HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3301370

Protocol: N/A

Comment: Data Source: AstraZeneca DMPK/physicochemical

Standard Type	Standard Relation	Standard Value	Standard Units
CL		8.33	mL.min-1.g-1
CL		4	mL.min-1.g-1
CL		13.49	mL.min-1.g-1
CL		48.98	mL.min-1.g-1
CL		5.75	mL.min-1.g-1
CL		6	mL.min-1.g-1
CL	<	3	mL.min-1.g-1
CL		43.65	mL.min-1.g-1
CL		35	mL.min-1.g-1
CL		6.31	mL.min-1.g-1
CL	<	3	mL.min-1.g-1
CL		15.14	mL.min-1.g-1
CL	<	3	mL.min-1.g-1
CL		5.75	mL.min-1.g-1
CL	<	3	mL.min-1.g-1
CL		82	mL.min-1.g-1
CL		29.51	mL.min-1.g-1
CL		6.46	mL.min-1.g-1
CL		116	mL.min-1.g-1
CL		8	mL.min-1.g-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：C-C chemokine receptor type 3

External ID: CHEMBL2173970

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2012
Volume: 22
Issue: 21
First Page: 6688
Last Page: 6693
DOI: 10.1016/j.bmcl.2012.08.124

Target ChEMBL ID: CHEMBL3473
ChEMBL Target Name: C-C chemokine receptor type 3
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.02512	Ki	=	25.12	nM
0.07943	Ki	=	79.43	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Histamine H1 receptor

External ID: CHEMBL2173976

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2012
Volume: 22
Issue: 21
First Page: 6688
Last Page: 6693
DOI: 10.1016/j.bmcl.2012.08.124

Target ChEMBL ID: CHEMBL231
ChEMBL Target Name: Histamine H1 receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.01585	Ki	=	15.85	nM
0.1	Ki	=	100	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3301363

Protocol: N/A

Comment: Data Source: AstraZeneca DMPK/physicochemical

Standard Type	Standard Value
LogD7.4	1.56
LogD7.4	1.39
LogD7.4	-0.78
LogD7.4	2.22
LogD7.4	3
LogD7.4	1.91
LogD7.4	-0.84
LogD7.4	1.19
LogD7.4	-1.08
LogD7.4	3.08
LogD7.4	3.65
LogD7.4	-0.5
LogD7.4	2.43
LogD7.4	2.3
LogD7.4	3.65
LogD7.4	4.3
LogD7.4	3.26
LogD7.4	2.55
LogD7.4	1.69
LogD7.4	1.46

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3301365

Protocol: N/A

Comment: Data Source: AstraZeneca DMPK/physicochemical

Standard Type	Standard Value	Standard Units
PPB	96	%
PPB	34.42	%
PPB	87.87	%
PPB	79.55	%
PPB	55.73	%
PPB	99.91	%
PPB	98.61	%
PPB	99.81	%
PPB	87.11	%
PPB	96.26	%
PPB	92.32	%
PPB	66.1	%
PPB	75.97	%
PPB	99.19	%
PPB	62.4	%
PPB	30.88	%
PPB	71.99	%
PPB	98.37	%
PPB	92.64	%
PPB	95.72	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3301367

Protocol: N/A

Comment: Data Source: AstraZeneca DMPK/physicochemical

Standard Type	Standard Value	Standard Units
PPB	99.72	%
PPB	31.37	%
PPB	95.63	%
PPB	65.06	%
PPB	96.93	%
PPB	92.64	%
PPB	86.59	%
PPB	67.12	%
PPB	69.61	%
PPB	95.33	%
PPB	99.43	%
PPB	85.77	%
PPB	38.69	%
PPB	78.79	%
PPB	59.66	%
PPB	72.91	%
PPB	14.52	%
PPB	60.77	%
PPB	52.3	%
PPB	14.52	%

367500-41-2 靶点实验数据