HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Cyclin-dependent kinase 5

External ID: CHEMBL666138

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2002
Volume: 12
Issue: 7
First Page: 1129
Last Page: 1132
DOI: 10.1016/s0960-894x(02)00094-x

Target ChEMBL ID: CHEMBL4036
ChEMBL Target Name: Cyclin-dependent kinase 5
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	68	%
Inhibition	=	65	%
Inhibition	=	35	%
Inhibition	=	41	%
Inhibition	=	69	%
Inhibition	=	26	%
Inhibition	=	5	%
Inhibition	=	9	%
Inhibition	=	46	%
Inhibition	=	25	%
Inhibition	=	0	%
Inhibition	=	64	%
Inhibition	=	45	%
Inhibition	=	8	%
Inhibition	=	44	%
Inhibition	=	2	%
Inhibition	=	55	%
Inhibition	=	27	%
Inhibition	=	32	%
Inhibition	=	5	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：5-hydroxytryptamine receptor 5A

External ID: CHEMBL618086

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2003
Volume: 46
Issue: 18
First Page: 3930
Last Page: 3937
DOI: 10.1021/jm030080s

Target ChEMBL ID: CHEMBL3426
ChEMBL Target Name: Serotonin 5a (5-HT5a) receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
10	Ki	>	10000	nM
10	Ki	>	10000	nM
10	Ki	>	10000	nM
1.92	Ki	=	1920	nM
1.08	Ki	=	1080	nM
10	Ki	>	10000	nM
10	Ki	>	10000	nM
10	Ki	>	10000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：CHO

External ID: CHEMBL956919

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 1983
Volume: 46
Issue: 4
First Page: 576
Last Page: 581
DOI: 10.1021/np50028a027

Target ChEMBL ID: CHEMBL613853
ChEMBL Target Name: CHO
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
Activity	=	6.7	%
Activity				Toxic
Activity				Toxic
Activity	=	0	%
Activity				Toxic
Activity	=	6.7	%
Activity	=	0	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：CHO

External ID: CHEMBL956131

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 1983
Volume: 46
Issue: 4
First Page: 576
Last Page: 581
DOI: 10.1021/np50028a027

Target ChEMBL ID: CHEMBL613853
ChEMBL Target Name: CHO
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
Activity				Toxic
Activity				Toxic
Activity				Active
Activity				Toxic
Activity				Toxic
Activity	=	43.2	%
Activity				Toxic
Activity				Toxic
Activity	=	35.2	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：CHO

External ID: CHEMBL956133

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 1983
Volume: 46
Issue: 4
First Page: 576
Last Page: 581
DOI: 10.1021/np50028a027

Target ChEMBL ID: CHEMBL613853
ChEMBL Target Name: CHO
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
Activity				Toxic
Activity				Toxic
Activity	=	82.4	%
Activity				Toxic
Activity				Toxic
Activity	=	22.1	%
Activity				Toxic
Activity				Toxic
Activity	=	5.7	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：CHO

External ID: CHEMBL956920

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 1983
Volume: 46
Issue: 4
First Page: 576
Last Page: 581
DOI: 10.1021/np50028a027

Target ChEMBL ID: CHEMBL613853
ChEMBL Target Name: CHO
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	8.9	%
Activity	=	21.7	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：CHO

External ID: CHEMBL956944

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 1983
Volume: 46
Issue: 4
First Page: 576
Last Page: 581
DOI: 10.1021/np50028a027

Target ChEMBL ID: CHEMBL613853
ChEMBL Target Name: CHO
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Units
Activity	=	%
Activity	=	%
Activity	=	%
Activity	=	%
Activity	=	%
Activity	=	%
Activity	=	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：CHO

External ID: CHEMBL956917

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 1983
Volume: 46
Issue: 4
First Page: 576
Last Page: 581
DOI: 10.1021/np50028a027

Target ChEMBL ID: CHEMBL613853
ChEMBL Target Name: CHO
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	0	%
Activity	=	22.1	%
Activity	=	7.5	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Acetylcholinesterase

External ID: CHEMBL911302

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2006
Volume: 16
Issue: 22
First Page: 5840
Last Page: 5843
DOI: 10.1016/j.bmcl.2006.08.067

Target ChEMBL ID: CHEMBL220
ChEMBL Target Name: Acetylcholinesterase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
10	IC50	>	10000	nM
48	IC50	=	48000	nM
0.6	IC50	=	600	nM
0.63533	IC50	=	635.33	nM
10	IC50	>	10000	nM
11.8	IC50	=	11800	nM
11.7761	IC50	=	11776.06	nM
2.208	IC50	=	2208	nM
1.3	IC50	=	1300	nM
10	IC50	>	10000	nM
10	IC50	>	10000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Cholinesterase

External ID: CHEMBL911303

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2006
Volume: 16
Issue: 22
First Page: 5840
Last Page: 5843
DOI: 10.1016/j.bmcl.2006.08.067

Target ChEMBL ID: CHEMBL1914
ChEMBL Target Name: Butyrylcholinesterase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
10	IC50	>	10000	nM
54	IC50	=	54000	nM
8.4	IC50	=	8400	nM
8.3946	IC50	=	8394.6	nM
10	IC50	>	10000	nM
17.4	IC50	=	17400	nM
17.4582	IC50	=	17458.22	nM
17.4582	IC50	=	17458.22	nM
20.9	IC50	=	20900	nM
10	IC50	>	10000	nM
10	IC50	>	10000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：CHO

External ID: CHEMBL956142

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 1983
Volume: 46
Issue: 4
First Page: 576
Last Page: 581
DOI: 10.1021/np50028a027

Target ChEMBL ID: CHEMBL613853
ChEMBL Target Name: CHO
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
Activity				Toxic
Activity				Toxic
Activity				Toxic
Activity				Toxic
Activity	=	63.4	%
Activity				Toxic
Activity				Toxic

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Cyclin-dependent kinase 2

External ID: CHEMBL666137

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2002
Volume: 12
Issue: 7
First Page: 1129
Last Page: 1132
DOI: 10.1016/s0960-894x(02)00094-x

Target ChEMBL ID: CHEMBL301
ChEMBL Target Name: Cyclin-dependent kinase 2
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	62	%
Inhibition	=	47	%
Inhibition	=	37	%
Inhibition	=	29	%
Inhibition	=	65	%
Inhibition	=	20	%
Inhibition	=	6	%
Inhibition	=	12	%
Inhibition	=	46	%
Inhibition	=	43	%
Inhibition	=	2	%
Inhibition	=	55	%
Inhibition	=	39	%
Inhibition	=	4	%
Inhibition	=	48	%
Inhibition	=	11	%
Inhibition	=	30	%
Inhibition	=	44	%
Inhibition	=	31	%
Inhibition	=	13	%

3589-72-8 靶点实验数据