HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NACHT, LRR and PYD domains-containing protein 3

External ID: CHEMBL4324159

Protocol: N/A

Comment: Journal: Eur J Med Chem
Year: 2020
Volume: 185
First Page: 111822
Last Page: 111822
DOI: 10.1016/j.ejmech.2019.111822

Target ChEMBL ID: CHEMBL1741208
ChEMBL Target Name: NACHT, LRR and PYD domains-containing protein 3
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	30	%
Inhibition	=	30	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL5634866

Protocol: N/A

Comment: Journal: Eur J Med Chem
Year: 2023
Volume: 259
First Page: 115718
Last Page: 115718
DOI: 10.1016/j.ejmech.2023.115718

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	30	%
Activity	=	30	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：HUVEC

External ID: CHEMBL3587104

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2015
Volume: 23
Issue: 13
First Page: 3774
Last Page: 3780
DOI: 10.1016/j.bmc.2015.03.085

Target ChEMBL ID: CHEMBL613979
ChEMBL Target Name: HUVEC
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	0	%
Inhibition	=	0	%
Inhibition	=	4	%
Inhibition	=	7	%
Inhibition	=	2	%
Inhibition	=	7	%
Inhibition	=	50	%
Inhibition	=	7	%
Inhibition	=	0	%
Inhibition	=	8	%
Inhibition	=	7	%
Inhibition	=	3	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Methionine aminopeptidase

External ID: CHEMBL865845

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2006
Volume: 49
Issue: 2
First Page: 511
Last Page: 522
DOI: 10.1021/jm050476z

Target ChEMBL ID: CHEMBL3423
ChEMBL Target Name: Methionine aminopeptidase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Standard Type	Standard Units	Activity Comment
Inhibition	%	Not Active
Inhibition	%	Not Active
Inhibition	%	Not Active
Inhibition	%	Not Active
Inhibition	%	Not Active
Inhibition	%	Not Active
Inhibition	%	Not Active
Inhibition	%	Not Active
Inhibition	%	Not Active
Inhibition	%	Not Active
Inhibition	%	Not Active
Inhibition	%	Not Active
Inhibition	%	Not Active
Inhibition	%	Not Active
Inhibition	%	Not Active
Inhibition	%	Not Active
Inhibition	%	Not Active
Inhibition	%	Not Active
Inhibition	%	Not Active
Inhibition	%	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：HUVEC

External ID: CHEMBL3587105

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2015
Volume: 23
Issue: 13
First Page: 3774
Last Page: 3780
DOI: 10.1016/j.bmc.2015.03.085

Target ChEMBL ID: CHEMBL613979
ChEMBL Target Name: HUVEC
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	11	%
Inhibition	=	3	%
Inhibition	=	46	%
Inhibition	=	30	%
Inhibition	=	28	%
Inhibition	=	53	%
Inhibition	=	58	%
Inhibition	=	0	%
Inhibition	=	0	%
Inhibition	=	0	%
Inhibition	=	38	%
Inhibition	=	19	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Methionine aminopeptidase

External ID: CHEMBL865844

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2006
Volume: 49
Issue: 2
First Page: 511
Last Page: 522
DOI: 10.1021/jm050476z

Target ChEMBL ID: CHEMBL3423
ChEMBL Target Name: Methionine aminopeptidase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
10	IC50	>	10000	nM
0.574	IC50	=	574	nM
10	IC50	>	10000	nM
1.695	IC50	=	1695	nM
2.086	IC50	=	2086	nM
1.343	IC50	=	1343	nM
0.992	IC50	=	992	nM
0.777	IC50	=	777	nM
0.461	IC50	=	461	nM
10	IC50	>	10000	nM
10	IC50	>	10000	nM
10	IC50	>	10000	nM
8.956	IC50	=	8956	nM
0.54	IC50	=	540	nM
0.24	IC50	=	240	nM
0.376	IC50	=	376	nM
3.906	IC50	=	3906	nM
2.433	IC50	=	2433	nM
0.967	IC50	=	967	nM
4.307	IC50	=	4307	nM

3575-05-1 靶点实验数据