1/MIC)	=	1.7	-
MIC	=	1	ug.mL-1
MIC	=	0.02	ug.mL-1
log(1/MIC)	=	-2.78	-
MIC	=	600	ug.mL-1
log(1/MIC)	=	-2.78	-
MIC	=	600	ug.mL-1
log(1/MIC)	=	0.22	-
MIC	=	0.6	ug.mL-1
log(1/MIC)	=	-1.61	-
MIC	=	40.33	ug.mL-1
log(1/MIC)	=	0.22	-
MIC	=	0.6	ug.mL-1
log(1/MIC)	=	-1.9	-
MIC	=	80	ug.mL-1
log(1/MIC)	=	-1.08	-
MIC	=	12	ug.mL-1
log(1/MIC)	=	-2.12	-
MIC	=	133.08	ug.mL-1

369-24-4 靶点实验数据