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36062-05-2 靶点实验数据

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:PC-12
External ID: CHEMBL5389940
Protocol: N/A
Comment: Journal: RSC Med Chem
Year: 2024
Volume: 15
Issue: 4
First Page: 1307
Last Page: 1319
DOI: 10.1039/d3md00455d

Target ChEMBL ID: CHEMBL612556
ChEMBL Target Name: PC-12
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular
Standard TypeStandard RelationStandard ValueStandard Units
Activity=35.25%
Activity=101.5%
Activity=77.77%
Activity=53.59%
Activity=66.55%
Activity=87.52%
Activity=62.75%
Activity=70.1%
Activity=46.03%
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:PC-12
External ID: CHEMBL5389939
Protocol: N/A
Comment: Journal: RSC Med Chem
Year: 2024
Volume: 15
Issue: 4
First Page: 1307
Last Page: 1319
DOI: 10.1039/d3md00455d

Target ChEMBL ID: CHEMBL612556
ChEMBL Target Name: PC-12
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular
Standard TypeStandard RelationStandard ValueStandard Units
Activity=57.29%
Activity=76.13%
Activity=69.46%
Activity=75.17%
Activity=52.41%
Activity=68.16%
Activity=66.47%
Activity=69.05%
Activity=62.44%
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:PC-12
External ID: CHEMBL5389938
Protocol: N/A
Comment: Journal: RSC Med Chem
Year: 2024
Volume: 15
Issue: 4
First Page: 1307
Last Page: 1319
DOI: 10.1039/d3md00455d

Target ChEMBL ID: CHEMBL612556
ChEMBL Target Name: PC-12
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular
Standard TypeStandard RelationStandard ValueStandard Units
Activity=66.2%
Activity=66.1%
Activity=62.56%
Activity=74.06%
Activity=66.05%
Activity=63.89%
Activity=64.15%
Activity=67.39%
Activity=54.34%
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:Glutamate receptor ionotropic, NMDA 2B
External ID: CHEMBL5389935
Protocol: N/A
Comment: Journal: RSC Med Chem
Year: 2024
Volume: 15
Issue: 4
First Page: 1307
Last Page: 1319
DOI: 10.1039/d3md00455d

Target ChEMBL ID: CHEMBL1907603
ChEMBL Target Name: Glutamate NMDA receptor; GRIN1/GRIN2B
ChEMBL Target Type: PROTEIN COMPLEX - Target is a defined protein complex, consisting of multiple subunits
Relationship Type: D - Direct protein target assigned
Confidence: Direct protein complex subunits assigned
Standard TypeActivity Comment
ActivityNot Active
ActivityNot Active
ActivityNot Active
ActivityNot Active
ActivityNot Active
ActivityNot Active
ActivityNot Active
ActivityNot Active
ActivityNot Active
ActivityNot Active
ActivityNot Active
ActivityNot Active
ActivityNot Active
ActivityNot Active
ActivityNot Active
ActivityNot Active
ActivityNot Active
ActivityNot Active
ActivityNot Active
ActivityNot Active
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:Glutamate receptor ionotropic, NMDA 2A
External ID: CHEMBL5389934
Protocol: N/A
Comment: Journal: RSC Med Chem
Year: 2024
Volume: 15
Issue: 4
First Page: 1307
Last Page: 1319
DOI: 10.1039/d3md00455d

Target ChEMBL ID: CHEMBL1907604
ChEMBL Target Name: Glutamate NMDA receptor; GRIN1/GRIN2A
ChEMBL Target Type: PROTEIN COMPLEX - Target is a defined protein complex, consisting of multiple subunits
Relationship Type: D - Direct protein target assigned
Confidence: Direct protein complex subunits assigned
Standard TypeActivity Comment
ActivityActive
ActivityDose-Dependent Effect
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:Beta-secretase 1
External ID: CHEMBL3107153
Protocol: N/A
Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2014
Volume: 24
Issue: 2
First Page: 685
Last Page: 690
DOI: 10.1016/j.bmcl.2013.11.039

Target ChEMBL ID: CHEMBL4822
ChEMBL Target Name: Beta-secretase 1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned
Standard TypeStandard RelationStandard ValueStandard Units
Inhibition=7%
Inhibition=7%
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:NIAID 靶标:N/A
External ID: HIV Cellular Data
Protocol: N/A
Comment: N/A
SpeciesStrainIsPseudotypeVirusAssayMethCellTypeCellType2TargetMutationsEC50ModEC50EC50UnitECOtherPctECOtherPctUnitECOtherConcECOtherConcUnitToxAssayMethToxCellTypeCC50ModCC50CC50UnitTIModTIRelResFoldChgCommentsReferenceCitationOther Information
HIV-1LAIRTHuT TK+HuT 78Reverse transcriptase<1uM100%1uMMTT>10uM>10HuT TK+=HuT 78 CELLS EXPRESSING HSV-1 THYMIDINE KINASE; MEASUREMENT WAS MADE ON DAY10 POSTINFECTION AT 10 TCID509281520USE OF HERPES SIMPLEX VIRUS THYMIDINE KINASE TO IMPROVE THE ANTIVIRAL ACTIVITY OF ZIDOVUDINE. Virology 1997, 235, 398-405.
HIV-1MNRTHuT TK+HuT 78Reverse transcriptase<0.3uM76.74%0.3uMMTT>10uM>33.3HuT TK+=HuT 78 CELLS EXPRESSING HSV-1 THYMIDINE KINASE; MEASUREMENT WAS MADE ON DAY14 POSTINFECTION AT 10 TCID509281520USE OF HERPES SIMPLEX VIRUS THYMIDINE KINASE TO IMPROVE THE ANTIVIRAL ACTIVITY OF ZIDOVUDINE. Virology 1997, 235, 398-405.
HIV-1MNRTHuT TK+HuT 78Reverse transcriptase<0.3uM69%0.3uMMTT>10uM>33.3HuT TK+=HuT 78 CELLS EXPRESSING HSV-1 THYMIDINE KINASE; MEASUREMENT WAS MADE ON DAY14 POSTINFECTION AT 100 TCID509281520USE OF HERPES SIMPLEX VIRUS THYMIDINE KINASE TO IMPROVE THE ANTIVIRAL ACTIVITY OF ZIDOVUDINE. Virology 1997, 235, 398-405.
R5; CLINICAL ISOLATE1(JSL)P24PBMCReverse transcriptaseMDR0.07uM90%1uMMTT>100uM>1428HIV-1(JSL) WAS ISOLATED FROM PATIENTS WHO RECEIVED ANTIRETROVIRAL THERAPY FOR A LONG PERIOD AND WHOSE VIRUS ACQUIRED A NUMBER OF MUTATIONS IN THE RT- AND PR-ENCODING GENES; DETAILS OF MUTATIONS NOT GIVEN15280474SPIRODIKETOPIPERAZINE-BASED CCR5 INHIBITOR WHICH PRESERVES CC-CHEMOKINE/CCR5 INTERACTIONS AND EXERTS POTENT ACTIVITY AGAINST R5 HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 IN VITRO. Journal of Virology 2004, 78(16), 8654-8662.ECOtherConcMod:>
HIV-1NL4-3LUCIFERASE1G5 TReverse transcriptase<1uM99%1uMTRYPAN BLUE>1uM>1ASSAY WAS CONDUCTED ON DAY 3 POST-INFECTION16725040INHIBITION OF HIGHLY PRODUCTIVE HIV-1 INFECTION IN T CELLS, PRIMARY HUMAN MACROPHAGES, MICROGLIA, AND ASTROCYTES BY SARGASSUM FUSIFORME. AIDS Research and Therapy 2006, 3(1), 15 PP.CCOtherPct:6 | CCOtherPctUnit:% | CCOtherConc:1 | CCOtherConcUnit:uM
HIV-1NL4-3LUCIFERASE1G5 TReverse transcriptase<1uM99%1uMTRYPAN BLUE>1uM>1ASSAY WAS CONDUCTED ON DAY 5 POST-INFECTION16725040INHIBITION OF HIGHLY PRODUCTIVE HIV-1 INFECTION IN T CELLS, PRIMARY HUMAN MACROPHAGES, MICROGLIA, AND ASTROCYTES BY SARGASSUM FUSIFORME. AIDS Research and Therapy 2006, 3(1), 15 PP.CCOtherPct:7 | CCOtherPctUnit:% | CCOtherConc:1 | CCOtherConcUnit:uM
HIV-1NL4-3LUCIFERASE1G5 TReverse transcriptase<1uM99%1uMTRYPAN BLUE>1uM>1ASSAY WAS CONDUCTED ON DAY 7 POST-INFECTION16725040INHIBITION OF HIGHLY PRODUCTIVE HIV-1 INFECTION IN T CELLS, PRIMARY HUMAN MACROPHAGES, MICROGLIA, AND ASTROCYTES BY SARGASSUM FUSIFORME. AIDS Research and Therapy 2006, 3(1), 15 PP.CCOtherPct:3 | CCOtherPctUnit:% | CCOtherConc:1 | CCOtherConcUnit:uM
HIV-1LAVRTU1(THF-.alpha. STIM)U1Tumor necrosis factor alpha~30ug/mL70%50ug/mL>50ug/mL>1.66CHRONICALLY HIV-1 INFECTED PROMONOCYTE CELL LINE8327469THALIDOMIDE INHIBITS THE REPLICATION OF HUMAN IMMUNODEFICIENCY VIRUS TYPE 1. Proceedings of the National Academy of Sciences of the United States of America 1993, 90, 5974-5978.CCOtherPct:0 | CCOtherPctUnit:% | CCOtherConc:50 | CCOtherConcUnit:ug/mL
HIV-1BaLP24 (DAY 18)MACROPHAGES(GM-CSF)MacrophageRibonucleotide reductase<10uM75%10uM>1000uM>10MAXIMAL P24 EXPRESSION AT DAY 187973634HYDROXYUREA AS AN INHIBITOR OF HUMAN IMMUNODEFICIENCY VIRUS-TYPE 1 REPLICATION. Science 1994, 266(5186), 801-805.CCOtherPct:0 | CCOtherPctUnit:% | CCOtherConc:1000 | CCOtherConcUnit:uM
HIV-1BaLP24 (DAY 18)MACROPHAGES(GM-CSF)MacrophageRibonucleotide reductase<10uM38%2uM>1000uM>10MAXIMAL P24 EXPRESSION AT DAY 187973634HYDROXYUREA AS AN INHIBITOR OF HUMAN IMMUNODEFICIENCY VIRUS-TYPE 1 REPLICATION. Science 1994, 266(5186), 801-805.CCOtherPct:0 | CCOtherPctUnit:% | CCOtherConc:1000 | CCOtherConcUnit:uM
HIV-1BaLP24 (DAY 18)MACROPHAGES(GM-CSF)MacrophageRibonucleotide reductase<10uM99%50uM>1000uM>10MAXIMAL P24 EXPRESSION AT DAY 187973634HYDROXYUREA AS AN INHIBITOR OF HUMAN IMMUNODEFICIENCY VIRUS-TYPE 1 REPLICATION. Science 1994, 266(5186), 801-805.ECOtherPctMod:> | CCOtherPct:0 | CCOtherPctUnit:% | CCOtherConc:1000 | CCOtherConcUnit:uM
HIV-1IIIBRTHT4(R116; AZT RESISTANT CELLS)HT4Reverse transcriptase~0.01uM70%0.01uM~`1uM~100FLOXURIDINE APPEARS TO POTENTIATE AZT ACTIVITY AND ALSO HAVE SOME ANTI-HIV ACTIVITY IN AZT RESISTANT CELL LINES8827211USE OF FLOXURIDINE TO MODULATE THE ANTIVIRAL ACTIVITY OF ZIDOVUDINE. AIDS Research and Human Retroviruses 1996, 12(11), 965-968.ECOtherPctMod:~ | CCOtherPct:35 | CCOtherPctUnit:% | CCOtherConc:.1 | CCOtherConcUnit:uM
HIV-11.beta.GAL AS A MEASURE OF TAT-MEDIATED TRANSACTIVATIONHeLa H12(HIV-1 LTR-Laz, TAT)HeLaTat:TAR/LTR<0.1uM52%0.1uMTRYPAN BLUE>100uM>1000DRUG AND RECOMBINANT TAT WERE INTRODUCED INTO CELLS THROUGH ELECTROPORATION9561563CURCUMIN AND CURCUMIN DERIVATIVES INHIBIT TAT-MEDIATED TRANSACTIVATION OF TYPE 1 HUMAN IMMUNODEFICIENCY VIRUS LONG TERMINAL REPEAT. Research in Virology 1998, 149(1), 43-52.
HIV-11.beta.GAL AS A MEASURE OF TAT-MEDIATED TRANSACTIVATIONHeLa H12(HIV-1 LTR-Laz, TAT)HeLaTat:TAR/LTR<0.01uM78%0.01uMTRYPAN BLUE>100uM>10000DRUG AND RECOMBINANT TAT WERE INTRODUCED INTO CELLS THROUGH ELECTROPORATION9561563CURCUMIN AND CURCUMIN DERIVATIVES INHIBIT TAT-MEDIATED TRANSACTIVATION OF TYPE 1 HUMAN IMMUNODEFICIENCY VIRUS LONG TERMINAL REPEAT. Research in Virology 1998, 149(1), 43-52.
HIV-1IIIBSYNCYT FORMMOLT-4/H9(HIV-1(IIIB))MOLT-4gp120<1uM95%10uM-10010uM>10CHRONICALLY INFECTED H9 CELLS9343823TRIAZINE DYES INHIBIT HIV-1 ENTRY BY BINDING TO ENVELOPE GLYCOPROTEINS. Microbiology and Immunology 1997, 41(9), 717-724.CCOtherPct:30 | CCOtherPctUnit:% | CCOtherConc:10 | CCOtherConcUnit:uM
HIV-11.beta.GAL AS A MEASURE OF TAT-MEDIATED TRANSACTIVATIONHeLa H12(HIV-1 LTR-Laz, TAT)HeLaTat:TAR/LTR<0.01uM75%0.01uMTRYPAN BLUE>100uM>10000DRUG AND RECOMBINANT TAT WERE INTRODUCED INTO CELLS THROUGH ELECTROPORATION9561563CURCUMIN AND CURCUMIN DERIVATIVES INHIBIT TAT-MEDIATED TRANSACTIVATION OF TYPE 1 HUMAN IMMUNODEFICIENCY VIRUS LONG TERMINAL REPEAT. Research in Virology 1998, 149(1), 43-52.
HIV-11P24MT-4Integrase<0.25uM95%0.25uMMICROSCOPIC EXAMINATION>20uM>80IN THE PRESENCE OF 50% NHS16554152A SERIES OF 5-AMINOSUBSTITUTED 4-FLUOROBENZYL-8-HYDROXY-[1,6]NAPHTHYRIDINE-7-CARBOXAMIDE HIV-1 INTEGRASE INHIBITORS. Bioorganic & Medical Chemistry Letters 2006, 16(11), 2900-2904.ECOtherPctMod:>
HIV-11P24MT-4Integrase<0.103uM95%0.103uMMICROSCOPIC EXAMINATION>20uM>194IN THE PRESENCE OF 10% FBS16554152A SERIES OF 5-AMINOSUBSTITUTED 4-FLUOROBENZYL-8-HYDROXY-[1,6]NAPHTHYRIDINE-7-CARBOXAMIDE HIV-1 INTEGRASE INHIBITORS. Bioorganic & Medical Chemistry Letters 2006, 16(11), 2900-2904.ECOtherPctMod:>
HIV-1NL4-3RTMT-4Reverse transcriptase<1uM100%1uMWST-8>1uM>1MEASUREMENTS WERE MADE ON DAY 4, 6 AND 8 POST INFECTION15371436POLYARGININE INHIBITS GP160 PROCESSING BY FURIN AND SUPPRESSES PRODUCTIVE HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 INFECTION. The Journal of Biological Chemistry 2004, 279(47), 49055-49063.
HIV-1LAIRTHuT 78Reverse transcriptase<1uM57.14%1uMMTT>10uM>10MEASUREMENT WAS MADE ON DAY10 POSTINFECTION AT 10 TCID509281520USE OF HERPES SIMPLEX VIRUS THYMIDINE KINASE TO IMPROVE THE ANTIVIRAL ACTIVITY OF ZIDOVUDINE. Virology 1997, 235, 398-405.
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:Mycobacterium tuberculosis
External ID: CHEMBL1252095
Protocol: N/A
Comment: Journal: Eur J Med Chem
Year: 2010
Volume: 45
Issue: 10
First Page: 4446
Last Page: 4457
DOI: 10.1016/j.ejmech.2010.07.003

Target ChEMBL ID: CHEMBL360
ChEMBL Target Name: Mycobacterium tuberculosis
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular
Standard TypeStandard RelationStandard ValueStandard UnitsActivity Comment
MIC=0.06ug.mL-1
MIC=50ug.mL-1
MIC=25ug.mL-1
MIC=100ug.mL-1
MIC=200ug.mL-1
MIC=200ug.mL-1
MIC=1.56ug.mL-1
MIC=2.5ug.mL-1
MIC=25ug.mL-1
MIC=100ug.mL-1
MIC=200ug.mL-1
MIC=100ug.mL-1
MIC=12.5ug.mL-1
MIC=25ug.mL-1
MIC=25ug.mL-1
MIC=200ug.mL-1
MIC=50ug.mL-1
MIC=0.004ug.mL-1
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:Trypanosoma brucei brucei
External ID: CHEMBL1099526
Protocol: N/A
Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Eur J Med Chem
Year: 2010
Volume: 45
Issue: 3
First Page: 941
Last Page: 956
DOI: 10.1016/j.ejmech.2009.11.035

Target ChEMBL ID: CHEMBL612851
ChEMBL Target Name: Trypanosoma brucei brucei
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular
PubChem Standard ValueStandard TypeStandard RelationStandard ValueStandard UnitsActivity Comment
12EC50=12000nM
4.5EC50=4500nM
3.4EC50=3400nM
2.7EC50=2700nM
2.9EC50=2900nM
19EC50=19000nM
2.2EC50=2200nM
1.2EC50=1200nM
0.58EC50=580nM
EC50Not Determined
5.1EC50=5100nM
7.8EC50=7800nM
4.7EC50=4700nM
EC50ND(Insoluble)
1.7EC50=1700nM
0.023EC50=23nM
2.2EC50=2200nM
0.1EC50=100nM
12EC50=12000nM
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:Trypanosoma brucei brucei
External ID: CHEMBL1099525
Protocol: N/A
Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Eur J Med Chem
Year: 2010
Volume: 45
Issue: 3
First Page: 941
Last Page: 956
DOI: 10.1016/j.ejmech.2009.11.035

Target ChEMBL ID: CHEMBL612851
ChEMBL Target Name: Trypanosoma brucei brucei
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular
PubChem Standard ValueStandard TypeStandard RelationStandard ValueStandard UnitsActivity Comment
9.5EC50=9500nM
2.5EC50=2500nM
1.1EC50=1100nM
4.7EC50=4700nM
22EC50=22000nM
5.9EC50=5900nM
2.2EC50=2200nM
1.4EC50=1400nM
3.2EC50=3200nM
4EC50=4000nM
7.8EC50=7800nM
1.6EC50=1600nM
EC50ND(Insoluble)
1.5EC50=1500nM
0.082EC50=82nM
9.7EC50=9700nM
0.22EC50=220nM
2.2EC50=2200nM
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:Trypanosoma brucei brucei
External ID: CHEMBL1099524
Protocol: N/A
Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Eur J Med Chem
Year: 2010
Volume: 45
Issue: 3
First Page: 941
Last Page: 956
DOI: 10.1016/j.ejmech.2009.11.035

Target ChEMBL ID: CHEMBL612851
ChEMBL Target Name: Trypanosoma brucei brucei
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular
PubChem Standard ValueStandard TypeStandard RelationStandard ValueStandard UnitsActivity Comment
7.7EC50=7700nM
1.8EC50=1800nM
0.87EC50=870nM
2.5EC50=2500nM
33EC50=33000nM
4.6EC50=4600nM
1.6EC50=1600nM
1.1EC50=1100nM
2.5EC50=2500nM
2.5EC50=2500nM
3.7EC50=3700nM
1.2EC50=1200nM
EC50ND(Insoluble)
1.9EC50=1900nM
0.053EC50=53nM
4.1EC50=4100nM
0.22EC50=220nM
2.4EC50=2400nM
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:DNA (cytosine-5)-methyltransferase 1
External ID: CHEMBL1035629
Protocol: N/A
Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2009
Volume: 19
Issue: 3
First Page: 706
Last Page: 709
DOI: 10.1016/j.bmcl.2008.12.041

Target ChEMBL ID: CHEMBL1993
ChEMBL Target Name: DNA (cytosine-5)-methyltransferase 1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned
Standard TypeActivity Comment
ActivityActive
ActivityActive
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:DNA (cytosine-5)-methyltransferase 1
External ID: CHEMBL1035628
Protocol: N/A
Comment: Journal: Bioorg Med Chem Lett
Year: 2009
Volume: 19
Issue: 3
First Page: 706
Last Page: 709
DOI: 10.1016/j.bmcl.2008.12.041

Target ChEMBL ID: CHEMBL1993
ChEMBL Target Name: DNA (cytosine-5)-methyltransferase 1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned
Standard TypeActivity Comment
ActivityActive
ActivityActive
ActivityActive
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:Orphan methyltransferase M.SssI
External ID: CHEMBL1035631
Protocol: N/A
Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2009
Volume: 19
Issue: 3
First Page: 706
Last Page: 709
DOI: 10.1016/j.bmcl.2008.12.041

Target ChEMBL ID: CHEMBL4373
ChEMBL Target Name: CpG DNA methylase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned
Standard TypeActivity Comment
ActivityNot Active
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:RBL-2H3
External ID: CHEMBL1052291
Protocol: N/A
Comment: Journal: J. Nat. Prod.
Year: 2009
Volume: 72
Issue: 5
First Page: 950
Last Page: 953
DOI: 10.1021/np800555y

Target ChEMBL ID: CHEMBL614632
ChEMBL Target Name: RBL-2H3
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular
Standard TypeStandard UnitsActivity Comment
Inhibition%tde
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:N/A
External ID: CHEMBL1052286
Protocol: N/A
Comment: Journal: J. Nat. Prod.
Year: 2009
Volume: 72
Issue: 5
First Page: 950
Last Page: 953
DOI: 10.1021/np800555y
Standard TypeActivity Comment
ActivityToxic
ActivityToxic
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:HEK293
External ID: CHEMBL1099529
Protocol: N/A
Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Eur J Med Chem
Year: 2010
Volume: 45
Issue: 3
First Page: 941
Last Page: 956
DOI: 10.1016/j.ejmech.2009.11.035

Target ChEMBL ID: CHEMBL614818
ChEMBL Target Name: HEK293
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular
PubChem Standard ValueStandard TypeStandard RelationStandard ValueStandard UnitsActivity CommentData Validity Comment
39EC50=39000nM
36EC50=36000nM
37EC50=37000nM
370EC50=370000nMOutside typical range
40EC50=40000nM
80EC50=80000nM
22EC50=22000nM
220EC50=220000nMOutside typical range
350EC50=350000nMOutside typical range
500EC50>500000nMOutside typical range
370EC50=370000nMOutside typical range
EC50ND(Insoluble)
150EC50=150000nMOutside typical range
24EC50=24000nM
76EC50=76000nM
8.1EC50=8100nM
270EC50=270000nMOutside typical range
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:RAW264.7
External ID: CHEMBL5235292
Protocol: N/A
Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem
Year: 2021
Volume: 31
First Page: 115971
Last Page: 115971
DOI: 10.1016/j.bmc.2020.115971

Target ChEMBL ID: CHEMBL612557
ChEMBL Target Name: RAW264.7
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular
PubChem Standard ValueStandard TypeStandard RelationStandard ValueStandard Units
0.6IC50=600nM
22.8IC50=22800nM
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:Leishmania mexicana
External ID: CHEMBL1099528
Protocol: N/A
Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Eur J Med Chem
Year: 2010
Volume: 45
Issue: 3
First Page: 941
Last Page: 956
DOI: 10.1016/j.ejmech.2009.11.035

Target ChEMBL ID: CHEMBL612880
ChEMBL Target Name: Leishmania mexicana
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular
PubChem Standard ValueStandard TypeStandard RelationStandard ValueStandard UnitsActivity Comment
63EC50=63000nM
12EC50=12000nM
3.2EC50=3200nM
16EC50=16000nM
100EC50>100000nM
37EC50=37000nM
34EC50=34000nM
4.8EC50=4800nM
17EC50=17000nM
64EC50=64000nM
100EC50>100000nM
100EC50>100000nM
EC50ND(Insoluble)
53EC50=53000nM
17EC50=17000nM
22EC50=22000nM
4.6EC50=4600nM
12EC50=12000nM
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:Leishmania major
External ID: CHEMBL1099527
Protocol: N/A
Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Eur J Med Chem
Year: 2010
Volume: 45
Issue: 3
First Page: 941
Last Page: 956
DOI: 10.1016/j.ejmech.2009.11.035

Target ChEMBL ID: CHEMBL612879
ChEMBL Target Name: Leishmania major
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular
PubChem Standard ValueStandard TypeStandard RelationStandard ValueStandard UnitsActivity Comment
72EC50=72000nM
26EC50=26000nM
4.3EC50=4300nM
33EC50=33000nM
41EC50=41000nM
37EC50=37000nM
73EC50=73000nM
7.4EC50=7400nM
100EC50>100000nM
80EC50=80000nM
20EC50=20000nM
42EC50=42000nM
EC50ND(Insoluble)
100EC50>100000nM
8.9EC50=8900nM
30EC50=30000nM
2.7EC50=2700nM
5.7EC50=5700nM
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:RAW264.7
External ID: CHEMBL5235291
Protocol: N/A
Comment: Journal: Bioorg Med Chem
Year: 2021
Volume: 31
First Page: 115971
Last Page: 115971
DOI: 10.1016/j.bmc.2020.115971

Target ChEMBL ID: CHEMBL612557
ChEMBL Target Name: RAW264.7
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular
Standard TypeStandard RelationStandard ValueStandard Units
Inhibition=32%
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:RBL-2H3
External ID: CHEMBL1052292
Protocol: N/A
Comment: Journal: J. Nat. Prod.
Year: 2009
Volume: 72
Issue: 5
First Page: 950
Last Page: 953
DOI: 10.1021/np800555y

Target ChEMBL ID: CHEMBL614632
ChEMBL Target Name: RBL-2H3
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular
Standard TypeStandard UnitsActivity Comment
Inhibition%Dose-dependent effect
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:HT-22
External ID: CHEMBL5389945
Protocol: N/A
Comment: Journal: RSC Med Chem
Year: 2024
Volume: 15
Issue: 4
First Page: 1307
Last Page: 1319
DOI: 10.1039/d3md00455d

Target ChEMBL ID: CHEMBL614316
ChEMBL Target Name: HT-22
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular
Standard TypeStandard RelationStandard ValueStandard Units
Activity=81.71%
Activity=55.8%
Activity=89.66%
Activity=22.38%
Activity=92.06%
Activity=93.03%
Activity=86.01%
Activity=76.87%
Activity=90.29%
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:HT-22
External ID: CHEMBL5389944
Protocol: N/A
Comment: Journal: RSC Med Chem
Year: 2024
Volume: 15
Issue: 4
First Page: 1307
Last Page: 1319
DOI: 10.1039/d3md00455d

Target ChEMBL ID: CHEMBL614316
ChEMBL Target Name: HT-22
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular
Standard TypeStandard RelationStandard ValueStandard Units
Activity=24.5%
Activity=43.33%
Activity=52.41%
Activity=25.64%
Activity=42.92%
Activity=37.43%
Activity=39.58%
Activity=41.38%
Activity=42.92%
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:HT-22
External ID: CHEMBL5389943
Protocol: N/A
Comment: Journal: RSC Med Chem
Year: 2024
Volume: 15
Issue: 4
First Page: 1307
Last Page: 1319
DOI: 10.1039/d3md00455d

Target ChEMBL ID: CHEMBL614316
ChEMBL Target Name: HT-22
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular
Standard TypeStandard RelationStandard ValueStandard Units
Activity=87.83%
Activity=95.37%
Activity=71.03%
Activity=80.44%
Activity=102.9%
Activity=73.81%
Activity=77.57%
Activity=69%
Activity=71.13%
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:HT-22
External ID: CHEMBL5389942
Protocol: N/A
Comment: Journal: RSC Med Chem
Year: 2024
Volume: 15
Issue: 4
First Page: 1307
Last Page: 1319
DOI: 10.1039/d3md00455d

Target ChEMBL ID: CHEMBL614316
ChEMBL Target Name: HT-22
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular
Standard TypeStandard RelationStandard ValueStandard Units
Activity=36.45%
Activity=32.62%
Activity=24.82%
Activity=46.26%
Activity=41.44%
Activity=37.73%
Activity=42.66%
Activity=34.92%
Activity=41.11%
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:PC-12
External ID: CHEMBL5389941
Protocol: N/A
Comment: Journal: RSC Med Chem
Year: 2024
Volume: 15
Issue: 4
First Page: 1307
Last Page: 1319
DOI: 10.1039/d3md00455d

Target ChEMBL ID: CHEMBL612556
ChEMBL Target Name: PC-12
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular
Standard TypeStandard RelationStandard ValueStandard Units
Activity=98.35%
Activity=103.9%
Activity=95.53%
Activity=69.64%
Activity=73.31%
Activity=94.79%
Activity=96.62%
Activity=74.71%
Activity=97.6%