HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mycobacterium tuberculosis

External ID: CHEMBL750947

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1995
Volume: 38
Issue: 20
First Page: 3902
Last Page: 3907
DOI: 10.1021/jm00020a003

Target ChEMBL ID: CHEMBL360
ChEMBL Target Name: Mycobacterium tuberculosis
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MIC	=	32	ug.mL-1
MIC	=	16	ug.mL-1
MIC	=	4	ug.mL-1
MIC	=	1	ug.mL-1
MIC	<	8	ug.mL-1
MIC	=	0.25	ug.mL-1
MIC	=	2	ug.mL-1
MIC	<	0.03	ug.mL-1
MIC	=	16	ug.mL-1
MIC	<	8	ug.mL-1
MIC	=	0.25	ug.mL-1
MIC	=	2	ug.mL-1
MIC	=	4	ug.mL-1
MIC	=	64	ug.mL-1
MIC	=	64	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3615895

Protocol: N/A

Comment: Journal: Eur J Med Chem
Year: 2015
Volume: 101
First Page: 692
Last Page: 704
DOI: 10.1016/j.ejmech.2015.07.001

Standard Type	Standard Text Value
Drug metabolism	metabolite_detected

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mycobacterium kansasii

External ID: CHEMBL751696

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1995
Volume: 38
Issue: 20
First Page: 3902
Last Page: 3907
DOI: 10.1021/jm00020a003

Target ChEMBL ID: CHEMBL614984
ChEMBL Target Name: Mycobacterium kansasii
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MIC	=	256	ug.mL-1
MIC	=	2048	ug.mL-1
MIC	=	2	ug.mL-1
MIC	=	2	ug.mL-1
MIC	>	64	ug.mL-1
MIC	<	1	ug.mL-1
MIC	=	8	ug.mL-1
MIC	=	0.125	ug.mL-1
MIC	=	32	ug.mL-1
MIC	>	64	ug.mL-1
MIC	<	1	ug.mL-1
MIC	<	1	ug.mL-1
MIC	=	8	ug.mL-1
MIC	=	1024	ug.mL-1
MIC	=	64	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3615892

Protocol: N/A

Comment: Journal: Eur. J. Med. Chem.
Year: 2015
Volume: 101
First Page: 692
Last Page: 704
DOI: 10.1016/j.ejmech.2015.07.001

Standard Type	Standard Relation	Standard Value	Standard Units
Retention_time	=	12.3	min

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mycobacterium avium

External ID: CHEMBL747039

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1995
Volume: 38
Issue: 20
First Page: 3902
Last Page: 3907
DOI: 10.1021/jm00020a003

Target ChEMBL ID: CHEMBL614982
ChEMBL Target Name: Mycobacterium avium
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MIC	>	1024	ug.mL-1
MIC	>	2048	ug.mL-1
MIC	>	1024	ug.mL-1
MIC	>	1024	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mycobacterium tuberculosis

External ID: CHEMBL750949

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1995
Volume: 38
Issue: 20
First Page: 3902
Last Page: 3907
DOI: 10.1021/jm00020a003

Target ChEMBL ID: CHEMBL360
ChEMBL Target Name: Mycobacterium tuberculosis
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MIC	=	64	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mycobacterium avium

External ID: CHEMBL747038

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1995
Volume: 38
Issue: 20
First Page: 3902
Last Page: 3907
DOI: 10.1021/jm00020a003

Target ChEMBL ID: CHEMBL614982
ChEMBL Target Name: Mycobacterium avium
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MIC	>	1024	ug.mL-1
MIC	>	2048	ug.mL-1
MIC	=	256	ug.mL-1
MIC	=	128	ug.mL-1
MIC	=	256	ug.mL-1
MIC	=	64	ug.mL-1
MIC	>	64	ug.mL-1
MIC	=	32	ug.mL-1
MIC	>	256	ug.mL-1
MIC	=	256	ug.mL-1
MIC	=	128	ug.mL-1
MIC	=	64	ug.mL-1
MIC	=	64	ug.mL-1
MIC	=	1024	ug.mL-1
MIC	>	1024	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mycobacterium tuberculosis

External ID: CHEMBL750950

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1995
Volume: 38
Issue: 20
First Page: 3902
Last Page: 3907
DOI: 10.1021/jm00020a003

Target ChEMBL ID: CHEMBL360
ChEMBL Target Name: Mycobacterium tuberculosis
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MIC	=	32	ug.mL-1
MIC	=	2048	ug.mL-1
MIC	=	16	ug.mL-1
MIC	>	16	ug.mL-1
MIC	=	64	ug.mL-1
MIC	=	0.5	ug.mL-1
MIC	<	0.03	ug.mL-1
MIC	=	64	ug.mL-1
MIC	=	0.5	ug.mL-1
MIC	=	2	ug.mL-1
MIC	>	64	ug.mL-1
MIC	=	64	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mycobacterium tuberculosis variant bovis

External ID: CHEMBL5099097

Protocol: N/A

Comment: Journal: Bioorg Med Chem
Year: 2022
Volume: 74
First Page: 117046
Last Page: 117046
DOI: 10.1016/j.bmc.2022.117046

Target ChEMBL ID: CHEMBL613086
ChEMBL Target Name: Mycobacterium tuberculosis variant bovis
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
700	MIC50	=	700000	nM
3200	MIC50	=	3200000	nM
1700	MIC50	=	1700000	nM
2700	MIC50	=	2700000	nM
700	MIC50	=	700000	nM
5000	MIC50	>	5000000	nM
4000	MIC50	>	4000000	nM
5000	MIC50	>	5000000	nM
2700	MIC50	=	2700000	nM
5000	MIC50	>	5000000	nM
4000	MIC50	>	4000000	nM
1400	MIC50	=	1400000	nM
3000	MIC50	>	3000000	nM
4000	MIC50	>	4000000	nM
2500	MIC50	>	2500000	nM
1500	MIC50	=	1500000	nM
700	MIC50	=	700000	nM
4000	MIC50	>	4000000	nM
3500	MIC50	=	3500000	nM
700	MIC50	=	700000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mycobacteroides abscessus

External ID: CHEMBL3615874

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Eur J Med Chem
Year: 2015
Volume: 101
First Page: 692
Last Page: 704
DOI: 10.1016/j.ejmech.2015.07.001

Target ChEMBL ID: CHEMBL612951
ChEMBL Target Name: Mycobacteroides abscessus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
3.2	MIC	=	3200	nM
	Activity	=	0	CFU
632.9	MIC	>	632900	nM
3.2	MIC	=	3200	nM
	Activity	=	0	CFU
10.5	MIC	=	10500	nM
	Activity	=	0	CFU
25.3	MIC	=	25300	nM
	Activity	=	0	CFU
5.5	MIC	=	5500	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mycobacterium tuberculosis

External ID: CHEMBL3615875

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Eur J Med Chem
Year: 2015
Volume: 101
First Page: 692
Last Page: 704
DOI: 10.1016/j.ejmech.2015.07.001

Target ChEMBL ID: CHEMBL360
ChEMBL Target Name: Mycobacterium tuberculosis
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
	Activity	=	2	CFU
632.9	MIC	>	632900	nM
1.6	MIC	=	1600	nM
	Activity	=	0	CFU
0.2	MIC	=	200	nM
	Activity	=	2	CFU
12.7	MIC	=	12700	nM
	Activity	=	2	CFU
1.1	MIC	=	1100	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3615873

Protocol: N/A

Comment: Journal: Eur. J. Med. Chem.
Year: 2015
Volume: 101
First Page: 692
Last Page: 704
DOI: 10.1016/j.ejmech.2015.07.001

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
50	Solubility	<	50000	nM
100	Solubility	<	100000	nM
100	Solubility	<	100000	nM
100	Solubility	<	100000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mycobacterium tuberculosis

External ID: CHEMBL3615876

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Eur. J. Med. Chem.
Year: 2015
Volume: 101
First Page: 692
Last Page: 704
DOI: 10.1016/j.ejmech.2015.07.001

Target ChEMBL ID: CHEMBL360
ChEMBL Target Name: Mycobacterium tuberculosis
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
	Activity	=	8	CFU
632.9	MIC	>	632900	nM
1.6	MIC	=	1600	nM
	Activity	=	0	CFU
1.3	MIC	=	1300	nM
	Activity	=	0	CFU
12.7	MIC	=	12700	nM
	Activity	=	1	CFU
1.1	MIC	=	1100	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：MONO-MAC-6

External ID: CHEMBL3615881

Protocol: N/A

Comment: Journal: Eur. J. Med. Chem.
Year: 2015
Volume: 101
First Page: 692
Last Page: 704
DOI: 10.1016/j.ejmech.2015.07.001

Target ChEMBL ID: CHEMBL2366062
ChEMBL Target Name: MONO-MAC-6
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Non-toxic

36070-80-1 靶点实验数据