HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL1273655

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2010
Volume: 53
Issue: 22
First Page: 7992
Last Page: 7999
DOI: 10.1021/jm1006929

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.16	Kd	=	160	nM
0.054	Kd	=	54	nM
0.8	Kd	=	800	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL1273656

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2010
Volume: 53
Issue: 22
First Page: 7992
Last Page: 7999
DOI: 10.1021/jm1006929

Standard Type	Standard Relation	Standard Value
Ratio	=	3.5
Ratio	=	5.2
Ratio	=	9.6

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Amyloid-beta precursor protein

External ID: CHEMBL1273657

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2010
Volume: 53
Issue: 22
First Page: 7992
Last Page: 7999
DOI: 10.1021/jm1006929

Target ChEMBL ID: CHEMBL2487
ChEMBL Target Name: Amyloid-beta A4 protein
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Activity Comment
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Amyloid-beta precursor protein

External ID: CHEMBL1273658

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2010
Volume: 53
Issue: 22
First Page: 7992
Last Page: 7999
DOI: 10.1021/jm1006929

Target ChEMBL ID: CHEMBL2487
ChEMBL Target Name: Amyloid-beta A4 protein
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Activity Comment
Activity	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mus musculus

External ID: CHEMBL1273659

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2010
Volume: 53
Issue: 22
First Page: 7992
Last Page: 7999
DOI: 10.1021/jm1006929

Target ChEMBL ID: CHEMBL375
ChEMBL Target Name: Mus musculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mus musculus

External ID: CHEMBL1273660

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2010
Volume: 53
Issue: 22
First Page: 7992
Last Page: 7999
DOI: 10.1021/jm1006929

Target ChEMBL ID: CHEMBL375
ChEMBL Target Name: Mus musculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mus musculus

External ID: CHEMBL1273661

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2010
Volume: 53
Issue: 22
First Page: 7992
Last Page: 7999
DOI: 10.1021/jm1006929

Target ChEMBL ID: CHEMBL375
ChEMBL Target Name: Mus musculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL1273662

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2010
Volume: 53
Issue: 22
First Page: 7992
Last Page: 7999
DOI: 10.1021/jm1006929

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
1.8	IC50	=	1800	nM
5.1	IC50	=	5100	nM
45	IC50	=	45000	nM
4	IC50	=	4000	nM

360784-23-2 靶点实验数据