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3563-27-7 靶点实验数据

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:Estrogen receptor beta
External ID: CHEMBL679678
Protocol: N/A
Comment: Journal: J. Med. Chem.
Year: 1997
Volume: 40
Issue: 22
First Page: 3659
Last Page: 3669
DOI: 10.1021/jm9703294

Target ChEMBL ID: CHEMBL2093866
ChEMBL Target Name: Estrogen receptor
ChEMBL Target Type: PROTEIN FAMILY - Target is a group of closely related proteins
Relationship Type: H - Homologous protein target assigned
Confidence: Multiple homologous protein targets may be assigned
Standard TypeStandard RelationStandard ValueStandard Units
Ka=3700000000M-1
Ka=18000000M-1
Ka=1520000000M-1
Ka=2850000000M-1
Ka<1850000M-1
Ka=614000000M-1
Ka=821000000M-1
Ka=70000000M-1
Ka=1090000000M-1
Ka=2930000000M-1
Ka=807000000M-1
Ka=3700000M-1
Ka=2600000000M-1
Ka=88800000M-1
Ka=211000000M-1
Ka=2970000000M-1
Ka=410000000M-1
Ka=62200000M-1
Ka=21500000M-1
Ka=63000000M-1
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:MCF7
External ID: CHEMBL710197
Protocol: N/A
Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 1997
Volume: 40
Issue: 22
First Page: 3659
Last Page: 3669
DOI: 10.1021/jm9703294

Target ChEMBL ID: CHEMBL387
ChEMBL Target Name: MCF7
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular
PubChem Standard ValueStandard TypeStandard RelationStandard ValueStandard UnitsData Validity Comment
1.54E-6EC50=0.00154nMOutside typical range
4.19E-6EC50=0.00419nMOutside typical range
0.00141EC50=1.41nM
9.9E-5EC50=0.099nM
5.71E-5EC50=0.0571nM
3.38E-6EC50=0.00338nMOutside typical range
1.18E-4EC50=0.118nM
3.82E-4EC50=0.382nM
0.0335EC50=33.5nM
0.0604EC50=60.4nM
0.00897EC50=8.97nM
3.3E-5EC50=0.033nM
0.0342EC50=34.2nM
0.0284EC50=28.4nM
1.6E-5EC50=0.016nM
3.16E-4EC50=0.316nM
0.00159EC50=1.59nM
0.00167EC50=1.67nM
0.00216EC50=2.16nM
3.65E-5EC50=0.0365nM
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:Sex hormone-binding globulin
External ID: CHEMBL922711
Protocol: N/A
Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2008
Volume: 51
Issue: 7
First Page: 2047
Last Page: 2056
DOI: 10.1021/jm7011485

Target ChEMBL ID: CHEMBL3305
ChEMBL Target Name: Testis-specific androgen-binding protein
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned
PubChem Standard ValueStandard TypeStandard RelationStandard ValueStandard Units
0.03467Kd=34.67nM
4.7863Kd=4786.3nM
0.11482Kd=114.82nM
0.001479Kd=1.479nM
0.15488Kd=154.88nM
0.63096Kd=630.96nM
1.14815Kd=1148.15nM
0.50119Kd=501.19nM
6.761E-4Kd=0.6761nM
8.318E-4Kd=0.8318nM
0.07079Kd=70.79nM
0.70795Kd=707.95nM
0.1Kd=100nM
0.01445Kd=14.45nM
0.00309Kd=3.09nM
0.45709Kd=457.09nM
0.01072Kd=10.72nM
0.002399Kd=2.399nM
7.762E-4Kd=0.7762nM
1.20226Kd=1202.26nM
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7
External ID: CHEMBL1106725
Protocol: N/A
Comment: Journal: J. Med. Chem.
Year: 2009
Volume: 52
Issue: 23
First Page: 7488
Last Page: 7502
DOI: 10.1021/jm900921c

Target ChEMBL ID: CHEMBL5999
ChEMBL Target Name: 3-keto-steroid reductase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned
Standard TypeStandard RelationStandard ValueStandard Units
Inhibition=3%
Inhibition=0%
Inhibition=8.2%
Inhibition=3.2%
Inhibition=7.3%
Inhibition=19.1%
Inhibition=5.1%
Inhibition=0%
Inhibition=3.4%
Inhibition=5.4%
Inhibition=29.7%
Inhibition=2.3%
Inhibition=10.8%
Inhibition=4.2%
Inhibition=0%
Inhibition=2.2%
Inhibition=4.5%
Inhibition=20.8%
Inhibition=12.1%
Inhibition=0%
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7
External ID: CHEMBL1106724
Protocol: N/A
Comment: Journal: J. Med. Chem.
Year: 2009
Volume: 52
Issue: 23
First Page: 7488
Last Page: 7502
DOI: 10.1021/jm900921c

Target ChEMBL ID: CHEMBL5999
ChEMBL Target Name: 3-keto-steroid reductase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned
Standard TypeStandard RelationStandard ValueStandard UnitsActivity Comment
InhibitionNot Determined
Inhibition=0%
InhibitionNot Determined
Inhibition=8.9%
Inhibition=14.4%
Inhibition=7.3%
Inhibition=6.8%
Inhibition=1.1%
Inhibition=8.3%
Inhibition=3.7%
InhibitionNot Determined
Inhibition=5.5%
Inhibition=18.6%
Inhibition=3.1%
Inhibition=0%
InhibitionNot Determined
InhibitionNot Determined
InhibitionNot Determined
Inhibition=5.7%
InhibitionNot Determined
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:17-beta-hydroxysteroid dehydrogenase type 1
External ID: CHEMBL914640
Protocol: N/A
Comment: Journal: Bioorg. Med. Chem.
Year: 2007
Volume: 15
Issue: 2
First Page: 714
Last Page: 726
DOI: 10.1016/j.bmc.2006.10.055

Target ChEMBL ID: CHEMBL3181
ChEMBL Target Name: Estradiol 17-beta-dehydrogenase 1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned
Standard TypeActivity Comment
ActivityNot Active
ActivityNot Active
ActivityNot Active
ActivityNot Active